FI875295L - Menetelmä hirudiinivariantin valmistamiseksi - Google Patents

Menetelmä hirudiinivariantin valmistamiseksi Download PDF

Info

Publication number: FI875295L
Authority: FI; Finland
Prior art keywords: preparing; hirudin variant; hirudin; variant
Prior art date: 1986-12-01

Application number

FI875295A

Other languages

English (en)

Swedish (sv)

Other versions

FI875295A0 (fi

FI99211B (fi

FI99211C (fi

Inventor

Michael Courtney

Eric Degryse

Gerard Loison

Yves Lemoine

Original Assignee

Transgene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-01

Filing date

1987-12-01

Publication date

1988-06-02

1987-12-01 Application filed by Transgene Sa filed Critical Transgene Sa

1987-12-01 Publication of FI875295A0 publication Critical patent/FI875295A0/fi

1988-06-02 Publication of FI875295L publication Critical patent/FI875295L/fi

1997-07-15 Publication of FI99211B publication Critical patent/FI99211B/fi

1997-10-27 Application granted granted Critical

1997-10-27 Publication of FI99211C publication Critical patent/FI99211C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Control Of Multiple Motors (AREA)

FI875295A 1986-12-01 1987-12-01 Menetelmä hirudiinivariantin valmistamiseksi FI99211C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR868616723A FR2607517B2 (fr)	1986-12-01	1986-12-01	Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu
FR8616723		1986-12-01

Publications (4)

Publication Number	Publication Date
FI875295A0 FI875295A0 (fi)	1987-12-01
FI875295L true FI875295L (fi)	1988-06-02
FI99211B FI99211B (fi)	1997-07-15
FI99211C FI99211C (fi)	1997-10-27

Family

ID=9341393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI875295A FI99211C (fi)	1986-12-01	1987-12-01	Menetelmä hirudiinivariantin valmistamiseksi

Country Status (24)

Country	Link
US (1)	US5650301A (fi)
EP (1)	EP0273800B1 (fi)
JP (1)	JP2567263B2 (fi)
KR (1)	KR960011918B1 (fi)
AT (1)	ATE73462T1 (fi)
AU (1)	AU617989B2 (fi)
BG (1)	BG49719A3 (fi)
CA (1)	CA1341416C (fi)
CS (1)	CS276245B6 (fi)
DE (1)	DE3777367D1 (fi)
DK (1)	DK173247B1 (fi)
ES (1)	ES2032465T3 (fi)
FI (1)	FI99211C (fi)
FR (1)	FR2607517B2 (fi)
GR (1)	GR3004556T3 (fi)
HU (1)	HU213871B (fi)
IE (1)	IE60544B1 (fi)
MC (1)	MC1884A1 (fi)
NO (1)	NO177500C (fi)
PL (1)	PL157254B1 (fi)
PT (1)	PT86233B (fi)
RO (1)	RO106890B1 (fi)
SU (1)	SU1687032A3 (fi)
ZA (1)	ZA879011B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2628429B1 (fr) *	1988-03-08	1990-12-28	Transgene Sa	Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
GB8817161D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Modified proteins
GB8817160D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Novel proteins
US5284768A (en) *	1988-08-24	1994-02-08	Sanofi	Signal peptide, DNA sequences coding for the latter, expression vectors carrying one of these sequences, gram-negative bacteria transformed by these vectors, and process for the periplasmic production of a polypeptide
FR2645175B1 (fr) *	1989-03-31	1994-02-18	Transgene Sa	Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
FR2645174B1 (fr) *	1989-03-31	1994-01-07	Transgene Sa	Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
US5879926A (en) *	1989-03-31	1999-03-09	Transgene S.A.	Yeast strains for the production of mature heterologous proteins, especially hirudin
FR2646437B1 (fr) *	1989-04-28	1991-08-30	Transgene Sa	Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
FR2656531B1 (fr) *	1989-12-29	1992-04-24	Sanofi Sa	Promoteur artificiel pour l'expression de proteines dans le levure.
US5118790A (en) *	1990-07-24	1992-06-02	Sri International	Analogs of hirudin
WO1992008736A1 (en) *	1990-11-08	1992-05-29	Nippon Mining Company Limited	Hirudine mutant, production thereof, anticoagulant, secretory vector, microorganism transformed by said vector, and production of product from said microorganism
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
US5407822A (en) *	1991-10-02	1995-04-18	Sanofi	Artificial promoter for the expression of proteins in yeast
US20210317162A1 (en) *	2019-04-16	2021-10-14	Sungen Bioscience Co., Ltd.	Method for extraction and purification of hirudin mutant and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341417C (fr) *	1984-03-27	2003-01-21	Paul Tolstoshev	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
EP0168342B1 (de) *	1984-06-14	1991-07-03	Ciba-Geigy Ag	Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
DE3689525D1 (de) *	1985-07-17	1994-02-24	Hoechst Ag	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.

