FI911443L - Foerfarande foer framstaellning av 3,5-di-tert.butyl-4-hydroxifenylmetylenderivat av 2-substituerade tiazolidinoner, oxazolidinoner och imidazolidinoner med antiinflammatorisk aktivitet. - Google Patents

Foerfarande foer framstaellning av 3,5-di-tert.butyl-4-hydroxifenylmetylenderivat av 2-substituerade tiazolidinoner, oxazolidinoner och imidazolidinoner med antiinflammatorisk aktivitet. Download PDF

Info

Publication number: FI911443L
Authority: FI; Finland
Prior art keywords: thiazolidinoner; oxazolidinoner; imidazolidinoner; hydroxifenylmethylenderivat; antiinflammatorisk
Prior art date: 1990-03-27

Application number

FI911443A

Other languages

English (en)

Other versions

FI103508B (fi

FI911443A0 (fi

FI103508B1 (fi

Inventor

Wiaczeslaw Antin Cetenko

Roderick Joseph Sorenson

David Thomas Connor

Paul Charles Unangst

Jagadish Chandra Sircar

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-27

Filing date

1991-03-25

Publication date

1991-09-28

1991-03-25 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1991-03-25 Publication of FI911443A0 publication Critical patent/FI911443A0/fi

1991-09-28 Publication of FI911443L publication Critical patent/FI911443L/fi

1999-07-15 Application granted granted Critical

1999-07-15 Publication of FI103508B publication Critical patent/FI103508B/fi

1999-07-15 Publication of FI103508B1 publication Critical patent/FI103508B1/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/40—One oxygen atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

FI911443A 1990-03-27 1991-03-25 Menetelmä anti-inflammatorisen aktiivisuuden omaavien 2-substituoitujen tiatsolidinonien, oksatsolidinonien ja imidatsolidinonien 3,5-di-tert.butyyli-4-hydroksifenyylimetyleenijohdannaisten valmistamiseksi FI103508B1 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49993790A	1990-03-27	1990-03-27
US07/640,711 US5143928A (en)	1990-03-27	1991-01-18	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents

Publications (4)

Publication Number	Publication Date
FI911443A0 FI911443A0 (fi)	1991-03-25
FI911443L true FI911443L (fi)	1991-09-28
FI103508B FI103508B (fi)	1999-07-15
FI103508B1 FI103508B1 (fi)	1999-07-15

Family

ID=27053353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI911443A FI103508B1 (fi)	1990-03-27	1991-03-25	Menetelmä anti-inflammatorisen aktiivisuuden omaavien 2-substituoitujen tiatsolidinonien, oksatsolidinonien ja imidatsolidinonien 3,5-di-tert.butyyli-4-hydroksifenyylimetyleenijohdannaisten valmistamiseksi

Country Status (20)

Country	Link
US (3)	US5143928A (fi)
EP (1)	EP0449216B1 (fi)
JP (1)	JP3028628B2 (fi)
KR (1)	KR0156533B1 (fi)
CN (1)	CN1055180A (fi)
AT (1)	ATE133945T1 (fi)
AU (1)	AU640468B2 (fi)
CA (1)	CA2039056C (fi)
DE (1)	DE69116909T2 (fi)
DK (1)	DK0449216T3 (fi)
ES (1)	ES2082875T3 (fi)
FI (1)	FI103508B1 (fi)
GR (1)	GR3019272T3 (fi)
HK (1)	HK1005186A1 (fi)
HU (1)	HU911001D0 (fi)
IE (1)	IE911006A1 (fi)
IL (1)	IL97403A0 (fi)
NO (1)	NO302294B1 (fi)
NZ (1)	NZ237565A (fi)
PT (1)	PT97169B (fi)

