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FI91401B - Förfarande för framställning av terapeutiskt aktiva 9-aminotetrahydroakridiner och därmed närbesläktade föreningar - Google Patents

Förfarande för framställning av terapeutiskt aktiva 9-aminotetrahydroakridiner och därmed närbesläktade föreningar Download PDF

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Publication number
FI91401B
FI91401B FI881223A FI881223A FI91401B FI 91401 B FI91401 B FI 91401B FI 881223 A FI881223 A FI 881223A FI 881223 A FI881223 A FI 881223A FI 91401 B FI91401 B FI 91401B
Authority
FI
Finland
Prior art keywords
formula
tetrahydroacridine
compound
compounds
preparation
Prior art date
Application number
FI881223A
Other languages
English (en)
Finnish (fi)
Other versions
FI881223A0 (sv
FI91401C (sv
FI881223A (sv
Inventor
Gregory Michael Shutske
Grover Cleveland Helsley
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI881223A0 publication Critical patent/FI881223A0/sv
Publication of FI881223A publication Critical patent/FI881223A/sv
Application granted granted Critical
Publication of FI91401B publication Critical patent/FI91401B/sv
Publication of FI91401C publication Critical patent/FI91401C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (3)

1. Förfarande för framstälining av terapeutiskt aktiva 9-aminotetrahydroakridiner och därmed närbesläktade 5 föreningar med formeln (I) fl NH (I)
10 X— väri X är C7_12-alkyl eller C3.7-cykloalkyl och R! är väte el-ler fenyl-C^-alkyl, eller farmaceutiskt godtagbara syra-15 additionssalter därav, kännetecknat därav, att en förening med formeln (IV) Y
20 X 4“ (IV) väri Y är halogen och X är som ovan definierats, omsätts med en amin med följande forme1 25 H2NR (IX) väri Rj är som ovan definierats, i närvaro av en sur kata-lysator. 30
2. Förfarande enligt patentkrav 1, känne tecknat därav, att det utförs vid en temperatur av 120 - 220 °C.
3. Förfarande enligt patentkrav 1, kännetecknat därav, att X är cyklohexyl eller dodecyl 35 och R! är väte eller bensyl.
FI881223A 1987-03-17 1988-03-15 Förfarande för framställning av terapeutiskt aktiva 9-aminotetrahydroakridiner och därmed närbesläktade föreningar FI91401C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2673087A 1987-03-17 1987-03-17
US2673087 1987-03-17

Publications (4)

Publication Number Publication Date
FI881223A0 FI881223A0 (sv) 1988-03-15
FI881223A FI881223A (sv) 1988-09-18
FI91401B true FI91401B (sv) 1994-03-15
FI91401C FI91401C (sv) 1994-06-27

Family

ID=21833471

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881223A FI91401C (sv) 1987-03-17 1988-03-15 Förfarande för framställning av terapeutiskt aktiva 9-aminotetrahydroakridiner och därmed närbesläktade föreningar

Country Status (15)

Country Link
US (1) US5391553A (sv)
EP (1) EP0282959A3 (sv)
JP (1) JP2888485B2 (sv)
KR (1) KR960015001B1 (sv)
AU (2) AU635370B2 (sv)
CA (1) CA1318675C (sv)
DK (1) DK172864B1 (sv)
FI (1) FI91401C (sv)
HU (1) HU201018B (sv)
IL (1) IL85741A (sv)
NO (1) NO173498C (sv)
NZ (1) NZ223875A (sv)
PH (1) PH25124A (sv)
PT (1) PT86986B (sv)
ZA (1) ZA881865B (sv)

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US5008853A (en) 1987-12-02 1991-04-16 Xerox Corporation Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
DE3889302T2 (de) 1987-12-03 1994-10-20 Mitsubishi Chem Ind 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff.
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US5112829A (en) * 1989-11-28 1992-05-12 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
GB9524346D0 (en) * 1995-11-29 1996-01-31 Univ Strathclyde Polycyclic compounds
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
TW521072B (en) * 1997-06-02 2003-02-21 Meiji Seika Kaisha 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture
JP4685742B2 (ja) * 1997-06-02 2011-05-18 明治製菓株式会社 ４−キノリノール誘導体及びこれを有効成分として含有する農園芸用殺菌剤
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
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ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
WO2003013522A1 (fr) * 2001-08-06 2003-02-20 Mitsubishi Pharma Corporation Compositions prophylactiques/therapeutiques destinees a la neuropathie cholinergique
JP4598674B2 (ja) * 2003-01-08 2010-12-15 田辺三菱製薬株式会社 統合失調症治療剤
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
CN102219740B (zh) * 2010-09-10 2013-02-13 长春华洋高科技有限公司 1，2，3，4，5，6，7，8-八氢-9-苯乙酰胺基吖啶及制备方法和药用用途
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
RU2567388C1 (ru) * 2014-12-10 2015-11-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида
EA034167B8 (ru) 2015-05-22 2021-04-27 Эйджинбайо, Инк. Фармацевтические композиции леветирацетама пролонгированного высвобождения
US10865191B2 (en) 2015-08-03 2020-12-15 Bristol-Myers Squibb Company Heterocyclic compounds useful as modulators of TNF alpha
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Also Published As

Publication number Publication date
JPS63238063A (ja) 1988-10-04
EP0282959A3 (en) 1989-05-31
DK143588D0 (da) 1988-03-16
DK172864B1 (da) 1999-08-23
IL85741A (en) 1996-05-14
FI881223A0 (sv) 1988-03-15
AU608300B2 (en) 1991-03-28
FI91401C (sv) 1994-06-27
PT86986B (pt) 1992-06-30
FI881223A (sv) 1988-09-18
CA1318675C (en) 1993-06-01
ZA881865B (en) 1988-11-30
AU633668B2 (en) 1993-02-04
DK143588A (da) 1988-09-18
AU6824190A (en) 1991-03-14
HUT46672A (en) 1988-11-28
NZ223875A (en) 1991-01-29
KR960015001B1 (ko) 1996-10-23
NO881164L (no) 1988-09-19
HU201018B (en) 1990-09-28
NO881164D0 (no) 1988-03-16
AU6824090A (en) 1991-05-02
EP0282959A2 (en) 1988-09-21
JP2888485B2 (ja) 1999-05-10
US5391553A (en) 1995-02-21
NO173498B (no) 1993-09-13
PH25124A (en) 1991-02-19
NO173498C (no) 1993-12-22
AU635370B2 (en) 1993-03-18
PT86986A (pt) 1988-04-01
KR880011111A (ko) 1988-10-26
AU1314188A (en) 1988-09-15
IL85741A0 (en) 1988-08-31

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BB Publication of examined application
PC Transfer of assignment of patent

Owner name: HOECHST MARION ROUSSEL, INC.

MM Patent lapsed

Owner name: HOECHST MARION ROUSSEL INC., INC.

MA Patent expired