1986
- 1986-12-01 FR FR868616723A patent/FR2607517B2/fr not_active Expired
1987
- 1987-11-25 NO NO874905A patent/NO177500C/no not_active IP Right Cessation
- 1987-11-27 IE IE323987A patent/IE60544B1/en not_active IP Right Cessation
- 1987-11-27 AU AU81880/87A patent/AU617989B2/en not_active Expired
- 1987-11-27 PT PT86233A patent/PT86233B/pt unknown
- 1987-11-30 AT AT87402696T patent/ATE73462T1/de not_active IP Right Cessation
- 1987-11-30 ES ES198787402696T patent/ES2032465T3/es not_active Expired - Lifetime
- 1987-11-30 CA CA000553153A patent/CA1341416C/fr not_active Expired - Fee Related
- 1987-11-30 EP EP87402696A patent/EP0273800B1/fr not_active Expired - Lifetime
- 1987-11-30 DE DE8787402696T patent/DE3777367D1/de not_active Expired - Lifetime
- 1987-11-30 RO RO130679A patent/RO106890B1/ro unknown
- 1987-11-30 SU SU874203831A patent/SU1687032A3/ru active
- 1987-11-30 DK DK198706276A patent/DK173247B1/da not_active IP Right Cessation
- 1987-12-01 HU HU875394A patent/HU213871B/hu unknown
- 1987-12-01 JP JP62305504A patent/JP2567263B2/ja not_active Expired - Lifetime
- 1987-12-01 FI FI875295A patent/FI99211C/fi not_active IP Right Cessation
- 1987-12-01 KR KR1019870013708A patent/KR960011918B1/ko not_active IP Right Cessation
- 1987-12-01 ZA ZA879011A patent/ZA879011B/xx unknown
- 1987-12-01 PL PL1987269164A patent/PL157254B1/pl unknown
- 1987-12-01 BG BG082035A patent/BG49719A3/xx unknown
- 1987-12-01 CS CS878732A patent/CS276245B6/cs not_active IP Right Cessation
- 1987-12-01 MC MC871932A patent/MC1884A1/xx unknown
1992
- 1992-05-12 GR GR920400903T patent/GR3004556T3/el unknown
1995
- 1995-06-07 US US08/480,511 patent/US5650301A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK173247B1 (da)	2000-05-22
RO106890B1 (ro)	1993-07-30
AU8188087A (en)	1988-06-02
NO177500C (no)	1995-09-27
ATE73462T1 (de)	1992-03-15
KR880007729A (ko)	1988-08-29
JP2567263B2 (ja)	1996-12-25
MC1884A1 (fr)	1989-01-24
EP0273800A3 (en)	1988-07-20
DK627687A (da)	1988-06-02
GR3004556T3 (fi)	1993-04-28
CS8708732A2 (en)	1991-07-16
CA1341416C (fr)	2003-01-21
PL269164A1 (en)	1988-08-18
US5650301A (en)	1997-07-22
FI875295A0 (fi)	1987-12-01
IE60544B1 (en)	1994-07-27
PT86233A (fr)	1987-12-01
EP0273800B1 (fr)	1992-03-11
BG49719A3 (bg)	1992-01-15
ZA879011B (en)	1988-05-27
NO874905L (no)	1988-06-02
FI99211B (fi)	1997-07-15
CS276245B6 (en)	1992-05-13
KR960011918B1 (ko)	1996-09-04
FI99211C (fi)	1997-10-27
EP0273800A2 (fr)	1988-07-06
FR2607517B2 (fr)	1989-12-22
DE3777367D1 (de)	1992-04-16
IE873239L (en)	1988-06-01
HUT45564A (en)	1988-07-28
PT86233B (pt)	1990-11-07
NO177500B (no)	1995-06-19
PL157254B1 (pl)	1992-05-29
FR2607517A2 (fr)	1988-06-03
NO874905D0 (no)	1987-11-25
AU617989B2 (en)	1991-12-12
DK627687D0 (da)	1987-11-30
HU213871B (en)	1997-11-28
JPS63152987A (ja)	1988-06-25
ES2032465T3 (es)	1993-02-16
SU1687032A3 (ru)	1991-10-23

