[go: up one dir, main page]

AU8280587A - New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing them - Google Patents

New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing them

Info

Publication number
AU8280587A
AU8280587A AU82805/87A AU8280587A AU8280587A AU 8280587 A AU8280587 A AU 8280587A AU 82805/87 A AU82805/87 A AU 82805/87A AU 8280587 A AU8280587 A AU 8280587A AU 8280587 A AU8280587 A AU 8280587A
Authority
AU
Australia
Prior art keywords
derivatives
image
preparation
application
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU82805/87A
Other versions
AU617094B2 (en
Inventor
Francois Clemence
Jacques Guillaume
Gilles Hamon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR868617810A external-priority patent/FR2608601B2/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU8280587A publication Critical patent/AU8280587A/en
Application granted granted Critical
Publication of AU617094B2 publication Critical patent/AU617094B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Products (I): <IMAGE> in which either R2, R3 = H, B = COHN, b = H, a and c = double bond, or <IMAGE> or R1 and R with N = morpholine, or A = -(CH2)3, R1 = H, R = 1,1-dimethylpropyl, cyclohexyl, cyclohexylmethyl, propyl, isopropyl, <IMAGE> or R1, R2, R3 = H, B = NHCO, b = H, a and c = double bond, or A = -(CH2)3, R = cyclopentyl, cyclohexyl, 1,1-dimethylpropyl, <IMAGE> or A = -(CH2)4, R = 1,1-(dimethylethyl), or R2 = CH3, R3 = H, B = NHCO, b = H, a and c = double bond, <IMAGE> R = 1,1-(dimethylethyl), or R1 and R with <IMAGE> A = -(CH2)n, <IMAGE> R3 = H, C1-C5 alk, C1-C5 Oalk, Cl, Br, I, NO2, HN2, optionally substituted, a and b = oxo or a and c = double bond, R2 = H, alk, alkenyl, alkynyl, optionally substituted aralkyl, cycloallylalkyl, their preparation, their application as antiarrhythmic medications.
AU82805/87A 1986-12-19 1987-12-18 New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing them Ceased AU617094B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR868617810A FR2608601B2 (en) 1985-07-11 1986-12-19 NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
FR8617810 1986-12-19

Publications (2)

Publication Number Publication Date
AU8280587A true AU8280587A (en) 1988-06-23
AU617094B2 AU617094B2 (en) 1991-11-21

Family

ID=9342092

Family Applications (1)

Application Number Title Priority Date Filing Date
AU82805/87A Ceased AU617094B2 (en) 1986-12-19 1987-12-18 New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing them

Country Status (12)

Country Link
EP (1) EP0275762B1 (en)
JP (1) JPS63233972A (en)
KR (1) KR880007459A (en)
AT (1) ATE97403T1 (en)
AU (1) AU617094B2 (en)
DE (1) DE3788207T2 (en)
DK (1) DK169328B1 (en)
ES (1) ES2059402T3 (en)
FI (1) FI85139C (en)
HU (1) HU199792B (en)
IE (1) IE61987B1 (en)
ZA (1) ZA879523B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU601687B2 (en) * 1985-07-11 1990-09-20 Roussel-Uclaf New derivatives of carboxamide indole, their salts, process and intermediates for preparation, use as medicaments and compositions containing them
AU619728B2 (en) * 1987-01-09 1992-02-06 Roussel-Uclaf New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528043A1 (en) * 1982-06-03 1983-12-09 Roussel Uclaf NOVEL 1,3-DIHYDRO 4- / 1-HYDROXY-2-AMINO-ETHYL / 2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2558158B1 (en) * 1984-01-13 1986-05-16 Roussel Uclaf ETHENYL PHENOL INDOLE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2583047B1 (en) * 1985-06-05 1988-01-08 Roussel Uclaf PROCESS FOR THE PREPARATION OF INDOLE 4-PHENYLPROPYL DERIVATIVES AND INTERMEDIATES
JP2950710B2 (en) * 1992-07-15 1999-09-20 小島プレス工業株式会社 Shift lever device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU601687B2 (en) * 1985-07-11 1990-09-20 Roussel-Uclaf New derivatives of carboxamide indole, their salts, process and intermediates for preparation, use as medicaments and compositions containing them
AU619728B2 (en) * 1987-01-09 1992-02-06 Roussel-Uclaf New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them

