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FI842622A - NYA 2-PIPERAZINOPTREIDINER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEKEMEDEL. - Google Patents

NYA 2-PIPERAZINOPTREIDINER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEKEMEDEL. Download PDF

Info

Publication number
FI842622A
FI842622A FI842622A FI842622A FI842622A FI 842622 A FI842622 A FI 842622A FI 842622 A FI842622 A FI 842622A FI 842622 A FI842622 A FI 842622A FI 842622 A FI842622 A FI 842622A
Authority
FI
Finland
Prior art keywords
piperazinoptreidiner
ceekemedel
nya
group
foerfarande foer
Prior art date
Application number
FI842622A
Other languages
Finnish (fi)
Other versions
FI80454C (en
FI80454B (en
FI842622A0 (en
Inventor
Josef Roch
Josef Nickl
Erich Mueller
Berthold Narr
Johannes Weisenberger
Rainer Zimmermann
Walter Haarmann
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI842622A0 publication Critical patent/FI842622A0/en
Publication of FI842622A publication Critical patent/FI842622A/en
Application granted granted Critical
Publication of FI80454B publication Critical patent/FI80454B/en
Publication of FI80454C publication Critical patent/FI80454C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

New 2-piperazino-pteridines of general formula <IMAGE> are described wherein R1 represents a phenylalkylamino, alkylamino or dialkylamino group, a piperidino, morpholino, thiomorpholino, or 1-oxidothiomorpholino group, R2 represents a dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxidothiomorpholino group and R3 represents a halogen atom, an alkoxy, alkylthio, phenylalkoxy or phenylalkylthio group, wherein the alkyl moiety may contain from 1 to 3 carbon atoms, and the acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable pharmacological properties, particularly antithrombotic and metastasis-inhibiting effects. Processes for preparing the compounds of formula (I) are also described.
FI842622A 1983-07-02 1984-06-29 Process for the preparation of pharmacologically valuable 2-piperazino-pteridines FI80454C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3323932 1983-07-02
DE19833323932 DE3323932A1 (en) 1983-07-02 1983-07-02 NEW 2-PIPERAZINO-PTERIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND

Publications (4)

Publication Number Publication Date
FI842622A0 FI842622A0 (en) 1984-06-29
FI842622A true FI842622A (en) 1985-01-03
FI80454B FI80454B (en) 1990-02-28
FI80454C FI80454C (en) 1990-06-11

Family

ID=6203017

Family Applications (1)

Application Number Title Priority Date Filing Date
FI842622A FI80454C (en) 1983-07-02 1984-06-29 Process for the preparation of pharmacologically valuable 2-piperazino-pteridines

Country Status (17)

Country Link
EP (1) EP0134922B1 (en)
JP (1) JPS6025991A (en)
AT (1) ATE39253T1 (en)
AU (1) AU565105B2 (en)
CA (1) CA1233179A (en)
DD (1) DD229990A5 (en)
DE (2) DE3323932A1 (en)
DK (1) DK159113C (en)
ES (2) ES8503352A1 (en)
FI (1) FI80454C (en)
GB (1) GB2143232B (en)
HU (1) HU190932B (en)
IL (1) IL72265A (en)
NO (1) NO160920C (en)
NZ (1) NZ208725A (en)
PH (1) PH22493A (en)
ZA (1) ZA844968B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445298A1 (en) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach NEW PTERIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF AS INTERMEDIATE PRODUCTS OR AS A MEDICINAL PRODUCT
DE3540952C2 (en) * 1985-11-19 1997-08-14 Thomae Gmbh Dr K 2-Piperazino-pteridines, process for their preparation and medicaments containing these compounds
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (en) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridine derivatives, process for their preparation and their use
ES2295897T3 (en) * 2003-08-29 2008-04-16 4 Aza Ip Nv IMMUNODEPRESSING EFFECTS OF PTERIDINE DERIVATIVES.
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
DE102004057645A1 (en) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
DE102004057595A1 (en) * 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057594A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitute pteridine for the treatment of inflammatory diseases
DE102004057618A1 (en) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
EP2032585B1 (en) 2006-05-24 2014-07-23 Boehringer Ingelheim International GmbH Substituted pteridines as therapeutic agents
WO2007135027A1 (en) * 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituted pteridines substituted with a four-membered heterocycle
WO2008003149A2 (en) * 2006-07-06 2008-01-10 Gilead Sciences , Inc. Substituted pteridines for the treatment and prevention of viral infections
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
EP3722297A1 (en) 2015-03-04 2020-10-14 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
EP3507288B1 (en) 2016-09-02 2020-08-26 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
PL3507276T3 (en) 2016-09-02 2022-02-21 Gilead Sciences, Inc. Toll like receptor modulator compounds
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TWI751517B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202115056A (en) 2019-06-28 2021-04-16 美商基利科學股份有限公司 Processes for preparing toll-like receptor modulator compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) * 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
FR1352111A (en) * 1962-01-25 1964-02-14 Lumiere Lab Triamino pteridines and their preparation

Also Published As

Publication number Publication date
DK316284D0 (en) 1984-06-28
ES537785A0 (en) 1985-10-16
EP0134922B1 (en) 1988-12-14
NO160920C (en) 1989-06-14
IL72265A0 (en) 1984-10-31
NO160920B (en) 1989-03-06
NO842631L (en) 1985-01-03
ES533298A0 (en) 1985-02-16
FI80454C (en) 1990-06-11
AU3009284A (en) 1985-01-03
ZA844968B (en) 1986-03-26
HU190932B (en) 1986-12-28
IL72265A (en) 1987-08-31
ES8601205A1 (en) 1985-10-16
GB2143232B (en) 1986-11-05
AU565105B2 (en) 1987-09-03
DK159113B (en) 1990-09-03
CA1233179A (en) 1988-02-23
DE3323932A1 (en) 1985-01-10
DK316284A (en) 1985-01-03
PH22493A (en) 1988-09-12
ATE39253T1 (en) 1988-12-15
HUT34487A (en) 1985-03-28
DK159113C (en) 1991-02-18
GB2143232A (en) 1985-02-06
DD229990A5 (en) 1985-11-20
JPS6025991A (en) 1985-02-08
EP0134922A1 (en) 1985-03-27
FI80454B (en) 1990-02-28
GB8416682D0 (en) 1984-08-01
ES8503352A1 (en) 1985-02-16
DE3475620D1 (en) 1989-01-19
FI842622A0 (en) 1984-06-29
NZ208725A (en) 1988-10-28

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: DR. KARL THOMAE GESELLSCHAFT MIT