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FI945319A - Substituoidut indolit ja atsaindolit angiotensiini II:n antagonisteina - Google Patents

Substituoidut indolit ja atsaindolit angiotensiini II:n antagonisteina Download PDF

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Publication number
FI945319A
FI945319A FI945319A FI945319A FI945319A FI 945319 A FI945319 A FI 945319A FI 945319 A FI945319 A FI 945319A FI 945319 A FI945319 A FI 945319A FI 945319 A FI945319 A FI 945319A
Authority
FI
Finland
Prior art keywords
lower alkyl
hydrogen
angiotensin
antagonists
halogen
Prior art date
Application number
FI945319A
Other languages
English (en)
Swedish (sv)
Other versions
FI110512B (fi
FI945319A0 (fi
Inventor
Lawrence E Fisher
David E Clarke
Alam Jahangir
Robin D Clark
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/882,390 external-priority patent/US5212195A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI945319A publication Critical patent/FI945319A/fi
Publication of FI945319A0 publication Critical patent/FI945319A0/fi
Application granted granted Critical
Publication of FI110512B publication Critical patent/FI110512B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI945319A 1992-05-13 1994-11-11 Menetelmä angiotensiini II:n antagonisteina käyttökelpoisten substituoitujen indolien valmistamiseksi FI110512B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88239092 1992-05-13
US07/882,390 US5212195A (en) 1992-05-13 1992-05-13 Substituted indole antagonists derivatives which are angiotensin II
US08/004,869 US5380739A (en) 1992-05-13 1993-02-04 Substituted indole derivatives
US486993 1993-02-04
PCT/US1993/001533 WO1993023391A1 (en) 1992-05-13 1993-02-26 Substituted indoles and azaindoles as angiotensin ii antagonists
US9301533 1993-02-26

Publications (3)

Publication Number Publication Date
FI945319A true FI945319A (fi) 1994-11-11
FI945319A0 FI945319A0 (fi) 1994-11-11
FI110512B FI110512B (fi) 2003-02-14

Family

ID=26673598

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945319A FI110512B (fi) 1992-05-13 1994-11-11 Menetelmä angiotensiini II:n antagonisteina käyttökelpoisten substituoitujen indolien valmistamiseksi

Country Status (17)

Country Link
EP (1) EP0640080B1 (fi)
JP (1) JP3332234B2 (fi)
CN (1) CN1039714C (fi)
AT (1) ATE159524T1 (fi)
AU (1) AU672599B2 (fi)
CA (1) CA2135605A1 (fi)
DE (1) DE69314786T2 (fi)
DK (1) DK0640080T3 (fi)
ES (1) ES2110086T3 (fi)
FI (1) FI110512B (fi)
GR (1) GR3025118T3 (fi)
HU (2) HU221616B1 (fi)
IL (1) IL104869A (fi)
MX (1) MX9301088A (fi)
NO (1) NO308535B1 (fi)
NZ (2) NZ249729A (fi)
WO (1) WO1993023391A1 (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569539B2 (en) 1996-10-30 2003-05-27 Tetra Level Holdings & Finance S.A. Gas barrier packaging laminate method for production thereof and packaging containers
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
ID27280A (id) * 1998-02-25 2001-03-22 Genetics Inst Inhibitor-inhibitor dari enzim-enzim fosfolipase
EP1243268A4 (en) * 1999-12-14 2003-05-21 Nippon Shinyaku Co Ltd MEDICINAL COMPOSITION
ES2236332T3 (es) * 2000-12-14 2005-07-16 Clariant Gmbh Procedimiento para la preparacion de acidos formil-fenil-boricos.
US20040199002A1 (en) * 2001-09-28 2004-10-07 Tetsuya Abe Process for producing(2-nitrophenyl)acetonitrile derivative and intermediate therefor
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6797708B2 (en) 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
GT200600228A (es) 2005-05-27 2006-12-26 Inhibidores de la fosfolipasa a2 citosolica
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
KR20100121610A (ko) * 2008-01-31 2010-11-18 사노피-아벤티스 사이클릭 인돌―3―카복스아미드, 이들의 제조방법 및 약제로서의 이들의 용도
CN101970437B (zh) * 2008-01-31 2013-04-03 赛诺菲-安万特 环状氮杂吲哚-3-甲酰胺、其制备和其作为药物的用途
CN101940568B (zh) * 2010-08-17 2012-11-14 合肥博太医药生物技术发展有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗蒽环抗癌药引起的心脏衰竭药物中的应用
CN107056781A (zh) * 2017-05-18 2017-08-18 康化(上海)新药研发有限公司 一种(E)‑5‑甲基‑1H‑吡咯并[2,3‑b]吡啶‑3‑甲醛肟的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5124335A (en) * 1991-01-30 1992-06-23 Merck & Co., Inc. Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists

Also Published As

Publication number Publication date
GR3025118T3 (en) 1998-01-30
CA2135605A1 (en) 1993-11-25
NO308535B1 (no) 2000-09-25
NO944311D0 (no) 1994-11-11
HUT68056A (en) 1995-05-29
FI110512B (fi) 2003-02-14
AU672599B2 (en) 1996-10-10
CN1039714C (zh) 1998-09-09
DE69314786D1 (de) 1997-11-27
IL104869A (en) 1997-11-20
IL104869A0 (en) 1993-06-10
NO944311L (no) 1994-11-14
WO1993023391A1 (en) 1993-11-25
NZ249729A (en) 1996-12-20
JP3332234B2 (ja) 2002-10-07
FI945319A0 (fi) 1994-11-11
EP0640080A1 (en) 1995-03-01
DK0640080T3 (da) 1998-05-25
ES2110086T3 (es) 1998-02-01
AU3727493A (en) 1993-12-13
MX9301088A (es) 1993-11-01
ATE159524T1 (de) 1997-11-15
EP0640080B1 (en) 1997-10-22
CN1078469A (zh) 1993-11-17
JPH07506826A (ja) 1995-07-27
HU221616B1 (hu) 2002-12-28
NZ299146A (en) 2000-06-23
DE69314786T2 (de) 1998-02-19
HU210709A9 (en) 1995-06-28

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