Publication	Publication Date	Title
FI893929L (fi)	1989-08-22	Menetelmä stabiilin sinkki-protamiini- -interferonikompleksin valmistamiseksi
FI892055L (fi)	1989-04-28	Menetelmä nikotiinia luovuttavan laitteen valmistamiseksi
FI891711L (fi)	1989-12-26	Menetelmä diorganodialkoksisilaanien valmistamiseksi
ES540443A0 (es)	1986-04-16	Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos
FI875295L (fi)	1988-06-02	Menetelmä hirudiinivariantin valmistamiseksi
FI892686L (fi)	1989-12-05	Menetelmä hirudiinijohdannaisen valmistamiseksi
FI871670A0 (fi)	1987-04-15	Menetelmä osseiini-hydroksiapatiittiyhdisteen valmistamiseksi
FI890127L (fi)	1989-07-14	Menetelmä terapeuttisesti käyttökelpoisen hirudiinijohdannaisen valmistamiseksi
FI870050L (fi)	1988-07-08	Menetelmä hajunpoistoaineen valmistamiseksi
FI871131L (fi)	1987-09-18	Menetelmä rokotteen valmistamiseksi
FI891062L (fi)	1989-09-11	Menetelmä terapeuttisesti käyttökelpoisen sialosyyliglyseridin valmistamiseksi
FI874852L (fi)	1988-05-05	Analogiamenetelmä sytotoksisen koostumuksen valmistamiseksi
FR2616694B1 (fr)	1989-10-20	Machine a brocher
ES540923A0 (es)	1986-11-16	Un procedimiento de preparar un compuesto de piridobenzodia-zepina
FI882314L (fi)	1988-11-19	Halogeeni-imidien valmistusmenetelmä
RO93557A2 (ro)	1988-01-30	Procedeu de obtinere a monometiladipatului
MD126B1 (ro)	1994-12-31	Procedeu de obtinere a 6-esterilor zaharozei
RO94201A (ro)	1988-03-30	Procedeu de obtinere a bisoxalato-oxotitanatului dipotasuc dihidrat
RO92960A2 (ro)	1987-11-30	Procedeu de obtinere a 2-hidroxi-1-naftaldehidei
RO94030A2 (ro)	1988-05-30	Procedeu de obtinere a foliei de policlorura de vinil antistatizata
ES537428A0 (es)	1985-09-16	Procedimiento de preparacion de un derivado de la pirazolona
ES539143A0 (es)	1986-04-01	Procedimiento de preparacion de un derivado de pirrolidina
ES539142A0 (es)	1985-11-16	Procedimiento de preparacion de un derivado de piperidinobutanol
RO90835A2 (ro)	1987-01-30	Procedeu de preparare a 5-baloveratraldehidelor
RO90635A2 (ro)	1986-12-10	Procedeu de preparare a 5-haloveratraldehidelor

Legal Events

Date	Code	Title	Description
1987-12-01	FG	Patent granted	Owner name: TRANSGENE S.A.
1997-06-17	BB	Publication of examined application
2004-08-31	FG	Patent granted	Owner name: SCHERING AKTIENGESELLSCHAFT
2008-01-21	MA	Patent expired