FI84064C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat. - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat. Download PDF

Info

Publication number: FI84064C
Authority: FI; Finland
Prior art keywords: silibinin; ethanol; ethyl acetate; animals; parts
Prior art date: 1984-11-22

Application number

FI854535A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI854535A0 (fi

FI84064B (fi

FI854535A (fi

Inventor

Reinhard Braatz

Klaus Goerler

Guenter Halbach

Hartwig Soicke

Karlheinz Schmidt

Original Assignee

Madaus Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-18

Publication date

1991-10-10

1985-11-18 Application filed by Madaus Ag filed Critical Madaus Ag

1985-11-18 Publication of FI854535A0 publication Critical patent/FI854535A0/fi

1986-05-23 Publication of FI854535A publication Critical patent/FI854535A/fi

1991-06-28 Application granted granted Critical

1991-06-28 Publication of FI84064B publication Critical patent/FI84064B/fi

1991-10-10 Publication of FI84064C publication Critical patent/FI84064C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Silicon Compounds (AREA)

FI854535A 1984-11-22 1985-11-18 Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat. FI84064C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19843442639 DE3442639A1 (de)	1984-11-22	1984-11-22	Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
DE3442639		1984-11-22

Publications (4)

Publication Number	Publication Date
FI854535A0 FI854535A0 (fi)	1985-11-18
FI854535A FI854535A (fi)	1986-05-23
FI84064B FI84064B (fi)	1991-06-28
FI84064C true FI84064C (fi)	1991-10-10

Family

ID=6250903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI854535A FI84064C (fi)	1984-11-22	1985-11-18	Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat.

Country Status (29)

Country	Link
JP (1)	JPS61143377A (da)
KR (1)	KR870001020B1 (da)
AR (1)	AR240931A1 (da)
AT (1)	AT393268B (da)
BE (1)	BE903693A (da)
CA (1)	CA1337124C (da)
CH (1)	CH659473A5 (da)
CS (1)	CS273610B2 (da)
DD (1)	DD259191A1 (da)
DE (1)	DE3442639A1 (da)
DK (1)	DK164865C (da)
EG (1)	EG19424A (da)
ES (1)	ES8609311A1 (da)
FI (1)	FI84064C (da)
FR (1)	FR2573427B1 (da)
GB (1)	GB2167414B (da)
HU (1)	HU195503B (da)
IE (1)	IE58791B1 (da)
IT (1)	IT1190426B (da)
LU (1)	LU86163A1 (da)
MX (1)	MX168415B (da)
NL (1)	NL192387C (da)
NO (1)	NO160205C (da)
PL (1)	PL146890B1 (da)
PT (1)	PT81532B (da)
SE (1)	SE465676B (da)
SU (1)	SU1436875A3 (da)
YU (1)	YU43689B (da)
ZA (1)	ZA858951B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8716918D0 (en) *	1987-07-17	1987-08-26	Inverni Della Beffa Spa	Soluble derivatives of silybin
US5262439A (en) *	1992-04-30	1993-11-16	The Regents Of The University Of California	Soluble analogs of probucol
DK1856085T3 (da) *	2005-03-11	2015-10-05	Howard Florey Inst Pty Ltd	Flavonoidforbindelser og anvendelser deraf
RU2482844C2 (ru) *	2007-11-15	2013-05-27	Мадаус Гмбх	Силибининовый компонент для лечения гепатита
WO2009062737A1 (en) *	2007-11-15	2009-05-22	Madaus Gmbh	Silibinin component for the treatment of hepatitis
AU2010247716B2 (en) *	2009-05-14	2015-11-05	Madaus Gmbh	Amorphous silibinin for the treatment of viral hepatitis
US20150174213A1 (en)	2012-07-05	2015-06-25	Nutramax Laboratories, Inc.	Compositions comprising sulforaphane or a sulforaphane precursor and ursolic acid
CN103113359B (zh) *	2013-02-22	2016-01-06	西安安健药业有限公司	水飞蓟宾二偏琥珀酸酯及其药用盐
CN103193768B (zh) *	2013-02-22	2016-03-30	西安安健药业有限公司	治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) *	2013-02-22	2015-11-04	西安安健药业有限公司	水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963318A1 (de) *	1969-12-17	1971-06-24	Schwabe Willmar Gmbh & Co	Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

