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FI942976A - 5-amino-8-metyl-7-pyrrolidinylkinolin-3-karboxylsyraderivat - Google Patents

5-amino-8-metyl-7-pyrrolidinylkinolin-3-karboxylsyraderivat Download PDF

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Publication number
FI942976A
FI942976A FI942976A FI942976A FI942976A FI 942976 A FI942976 A FI 942976A FI 942976 A FI942976 A FI 942976A FI 942976 A FI942976 A FI 942976A FI 942976 A FI942976 A FI 942976A
Authority
FI
Finland
Prior art keywords
compounds
hydrogen atom
alkyl group
lower alkyl
carboxylic acid
Prior art date
Application number
FI942976A
Other languages
English (en)
Finnish (fi)
Other versions
FI113174B (sv
FI942976A0 (sv
Inventor
Yasuo Ito
Hideo Kato
Singo Yasuda
Noriyaki Kado
Toshihiko Yoshida
Yoichi Yamamoto
Original Assignee
Hokuriku Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical filed Critical Hokuriku Pharmaceutical
Publication of FI942976A0 publication Critical patent/FI942976A0/sv
Publication of FI942976A publication Critical patent/FI942976A/sv
Application granted granted Critical
Publication of FI113174B publication Critical patent/FI113174B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Epoxy Resins (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI942976A 1993-08-27 1994-06-21 Förfarande och mellanprodukt för framställning av 5-amino-8-metyl-7-pyrrolidinylkinolin-3-karboxylsyraderivat FI113174B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP23431093 1993-08-27
JP23431093 1993-08-27
JP28627293 1993-10-22
JP28627293 1993-10-22
JP7631894 1994-03-24
JP7631894 1994-03-24

Publications (3)

Publication Number Publication Date
FI942976A0 FI942976A0 (sv) 1994-06-21
FI942976A true FI942976A (sv) 1995-02-28
FI113174B FI113174B (sv) 2004-03-15

Family

ID=27302121

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942976A FI113174B (sv) 1993-08-27 1994-06-21 Förfarande och mellanprodukt för framställning av 5-amino-8-metyl-7-pyrrolidinylkinolin-3-karboxylsyraderivat

Country Status (23)

Country Link
US (1) US5547962A (sv)
EP (1) EP0641793B1 (sv)
JP (1) JP2673937B2 (sv)
KR (1) KR100218807B1 (sv)
CN (1) CN1048242C (sv)
AT (1) ATE144508T1 (sv)
AU (1) AU676729B2 (sv)
CA (1) CA2126118C (sv)
CZ (1) CZ286524B6 (sv)
DE (1) DE69400791T2 (sv)
DK (1) DK0641793T3 (sv)
ES (1) ES2096413T3 (sv)
FI (1) FI113174B (sv)
GR (1) GR3021715T3 (sv)
HU (1) HU221952B1 (sv)
IL (1) IL110060A (sv)
MY (1) MY111702A (sv)
NO (1) NO305515B1 (sv)
NZ (1) NZ260851A (sv)
PL (1) PL175870B1 (sv)
SG (1) SG52147A1 (sv)
TW (1) TW252107B (sv)
UA (1) UA39859C2 (sv)

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Publication number Priority date Publication date Assignee Title
CA2210007A1 (en) * 1995-01-24 1996-08-01 Yasuo Ito Quinoline carboxylic acid
US6121285A (en) * 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
MY138335A (en) * 1997-09-15 2009-05-29 Procter & Gamble Antimicrobial quinolones, their compositions and uses
ES2203254T3 (es) * 1998-11-18 2004-04-01 Asahi Glass Company Ltd. Derivados de acido aminoacrilico y procedimiento de produccion correspondiente.
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
CA2398988C (en) 2000-02-09 2010-06-22 Makoto Takemura Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
US6825353B2 (en) 2000-02-25 2004-11-30 Daiichi Pharmaceutical Co., Ltd. Process for producing quinolonecarboxylic acids and intermediates thereof
RU2002122758A (ru) * 2000-02-25 2004-01-10 Дайити Фармасьютикал Ко., Лтд. (JP) Способ получения хинолонкарбоновых кислот и их промежуточные соединения
KR20010044286A (ko) * 2001-02-01 2001-06-05 남근수 알킬-3-(2,6-디할로겐-5-플루오로)-옥소-3-피리딘프로피오네이트의 제조방법
US7928232B2 (en) * 2005-05-20 2011-04-19 Daiichi Sankyo Company, Limited Method for producing asymmetric tetrasubstituted carbon atom-containing compound
WO2007037303A1 (ja) * 2005-09-28 2007-04-05 Daiichi Sankyo Company, Limited テトラ置換－５－アザスピロ[２．４]へプタン誘導体の製法およびその光学活性中間体
CA2647457C (en) * 2006-03-28 2011-05-24 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
MX2008012488A (es) * 2006-03-28 2008-10-10 Procter & Gamble Un proceso de acoplamiento para preparar intermedios de quinolona.
BRPI0709772B8 (pt) * 2006-03-28 2021-05-25 The Protecter & Gamble Company sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
TWI362386B (en) * 2007-03-30 2012-04-21 Daiichi Sankyo Co Ltd A production method for the qunolon-carboxylic acid derivative
FR2928150A1 (fr) * 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens

