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FI875586A - FOERFARANDE FOER FRAMSTAELLNING AV NYA INDOLKARBOXAMIDDERIVAT SAMT DERAS SALTER. - Google Patents

FOERFARANDE FOER FRAMSTAELLNING AV NYA INDOLKARBOXAMIDDERIVAT SAMT DERAS SALTER. Download PDF

Info

Publication number
FI875586A
FI875586A FI875586A FI875586A FI875586A FI 875586 A FI875586 A FI 875586A FI 875586 A FI875586 A FI 875586A FI 875586 A FI875586 A FI 875586A FI 875586 A FI875586 A FI 875586A
Authority
FI
Finland
Prior art keywords
image
indolkarboxamidderivat
nya
foerfarande foer
foer framstaellning
Prior art date
Application number
FI875586A
Other languages
Finnish (fi)
Other versions
FI85139C (en
FI85139B (en
FI875586A0 (en
Inventor
Francois Clemence
Jacques Guillaume
Gilles Hamon
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR868617810A external-priority patent/FR2608601B2/en
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI875586A0 publication Critical patent/FI875586A0/en
Publication of FI875586A publication Critical patent/FI875586A/en
Application granted granted Critical
Publication of FI85139B publication Critical patent/FI85139B/en
Publication of FI85139C publication Critical patent/FI85139C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Products (I): <IMAGE> in which either R2, R3 = H, B = COHN, b = H, a and c = double bond, or <IMAGE> or R1 and R with N = morpholine, or A = -(CH2)3, R1 = H, R = 1,1-dimethylpropyl, cyclohexyl, cyclohexylmethyl, propyl, isopropyl, <IMAGE> or R1, R2, R3 = H, B = NHCO, b = H, a and c = double bond, or A = -(CH2)3, R = cyclopentyl, cyclohexyl, 1,1-dimethylpropyl, <IMAGE> or A = -(CH2)4, R = 1,1-(dimethylethyl), or R2 = CH3, R3 = H, B = NHCO, b = H, a and c = double bond, <IMAGE> R = 1,1-(dimethylethyl), or R1 and R with <IMAGE> A = -(CH2)n, <IMAGE> R3 = H, C1-C5 alk, C1-C5 Oalk, Cl, Br, I, NO2, HN2, optionally substituted, a and b = oxo or a and c = double bond, R2 = H, alk, alkenyl, alkynyl, optionally substituted aralkyl, cycloallylalkyl, their preparation, their application as antiarrhythmic medications.
FI875586A 1986-12-19 1987-12-18 Process for the preparation of novel therapeutically useful indole carboxamide derivatives and their salts FI85139C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR868617810A FR2608601B2 (en) 1985-07-11 1986-12-19 NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
FR8617810 1986-12-19

Publications (4)

Publication Number Publication Date
FI875586A0 FI875586A0 (en) 1987-12-18
FI875586A true FI875586A (en) 1988-06-20
FI85139B FI85139B (en) 1991-11-29
FI85139C FI85139C (en) 1992-03-10

Family

ID=9342092

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875586A FI85139C (en) 1986-12-19 1987-12-18 Process for the preparation of novel therapeutically useful indole carboxamide derivatives and their salts

Country Status (12)

Country Link
EP (1) EP0275762B1 (en)
JP (1) JPS63233972A (en)
KR (1) KR880007459A (en)
AT (1) ATE97403T1 (en)
AU (1) AU617094B2 (en)
DE (1) DE3788207T2 (en)
DK (1) DK169328B1 (en)
ES (1) ES2059402T3 (en)
FI (1) FI85139C (en)
HU (1) HU199792B (en)
IE (1) IE61987B1 (en)
ZA (1) ZA879523B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
FR2584713B1 (en) * 1985-07-11 1988-09-09 Roussel Uclaf NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
FR2609464B1 (en) * 1987-01-09 1990-12-07 Roussel Uclaf NOVEL N- (1H-INDOL 4-YL) BENZAMIDE DERIVATIVES AND THEIR SALTS, THEIR USE AS MEDICAMENTS, AND THE COMPOSITIONS CONTAINING THEM
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528043A1 (en) * 1982-06-03 1983-12-09 Roussel Uclaf NOVEL 1,3-DIHYDRO 4- / 1-HYDROXY-2-AMINO-ETHYL / 2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2558158B1 (en) * 1984-01-13 1986-05-16 Roussel Uclaf ETHENYL PHENOL INDOLE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2583047B1 (en) * 1985-06-05 1988-01-08 Roussel Uclaf PROCESS FOR THE PREPARATION OF INDOLE 4-PHENYLPROPYL DERIVATIVES AND INTERMEDIATES
JP2950710B2 (en) * 1992-07-15 1999-09-20 小島プレス工業株式会社 Shift lever device

Also Published As

Publication number Publication date
JPS63233972A (en) 1988-09-29
EP0275762A1 (en) 1988-07-27
DK668687D0 (en) 1987-12-18
EP0275762B1 (en) 1993-11-18
AU8280587A (en) 1988-06-23
ZA879523B (en) 1989-02-22
HUT47245A (en) 1989-02-28
HU199792B (en) 1990-03-28
DK169328B1 (en) 1994-10-10
FI85139C (en) 1992-03-10
IE873441L (en) 1988-06-19
KR880007459A (en) 1988-08-27
FI85139B (en) 1991-11-29
ES2059402T3 (en) 1994-11-16
FI875586A0 (en) 1987-12-18
IE61987B1 (en) 1994-12-14
DE3788207D1 (en) 1993-12-23
AU617094B2 (en) 1991-11-21
ATE97403T1 (en) 1993-12-15
DK668687A (en) 1988-06-20
DE3788207T2 (en) 1994-03-31

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MM Patent lapsed
MM Patent lapsed

Owner name: ROUSSEL UCLAF SOCIETE ANONYME