FI86733C - Analogifoerfarande foer framstaellning av terapeutiskt anvaendbar piperazinkarboxylsyra - Google Patents

Analogifoerfarande foer framstaellning av terapeutiskt anvaendbar piperazinkarboxylsyra Download PDF

Info

Publication number: FI86733C
Authority: FI; Finland
Prior art keywords: compound; formula; alkyl; preparation; dose
Prior art date: 1987-02-18

Application number

FI880744A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI880744A0 (fi

FI86733B (fi

FI880744A (fi

Inventor

Bernhard Aebischer

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-18

Filing date

1988-02-17

Publication date

1992-10-12

1988-02-17 Application filed by Sandoz Ag filed Critical Sandoz Ag

1988-02-17 Publication of FI880744A0 publication Critical patent/FI880744A0/fi

1988-08-19 Publication of FI880744A publication Critical patent/FI880744A/fi

1992-06-30 Publication of FI86733B publication Critical patent/FI86733B/fi

1992-10-12 Application granted granted Critical

1992-10-12 Publication of FI86733C publication Critical patent/FI86733C/fi

Links

238000000034 method Methods 0.000 title claims description 7
238000002360 preparation method Methods 0.000 title claims description 5
RFIOZSIHFNEKFF-UHFFFAOYSA-N piperazine-1-carboxylic acid Chemical compound OC(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 80
150000003839 salts Chemical class 0.000 claims description 14
125000000217 alkyl group Chemical group 0.000 claims description 12
-1 3-phosphono-2-propenyl Chemical group 0.000 claims description 6
125000003118 aryl group Chemical group 0.000 claims description 5
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
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150000004682 monohydrates Chemical class 0.000 description 16
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DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
210000002332 leydig cell Anatomy 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229940040129 luteinizing hormone Drugs 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000028161 membrane depolarization Effects 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
YNAVUWVOSKDBBP-UHFFFAOYSA-O morpholinium Chemical compound [H+].C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-O 0.000 description 1
230000003961 neuronal insult Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
210000003101 oviduct Anatomy 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
230000007180 physiological regulation Effects 0.000 description 1
JSSXHAMIXJGYCS-UHFFFAOYSA-N piperazin-4-ium-2-carboxylate Chemical class OC(=O)C1CNCCN1 JSSXHAMIXJGYCS-UHFFFAOYSA-N 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000002040 relaxant effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
238000012982 x-ray structure analysis Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI880744A 1987-02-18 1988-02-17 Analogifoerfarande foer framstaellning av terapeutiskt anvaendbar piperazinkarboxylsyra FI86733C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878703749A GB8703749D0 (en)	1987-02-18	1987-02-18	Piperazinecarboxylic acid
GB8703749		1987-02-18

Publications (4)

Publication Number	Publication Date
FI880744A0 FI880744A0 (fi)	1988-02-17
FI880744A FI880744A (fi)	1988-08-19
FI86733B FI86733B (fi)	1992-06-30
FI86733C true FI86733C (fi)	1992-10-12

Family

ID=10612501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI880744A FI86733C (fi)	1987-02-18	1988-02-17	Analogifoerfarande foer framstaellning av terapeutiskt anvaendbar piperazinkarboxylsyra

Country Status (28)

Country	Link
JP (1)	JPH0723387B2 (pt)
KR (1)	KR960015190B1 (pt)
AT (1)	AT391320B (pt)
AU (1)	AU613009B2 (pt)
BE (1)	BE1002427A3 (pt)
CA (1)	CA1327799C (pt)
CH (1)	CH675125A5 (pt)
CY (1)	CY1739A (pt)
DE (1)	DE3804936C2 (pt)
DK (1)	DK168441B1 (pt)
ES (2)	ES2011319A6 (pt)
FI (1)	FI86733C (pt)
FR (1)	FR2610932B1 (pt)
GB (2)	GB8703749D0 (pt)
GR (1)	GR1002471B (pt)
HK (1)	HK142093A (pt)
HU (2)	HU199858B (pt)
IE (1)	IE59098B1 (pt)
IL (1)	IL85436A0 (pt)
IT (1)	IT1219447B (pt)
LU (1)	LU87129A1 (pt)
MY (1)	MY103206A (pt)
NL (1)	NL8800412A (pt)
NZ (1)	NZ223529A (pt)
PH (1)	PH25512A (pt)
PT (1)	PT86776B (pt)
SE (1)	SE467256B (pt)
ZA (1)	ZA881146B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU202111B (en) *	1988-03-11	1991-02-28	Sandoz Ag	Process for producing pharmaceutical compositions containing (r)-(e)-4--(3-phosphono-2-propenyl)-2-piperazine-carboxylic acid as active component
US5086072A (en) *	1990-06-18	1992-02-04	The United States Of America As Represented By The Department Of Health And Human Services	Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex
EP0488959A3 (en) *	1990-11-28	1992-08-05	Sandoz Ltd.	New uses of competitive nmda receptor antagonists
US5260286A (en) *	1992-10-16	1993-11-09	Japan Tobacco, Inc.	2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
AU5693996A (en) *	1995-05-08	1996-11-29	Lonza A.G.	Biotechnical production process of piperazine r-alpha-carbox ylic acids and piperazine s-alpha-carboxylic acid amide
ES2206928T3 (es)	1997-05-12	2004-05-16	Ortho-Mcneil Pharmaceutical, Inc.	Piperacinas sustituidas con arilo utiles en el tratamiento de la hiperplasia benigna de prostata.
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
JP2008124531A (ja)	2006-11-08	2008-05-29	Nec Electronics Corp	半導体装置およびオーディオプロセッサチップ
EP3427729A1 (en)	2017-07-13	2019-01-16	Paris Sciences et Lettres - Quartier Latin	Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids

