FI916017A0 - Menetelmä terapeuttisesti käyttökelpoisten amino- ja nitrosubstituoitujen trisyklisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten amino- ja nitrosubstituoitujen trisyklisten yhdisteiden valmistamiseksi

Info

Publication number: FI916017A0
Authority: FI; Finland
Prior art keywords: nitro; preparation; hydrogen; therapeutically useful; amino
Prior art date: 1990-12-21

Application number

FI916017A

Other languages

English (en)

Swedish (sv)

Other versions

FI916017A (fi

FI95800B (fi

FI95800C (fi

Inventor

Gary Alan Flynn

Douglas Wade Beight

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-19

Publication date

1991-12-19

1991-12-19 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-12-19 Publication of FI916017A0 publication Critical patent/FI916017A0/fi

1992-06-22 Publication of FI916017A publication Critical patent/FI916017A/fi

1995-12-15 Publication of FI95800B publication Critical patent/FI95800B/fi

1996-03-25 Application granted granted Critical

1996-03-25 Publication of FI95800C publication Critical patent/FI95800C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI916017A 1990-12-21 1991-12-19 Menetelmä terapeuttisesti käyttökelpoisten amino- ja nitrosubstituoitujen trisyklisten yhdisteiden valmistamiseksi FI95800C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US63357290A	1990-12-21	1990-12-21
US63357290		1990-12-21
US77762591A	1991-10-23	1991-10-23
US77762591		1991-10-23

Publications (4)

Publication Number	Publication Date
FI916017A0 true FI916017A0 (fi)	1991-12-19
FI916017A FI916017A (fi)	1992-06-22
FI95800B FI95800B (fi)	1995-12-15
FI95800C FI95800C (fi)	1996-03-25

Family

ID=27091923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI916017A FI95800C (fi)	1990-12-21	1991-12-19	Menetelmä terapeuttisesti käyttökelpoisten amino- ja nitrosubstituoitujen trisyklisten yhdisteiden valmistamiseksi

Country Status (18)

Country	Link
EP (1)	EP0492369B1 (fi)
JP (1)	JP3112327B2 (fi)
KR (2)	KR100220880B1 (fi)
CN (1)	CN1040985C (fi)
AT (1)	ATE158303T1 (fi)
AU (1)	AU642321B2 (fi)
CA (1)	CA2057786C (fi)
DE (1)	DE69127681T2 (fi)
DK (1)	DK0492369T3 (fi)
ES (1)	ES2108027T3 (fi)
FI (1)	FI95800C (fi)
GR (1)	GR3025622T3 (fi)
HU (1)	HU210167B (fi)
IE (1)	IE914507A1 (fi)
IL (1)	IL100416A (fi)
NO (1)	NO180196C (fi)
NZ (1)	NZ241023A (fi)
PT (1)	PT99849B (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) *	1991-09-27	2003-09-16	Alan M. Warshawsky	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DK0534363T3 (da) *	1991-09-27	1997-09-22	Merrell Pharma Inc	2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE.
AU657793B2 (en) *	1991-09-27	1995-03-23	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
WO1993023403A1 (en) *	1992-05-15	1993-11-25	Merrell Dow Pharmaceuticals Inc.	NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
NZ256589A (en) *	1992-10-30	1996-05-28	Merrell Dow Pharma	Condensed azepine analogues and medicaments (where a is c, o or s and b is o or s)
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
CA2183314C (en) *	1994-02-14	1999-08-31	Gary A. Flynn	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
DE69416873T2 (de) *	1994-02-14	1999-07-29	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
PT750631E (pt) *	1994-02-14	2000-07-31	Merrell Pharma Inc	Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
HUT74584A (en) *	1994-02-14	1997-01-28	Merrell Pharma Inc	Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
DE69514912T2 (de) *	1994-03-24	2000-10-05	Merrell Pharmaceuticals Inc., Cincinnati	Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
DK0751774T3 (da) *	1994-03-24	2003-12-08	Merrell Pharma Inc	Hypocholesterolæmiske mercaptoacetylamiddisulfid-derivater
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
DK0800527T3 (da) *	1994-12-21	2000-06-05	Aventis Pharma Inc	Nye fremgangsmåder til fremstilling af mellemprodukter for inhibitorer af enkephalinase og angiotensinomdannende enzym og m
US7078225B2 (en)	2000-06-02	2006-07-18	Nippon Shokubai Co., Ltd.	Method for enzymatically producing an optically active cyanohydrin
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4584294A (en) *	1984-11-07	1986-04-22	Merck & Co., Inc.	Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
ZA874107B (fi) *	1986-06-13	1987-12-09
AU636101B2 (en) *	1987-04-10	1993-04-22	Monash University	1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino-(1,2-a)azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
US4824832A (en) *	1987-12-30	1989-04-25	Merrell Dow Pharmaceuticals Inc.	Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

