FI962022L - 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents - Google Patents
5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents Download PDFInfo
- Publication number
- FI962022L FI962022L FI962022A FI962022A FI962022L FI 962022 L FI962022 L FI 962022L FI 962022 A FI962022 A FI 962022A FI 962022 A FI962022 A FI 962022A FI 962022 L FI962022 L FI 962022L
- Authority
- FI
- Finland
- Prior art keywords
- protease inhibitors
- antiviral agents
- dihydropyrone derivatives
- dihydropyrone
- derivatives
- Prior art date
Links
- QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15544393A | 1993-11-19 | 1993-11-19 | |
| US08/319,820 US5840751A (en) | 1993-11-19 | 1994-10-12 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
| PCT/US1994/012269 WO1995014012A1 (en) | 1993-11-19 | 1994-10-26 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI962022A0 FI962022A0 (en) | 1996-05-13 |
| FI962022L true FI962022L (en) | 1996-07-12 |
Family
ID=26852338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI962022A FI962022L (en) | 1993-11-19 | 1996-05-13 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0729464A1 (en) |
| JP (1) | JP3684426B2 (en) |
| AT (1) | ATE263761T1 (en) |
| AU (1) | AU689158B2 (en) |
| CA (1) | CA2176043A1 (en) |
| DE (1) | DE69433705T2 (en) |
| DK (1) | DK1142887T3 (en) |
| ES (1) | ES2219457T3 (en) |
| FI (1) | FI962022L (en) |
| HR (1) | HRP940935B1 (en) |
| HU (1) | HUT77668A (en) |
| IL (1) | IL111674A0 (en) |
| NO (1) | NO316172B1 (en) |
| NZ (1) | NZ275961A (en) |
| PT (1) | PT1142887E (en) |
| RU (1) | RU2140917C1 (en) |
| SI (1) | SI1142887T1 (en) |
| WO (1) | WO1995014012A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69627397T2 (en) * | 1995-08-11 | 2003-12-04 | Zenon Environmental Inc., Oakville | System for permeate removal from a liquid substrate with several components |
| US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| ATE266654T1 (en) | 1997-09-11 | 2004-05-15 | Upjohn Co | METHOD FOR PRODUCING 4-HYDROXY-2-OXO-PYRANE DERIVATIVES USED AS PROTEASE INHIBITORS |
| NZ510013A (en) * | 1998-09-11 | 2003-11-28 | Warner Lambert Co | Dihydropyrones with selected heterocycles replacing the phenyls bearing polar substituents used as HIV protease inhibitors |
| US6288235B1 (en) | 1999-04-14 | 2001-09-11 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries |
| DE10030094A1 (en) * | 2000-06-19 | 2001-12-20 | Bayer Ag | New phenyl-substituted 5,6-dihydro-pyrone derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| DE10108471C1 (en) | 2001-02-22 | 2002-11-21 | Boehringer Ingelheim Pharma | Continuous process for the preparation of 5,6-dihydro-4-hydroxy-2-pyrones |
| DE10108470A1 (en) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Process for the production of optically active dihydropyrones |
| US7141681B2 (en) | 2001-02-22 | 2006-11-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Continuous process for preparing dihydropyrones |
| US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| DOP2003000641A (en) | 2002-05-10 | 2003-11-15 | Pfizer | INHIBITORS OF RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUSES AND COMPOSITIONS AND TREATMENT USED |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| PL1781662T3 (en) | 2004-08-18 | 2011-08-31 | Pfizer | Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same |
| DE102005059469A1 (en) | 2005-12-13 | 2007-06-14 | Bayer Cropscience Ag | Insecticidal compositions having improved activity |
| DE102006007882A1 (en) | 2006-02-21 | 2007-08-30 | Bayer Cropscience Ag | New cyclic keto enol derivatives useful for controlling animal pests and/or unwanted plant growth |
