[go: up one dir, main page]

FI961219A0 - Kemialliset yhdisteet, niiden valmistus ja käyttö - Google Patents

Kemialliset yhdisteet, niiden valmistus ja käyttö

Info

Publication number
FI961219A0
FI961219A0 FI961219A FI961219A FI961219A0 FI 961219 A0 FI961219 A0 FI 961219A0 FI 961219 A FI961219 A FI 961219A FI 961219 A FI961219 A FI 961219A FI 961219 A0 FI961219 A0 FI 961219A0
Authority
FI
Finland
Prior art keywords
preparation
chemical compounds
compounds
chemical
Prior art date
Application number
FI961219A
Other languages
English (en)
Swedish (sv)
Other versions
FI961219A (fi
Inventor
Jesper Lau
Lars Jacob Stray Knutsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK104393A external-priority patent/DK104393D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI961219A0 publication Critical patent/FI961219A0/fi
Publication of FI961219A publication Critical patent/FI961219A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI961219A 1993-09-17 1996-03-15 Kemialliset yhdisteet, niiden valmistus ja käyttö FI961219A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK104393A DK104393D0 (da) 1993-09-17 1993-09-17 Kemiske forbindelser, deres fremstilling og anvendelse
DK31094 1994-03-16
PCT/DK1994/000344 WO1995007921A1 (en) 1993-09-17 1994-09-15 Chemical compounds, their preparation and use

Publications (2)

Publication Number Publication Date
FI961219A0 true FI961219A0 (fi) 1996-03-15
FI961219A FI961219A (fi) 1996-05-15

Family

ID=26063751

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961219A FI961219A (fi) 1993-09-17 1996-03-15 Kemialliset yhdisteet, niiden valmistus ja käyttö

Country Status (10)

