FI883050L - Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI883050L FI883050L FI883050A FI883050A FI883050L FI 883050 L FI883050 L FI 883050L FI 883050 A FI883050 A FI 883050A FI 883050 A FI883050 A FI 883050A FI 883050 L FI883050 L FI 883050L
- Authority
- FI
- Finland
- Prior art keywords
- pyranoindolizinoquinoline
- derivatives
- preparation
- therapeutically active
- therapeutically
- Prior art date
Links
- PUQBNSOXIHVXPQ-UHFFFAOYSA-N 7-oxa-11,15-diazapentacyclo[11.8.0.02,11.03,8.014,19]henicosa-1,3(8),4,9,12,14(19),15,17,20-nonaene Chemical class N1=CC=CC=2C=CC=3C(C1=2)=CN1C=CC2=C(C1=3)C=CCO2 PUQBNSOXIHVXPQ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Liquid Crystal Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Lubricants (AREA)
- Fats And Perfumes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15699087 | 1987-06-24 | ||
| JP15699087 | 1987-06-24 | ||
| JP550388 | 1988-01-13 | ||
| JP550388 | 1988-01-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI883050A0 FI883050A0 (fi) | 1988-06-23 |
| FI883050L true FI883050L (fi) | 1988-12-25 |
| FI91872B FI91872B (fi) | 1994-05-13 |
| FI91872C FI91872C (fi) | 1994-08-25 |
Family
ID=26339454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI883050A FI91872C (fi) | 1987-06-24 | 1988-06-23 | Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US4939255A (fi) |
| EP (1) | EP0296597B1 (fi) |
| KR (1) | KR960002853B1 (fi) |
| AT (1) | ATE111913T1 (fi) |
| AU (1) | AU610189B2 (fi) |
| CA (1) | CA1304370C (fi) |
| DE (1) | DE3851577T2 (fi) |
| DK (1) | DK344488A (fi) |
| ES (1) | ES2064329T3 (fi) |
| FI (1) | FI91872C (fi) |
| IE (1) | IE61281B1 (fi) |
| NO (1) | NO167738C (fi) |
| PH (1) | PH27557A (fi) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US5658920A (en) * | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
| US6407115B1 (en) * | 1991-01-16 | 2002-06-18 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
| JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| US5663177A (en) * | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| EP0835303A4 (en) * | 1995-06-07 | 2000-09-13 | Univ Jefferson | Anti-fungal agents and methods of identifying and using the same |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| SG88737A1 (en) * | 1996-10-30 | 2002-05-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| KR19980076076A (ko) * | 1997-04-04 | 1998-11-16 | 유현식 | 전선용 발포성 수지조성물 |
| US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| IN189180B (fi) | 1997-07-09 | 2003-01-04 | Chong Kun Dang Corp | |
| JP4094710B2 (ja) | 1997-11-06 | 2008-06-04 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| FR2801309B1 (fr) * | 1999-11-18 | 2002-01-04 | Adir | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PL207510B1 (pl) | 2001-11-30 | 2010-12-31 | Chugai Pharmaceutical Co Ltd | Związki heksacykliczne, kompozycje je zawierające oraz ich zastosowanie |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| JP4566187B2 (ja) | 2003-02-21 | 2010-10-20 | 中外製薬株式会社 | 六環式化合物の調製法 |
| TWI351284B (en) | 2004-04-09 | 2011-11-01 | Chugai Pharmaceutical Co Ltd | Novel water-soluble prodrugs |
| TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| CN102060713A (zh) * | 2010-12-09 | 2011-05-18 | 中华人民共和国嘉兴出入境检验检疫局 | 用于检测偶氮类染料的芳香胺半抗原及其制备方法 |
| DK3946464T3 (da) | 2019-03-29 | 2022-10-31 | Medimmune Ltd | Forbindelser og konjugater deraf |
| EP4093439A1 (en) | 2020-01-22 | 2022-11-30 | MedImmune Limited | Compounds and conjugates thereof |