1987
- 1987-02-18 GB GB878703749A patent/GB8703749D0/en active Pending
1988
- 1988-02-11 LU LU87129A patent/LU87129A1/fr unknown
- 1988-02-12 FR FR888801782A patent/FR2610932B1/fr not_active Expired - Lifetime
- 1988-02-12 BE BE8800177A patent/BE1002427A3/fr active
- 1988-02-12 IT IT47631/88A patent/IT1219447B/it active
- 1988-02-15 MY MYPI88000155A patent/MY103206A/en unknown
- 1988-02-15 GB GB8803438A patent/GB2201676B/en not_active Expired - Lifetime
- 1988-02-16 NZ NZ223529A patent/NZ223529A/xx unknown
- 1988-02-16 DK DK079688A patent/DK168441B1/da not_active IP Right Cessation
- 1988-02-16 HU HU88746A patent/HU199858B/hu not_active IP Right Cessation
- 1988-02-16 PH PH36514A patent/PH25512A/en unknown
- 1988-02-16 CH CH549/88A patent/CH675125A5/de not_active IP Right Cessation
- 1988-02-16 CA CA000559170A patent/CA1327799C/en not_active Expired - Fee Related
- 1988-02-16 IE IE41388A patent/IE59098B1/en not_active IP Right Cessation
- 1988-02-16 AU AU11758/88A patent/AU613009B2/en not_active Ceased
- 1988-02-16 GR GR880100084A patent/GR1002471B/el not_active IP Right Cessation
- 1988-02-16 IL IL85436A patent/IL85436A0/xx not_active IP Right Cessation
- 1988-02-17 JP JP63036458A patent/JPH0723387B2/ja not_active Expired - Lifetime
- 1988-02-17 FI FI880744A patent/FI86733C/fi not_active IP Right Cessation
- 1988-02-17 DE DE3804936A patent/DE3804936C2/de not_active Expired - Fee Related
- 1988-02-17 KR KR1019880001680A patent/KR960015190B1/ko not_active IP Right Cessation
- 1988-02-17 SE SE8800541A patent/SE467256B/sv not_active IP Right Cessation
- 1988-02-17 PT PT86776A patent/PT86776B/pt not_active IP Right Cessation
- 1988-02-17 AT AT0036788A patent/AT391320B/de not_active IP Right Cessation
- 1988-02-18 ZA ZA881146A patent/ZA881146B/xx unknown
- 1988-02-18 NL NL8800412A patent/NL8800412A/nl not_active Application Discontinuation
- 1988-02-18 ES ES888800466A patent/ES2011319A6/es not_active Expired - Lifetime
1989
- 1989-10-16 ES ES8903482A patent/ES2021904A6/es not_active Expired - Lifetime
1993
- 1993-12-30 HK HK1420/93A patent/HK142093A/xx not_active IP Right Cessation
1995
- 1995-06-09 HU HU95P/P00176P patent/HU211269A9/hu unknown
- 1995-10-20 CY CY173995A patent/CY1739A/xx unknown

