FI96422B - Asymmetrisk syntes av furo/3,4-c/pyridinderivat - Google Patents
Asymmetrisk syntes av furo/3,4-c/pyridinderivat Download PDFInfo
- Publication number
- FI96422B FI96422B FI903735A FI903735A FI96422B FI 96422 B FI96422 B FI 96422B FI 903735 A FI903735 A FI 903735A FI 903735 A FI903735 A FI 903735A FI 96422 B FI96422 B FI 96422B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- acid
- racemic
- process according
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (6)
1. Förfarande för framställning av en förening med den allraänna formeIn I -0 HO. X. X. n Ri I i icke-racemisk form (dvs. som en enda enantiomer eller enantio-merblandning, där den ena enantiomeren är förhärskande), i vilken forme1 Rx är en fenylgrupp, som kan vara substituerad med en eller flera halogenatomer; R2 är väte eller en halogenatom; och R3 är en rakkedig eller förgrenad alkylgrupp, med högst 6 kolato-mer, kännetecknat därav, att en koncentrerad stark syra tillsätts en blandning av en icke-racemisk förening med den allmänna formeln II V°\ OH II | H 1 R3 N \R2 där Rx, R2 och R3 avser det samma som i det ta krav, i en mängd som är tillräcklig för att katalysera en deprotektions/cyklo-dehydratiseringsreaktion. Λ , . tll.i «Iti IIIB · 96422'
2. Förfarande enligt patentkravet 1, kännetecknat därav, att föreningens II loaning är en loaning, där löaninga-medlet med vatten bildar en azeotrop.
3. Förfarande enligt patentkravet 2, kännetecknat därav, att lösningsmedlet är bensen, toluen, etylacetat eller kloroform.
4. Förfarande enligt nägot av föregäende patentkraven, kännetecknat därav, att den atarka syran är aaltay-ra, avavelayra, perklorayra eller trifluorättiksyra.
5. Förfarande enligt nägot av föregäende patentkraven, kännetecknat därav, att föreningen II renats genom kriatalliaation ur alkohol eller etylacetat för upplöaningen.
6. Förfarande enligt nägot av föregäende patentkraven, kännetecknat därav, att föreningen I tillvarataa ur reaktionablandningen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8917168 | 1989-07-27 | ||
| GB898917168A GB8917168D0 (en) | 1989-07-27 | 1989-07-27 | Asymmetric synthesis of furo(3,4-c)pyridine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI903735A0 FI903735A0 (sv) | 1990-07-26 |
| FI96422B true FI96422B (sv) | 1996-03-15 |
| FI96422C FI96422C (sv) | 1996-06-25 |
Family
ID=10660707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI903735A FI96422C (sv) | 1989-07-27 | 1990-07-26 | Asymmetrisk syntes av furo/3,4-c/pyridinderivat |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5043448A (sv) |
| JP (1) | JP2705840B2 (sv) |
| KR (1) | KR910002859A (sv) |
| AT (1) | AT399151B (sv) |
| AU (1) | AU633122B2 (sv) |
| BE (1) | BE1004520A3 (sv) |
| CA (1) | CA2021737C (sv) |
| CH (1) | CH681983A5 (sv) |
| DE (1) | DE4023980C2 (sv) |
| DK (1) | DK177790A (sv) |
| DZ (1) | DZ1435A1 (sv) |
| ES (1) | ES2023758A6 (sv) |
| FI (1) | FI96422C (sv) |
| FR (1) | FR2650278B1 (sv) |
| GB (2) | GB8917168D0 (sv) |
| GR (1) | GR1000880B (sv) |
| HK (1) | HK57893A (sv) |
| IE (1) | IE64439B1 (sv) |
| IN (1) | IN175580B (sv) |
| IT (1) | IT1243375B (sv) |
| LU (1) | LU87776A1 (sv) |
| MA (1) | MA21919A1 (sv) |
| MY (1) | MY106738A (sv) |
| NL (1) | NL9001612A (sv) |
| NO (1) | NO174150C (sv) |
| NZ (1) | NZ234568A (sv) |
| OA (1) | OA09221A (sv) |
| PT (1) | PT94836B (sv) |
| SE (1) | SE509680C2 (sv) |
| SG (1) | SG57593G (sv) |
| TN (1) | TNSN90108A1 (sv) |