| TW202140076A (zh) | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | 化合物及其軛合物 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| KR20250024742A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | Ptk7을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| EP4496593A1 (en) | 2022-03-23 | 2025-01-29 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
| EP4496595A1 (en) | 2022-03-23 | 2025-01-29 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
| AU2023241225A1 (en) | 2022-03-23 | 2024-08-29 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
| WO2024140933A1 (zh) * | 2022-12-30 | 2024-07-04 | 长春金赛药业有限责任公司 | 喜树碱衍生物、药物组合物及其制备方法和应用 |
| WO2024235105A1 (en) * | 2023-05-12 | 2024-11-21 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Linker compounds and ligand-drug conjugates, preparation methods and uses thereof |
| CN119371430A (zh) * | 2023-07-26 | 2025-01-28 | 上海医药集团股份有限公司 | 喜树碱类小分子及其抗体药物偶联物、制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US32518A (en) * | 1861-06-11 | Improvement in city railroads | ||
| JPS51288A (ja) * | 1974-06-18 | 1976-01-05 | Tamura Seisakusho Kk | Hanshakyoshinhoshasochi |
| US4399282A (en) | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
| JPS5839685A (ja) * | 1981-09-04 | 1983-03-08 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体及びその製造法 |
| US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| DE3682874D1 (de) * | 1985-10-21 | 1992-01-23 | Daiichi Seiyaku Co | Pyranoindolizinderivate und verfahren zu ihrer herstellung. |
| US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
-
1988
- 1988-06-16 US US07/207,718 patent/US4939255A/en not_active Expired - Fee Related
- 1988-06-20 IE IE186088A patent/IE61281B1/en not_active IP Right Cessation
- 1988-06-21 CA CA000569969A patent/CA1304370C/en not_active Expired - Lifetime
- 1988-06-23 DE DE3851577T patent/DE3851577T2/de not_active Expired - Fee Related
- 1988-06-23 DK DK344488A patent/DK344488A/da not_active Application Discontinuation
- 1988-06-23 NO NO882785A patent/NO167738C/no unknown
- 1988-06-23 FI FI883050A patent/FI91872C/fi not_active IP Right Cessation
- 1988-06-23 AT AT88110044T patent/ATE111913T1/de not_active IP Right Cessation
- 1988-06-23 EP EP88110044A patent/EP0296597B1/en not_active Expired - Lifetime
- 1988-06-23 ES ES88110044T patent/ES2064329T3/es not_active Expired - Lifetime
- 1988-06-24 KR KR1019880007643A patent/KR960002853B1/ko not_active Expired - Fee Related
- 1988-06-24 AU AU18349/88A patent/AU610189B2/en not_active Ceased
- 1988-07-22 PH PH37104A patent/PH27557A/en unknown
-
1989
- 1989-12-27 US US07/457,921 patent/US5061795A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI91872C (fi) | 1994-08-25 |
| EP0296597A3 (en) | 1991-07-31 |
| NO167738B (no) | 1991-08-26 |
| DK344488A (da) | 1989-02-24 |
| KR890000489A (ko) | 1989-03-15 |
| CA1304370C (en) | 1992-06-30 |
| FI91872B (fi) | 1994-05-13 |
| NO882785D0 (no) | 1988-06-23 |
| FI883050A0 (fi) | 1988-06-23 |
| KR960002853B1 (ko) | 1996-02-27 |
| DK344488D0 (da) | 1988-06-23 |
| PH27557A (en) | 1993-08-18 |
| EP0296597B1 (en) | 1994-09-21 |
| IE61281B1 (en) | 1994-10-19 |
| DE3851577D1 (de) | 1994-10-27 |
| AU610189B2 (en) | 1991-05-16 |
| NO167738C (no) | 1991-12-04 |
| AU1834988A (en) | 1989-01-05 |
| ES2064329T3 (es) | 1995-02-01 |
| EP0296597A2 (en) | 1988-12-28 |
| US4939255A (en) | 1990-07-03 |
| DE3851577T2 (de) | 1995-04-27 |
| ATE111913T1 (de) | 1994-10-15 |
| NO882785L (no) | 1988-12-27 |
| IE881860L (en) | 1988-12-24 |
| US5061795A (en) | 1991-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: DAIICHI SEIYAKU CO., LTD. Owner name: KABUSHIKI KAISHA YAKULT HONSHA |