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US6218437B1 (en)	1996-09-30	2001-04-17	The Regents Of The University Of California	Treatment and prevention of hepatic disorders
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US6191154B1 (en)	1998-11-27	2001-02-20	Case Western Reserve University	Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
UA66401C2 (en)	1998-12-02	2004-05-17	Sentor Pharmaceuticals Inc	3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) *	1998-12-02	2004-05-04	Renovis, Inc.	3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
JP2001072592A (ja)	1999-07-01	2001-03-21	Kyowa Hakko Kogyo Co Ltd	テロメラーゼ阻害剤
US6444685B1 (en)	2000-07-17	2002-09-03	Wyeth	N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
US6525202B2 (en)	2000-07-17	2003-02-25	Wyeth	Cyclic amine phenyl beta-3 adrenergic receptor agonists
US6452014B1 (en)	2000-12-22	2002-09-17	Geron Corporation	Telomerase inhibitors and methods of their use
US7041650B2 (en) *	2001-07-09	2006-05-09	Ortho-Mcneil Pharmaceutical, Inc.	Anticonvulsant derivative salts
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
MXPA02010430A (es) *	2001-11-27	2003-06-02	Warner Lambert Co	Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
WO2004047760A2 (en) *	2002-11-22	2004-06-10	Smithkline Beecham Corporation	Novel chemical compounds
WO2004064781A2 (en) *	2003-01-14	2004-08-05	Adam Heller	Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
JP4570857B2 (ja) *	2003-03-31	2010-10-27	富士フイルム株式会社	感光性組成物及び平版印刷版原版
CN103259027A (zh)	2005-04-28	2013-08-21	普罗透斯数字保健公司	药物信息系统
CN100384828C (zh) *	2005-05-08	2008-04-30	山东大学	(z)-5-[[(3,5-二叔丁基)-4-羟基苯基]亚甲基]-2-亚氨基-4-噻唑啉酮甲磺酸盐的制备方法
TW200716580A (en) *	2005-06-08	2007-05-01	Smithkline Beecham Corp	(5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one
EP2063905B1 (en)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US20100286041A1 (en) *	2007-03-22	2010-11-11	Smithkline Beecham Corporation	(5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
FR2919608B1 (fr) *	2007-08-01	2012-10-05	Univ Rennes	Derives d'imidazolones,procede de preparation et applications biologiques
CN102316902B (zh)	2009-02-20	2014-09-24	to-BBB控股股份有限公司	基于谷胱甘肽的药物递送系统
SG175390A1 (en)	2009-04-29	2011-12-29	Amarin Corp Plc	Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
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1991
- 1991-01-18 US US07/640,711 patent/US5143928A/en not_active Expired - Lifetime
- 1991-03-04 IL IL97403A patent/IL97403A0/xx unknown
- 1991-03-22 AU AU73721/91A patent/AU640468B2/en not_active Ceased
- 1991-03-25 FI FI911443A patent/FI103508B1/fi not_active IP Right Cessation
- 1991-03-25 NZ NZ237565A patent/NZ237565A/xx unknown
- 1991-03-26 JP JP3086109A patent/JP3028628B2/ja not_active Expired - Fee Related
- 1991-03-26 DE DE69116909T patent/DE69116909T2/de not_active Expired - Fee Related
- 1991-03-26 CA CA002039056A patent/CA2039056C/en not_active Expired - Fee Related
- 1991-03-26 ES ES91104787T patent/ES2082875T3/es not_active Expired - Lifetime
- 1991-03-26 AT AT91104787T patent/ATE133945T1/de not_active IP Right Cessation
- 1991-03-26 EP EP91104787A patent/EP0449216B1/en not_active Expired - Lifetime
- 1991-03-26 IE IE100691A patent/IE911006A1/en not_active IP Right Cessation
- 1991-03-26 DK DK91104787.6T patent/DK0449216T3/da active
- 1991-03-26 NO NO911231A patent/NO302294B1/no not_active IP Right Cessation
- 1991-03-26 HU HU911001A patent/HU911001D0/hu unknown
- 1991-03-27 CN CN91101868A patent/CN1055180A/zh active Pending
- 1991-03-27 PT PT97169A patent/PT97169B/pt active IP Right Grant
- 1991-03-27 KR KR1019910004818A patent/KR0156533B1/ko not_active Expired - Fee Related
1992
- 1992-06-10 US US07/896,299 patent/US5290800A/en not_active Expired - Fee Related
1994
- 1994-12-09 US US08/353,166 patent/US5494927A/en not_active Expired - Fee Related
1996
- 1996-03-12 GR GR960400674T patent/GR3019272T3/el unknown
1998
- 1998-05-15 HK HK98104233A patent/HK1005186A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI103508B (fi)	1999-07-15
AU7372191A (en)	1991-10-03
EP0449216B1 (en)	1996-02-07
DE69116909T2 (de)	1996-06-13
PT97169A (pt)	1991-12-31
NO911231L (no)	1991-09-30
FI911443A0 (fi)	1991-03-25
KR910016724A (ko)	1991-11-05
CN1055180A (zh)	1991-10-09
PT97169B (pt)	1998-07-31
IL97403A0 (en)	1992-06-21
EP0449216A1 (en)	1991-10-02
US5494927A (en)	1996-02-27
NO911231D0 (no)	1991-03-26
IE911006A1 (en)	1991-10-09
JPH04221371A (ja)	1992-08-11
NO302294B1 (no)	1998-02-16
HK1005186A1 (en)	1998-12-24
CA2039056A1 (en)	1991-09-28
DK0449216T3 (da)	1996-07-01
ATE133945T1 (de)	1996-02-15
US5143928A (en)	1992-09-01
AU640468B2 (en)	1993-08-26
HU911001D0 (en)	1991-10-28
CA2039056C (en)	2001-09-18
FI103508B1 (fi)	1999-07-15
ES2082875T3 (es)	1996-04-01
JP3028628B2 (ja)	2000-04-04
US5290800A (en)	1994-03-01
DE69116909D1 (de)	1996-03-21
KR0156533B1 (ko)	1998-11-16
GR3019272T3 (en)	1996-06-30
NZ237565A (en)	1993-02-25

