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FI971202L - Levobupivakaiinin ja sen analogien valmistuksessa käytettäviä menetelmiä rasemisoinnin ja asymmetrisen muuntamisen tekemiseksi - Google Patents

Levobupivakaiinin ja sen analogien valmistuksessa käytettäviä menetelmiä rasemisoinnin ja asymmetrisen muuntamisen tekemiseksi Download PDF

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Publication number
FI971202L
FI971202L FI971202A FI971202A FI971202L FI 971202 L FI971202 L FI 971202L FI 971202 A FI971202 A FI 971202A FI 971202 A FI971202 A FI 971202A FI 971202 L FI971202 L FI 971202L
Authority
FI
Finland
Prior art keywords
levobupivacaine
racemization
analogues
preparation
methods
Prior art date
Application number
FI971202A
Other languages
English (en)
Swedish (sv)
Other versions
FI971202A0 (fi
FI117436B (fi
Inventor
Ulrich Conrad Dyer
Christopher James Lock
Martin Woods
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9504927.6A external-priority patent/GB9504927D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Publication of FI971202L publication Critical patent/FI971202L/fi
Publication of FI971202A0 publication Critical patent/FI971202A0/fi
Application granted granted Critical
Publication of FI117436B publication Critical patent/FI117436B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measurement Of Radiation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI971202A 1994-09-23 1997-03-21 Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi FI117436B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP94306962 1994-09-23
EP94306962 1994-09-23
GBGB9504927.6A GB9504927D0 (en) 1995-03-10 1995-03-10 Racemisation and asymmetric transformation
GB9504927 1995-03-10
PCT/GB1995/002247 WO1996009290A1 (en) 1994-09-23 1995-09-22 Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
GB9502247 1995-09-22

Publications (3)

Publication Number Publication Date
FI971202L true FI971202L (fi) 1997-03-21
FI971202A0 FI971202A0 (fi) 1997-03-21
FI117436B FI117436B (fi) 2006-10-13

Family

ID=26137306

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971202A FI117436B (fi) 1994-09-23 1997-03-21 Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi

Country Status (18)

Country Link
US (1) US5786484A (fi)
EP (1) EP0782569B1 (fi)
JP (1) JP3898220B2 (fi)
KR (1) KR100393133B1 (fi)
CN (1) CN1104416C (fi)
AT (1) ATE214695T1 (fi)
AU (1) AU695479B2 (fi)
CA (1) CA2200490C (fi)
DE (1) DE69525950T2 (fi)
DK (1) DK0782569T3 (fi)
ES (1) ES2173194T3 (fi)
FI (1) FI117436B (fi)
HU (1) HU216291B (fi)
MX (1) MX9702210A (fi)
NO (1) NO308074B1 (fi)
PL (1) PL183204B1 (fi)
PT (1) PT782569E (fi)
WO (1) WO1996009290A1 (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384227B2 (en) 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
JP2000256359A (ja) * 1999-03-11 2000-09-19 Japan Science & Technology Corp 面性キラリティーを有する分子群の高選択的不斉変換法
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
BR0002246A (pt) * 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
US6962998B2 (en) 2000-06-14 2005-11-08 Toray Industries, Inc. Processes for producing racemic piperidine derivative and for producing optically active piperidine derivative
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE482695T1 (de) * 2002-12-13 2010-10-15 Durect Corp Orale darreichungsform mit flüssigen hochviskosen trägersystemen
RS52198B (en) * 2004-09-17 2012-10-31 Durect Corporation LOCAL ANESTHETIC SOLUTION CONTAINING SAIB SUSTAINABLE ACTION
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
CA2706658A1 (en) 2007-12-06 2009-06-18 Durect Corporation Methods useful for the treatment of pain, arthritic conditions or inflammation associated with a chronic condition
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
AU2014233453A1 (en) 2013-03-15 2015-10-01 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
CN103664744B (zh) * 2013-11-30 2015-07-15 山东永泰化工有限公司 一种左布比卡因的制备方法
BR112020023559A2 (pt) * 2018-05-18 2021-02-09 Kura Oncology, Inc. método para preparar um enantiômero de tipifarnib desejado e método para transformar uma amina enantiomericamente enriquecida
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Also Published As

Publication number Publication date
FI971202A0 (fi) 1997-03-21
CN1159184A (zh) 1997-09-10
JPH10505855A (ja) 1998-06-09
PL183204B1 (pl) 2002-06-28
MX9702210A (es) 1998-05-31
WO1996009290A1 (en) 1996-03-28
HUT77055A (hu) 1998-03-02
NO308074B1 (no) 2000-07-17
JP3898220B2 (ja) 2007-03-28
PL319368A1 (en) 1997-08-04
AU3527995A (en) 1996-04-09
KR100393133B1 (ko) 2003-11-17
EP0782569A1 (en) 1997-07-09
ES2173194T3 (es) 2002-10-16
ATE214695T1 (de) 2002-04-15
DE69525950D1 (de) 2002-04-25
HU216291B (hu) 1999-06-28
NO971358D0 (no) 1997-03-21
EP0782569B1 (en) 2002-03-20
US5786484A (en) 1998-07-28
FI117436B (fi) 2006-10-13
CA2200490C (en) 2007-01-09
NO971358L (no) 1997-03-21
CN1104416C (zh) 2003-04-02
DE69525950T2 (de) 2002-09-19
PT782569E (pt) 2002-09-30
AU695479B2 (en) 1998-08-13
CA2200490A1 (en) 1996-03-28
DK0782569T3 (da) 2002-07-22

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