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FI954898A - Vesiliukoiset kamptotesiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö kasvaintenvastaisina aineina - Google Patents

Vesiliukoiset kamptotesiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö kasvaintenvastaisina aineina Download PDF

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Publication number
FI954898A
FI954898A FI954898A FI954898A FI954898A FI 954898 A FI954898 A FI 954898A FI 954898 A FI954898 A FI 954898A FI 954898 A FI954898 A FI 954898A FI 954898 A FI954898 A FI 954898A
Authority
FI
Finland
Prior art keywords
preparation
water
camptothecin derivatives
antitumor agents
soluble camptothecin
Prior art date
Application number
FI954898A
Other languages
English (en)
Swedish (sv)
Other versions
FI954898A0 (fi
Inventor
Angelo Bedeschi
Franco Zarini
Walter Cabri
Ilaria Candiani
Sergio Penco
Laura Capolongo
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of FI954898A publication Critical patent/FI954898A/fi
Publication of FI954898A0 publication Critical patent/FI954898A0/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI954898A 1994-02-16 1995-10-13 Vesiliukoiset kamptotesiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö kasvaintenvastaisina aineina FI954898A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9402934A GB9402934D0 (en) 1994-02-16 1994-02-16 Camptothecin derivatives and process for their preparation
PCT/EP1995/000393 WO1995022549A1 (en) 1994-02-16 1995-02-03 Water-soluble camptothecin derivatives, process for their preparation and their use as antitumor agents

Publications (2)

Publication Number Publication Date
FI954898A true FI954898A (fi) 1995-10-13
FI954898A0 FI954898A0 (fi) 1995-10-13

Family

ID=10750430

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954898A FI954898A0 (fi) 1994-02-16 1995-10-13 Vesiliukoiset kamptotesiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö kasvaintenvastaisina aineina

Country Status (20)

Country Link
US (2) US5602141A (fi)
EP (1) EP0694035B1 (fi)
JP (1) JPH08509244A (fi)
KR (1) KR960701878A (fi)
CN (1) CN1123548A (fi)
AT (1) ATE220681T1 (fi)
AU (1) AU681941B2 (fi)
CA (1) CA2158855C (fi)
DE (1) DE69527400T2 (fi)
ES (1) ES2180625T3 (fi)
FI (1) FI954898A0 (fi)
GB (1) GB9402934D0 (fi)
HU (1) HUT73423A (fi)
IL (1) IL112622A (fi)
MX (1) MX9504287A (fi)
NO (1) NO954072L (fi)
NZ (1) NZ279813A (fi)
PL (1) PL311122A1 (fi)
WO (1) WO1995022549A1 (fi)
ZA (1) ZA951227B (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
GB9410388D0 (en) * 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
NZ533568A (en) 2001-11-30 2006-01-27 Chugai Pharmaceutical Co Ltd Condensed hexacyclic camptothecin compounds as antitumor agents
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
RU2413731C2 (ru) 2004-04-09 2011-03-10 Чугаи Сейяку Кабусики Кайся Новые растворимые в воде пролекарства
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
JP5126900B2 (ja) * 2009-02-24 2013-01-23 株式会社渡辺オイスター研究所 カキ肉エキス顆粒の製造方法。
CN101555250B (zh) * 2009-05-19 2011-05-18 重庆泰濠制药有限公司 盐酸拓扑替康的制备方法
AU2022282813A1 (en) * 2021-05-27 2023-11-30 Zymeworks Bc Inc. Camptothecin analogues, conjugates and methods of use
CN117547535A (zh) 2021-10-15 2024-02-13 昆山新蕴达生物科技有限公司 包含抗肿瘤药物的组合物及其制备方法和用途
AU2023239448A1 (en) * 2022-03-25 2024-11-07 Zymeworks Bc Inc. Antibody-drug conjugates targeting folate receptor alpha and methods of use
WO2024082055A1 (en) * 2022-10-19 2024-04-25 Zymeworks Bc Inc. Antibody-drug conjugates targeting napi2b and methods of use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
ATE211142T1 (de) * 1989-09-15 2002-01-15 Res Triangle Inst Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog
WO1991004260A2 (en) * 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
WO1992005785A1 (en) * 1990-09-28 1992-04-16 Smithkline Beecham Corporation Water soluble camptothecin analogues, processes and methods
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5342947A (en) * 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation

Also Published As

Publication number Publication date
ATE220681T1 (de) 2002-08-15
JPH08509244A (ja) 1996-10-01
IL112622A0 (en) 1995-05-26
DE69527400T2 (de) 2003-03-06
HUT73423A (en) 1996-07-29
GB9402934D0 (en) 1994-04-06
PL311122A1 (en) 1996-02-05
WO1995022549A1 (en) 1995-08-24
IL112622A (en) 1997-09-30
FI954898A0 (fi) 1995-10-13
NO954072D0 (no) 1995-10-13
DE69527400D1 (de) 2002-08-22
AU1705695A (en) 1995-09-04
MX9504287A (es) 1997-05-31
ES2180625T3 (es) 2003-02-16
CN1123548A (zh) 1996-05-29
CA2158855C (en) 2006-01-31
US5801167A (en) 1998-09-01
NO954072L (no) 1995-12-11
CA2158855A1 (en) 1995-08-24
KR960701878A (ko) 1996-03-28
ZA951227B (en) 1996-01-19
AU681941B2 (en) 1997-09-11
NZ279813A (en) 1996-10-28
EP0694035A1 (en) 1996-01-31
HU9503273D0 (en) 1996-01-29
US5602141A (en) 1997-02-11
EP0694035B1 (en) 2002-07-17

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: PHARMACIA & UPJOHN S.P.A.

FD Application lapsed