Country Link
US (1) US5589467A (fi)
EP (1) EP0719275A1 (fi)
JP (1) JPH11511436A (fi)
AU (1) AU678053B2 (fi)
CA (1) CA2171940A1 (fi)
FI (1) FI961219A (fi)
IL (1) IL110992A0 (fi)
NO (1) NO961071L (fi)
NZ (1) NZ273284A (fi)
WO (1) WO1995007921A1 (fi)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033590A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033591A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
GB9610031D0 (en) * 1996-05-14 1996-07-17 Glaxo Group Ltd Chemical compounds
WO1998016539A1 (en) * 1996-10-14 1998-04-23 Novo Nordisk A/S Novel therapeutically active adenosine derivatives
US6110902A (en) * 1997-06-23 2000-08-29 Moehler; Hanns Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
GB9723590D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
GB9723589D0 (en) 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
US6605597B1 (en) 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6576620B2 (en) * 1999-12-03 2003-06-10 Cv Therapeutics, Inc. Method of identifying partial adenosine A1 receptor agonists
GB2372742A (en) * 2001-03-03 2002-09-04 Univ Leiden C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses
US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
US7265111B2 (en) 2002-06-27 2007-09-04 Sanofi-Aventis Deutschland Gmbh Adenosine analogues and their use as pharmaceutical agents
CN100480255C (zh) * 2002-08-15 2009-04-22 Cv医药有限公司 A1腺苷受体的部分和完全激动剂
CA2567289C (en) * 2004-05-26 2013-12-31 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
RU2007114887A (ru) * 2004-09-20 2008-10-27 Инотек Фармасьютикалз Корпорейшн (Us) Производные пурина и способы их применения
BRPI0619261A2 (pt) * 2005-11-30 2011-09-27 Inotek Pharmaceuticals Corp derivados de purina e métodos de uso desses
CN101857622B (zh) * 2009-04-07 2014-12-03 中国医学科学院药物研究所 一种腺苷衍生物及其制备方法和应用
EP2523669B1 (en) 2010-01-11 2016-12-07 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
US8476247B2 (en) 2010-03-26 2013-07-02 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans
GB2494851A (en) 2011-07-07 2013-03-27 Kalvista Pharmaceuticals Ltd Plasma kallikrein inhibitors
DK2807178T3 (en) 2012-01-26 2017-09-04 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2R, 3S, 4R, 5R) -5- (6- (cyclopentylamino) -9H-purin-9-yl) -3,4-dihydroxytetrahydrofuran-2-yl) methyl nitrate and processes for their preparation
GB201212081D0 (en) 2012-07-06 2012-08-22 Kalvista Pharmaceuticals Ltd New polymorph
GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
IL239682B (en) 2013-01-08 2018-10-31 Kalvista Pharmaceuticals Ltd History of benzylamine and 2-(aminomethyl)pyridine
GB2510407A (en) 2013-02-04 2014-08-06 Kalvista Pharmaceuticals Ltd Aqueous suspensions of kallikrein inhibitors for parenteral administration
BR112015021870A2 (pt) 2013-03-15 2017-07-18 Inotek Pharmaceuticals Corp formulações oftálmicas
KR102276700B1 (ko) 2013-05-23 2021-07-12 칼비스타 파마슈티컬즈 리미티드 헤테로사이클릭 유도체
GB2517908A (en) 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
MX366498B (es) 2013-08-14 2019-07-11 Kalvista Pharmaceuticals Ltd Inhibidores de calicreina plasmatica.
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421088D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
BR112018074395A2 (pt) 2016-05-31 2019-03-06 Kalvista Pharmaceuticals Limited derivados de pirazol como inibidores de calicreína plasmática
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
SMT202200112T1 (it) 2017-11-29 2022-05-12 Kalvista Pharmaceuticals Ltd Forme di dosaggio comprendenti un inibitore della callicreina plasmatica
GB201910125D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of angioedema
GB201910116D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of hereditary angioedema
EP4010333A1 (en) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
GB2591730A (en) 2019-12-09 2021-08-11 Kalvista Pharmaceuticals Ltd New polymorphs
GB201918994D0 (en) 2019-12-20 2020-02-05 Kalvista Pharmaceuticals Ltd Treatments of diabetic macular edema and impaired visual acuity
WO2022079446A1 (en) 2020-10-15 2022-04-21 Kalvista Pharmaceuticals Limited Treatments of angioedema
WO2022084693A1 (en) 2020-10-23 2022-04-28 Kalvista Pharmaceuticals Limited Treatments of angioedema
US20240122909A1 (en) 2021-02-09 2024-04-18 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
WO2023002219A1 (en) 2021-07-23 2023-01-26 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
CN119095589A (zh) 2022-04-27 2024-12-06 卡尔维斯塔制药有限公司 血浆激肽释放酶抑制剂的制剂
WO2024180100A1 (en) 2023-02-27 2024-09-06 Kalvista Pharmaceuticals Limited New solid form of a plasma kallikrein inhibitor