Also Published As

Publication number Publication date
JPS63233972A (en) 1988-09-29
EP0275762A1 (en) 1988-07-27
DK668687D0 (en) 1987-12-18
EP0275762B1 (en) 1993-11-18
ZA879523B (en) 1989-02-22
HUT47245A (en) 1989-02-28
HU199792B (en) 1990-03-28
DK169328B1 (en) 1994-10-10
FI85139C (en) 1992-03-10
FI875586A (en) 1988-06-20
IE873441L (en) 1988-06-19
KR880007459A (en) 1988-08-27
FI85139B (en) 1991-11-29
ES2059402T3 (en) 1994-11-16
FI875586A0 (en) 1987-12-18
IE61987B1 (en) 1994-12-14
DE3788207D1 (en) 1993-12-23
AU617094B2 (en) 1991-11-21
ATE97403T1 (en) 1993-12-15
DK668687A (en) 1988-06-20
DE3788207T2 (en) 1994-03-31

Similar Documents

Publication Publication Date Title
AU663200B2 (en) New 3-(hydroxybenzylidenyl)-indolin-2-ones, processes for their preparation and pharmaceutical compositions containing them
ATE114316T1 (en) NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDS, THEIR PRODUCTION AND USE AS ANTIVIRAL PHARMACEUTICALS.
AU3544593A (en) New naphthylalkylamines, process for preparing them and pharmaceutical compositions containing them
FR2662162B1 (en) NOVEL DERIVATIVES OF AMINO PIPERIDINE, AMINO PYRROLIDINE AND AMINO PERHYDROAZEPINE, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AU582601B2 (en) Benzoxazol-and benzothiazolamine derivatives
SE8404019L (en) Ophthalmic anti-inflammatory agents
HUT49986A (en) Composition comprising alpha, omega-aminoalcohol derivative as active ingredient, for expelling insects and mites and process for producing new alpha, omega-aminoalcohol derivatives
IT1228288B (en) COMPOUNDS WITH ANTI-SEROTONIN ACTIVITY
AU656466B2 (en) New benzimidazole compounds, a process for their preparation and pharmaceutical compositions containing them
ATE169623T1 (en) DIHYDROBENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE
AU8280587A (en) New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing them
ATE35812T1 (en) GAMMA BUTYROLACTONE DERIVATIVES, PROCESSES FOR MANUFACTURE THE SAME AND IMMUNOMODULATING PREPARATIONS CONTAINING THE SAME ACTIVE INGREDIENTS.
ATE110370T1 (en) 2,4,6-TRIAMINOPYRIMIDINE-3-OXIDE DERIVATIVES CONTAINING UREA, THEIR PRODUCTION AND USE FOR COSMETICS AND SKIN PHARMACEUTICALS.
AU5393190A (en) Derivatives of 4-phenylmethyl-1h-indole, process and intermediates of preparation, application as medicaments and compositions containing them
AU7546794A (en) Depression remedy
GR3021200T3 (en) (Cyclohexyl)-alken compounds, process for their preparation and pharmaceutical compositions containing them.
ATE23528T1 (en) +/- 2-((3,4-METHYLENEDIOXY)PHENETHYL)-5-((3CARBOXAMIDO-4-HYDROXY)-ALPHA-HYDROXYBENZYL)PYRROLIDINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR MANUFACTURE AND THEIR INTERMEDIATE PRODUCTS.
IL72726A (en) Crystalline salts of(s)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters with(r,s)1-pivaloyloxyethanol,their preparation and pharmaceutical compositions containing them