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ZA941088B - Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them - Google Patents

Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA941088B
ZA941088B ZA941088A ZA941088A ZA941088B ZA 941088 B ZA941088 B ZA 941088B ZA 941088 A ZA941088 A ZA 941088A ZA 941088 A ZA941088 A ZA 941088A ZA 941088 B ZA941088 B ZA 941088B
Authority
ZA
South Africa
Prior art keywords
ketophosphonates
substituted
processes
preparation
pharmaceutical compositions
Prior art date
Application number
ZA941088A
Inventor
Lan Nguyen
Vinh Van Diep
Hieu Phan Simon
Simon Floret
Raymond Azoulay
Yves Guyon-Gellin
Pierre Maechler
Eric Niesor
Craig L Bentzen
Original Assignee
Symphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa filed Critical Symphar Sa
Publication of ZA941088B publication Critical patent/ZA941088B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015Esters of acyclic unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • C07F9/4059Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44Amides thereof
    • C07F9/4403Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4411Amides of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA941088A 1993-02-19 1994-02-17 Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them ZA941088B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH52193 1993-02-19

Publications (1)

Publication Number Publication Date
ZA941088B true ZA941088B (en) 1995-09-27

Family

ID=4188911

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA941088A ZA941088B (en) 1993-02-19 1994-02-17 Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them

Country Status (8)

Country Link
EP (1) EP0638084A1 (en)
JP (1) JPH07506121A (en)
CN (1) CN1106611A (en)
AU (1) AU6205294A (en)
CA (1) CA2118409A1 (en)
MX (1) MX9401295A (en)
WO (1) WO1994019358A1 (en)
ZA (1) ZA941088B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4433244A1 (en) * 1994-09-19 1996-03-28 Hoechst Ag Aminomethylphosphonic and aminomethylphosphinic acid derivatives and their use for the treatment of degenerative joint diseases
DE19502209A1 (en) * 1995-01-25 1996-08-01 Hoechst Ag Phosphonoacetic acid derivatives and their use for the treatment of degenerative joint diseases
JP3588734B2 (en) * 1996-07-26 2004-11-17 コニカミノルタホールディングス株式会社 Electrophotographic photoreceptor
AU2003272513A1 (en) * 2002-09-19 2004-04-08 Ilex Oncology Research, Sarl Substituted ketophosphonate inhibitors of tumor cell proliferation
JP2006504697A (en) * 2002-09-19 2006-02-09 アイレックス オンコロジー リサーチ エスエーアールエル Substituted ketophosphonate compounds with bone anabolic activity
FR2876104B1 (en) * 2004-10-04 2007-02-23 Centre Nat Rech Scient FLUOROPHOSPHONOCINNAMIC COMPOUNDS, SYSTEM AND APLICATIONS
GB0613518D0 (en) 2006-07-06 2006-08-16 Phytopharm Plc Chemical compounds
KR101550085B1 (en) 2008-11-13 2015-09-03 바스프 에스이 Benzylidene compounds comprising phosphono-groups
EP2270021A1 (en) * 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
CN109154016B (en) * 2017-12-29 2021-11-16 邦泰生物工程(深圳)有限公司 Method for preparing ursodeoxycholic acid by chemical-enzymatic method
CN108794559A (en) * 2018-07-31 2018-11-13 重庆波克底科技开发有限责任公司 A method of using hyodesoxycholic acid as Material synthesis lithocholic acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2024030A1 (en) * 1970-05-16 1971-12-02 Deutsche Advance Produktion GmbH, 6141 Lautern 2,6-dialkyl phenols
JPS5921889B2 (en) * 1975-06-02 1984-05-23 帝人株式会社 Polyester manufacturing method
JPS5782828A (en) * 1980-11-11 1982-05-24 Canon Inc Heat developing photosensitive material
DE3362618D1 (en) * 1982-10-07 1986-04-24 Ciba Geigy Ag Phenols and their preparation
CH675422A5 (en) * 1988-03-31 1990-09-28 Symphar Sa
JPH0377894A (en) * 1989-08-18 1991-04-03 Toray Ind Inc Methylene diphosphonic acid compound
US5300687A (en) * 1991-07-18 1994-04-05 Ortho Pharmaceutical Corporation Trifluoromethylbenzylphosphonates useful in treating osteoporosis

Also Published As

Publication number Publication date
AU6205294A (en) 1994-09-14
EP0638084A1 (en) 1995-02-15
CA2118409A1 (en) 1994-09-01
JPH07506121A (en) 1995-07-06
CN1106611A (en) 1995-08-09
MX9401295A (en) 1994-08-31
WO1994019358A1 (en) 1994-09-01

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