Publication	Publication Date	Title
FI911443L (fi)	1991-09-28	Foerfarande foer framstaellning av 3,5-di-tert.butyl-4-hydroxifenylmetylenderivat av 2-substituerade tiazolidinoner, oxazolidinoner och imidazolidinoner med antiinflammatorisk aktivitet.
FI913101A0 (fi)	1991-06-25	Foerfarande foer framstaellning av blandningar av polysackarider med laog molekylvikt och anvaendning av dessa.
FI911330L (fi)	1991-09-20	1,4,7,10-tetra-azacyklododekan -butyltrioler, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska aemnen.
FI912075L (fi)	1991-10-31	Haorbehandlingskomposition i form av en mikroemulsion och foerfarande foer framstaellning och anvaendning av densamma.
FI922721A0 (fi)	1992-06-12	Ammunitionskomponent med laog skade- egenskaper, med en tvaokomponentig explosionsladdning och foerfarande foer uppnaoende av en fragmentationseffekt.
FI914487A0 (fi)	1991-09-24	1,3-bensoxazinderivat, deras framstaellning och anvaendning.
FI902771A0 (fi)	1990-06-04	Foerfarande foer framstaellning av antiinflammatoriska 1,3,4-tiadiazoler och 1,3,4-oxadiazoler.
FI913674A0 (fi)	1991-08-01	Med textilbaerband och sprutpressat spaerrorgan foersedd dragked och foerfarande foer framstaellning av en dylik dragked.
FI923458L (fi)	1992-07-31	4,5-cykloalkano-3-benzazepin-7-ol- derivat och deras anvaendning.
FI924545L (fi)	1993-04-09	Tvaettkomposition innehaollande signalstoppreagens, testfoerpackning och anvaendning av denna med peroxidasmaerkt, specifik bindningsligand
FI910325L (fi)	1991-07-23	Differentiering av mikroorganismer associerade med parodontala sjukdomar, och daervid anvaendbar artikel och testfoerpackning.
FI920400A0 (fi)	1992-01-29	2,5-diaryl-1,3,4-oxadiazol-hydroxiester, -hydroxiester,-hydroxisyra och -acetoxiester och deras syntesmetod.
FI913889A (fi)	1992-02-18	Foerfarande och en med toemningsanordning foersedd enplanspress foer samtidig tillverkning av tvao dekorationslaminatskivor.
FI922876A0 (fi)	1992-06-18	Heterocykliska foereningar med reninhaemmande egenskaper, foerfarande foer framstaellning av dessa och anvaendning av dessa.
FI925111L (fi)	1993-05-13	Substituerade 1,5-pentadioler och foerfarande foer deras framstaellning
FI913066L (fi)	1991-12-26	Oxikloreringsfoerfarande och -katalysator och deras anvaendning foer framstaellning av 1,2-dikloretan.
FI924756L (fi)	1992-10-20	1,5-benzotiazepinonderivat, deras framstaellning och farmaceutiska anvaendning
FI924577L (fi)	1992-10-09	Foerfarande foer framstaellning av 1,2,4-trifluorbenzen och 1-klor-3,4-difluorbenzen
FI913508A0 (fi)	1991-07-22	Foerfarande foer framstaellning av 6-acyl -, 7-acyl- och 6,7-diacylanaloger av forskolin och deras mellanprodukter.
FI915566L (fi)	1992-05-29	B-hydroxietylaminer, vilka innehaoller en 1,1-disubstituerad cyklopropylrest, foerfarande foer deras framstaellning och deras anvaendning.
FI900244A (fi)	1991-07-17	1. soemnskunskap 2.foerfarande foer upploesning av atomstruktur. 3. foerbraenningsenergi.
FI905997A (fi)	1992-06-05	Anordning foer fyllning av en paose med loesmaterial, och anvaendning av anordningen.
FI905998A (fi)	1992-06-05	Anordning foer fyllning av en paose med loesmaterial, och anvaendning av anordningen.
FI912065A0 (fi)	1991-04-29	Foerfarande foer aostadkommande av en installationsreservering i en prefabricerad byggnadsdel och en med en installationsreservering foersedd byggnadsdel.
FI914888A0 (fi)	1991-10-16	Foerfarande foer frmstaellning av elastisk bricka foer skruv och skruv med elastisk bricka.

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Date	Code	Title	Description
2005-09-30	MA	Patent expired