| CA2654334C (en) * | 2006-06-16 | 2014-06-10 | Pharma Mar, S.A. | Antitumoral dihydropyran-2-one compounds |
| CA2754847C (en) | 2009-03-11 | 2017-07-11 | Bayer Cropscience Ag | Halogenalkylmethylenoxy-phenyl-substituted ketoenols |
| DE102010008644A1 (en) | 2010-02-15 | 2011-08-18 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Cyclic ketoenols for therapy |
| RU2461555C1 (en) * | 2011-07-07 | 2012-09-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | Method of producing 5-aryl-3-phenyl-2-oxaspiro[5,6]dodec-3-en-1-ones, exhibiting analgesic activity |
| MY172133A (en) | 2012-01-26 | 2019-11-14 | Bayer Ip Gmbh | Phenyl-substituted ketoenols for controlling fish parasites |
| US9758502B2 (en) | 2012-11-28 | 2017-09-12 | Sumitomo Chemical Company, Limited | Dihydropyrone compounds and herbicides comprising the same |
| SE539512C2 (en) | 2015-12-02 | 2017-10-03 | Ultupharma Ab | Compounds and methods of treating bacterial infections |
| CN115916752A (en) * | 2020-06-26 | 2023-04-04 | 日本农药株式会社 | Aryltetrahydropyridine derivatives or salts thereof, and pesticides containing the same and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3818046A (en) * | 1972-12-18 | 1974-06-18 | Dow Chemical Co | Sulfur-containing hydroxy pyrones and alkali metal salts thereof |
| ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
-
1994
- 1994-10-26 HU HU9601348A patent/HUT77668A/en not_active Application Discontinuation
- 1994-10-26 PT PT01114943T patent/PT1142887E/en unknown
- 1994-10-26 SI SI9430463T patent/SI1142887T1/en unknown
- 1994-10-26 DK DK01114943T patent/DK1142887T3/en active
- 1994-10-26 EP EP95900429A patent/EP0729464A1/en not_active Withdrawn
- 1994-10-26 JP JP51445895A patent/JP3684426B2/en not_active Expired - Fee Related
- 1994-10-26 CA CA002176043A patent/CA2176043A1/en not_active Abandoned
- 1994-10-26 ES ES01114943T patent/ES2219457T3/en not_active Expired - Lifetime
- 1994-10-26 WO PCT/US1994/012269 patent/WO1995014012A1/en not_active Application Discontinuation
- 1994-10-26 DE DE69433705T patent/DE69433705T2/en not_active Expired - Fee Related
- 1994-10-26 AU AU81256/94A patent/AU689158B2/en not_active Ceased
- 1994-10-26 AT AT01114943T patent/ATE263761T1/en not_active IP Right Cessation
- 1994-10-26 RU RU96113098/04A patent/RU2140917C1/en not_active IP Right Cessation
- 1994-10-26 NZ NZ275961A patent/NZ275961A/en unknown
- 1994-11-17 HR HR940935A patent/HRP940935B1/en not_active IP Right Cessation
- 1994-11-17 IL IL11167494A patent/IL111674A0/en unknown
-
1996
- 1996-05-13 FI FI962022A patent/FI962022L/en unknown
- 1996-05-15 NO NO19962017A patent/NO316172B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO962017D0 (en) | 1996-05-15 |
| ES2219457T3 (en) | 2004-12-01 |
| FI962022A0 (en) | 1996-05-13 |
| PT1142887E (en) | 2004-08-31 |
| DE69433705T2 (en) | 2005-03-10 |
| RU2140917C1 (en) | 1999-11-10 |
| EP0729464A1 (en) | 1996-09-04 |
| JPH09505294A (en) | 1997-05-27 |
| DE69433705D1 (en) | 2004-05-13 |
| HUT77668A (en) | 1998-07-28 |
| NO316172B1 (en) | 2003-12-22 |
| AU8125694A (en) | 1995-06-06 |
| CA2176043A1 (en) | 1995-05-26 |
| NO962017L (en) | 1996-07-08 |
| SI1142887T1 (en) | 2004-08-31 |
| WO1995014012A1 (en) | 1995-05-26 |
| JP3684426B2 (en) | 2005-08-17 |
| HRP940935B1 (en) | 2004-08-31 |
| NZ275961A (en) | 2001-11-30 |
| HRP940935A2 (en) | 1997-04-30 |
| DK1142887T3 (en) | 2004-06-21 |
| HU9601348D0 (en) | 1996-07-29 |
| ATE263761T1 (en) | 2004-04-15 |
| IL111674A0 (en) | 1995-01-24 |
| AU689158B2 (en) | 1998-03-26 |
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