1984
- 1984-11-22 DE DE19843442639 patent/DE3442639A1/de active Granted
1985
- 1985-11-11 IE IE280885A patent/IE58791B1/en not_active IP Right Cessation
- 1985-11-13 LU LU86163A patent/LU86163A1/de unknown
- 1985-11-14 YU YU1786/85A patent/YU43689B/xx unknown
- 1985-11-14 AR AR302267A patent/AR240931A1/es active
- 1985-11-15 GB GB08528226A patent/GB2167414B/en not_active Expired
- 1985-11-18 NL NL8503171A patent/NL192387C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854535A patent/FI84064C/fi not_active IP Right Cessation
- 1985-11-19 CH CH4935/85A patent/CH659473A5/de not_active IP Right Cessation
- 1985-11-19 AT AT3371/85A patent/AT393268B/de not_active IP Right Cessation
- 1985-11-20 SE SE8505487A patent/SE465676B/sv not_active IP Right Cessation
- 1985-11-20 DD DD85283042A patent/DD259191A1/de not_active IP Right Cessation
- 1985-11-20 CS CS837885A patent/CS273610B2/cs unknown
- 1985-11-20 CA CA000495804A patent/CA1337124C/en not_active Expired - Fee Related
- 1985-11-21 SU SU853985401A patent/SU1436875A3/ru active
- 1985-11-21 ZA ZA858951A patent/ZA858951B/xx unknown
- 1985-11-21 EG EG74085A patent/EG19424A/xx active
- 1985-11-21 DK DK537785A patent/DK164865C/da not_active IP Right Cessation
- 1985-11-21 NO NO854655A patent/NO160205C/no not_active IP Right Cessation
- 1985-11-21 IT IT22932/85A patent/IT1190426B/it active
- 1985-11-21 PL PL1985256374A patent/PL146890B1/pl unknown
- 1985-11-21 ES ES549116A patent/ES8609311A1/es not_active Expired
- 1985-11-21 HU HU854448A patent/HU195503B/hu not_active IP Right Cessation
- 1985-11-21 PT PT81532A patent/PT81532B/pt not_active IP Right Cessation
- 1985-11-22 KR KR1019850008733A patent/KR870001020B1/ko not_active IP Right Cessation
- 1985-11-22 MX MX009022A patent/MX168415B/es unknown
- 1985-11-22 BE BE2/60850A patent/BE903693A/fr not_active IP Right Cessation
- 1985-11-22 FR FR858517321A patent/FR2573427B1/fr not_active Expired
- 1985-11-22 JP JP60261629A patent/JPS61143377A/ja active Granted

