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FI871869A - Kniv foer radiell hornhinneoperation och system foer dess anvaendning. - Google Patents

Kniv foer radiell hornhinneoperation och system foer dess anvaendning. Download PDF

Info

Publication number
FI871869A
FI871869A FI871869A FI871869A FI871869A FI 871869 A FI871869 A FI 871869A FI 871869 A FI871869 A FI 871869A FI 871869 A FI871869 A FI 871869A FI 871869 A FI871869 A FI 871869A
Authority
FI
Finland
Prior art keywords
foer
radiell
hornhinneoperation
kniv
dess anvaendning
Prior art date
Application number
FI871869A
Other languages
English (en)
Other versions
FI871869A0 (fi
Inventor
John W Berkman
Michael H Curtis
David A Dewey
Original Assignee
Coopervision Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coopervision Inc filed Critical Coopervision Inc
Publication of FI871869A publication Critical patent/FI871869A/fi
Publication of FI871869A0 publication Critical patent/FI871869A0/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/32Surgical cutting instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/013Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Laser Surgery Devices (AREA)
  • Surgical Instruments (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Dowels (AREA)
  • Soil Working Implements (AREA)
FI871869A 1985-08-29 1987-04-28 Kniv foer radiell hornhinneoperation och system foer dess anvaendning. FI871869A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/770,528 US4750489A (en) 1985-08-29 1985-08-29 Radial keratotomy knife and system using same
PCT/US1986/001742 WO1987001272A1 (en) 1985-08-29 1986-08-22 Radial keratotomy knife and system using same

Publications (2)

Publication Number Publication Date
FI871869A true FI871869A (fi) 1987-04-28
FI871869A0 FI871869A0 (fi) 1987-04-28

Family

ID=25088859

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871869A FI871869A0 (fi) 1985-08-29 1987-04-28 Kniv foer radiell hornhinneoperation och system foer dess anvaendning.

Country Status (13)