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB131501A (fi) *
DE1545645A1 (de) * 1965-12-06 1969-08-21 Boehringer Mannheim Gmbh Verfahren zur Herstellung von disubstituierten Adenosin-Derivaten
JPS4935635B1 (fi) * 1970-12-28 1974-09-25
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
JPH0655756B2 (ja) * 1984-04-18 1994-07-27 ネルソン・リサ−チ・アンド・デベロツプメント・カンパニ− 心臓血管拡張薬としてのｎ−６置換アデノシン誘導体
AU575438B2 (en) * 1984-10-26 1988-07-28 Warner-Lambert Company N6 - substituted deoxyribose analogues of adenosines
CA1254888A (en) * 1984-10-26 1989-05-30 Bharat Trivedi N.sup.6-bicycloadenosines
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
JPH0696534B2 (ja) * 1986-04-25 1994-11-30 ヘキストジヤパン株式会社 抗痴呆剤
WO1988003147A1 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Selected n6-substituted adenosines having selective a2 binding activity
US4962194A (en) * 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
DE68916036T2 (de) * 1988-11-15 1994-09-29 Toa Eiyo Ltd Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
US5017578A (en) * 1989-06-09 1991-05-21 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
AU643235B2 (en) * 1989-09-15 1993-11-11 Gensia Pharmaceuticals, Inc. Methods of treating neurodegenerative conditions
IE903747A1 (en) * 1989-10-19 1991-04-24 Searle & Co Method of treating gastrointestinal motility disorders
IL99124A (en) * 1990-08-10 1998-02-22 Gensia Pharma Substituted imidazole analogs of aica riboside
US5308837A (en) * 1990-08-22 1994-05-03 Merrell Dow Pharmaceuticals Inc. 5'-amine substituted adenosine analogs as immunosuppressants
HUT61567A (en) * 1990-12-07 1993-01-28 Sandoz Ag Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
DK62692D0 (fi) * 1992-05-14 1992-05-14 Novo Nordisk As
DK62592D0 (fi) * 1992-05-14 1992-05-14 Novo Nordisk As
WO1994002497A1 (en) * 1992-07-15 1994-02-03 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Sulfo-derivatives of adenosine
AU4845193A (en) * 1992-09-11 1994-04-12 Regents Of The University Of California, The Adenosine analogues and method of increasing adenosine release

Also Published As

Publication number Publication date
EP0719275A1 (en) 1996-07-03
IL110992A0 (en) 1994-11-28
CA2171940A1 (en) 1995-03-23
AU678053B2 (en) 1997-05-15
NO961071L (no) 1996-05-15
FI961219A (fi) 1996-05-15
US5589467A (en) 1996-12-31
WO1995007921A1 (en) 1995-03-23
NZ273284A (en) 1997-03-24
NO961071D0 (no) 1996-03-15
JPH11511436A (ja) 1999-10-05
AU7651994A (en) 1995-04-03

Similar Documents

Publication Publication Date Title
FI961219A0 (fi) Kemialliset yhdisteet, niiden valmistus ja käyttö
FI102070B1 (fi) Uusi kompleksiyhdiste, sen valmistus ja käyttö
FI944310A (fi) Heteroaryyliamino- ja heteroaryylisuolfonamidosubstituoituja 3-bentsyyliaminometyylipiperidiinejä ja vastaavia yhdisteitä
FI922424A (fi) Kemiska foereningar
FI930620A (fi) Bensimidazolylderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning
FI955587A (fi) Kemialliset yhdisteet
FI951817A0 (fi) Orgonaluminoksituote, sen valmistus ja käyttö
FI972245A0 (fi) Meso-monojodisubstituoidut tetramakrosykliset yhdisteet sekä niiden valmistus- ja käyttömenetelmät
DK155292D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse
BR9402143A (pt) Composto, composição e uso
FI941914A0 (fi) 2-amino-4-kinoliinidihydropyridiinejä, menetelmiä niiden valmistamiseksi ja niiden käyttö
DK60593D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse
FI934221A0 (fi) Piperidinderivat, framstaellning och terapeutisk anvaendning daerav
FI925478A0 (fi) Haord, flexibel och haollbar arkitektonisk belaeggning
FI931682A (fi) Tackykininreceptorantagonister, isokinoloner och deras framstaellning
TR199501553A2 (tr) Sefem bilesimleri ve bunlarin farmasötik olarak kullanilmasi.
FI942468A0 (fi) Kemialliset yhdisteet, niiden valmistus ja käyttö
DK60693D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse
FI935132A (fi) Fenolisk resolfanerharts, foerfarande och tillverkning
DK60493D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse
FI932549A0 (fi) Haollfast, enhetligt, plastbaserat kompositmaterial och foerfaranden foerframstaellning daerav
DK71092D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse
DK155392D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse
DK86592D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse
DK93593D0 (da) Kemiske forbindelser, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
FD Application lapsed