1991
- 1991-12-17 DK DK91121638.0T patent/DK0492369T3/da active
- 1991-12-17 NZ NZ241023A patent/NZ241023A/en unknown
- 1991-12-17 DE DE69127681T patent/DE69127681T2/de not_active Expired - Fee Related
- 1991-12-17 AT AT91121638T patent/ATE158303T1/de not_active IP Right Cessation
- 1991-12-17 EP EP91121638A patent/EP0492369B1/en not_active Expired - Lifetime
- 1991-12-17 ES ES91121638T patent/ES2108027T3/es not_active Expired - Lifetime
- 1991-12-17 CA CA002057786A patent/CA2057786C/en not_active Expired - Fee Related
- 1991-12-17 AU AU89819/91A patent/AU642321B2/en not_active Ceased
- 1991-12-18 PT PT99849A patent/PT99849B/pt not_active IP Right Cessation
- 1991-12-18 IL IL10041691A patent/IL100416A/en not_active IP Right Cessation
- 1991-12-19 FI FI916017A patent/FI95800C/fi active IP Right Grant
- 1991-12-20 CN CN91111735A patent/CN1040985C/zh not_active Expired - Fee Related
- 1991-12-20 JP JP03354999A patent/JP3112327B2/ja not_active Expired - Fee Related
- 1991-12-20 NO NO915068A patent/NO180196C/no unknown
- 1991-12-20 KR KR1019910023702A patent/KR100220880B1/ko not_active IP Right Cessation
- 1991-12-20 IE IE450791A patent/IE914507A1/en not_active IP Right Cessation
- 1991-12-20 HU HU914092A patent/HU210167B/hu not_active IP Right Cessation
1997
- 1997-12-10 GR GR970403274T patent/GR3025622T3/el unknown
1999
- 1999-03-27 KR KR1019990010649A patent/KR100220879B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1040985C (zh)	1998-12-02
AU8981991A (en)	1992-06-25
NO180196B (no)	1996-11-25
NZ241023A (en)	1994-10-26
KR920012082A (ko)	1992-07-25
FI916017A (fi)	1992-06-22
HU914092D0 (en)	1992-03-30
DE69127681D1 (de)	1997-10-23
IL100416A (en)	1995-11-27
FI95800B (fi)	1995-12-15
HUT60271A (en)	1992-08-28
AU642321B2 (en)	1993-10-14
CN1062729A (zh)	1992-07-15
EP0492369B1 (en)	1997-09-17
CA2057786A1 (en)	1992-06-22
HU210167B (en)	1995-02-28
IE914507A1 (en)	1992-07-01
ES2108027T3 (es)	1997-12-16
ATE158303T1 (de)	1997-10-15
PT99849A (pt)	1992-11-30
NO180196C (no)	1997-03-05
GR3025622T3 (en)	1998-03-31
CA2057786C (en)	2002-06-18
EP0492369A1 (en)	1992-07-01
FI95800C (fi)	1996-03-25
NO915068D0 (no)	1991-12-20
KR100220879B1 (ko)	2000-03-15
DE69127681T2 (de)	1998-01-15
KR100220880B1 (ko)	1999-09-15
DK0492369T3 (da)	1997-10-13
JP3112327B2 (ja)	2000-11-27
PT99849B (pt)	1999-06-30
JPH04342588A (ja)	1992-11-30
NO915068L (no)	1992-06-22
IL100416A0 (en)	1992-09-06

Publication	Publication Date	Title
FI95800B (fi)	1995-12-15	Menetelmä terapeuttisesti käyttökelpoisten amino- ja nitrosubstituoitujen trisyklisten yhdisteiden valmistamiseksi
TR199601032A2 (tr)	1997-07-21	Matris metalloprotaz önleyicileri.
EA199900591A1 (ru)	2000-08-28	АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха
DK359289A (da)	1990-01-21	4-oxoquinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf samt deres anvendelse
DK1265606T3 (da)	2007-02-12	Celleadhæsionsinhibitorer
AP2003002841A0 (en)	2003-09-30	Quinazolines as MMP-13 inhibitors
PE18095A1 (es)	1995-07-03	3-bencilaminometil piperidinas sustituidas con heteroarilamino y heteroarilsulfonamido y compuestos afines
DK0790987T3 (da)	2001-11-12	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
CO4970752A1 (es)	2000-11-07	Nuevos derivados de isatin y composiciones farmaceuticas conteniendo tales isatines
MXPA04005940A (es)	2004-09-13	Acidos 3-(imidazolil)-2-aminopropanoicos.
AR004413A1 (es)	1998-11-04	Compuestos de tiol que poseen actividad inhibitoria de metalopeptidasa; proceso para preparar dichos derivados; composiciones farmaceuticas que loscontienen
DK0696585T3 (da)	1999-08-23	Nyt bisoxadiazolidinderivat
AU5296199A (en)	2001-03-05	Antibacterial agents
NO972731D0 (no)	1997-06-13	Thiazolidinonforbindelser eller middel inneholdende disse for å behandle eller forhindre angina pectoris
ES2061868T3 (es)	1994-12-16	Derivados ariloxi-, ariltio-, heteroariloxi-, heteroariltio-alquenilen-aminas.
BR9600979A (pt)	1997-12-30	Composto processo para combater fungos fitopatogênicos composição fungicida e processo de preparação de um composto
CO4230083A1 (es)	1995-10-19	Novedosos carbomatos y ureas como modificaciones a la resis- tencia a multiples drogas
DK60793D0 (da)	1993-05-26	Kemiske forbindelser, deres fremstilling og anvendelse
ES2112774A1 (es)	1998-04-01	Nuevos derivados azolicos con actividad antifungica.

Legal Events

Date	Code	Title	Description
1991-12-19	FG	Patent granted	Owner name: MERRELL DOW PHARMACEUTICALS INC.
1995-11-16	BB	Publication of examined application