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AU3009284A - Piperazino substituted pteridines - Google Patents

Piperazino substituted pteridines

Info

Publication number
AU3009284A
AU3009284A AU30092/84A AU3009284A AU3009284A AU 3009284 A AU3009284 A AU 3009284A AU 30092/84 A AU30092/84 A AU 30092/84A AU 3009284 A AU3009284 A AU 3009284A AU 3009284 A AU3009284 A AU 3009284A
Authority
AU
Australia
Prior art keywords
group
thiomorpholino
piperidino
morpholino
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU30092/84A
Other versions
AU565105B2 (en
Inventor
Walter Haarmann
Erich Muller
Berthold Narr
Josef Nickl
Josef Roch
Johannes Weisenberger
Rainer Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of AU3009284A publication Critical patent/AU3009284A/en
Application granted granted Critical
Publication of AU565105B2 publication Critical patent/AU565105B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New 2-piperazino-pteridines of general formula <IMAGE> are described wherein R1 represents a phenylalkylamino, alkylamino or dialkylamino group, a piperidino, morpholino, thiomorpholino, or 1-oxidothiomorpholino group, R2 represents a dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxidothiomorpholino group and R3 represents a halogen atom, an alkoxy, alkylthio, phenylalkoxy or phenylalkylthio group, wherein the alkyl moiety may contain from 1 to 3 carbon atoms, and the acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable pharmacological properties, particularly antithrombotic and metastasis-inhibiting effects. Processes for preparing the compounds of formula (I) are also described.
AU30092/84A 1983-07-02 1984-07-02 Piperazino substituted pteridines Ceased AU565105B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833323932 DE3323932A1 (en) 1983-07-02 1983-07-02 NEW 2-PIPERAZINO-PTERIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND
DE3323932 1983-07-02

Publications (2)

Publication Number Publication Date
AU3009284A true AU3009284A (en) 1985-01-03
AU565105B2 AU565105B2 (en) 1987-09-03

Family

ID=6203017

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30092/84A Ceased AU565105B2 (en) 1983-07-02 1984-07-02 Piperazino substituted pteridines

Country Status (17)

Country Link
EP (1) EP0134922B1 (en)
JP (1) JPS6025991A (en)
AT (1) ATE39253T1 (en)
AU (1) AU565105B2 (en)
CA (1) CA1233179A (en)
DD (1) DD229990A5 (en)
DE (2) DE3323932A1 (en)
DK (1) DK159113C (en)
ES (2) ES8503352A1 (en)
FI (1) FI80454C (en)
GB (1) GB2143232B (en)
HU (1) HU190932B (en)
IL (1) IL72265A (en)
NO (1) NO160920C (en)
NZ (1) NZ208725A (en)
PH (1) PH22493A (en)
ZA (1) ZA844968B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576924B2 (en) * 1984-12-12 1988-09-08 Dr. Karl Thomae Gmbh 2-piperizino-pteridine derivatives

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3540952C2 (en) * 1985-11-19 1997-08-14 Thomae Gmbh Dr K 2-Piperazino-pteridines, process for their preparation and medicaments containing these compounds
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (en) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridine derivatives, process for their preparation and their use
AU2004267885A1 (en) * 2003-08-29 2005-03-10 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
DE102004057594A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitute pteridine for the treatment of inflammatory diseases
DE102004057645A1 (en) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
DE102004057595A1 (en) * 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057618A1 (en) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
WO2007135027A1 (en) * 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituted pteridines substituted with a four-membered heterocycle
EP2032585B1 (en) 2006-05-24 2014-07-23 Boehringer Ingelheim International GmbH Substituted pteridines as therapeutic agents
WO2008003149A2 (en) * 2006-07-06 2008-01-10 Gilead Sciences , Inc. Substituted pteridines for the treatment and prevention of viral infections
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US9259426B2 (en) 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
KR101756050B1 (en) 2015-03-04 2017-07-07 길리애드 사이언시즈, 인코포레이티드 Toll like receptor modulator compounds
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
WO2018045144A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Toll like receptor modulator compounds
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202115056A (en) 2019-06-28 2021-04-16 美商基利科學股份有限公司 Processes for preparing toll-like receptor modulator compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) * 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
FR1352111A (en) * 1962-01-25 1964-02-14 Lumiere Lab Triamino pteridines and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576924B2 (en) * 1984-12-12 1988-09-08 Dr. Karl Thomae Gmbh 2-piperizino-pteridine derivatives

Also Published As

Publication number Publication date
HU190932B (en) 1986-12-28
ES533298A0 (en) 1985-02-16
DE3475620D1 (en) 1989-01-19
NO842631L (en) 1985-01-03
DE3323932A1 (en) 1985-01-10
GB2143232A (en) 1985-02-06
ZA844968B (en) 1986-03-26
HUT34487A (en) 1985-03-28
DK159113C (en) 1991-02-18
CA1233179A (en) 1988-02-23
EP0134922A1 (en) 1985-03-27
DD229990A5 (en) 1985-11-20
EP0134922B1 (en) 1988-12-14
IL72265A (en) 1987-08-31
NO160920C (en) 1989-06-14
JPS6025991A (en) 1985-02-08
DK316284A (en) 1985-01-03
ATE39253T1 (en) 1988-12-15
AU565105B2 (en) 1987-09-03
ES537785A0 (en) 1985-10-16
PH22493A (en) 1988-09-12
DK159113B (en) 1990-09-03
FI80454C (en) 1990-06-11
ES8503352A1 (en) 1985-02-16
NZ208725A (en) 1988-10-28
FI80454B (en) 1990-02-28
GB2143232B (en) 1986-11-05
DK316284D0 (en) 1984-06-28
FI842622A (en) 1985-01-03
IL72265A0 (en) 1984-10-31
GB8416682D0 (en) 1984-08-01
FI842622A0 (en) 1984-06-29
ES8601205A1 (en) 1985-10-16
NO160920B (en) 1989-03-06

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