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US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
JPH0637489B2 (ja) * 1985-09-21 1994-05-18 杏林製薬株式会社 キノロンカルボン酸誘導体およびその製造方法
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
ATE58538T1 (de) * 1986-07-04 1990-12-15 Chemie Linz Gmbh 4-chinolon-3-carbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
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JPS63152318A (ja) * 1986-08-07 1988-06-24 Dainippon Pharmaceut Co Ltd 抗マイコプラズマ剤
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5190955A (en) * 1987-01-28 1993-03-02 Bayer Aktiengesellschaft Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
JPS63275567A (ja) * 1987-05-07 1988-11-14 Dainippon Pharmaceut Co Ltd 新規キノリン誘導体、そのエステルおよびその塩
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AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
JPH0219377A (ja) * 1988-07-08 1990-01-23 Kyorin Pharmaceut Co Ltd ８‐メチルキノロンカルボン酸誘導体
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
US5286723A (en) * 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
IL91648A (en) * 1988-09-22 1997-03-18 Abbott Lab Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
PT93420A (pt) * 1989-03-15 1990-11-07 Kanebo Ltd Processo para a preparacao de derivados de acido quinolinocarboxilico e de composicoes antibacterianas que os contem
DE69019859T2 (de) * 1989-03-30 1995-10-05 Wakunaga Seiyaku Kk Chinolon-Derivate und deren Salze, Verfahren zu deren Herstellung und diese enthaltende antibakterielle Wirkstoffe.
CA2012681A1 (en) * 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
DE3910920A1 (de) * 1989-04-05 1990-10-11 Bayer Ag Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren
DE4032560A1 (de) * 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
HUT64058A (en) * 1990-12-05 1993-11-29 Synphar Lab Inc Process for producing 7-substituted-6-fluoro-1,4-dihydro-4-oxoquinoline-3-cqrboxylic acid compounds having antibacterial effect and pharmaceutical compositions comprising such compounds
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
KR950014567B1 (ko) * 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체

Also Published As

Publication number Publication date
NZ260851A (en) 1996-03-26
TW252107B (sv) 1995-07-21
UA39859C2 (uk) 2001-07-16
HU221952B1 (hu) 2003-03-28
NO942309L (no) 1995-02-28
ATE144508T1 (de) 1996-11-15
SG52147A1 (en) 1998-09-28
CN1048242C (zh) 2000-01-12
FI113174B (sv) 2004-03-15
JPH07309864A (ja) 1995-11-28
AU6487094A (en) 1995-03-09
CN1117491A (zh) 1996-02-28
DE69400791T2 (de) 1997-03-06
EP0641793A1 (en) 1995-03-08
KR950005823A (ko) 1995-03-20
PL175870B1 (pl) 1999-02-26
AU676729B2 (en) 1997-03-20
CZ157494A3 (en) 1995-10-18
JP2673937B2 (ja) 1997-11-05
IL110060A (en) 1999-10-28
GR3021715T3 (en) 1997-02-28
DE69400791D1 (de) 1996-11-28
NO942309D0 (no) 1994-06-17
US5547962A (en) 1996-08-20
HU9401954D0 (en) 1994-09-28
CA2126118A1 (en) 1995-02-28
ES2096413T3 (es) 1997-03-01
KR100218807B1 (ko) 1999-09-01
IL110060A0 (en) 1994-10-07
CZ286524B6 (cs) 2000-05-17
FI942976A0 (sv) 1994-06-21
EP0641793B1 (en) 1996-10-23
PL304063A1 (en) 1995-03-06
DK0641793T3 (da) 1996-11-25
CA2126118C (en) 2001-02-06
NO305515B1 (no) 1999-06-14
HUT67259A (en) 1995-03-28
MY111702A (en) 2000-11-30

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