Also Published As

Publication number	Publication date
GB8528226D0 (en)	1985-12-18
JPS61143377A (ja)	1986-07-01
FI854535A0 (fi)	1985-11-18
FR2573427A1 (fr)	1986-05-23
ES549116A0 (es)	1986-09-01
HU195503B (en)	1988-05-30
BE903693A (fr)	1986-05-22
YU43689B (en)	1989-10-31
NO160205B (no)	1988-12-12
SE8505487D0 (sv)	1985-11-20
CA1337124C (en)	1995-09-26
DK164865C (da)	1993-01-18
CS837885A2 (en)	1990-08-14
DE3442639C2 (da)	1989-08-10
AR240931A1 (es)	1991-03-27
FR2573427B1 (fr)	1989-03-10
HUT40114A (en)	1986-11-28
YU178685A (en)	1988-02-29
DK164865B (da)	1992-08-31
FI84064B (fi)	1991-06-28
ES8609311A1 (es)	1986-09-01
AR240931A2 (es)	1991-03-27
LU86163A1 (de)	1986-03-24
GB2167414A (en)	1986-05-29
EG19424A (en)	1995-02-28
DE3442639A1 (de)	1986-05-22
DK537785D0 (da)	1985-11-21
JPH0432073B2 (da)	1992-05-28
IT1190426B (it)	1988-02-16
SU1436875A3 (ru)	1988-11-07
NL8503171A (nl)	1986-06-16
KR860004056A (ko)	1986-06-16
ZA858951B (en)	1986-08-27
DK537785A (da)	1986-05-23
NL192387B (nl)	1997-03-03
PT81532A (de)	1985-12-01
CS273610B2 (en)	1991-03-12
CH659473A5 (de)	1987-01-30
SE8505487L (sv)	1986-05-23
AT393268B (de)	1991-09-25
KR870001020B1 (ko)	1987-05-23
PT81532B (pt)	1987-11-11
ATA337185A (de)	1991-02-15
IE58791B1 (en)	1993-11-17
NO854655L (no)	1986-05-23
IT8522932A0 (it)	1985-11-21
NL192387C (nl)	1997-07-04
PL146890B1 (en)	1989-03-31
SE465676B (sv)	1991-10-14
MX168415B (es)	1993-05-24
DD259191A1 (de)	1988-08-17
PL256374A1 (en)	1986-12-02
GB2167414B (en)	1989-01-11
FI854535A (fi)	1986-05-23
NO160205C (no)	1989-03-22
IE852808L (en)	1986-05-22

Publication	Publication Date	Title
US4764508A (en)	1988-08-16	Complexes of flavanolignans with phospholipids, preparation thereof and associated pharmaceutical compositions
EP0275224B1 (fr)	1993-07-21	Complexes phospholipidiques d'extraits de Vitis vinifera, leur procédé de préparation et compositions pharmaceutiques et cosmétiques les contenant
EP1516866B1 (en)	2006-07-12	Natural compounds and derivatives thereof for the prevention and treatment of cardiovascular, hepatic and renal diseases and for cosmetic applications
FI84064C (fi)	1991-10-10	Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat.
US3988446A (en)	1976-10-26	Glycerides with anti-inflammatory properties
FI84065B (fi)	1991-06-28	Foerfarande foer framstaellning av isosilybinfri silibinin.
JPH06145174A (ja)	1994-05-24	ビロバリデ誘導体，この用途及びこれを含有する薬剤組成物
SK194892A3 (en)	1995-02-08	Method of production of diacetylreine
US8092845B2 (en)	2012-01-10	Anti-inflammatory extract and agent and method for the production thereof
KR20010052637A (ko)	2001-06-25	하이퍼포린 유도체, 그의 용도 및 그를 함유한 제제
GB2261434A (en)	1993-05-19	New radical scavenging and antipoperoxidant flavanolignans their preparation and formulations for therapeutic use
SI8511786A8 (sl)	1996-06-30	Postopek za pripravo derivatov silibinina
JP2005523301A (ja)	2005-08-04	Ｂａｒｌｅｒｉａｐｒｉｏｎｉｔｉｓｌｉｎｎからの抽出物を含む製薬組成物、およびその調製方法
WO1981003489A1 (en)	1981-12-10	Process for separating medicinal ingredient from corbicula by extraction and composition containing same
CH665642A5 (fr)	1988-05-31	Derives de l'aminomethyle-6 furo-(3,4-c)-pyridine, leur preparation et compositions therapeutiques en contenant.
JP4465432B2 (ja)	2010-05-19	新規なジテルペン化合物
Yusupova et al.	0	New Source Of Synthesis Of Physiologically Active Substonces
FR2650999A1 (fr)	1991-02-22	Chlorhydrate de 1-(2-ethoxyethyl)-4-phenyl-4-propionyloxypiperidine
BE877014A (fr)	1979-10-01	Nouveaux derives phospholipidiques a activite anti-lipemique et anti-arteriosclerotique.

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: MADAUS AKTIENGESELLSCHAFT