| ZA (1) | ZA905777B (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5130252A (en) * | 1990-05-14 | 1992-07-14 | Synthetech, Inc. | Resolution of furopyridine enantiomers and synthetic precursors thereof |
| GB0221494D0 (en) * | 2002-09-16 | 2002-10-23 | Generics Uk Ltd | Novel processes for the preparation of 1.3-dihydro-6-methylfuro (3,4-c) pyndin derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2008582B (en) * | 1977-11-25 | 1982-04-28 | Scras | Pyridine derivative |
| IN156817B (sv) * | 1981-02-10 | 1985-11-09 | Scras | |
| IN160104B (sv) * | 1983-04-05 | 1987-06-27 | Scras | |
| GB8327817D0 (en) * | 1983-10-18 | 1983-11-16 | Scras | 4-halo-furo-(3 4-c)-pyridine derivatives |
| GB8330517D0 (en) * | 1983-11-16 | 1983-12-21 | Scras | 6-vinyl-furo-(3,4-c)pyridine derivatives |
| GB2153824B (en) * | 1984-02-02 | 1987-04-01 | Scras | Furo-(3,4-c)-pyridine derivatives |
| GB8808001D0 (en) * | 1988-04-06 | 1988-05-05 | Scras | Stereospecific preparative process for furol(3,4-c)pyridine derivatives |
-
1989
- 1989-07-27 GB GB898917168A patent/GB8917168D0/en active Pending
-
1990
- 1990-07-16 NL NL9001612A patent/NL9001612A/nl active Search and Examination
- 1990-07-18 IN IN727DE1990 patent/IN175580B/en unknown
- 1990-07-18 GR GR900100556A patent/GR1000880B/el not_active IP Right Cessation
- 1990-07-19 NZ NZ234568A patent/NZ234568A/xx unknown
- 1990-07-23 ZA ZA905777A patent/ZA905777B/xx unknown
- 1990-07-23 AT AT0154490A patent/AT399151B/de not_active IP Right Cessation
- 1990-07-23 GB GB9016126A patent/GB2234244B/en not_active Expired - Fee Related
- 1990-07-23 CA CA002021737A patent/CA2021737C/en not_active Expired - Fee Related
- 1990-07-25 DZ DZ900136A patent/DZ1435A1/fr active
- 1990-07-26 SE SE9002508A patent/SE509680C2/sv not_active IP Right Cessation
- 1990-07-26 DK DK177790A patent/DK177790A/da not_active Application Discontinuation
- 1990-07-26 AU AU59813/90A patent/AU633122B2/en not_active Ceased
- 1990-07-26 KR KR1019900011369A patent/KR910002859A/ko not_active Application Discontinuation
- 1990-07-26 US US07/557,975 patent/US5043448A/en not_active Expired - Lifetime
- 1990-07-26 NO NO903329A patent/NO174150C/no unknown
- 1990-07-26 LU LU87776A patent/LU87776A1/fr unknown
- 1990-07-26 JP JP2196391A patent/JP2705840B2/ja not_active Expired - Fee Related
- 1990-07-26 FI FI903735A patent/FI96422C/sv not_active IP Right Cessation
- 1990-07-26 CH CH2482/90A patent/CH681983A5/fr not_active IP Right Cessation
- 1990-07-26 MA MA22189A patent/MA21919A1/fr unknown
- 1990-07-26 ES ES9002020A patent/ES2023758A6/es not_active Expired - Lifetime
- 1990-07-26 IE IE271990A patent/IE64439B1/en not_active IP Right Cessation
- 1990-07-27 MY MYPI90001266A patent/MY106738A/en unknown
- 1990-07-27 DE DE4023980A patent/DE4023980C2/de not_active Expired - Lifetime
- 1990-07-27 FR FR909009597A patent/FR2650278B1/fr not_active Expired - Lifetime
- 1990-07-27 TN TNTNSN90108A patent/TNSN90108A1/fr unknown
- 1990-07-27 PT PT94836A patent/PT94836B/pt not_active IP Right Cessation
- 1990-07-27 BE BE9000751A patent/BE1004520A3/fr not_active IP Right Cessation
- 1990-07-27 OA OA59825A patent/OA09221A/xx unknown
- 1990-07-27 IT IT02109390A patent/IT1243375B/it active IP Right Grant
-
1993
- 1993-05-04 SG SG575/93A patent/SG57593G/en unknown
- 1993-06-17 HK HK578/93A patent/HK57893A/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: SOCIETE DE CONSEILS DE RECHERCHES ET D APPLICATION |