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FI911863A0 - Metylendifosfonsyra och antiinflammatoriskt medel innehaollande denna foerening som aktivkomponent. - Google Patents

Metylendifosfonsyra och antiinflammatoriskt medel innehaollande denna foerening som aktivkomponent.

Info

Publication number
FI911863A0
FI911863A0 FI911863A FI911863A FI911863A0 FI 911863 A0 FI911863 A0 FI 911863A0 FI 911863 A FI911863 A FI 911863A FI 911863 A FI911863 A FI 911863A FI 911863 A0 FI911863 A0 FI 911863A0
Authority
FI
Finland
Prior art keywords
methylendiphosphonsyra
antiinflammatoriskt
aktivkomponent
foerening
denna
Prior art date
Application number
FI911863A
Other languages
English (en)
Inventor
Norio Kawabe
Keijiro Takanishi
Shu Matsumoto
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of FI911863A0 publication Critical patent/FI911863A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI911863A 1989-08-18 1991-04-17 Metylendifosfonsyra och antiinflammatoriskt medel innehaollande denna foerening som aktivkomponent. FI911863A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1213284A JPH0377894A (ja) 1989-08-18 1989-08-18 メチレンジホスホン酸化合物
PCT/JP1990/001051 WO1991002737A1 (fr) 1989-08-18 1990-08-17 Compose de l'acide methylenediphosphonique et agent anti-inflammatoire le contenant en tant qu'ingredient actif

Publications (1)

Publication Number Publication Date
FI911863A0 true FI911863A0 (fi) 1991-04-17

Family

ID=16636564

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911863A FI911863A0 (fi) 1989-08-18 1991-04-17 Metylendifosfonsyra och antiinflammatoriskt medel innehaollande denna foerening som aktivkomponent.

Country Status (9)

Country Link
US (1) US5153183A (fi)
EP (1) EP0440809A4 (fi)
JP (1) JPH0377894A (fi)
KR (1) KR920701213A (fi)
AU (1) AU6168190A (fi)
CA (1) CA2037932A1 (fi)
FI (1) FI911863A0 (fi)
HU (1) HUT56376A (fi)
WO (1) WO1991002737A1 (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5103036A (en) * 1991-05-13 1992-04-07 E. R. Squibb & Sons, Inc. Process for preparing 3-alkenylidene-1,1-bisphosphonates
ATE164163T1 (de) * 1991-06-19 1998-04-15 Upjohn Co Dialkyl (dialkoxyphosphinyl)methyl phosphate als antientzündungsmittel
JPH0826048B2 (ja) * 1991-09-05 1996-03-13 東レ株式会社 メタンジホスホン酸誘導体、その製造方法およびその医薬用途
FR2683528A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues et analogues gem-bisphosphoniques d'antiinflammatoires non-sterouidiens de type arylacetique ou arylpropionique.
EP0603401B1 (en) * 1992-07-10 2001-04-11 Toray Industries, Inc. Methanediphosphonate derivative, production thereof, and pharmaceutical use thereof
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
US5366965A (en) * 1993-01-29 1994-11-22 Boehringer Mannheim Gmbh Regimen for treatment or prophylaxis of osteoporosis
ZA941088B (en) * 1993-02-19 1995-09-27 Symphar Sa Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
JP2546067B2 (ja) * 1993-02-25 1996-10-23 東レ株式会社 メタンジホスホン酸化合物の製造方法
EP0725070B1 (en) * 1994-08-24 2003-03-26 Toray Industries, Inc. Process for producing methanediphosphonic acid compound
CH690163A5 (fr) * 1995-07-28 2000-05-31 Symphar Sa Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
GB9603637D0 (en) * 1996-02-21 1996-04-17 Smithkline Beecham Plc Process
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
GB0019272D0 (en) * 2000-08-04 2000-09-27 Symphar Sa Pharmaceutical compounds
AU2002337862A1 (en) * 2001-10-18 2003-04-28 Ilex Products, Inc. Methods of treating skin with diphosphonate derivatives
JP2006504697A (ja) * 2002-09-19 2006-02-09 アイレックス オンコロジー リサーチ エスエーアールエル 骨同化作用を有する置換ケトホスホネート化合物
WO2005123130A2 (en) * 2004-06-17 2005-12-29 Osteologix A/S Improved treatments of rheumatic and arthritic diseases comprising combinations of a 5-lipoxygenase inhibitor
CN106061984A (zh) 2014-02-13 2016-10-26 配体药物公司 前药化合物及其用途
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them
DE3203309A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
JPS63185993A (ja) * 1987-01-27 1988-08-01 Yamanouchi Pharmaceut Co Ltd ２−置換−２−オキソ−エチレン−１，１−ジホスホン酸
CH675422A5 (fi) * 1988-03-31 1990-09-28 Symphar Sa
JPH022285A (ja) * 1988-06-13 1990-01-08 Meidensha Corp 構内交換電話の電話番号案内方式

Also Published As

Publication number Publication date
CA2037932A1 (en) 1991-02-19
US5153183A (en) 1992-10-06
EP0440809A1 (en) 1991-08-14
EP0440809A4 (en) 1991-12-27
KR920701213A (ko) 1992-08-11
WO1991002737A1 (fr) 1991-03-07
HUT56376A (en) 1991-08-28
JPH0377894A (ja) 1991-04-03
AU6168190A (en) 1991-04-03
HU906721D0 (en) 1991-07-29

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