Also Published As

Publication number	Publication date
ES2021904A6 (es)	1991-11-16
IE59098B1 (en)	1994-01-12
HK142093A (en)	1994-01-07
KR960015190B1 (ko)	1996-11-01
PH25512A (en)	1991-07-24
MY103206A (en)	1993-05-29
IT8847631A0 (it)	1988-02-12
AU613009B2 (en)	1991-07-25
FI880744A0 (fi)	1988-02-17
ATA36788A (de)	1990-03-15
CA1327799C (en)	1994-03-15
NZ223529A (en)	1991-02-26
ZA881146B (en)	1989-10-25
ES2011319A6 (es)	1990-01-01
FR2610932A1 (fr)	1988-08-19
DE3804936C2 (de)	1997-02-13
HUT49361A (en)	1989-09-28
GB8803438D0 (en)	1988-03-16
IL85436A0 (en)	1988-07-31
DK79688D0 (da)	1988-02-16
DE3804936A1 (de)	1988-09-01
HU199858B (en)	1990-03-28
CH675125A5 (pt)	1990-08-31
DK79688A (da)	1988-08-19
IE880413L (en)	1988-08-18
PT86776B (pt)	1992-05-29
JPH0723387B2 (ja)	1995-03-15
GR880100084A (el)	1988-12-16
FI86733B (fi)	1992-06-30
GB2201676B (en)	1991-01-02
GB8703749D0 (en)	1987-03-25
KR880009944A (ko)	1988-10-06
IL85436A (pt)	1992-12-01
IT1219447B (it)	1990-05-18
BE1002427A3 (fr)	1991-02-05
DK168441B1 (da)	1994-03-28
LU87129A1 (fr)	1988-09-20
FI880744A (fi)	1988-08-19
AT391320B (de)	1990-09-25
GB2201676A (en)	1988-09-07
SE8800541D0 (sv)	1988-02-17
CY1739A (en)	1995-10-20
NL8800412A (nl)	1988-09-16
FR2610932B1 (fr)	1990-11-16
PT86776A (pt)	1988-03-01
HU211269A9 (en)	1995-11-28
GR1002471B (el)	1996-11-15
SE467256B (sv)	1992-06-22
AU1175888A (en)	1988-08-25
JPS63203691A (ja)	1988-08-23

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KR20150028971A (ko)	2015-03-17	항바이러스성 화합물의 고체 형태
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FI86733C (fi)	1992-10-12	Analogifoerfarande foer framstaellning av terapeutiskt anvaendbar piperazinkarboxylsyra
WO1998043638A1 (fr)	1998-10-08	Agent therapeutique pour maladies auto-immunes
DE69910787T2 (de)	2004-07-08	Neuartige, pharmazeutisch aktive verbindung
JPH072637B2 (ja)	1995-01-18	キノリジン誘導体を含有する医薬組成物
JPH0262544B2 (pt)	1990-12-26
EP0105632A1 (en)	1984-04-18	1-Phenyl-2-methyl-3-(1-pyrrolidinyl)-1-propanone derivative, process for preparation thereof, and composition containing the same
JPS61500437A (ja)	1986-03-13	ｎ−プロパノ−ルアミン誘導体のエ−テル
WO2006088080A1 (ja)	2006-08-24	シクロヘプタ［ｂ］ピリジン－３－カルボニルグアニジン誘導体およびそれを含有する医薬品
CA1278572C (en)	1991-01-02	Ameliorant of cerebral circulation and metabolism
CN113603689B (zh)	2023-07-21	多环吡啶酮化合物及其药物组合物和用途
US5508401A (en)	1996-04-16	Substituted dibenzo[a,d]cycloheptene NMDA antagonists
EP0171912B1 (en)	1990-05-02	Pyrrolizidine compounds, methods for their production, and their uses
EP0418655B1 (en)	1995-04-19	Conjugated gamma-hydroxybutenolide compounds and antiulcer agents containing the same as an effective ingredient
US4904670A (en)	1990-02-27	Pyridine derivatives having anxiety state or sleep thereapeutic properties
WO2006029549A1 (fr)	2006-03-23	Composes de quinuclidine a groupe ammonium quaternaire, procede d'elaboration et utilisation comme agents de blocage de l'acetycholine
GB2087889A (en)	1982-06-03	Naphthyridine derivatives
DE2843328A1 (de)	1979-04-19	Phenylacetamidverbindungen und sie enthaltende zusammensetzung
US4024259A (en)	1977-05-17	3-Anilino-2,4-diazabicyclo[3.2.1]octenes
RU2173146C2 (ru)	2001-09-10	Производные полициклических алкалоидов как антагонисты nmda-рецептора
FI88039C (fi)	1993-03-25	Foerfarande foer framstaellning av 2,3-dihydro-1-(8-metyl-1,2,4-triatsolo/4,3-b/pyridazin-6-yl)-4(1h)-pyridinon
RU2015964C1 (ru)	1994-07-15	Способ получения замещенных производных амина
CH635335A5 (en)	1983-03-31	2,3-Diphenylchromone derivatives, process for their preparation and their therapeutic application
EP0175331A1 (en)	1986-03-26	Piperazine Derivatives

Legal Events

Date	Code	Title	Description
1997-08-28	PC	Transfer of assignment of patent	Owner name: NOVARTIS AG
2004-08-31	MM	Patent lapsed	Owner name: NOVARTIS AG