Country Link
US (1) US4750489A (fi)
EP (1) EP0235260A4 (fi)
JP (1) JPS63500645A (fi)
KR (1) KR870700327A (fi)
AU (1) AU603065B2 (fi)
BR (1) BR8606852A (fi)
CA (1) CA1281962C (fi)
DK (1) DK215687A (fi)
ES (1) ES2001915A6 (fi)
FI (1) FI871869A0 (fi)
GR (1) GR861992B (fi)
PT (1) PT83282A (fi)
WO (1) WO1987001272A1 (fi)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426669A1 (en) * 1988-02-24 1991-05-15 REFRACTIVE LASER RESEARCH & DEVELOPMENT PROGRAM, LTD. Method and apparatus for controlling the depth of cut of a laser knife
US5599347A (en) * 1991-02-13 1997-02-04 Applied Medical Resources Corporation Surgical trocar with cutoff circuit
CA2080467A1 (en) * 1991-02-13 1992-08-14 Nabil Hilal Surgical trocar
US5984919A (en) * 1991-02-13 1999-11-16 Applied Medical Resources Corporation Surgical trocar
US5324288A (en) * 1991-04-30 1994-06-28 Utah Medical Products, Inc. Electrosurgical loop with a depth gauge
US5212505A (en) * 1991-12-16 1993-05-18 General Electric Company Alignment system for keratograph
WO1994005225A1 (en) * 1992-09-02 1994-03-17 Epstein Robert L Instrument for ophthalmological surgery
US5376099A (en) * 1992-09-17 1994-12-27 Kmi, Inc. Undercut diamond surgical blade and method of using the same
US5323543A (en) * 1992-09-29 1994-06-28 Keratron Group Apparatus and method for calibrating a surgical knife
US5423813A (en) * 1993-03-18 1995-06-13 Coopersurgical Resectoscope and electrode assembly
US5411511A (en) * 1993-11-12 1995-05-02 Hall; Gary W. Method and device for determining placement of keratotomy incisions
US5552822A (en) * 1993-11-12 1996-09-03 Nallakrishnan; Ravi Apparatus and method for setting depth of cut of micrometer surgical knife
US5611805A (en) * 1993-11-12 1997-03-18 Hall; Gary W. Method and device for determining placement of keratotomy incisions
US5486188A (en) * 1993-11-15 1996-01-23 Smith; Alan D. Keratoscopic surgical instrument for making radial and arcuate corneal incisions
US5591174A (en) * 1994-02-02 1997-01-07 Chiron Vision Corporation Microkeratome and method and apparatus for calibrating a microkeratome
DE19604156A1 (de) * 1996-02-06 1997-08-07 Boehringer Mannheim Gmbh Schneidvorrichtung für Haut zur schmerzarmen Entnahme kleiner Blutmengen
US7166117B2 (en) 1996-02-07 2007-01-23 Hellenkamp Johann F Automatic surgical device and control assembly for cutting a cornea
US7235056B2 (en) 1996-05-17 2007-06-26 Amira Medical Body fluid sampling device and methods of use
US7828749B2 (en) 1996-05-17 2010-11-09 Roche Diagnostics Operations, Inc. Blood and interstitial fluid sampling device
US7666150B2 (en) * 1996-05-17 2010-02-23 Roche Diagnostics Operations, Inc. Blood and interstitial fluid sampling device
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
EP1579814A3 (en) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US5766198A (en) * 1996-06-10 1998-06-16 Li; Bing Surgical knife employing a vacuum to ensure precise depth of incisions
US5913874A (en) * 1997-09-25 1999-06-22 Cabot Technology Corporation Cartridge for a surgical instrument
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US5938674A (en) * 1998-03-23 1999-08-17 Terry; Clifford M. Astigmatism reducing cutter
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6187000B1 (en) * 1998-08-20 2001-02-13 Endius Incorporated Cannula for receiving surgical instruments
WO2000078258A1 (en) * 1999-06-21 2000-12-28 Keravision, Inc. Corneal depth measuring system and method
DE10010694A1 (de) * 2000-03-04 2001-09-06 Roche Diagnostics Gmbh Blutlanzette mit hygienischen Spitzenschutz
EP1365974A2 (en) * 2000-07-03 2003-12-03 Kodiak Technologies, Inc. Thermal container with data monitoring system
DE10053974A1 (de) * 2000-10-31 2002-05-29 Roche Diagnostics Gmbh System zur Blutentnahme
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
CZ20031992A3 (cs) 2001-01-22 2004-11-10 F. Hoffmann-La Roche Ag Lancetové zařízení s kapilární vzlínavostí
US20020188223A1 (en) 2001-06-08 2002-12-12 Edward Perez Devices and methods for the expression of bodily fluids from an incision
EP1416851B1 (en) * 2001-06-08 2006-08-09 Roche Diagnostics GmbH Bodily fluid sampling device and test media cassette to be used with such a device
US7001344B2 (en) 2001-06-12 2006-02-21 Pelikan Technologies, Inc. Blood sampling device with diaphragm actuated lancet
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2002100461A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
DE60234597D1 (de) 2001-06-12 2010-01-14 Pelikan Technologies Inc Gerät und verfahren zur entnahme von blutproben
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
EP1404233B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
DE10142232B4 (de) 2001-08-29 2021-04-29 Roche Diabetes Care Gmbh Verfahren zur Herstellung eines analytischen Hilfsmittels mit Lanzette und Testelement
CA2458208A1 (en) * 2001-08-29 2003-03-13 F. Hoffmann-La Roche Ag Wicking methods and structures for use in sampling bodily fluids
CA2461370A1 (en) 2001-09-26 2003-05-15 F. Hoffmann-La Roche Ag Method and apparatus for sampling bodily fluid
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2003088824A2 (en) * 2002-04-19 2003-10-30 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7485128B2 (en) 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) * 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7244265B2 (en) 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7731900B2 (en) * 2002-11-26 2010-06-08 Roche Diagnostics Operations, Inc. Body fluid testing device
US7582258B2 (en) * 2002-12-23 2009-09-01 Roche Diagnostics Operations, Inc. Body fluid testing device
EP1578271B1 (en) 2002-12-23 2011-05-25 Roche Diagnostics GmbH Body fluid testing device
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
WO2004093762A1 (en) 2003-04-07 2004-11-04 Bausch & Lomb Incorporated Bar-link drive system for a microkeratome
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
ES2490740T3 (es) 2003-06-06 2014-09-04 Sanofi-Aventis Deutschland Gmbh Aparato para toma de muestras de fluido sanguíneo y detección de analitos
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US20050209618A1 (en) * 2004-03-05 2005-09-22 Auld Michael D Rigid shafted instrumentation for vitreoretinal surgery
US7488327B2 (en) 2004-04-12 2009-02-10 Synthes (U.S.A.) Free hand drill guide
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc METHOD AND APPARATUS FOR MANUFACTURING A DEVICE FOR SAMPLING LIQUIDS
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US8617195B2 (en) 2005-08-04 2013-12-31 Bayer Healthcare Llc Lancing device
EP2114502B1 (en) * 2006-12-08 2014-07-30 Boston Scientific Limited Therapeutic catheter with displacement sensing transducer
US20080319463A1 (en) * 2007-06-19 2008-12-25 Dyson William Hickingbotham Apparatus, system and method for illuminated membrane manipulator
EP2265324B1 (en) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integrated analyte measurement system
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8558408B2 (en) 2010-09-29 2013-10-15 General Electric Company System and method for providing redundant power to a device
US8278779B2 (en) 2011-02-07 2012-10-02 General Electric Company System and method for providing redundant power to a device
WO2018146636A1 (en) * 2017-02-12 2018-08-16 Alireza Ahmadian Location tracking on a surface

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324044A (en) * 1980-08-04 1982-04-13 Shahinian Jr Lee Surgical knife for precise depth of cut control
US4340059A (en) * 1980-10-23 1982-07-20 Marinoff Gerald P Radial keratotomy device
US4406285A (en) * 1981-01-23 1983-09-27 Richard A. Villasenor Manual radial and chordal keratotometry apparatus
US4546773A (en) * 1981-01-23 1985-10-15 Accutome, Inc. Apparatus to measure conical thickness
US4473076A (en) * 1982-04-07 1984-09-25 Vxtra Development Limited 700 Division Surgical knife
US4516575A (en) * 1982-06-03 1985-05-14 Coopervision, Inc. Surgical scalpel
US4499898A (en) * 1982-08-23 1985-02-19 Koi Associates Surgical knife with controllably extendable blade and gauge therefor

Also Published As

Publication number Publication date
AU603065B2 (en) 1990-11-08
ES2001915A6 (es) 1988-07-01
CA1281962C (en) 1991-03-26
DK215687D0 (da) 1987-04-28
JPS63500645A (ja) 1988-03-10
PT83282A (en) 1986-09-01
DK215687A (da) 1987-04-28
BR8606852A (pt) 1987-11-03
WO1987001272A1 (en) 1987-03-12
GR861992B (en) 1986-10-02
EP0235260A4 (en) 1988-06-27
KR870700327A (ko) 1987-12-28
EP0235260A1 (en) 1987-09-09
AU6334186A (en) 1987-03-24
FI871869A0 (fi) 1987-04-28
US4750489A (en) 1988-06-14

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Legal Events

Date Code Title Description
FA Application withdrawn

Owner name: COOPERVISION, INC.