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FI83509B - Foerfarande foer framstaellning av farmaceutiskt anvaendbara 1-(acetylaminofenyl)-2-aminopropanonderivat. - Google Patents

Foerfarande foer framstaellning av farmaceutiskt anvaendbara 1-(acetylaminofenyl)-2-aminopropanonderivat. Download PDF

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Publication number
FI83509B
FI83509B FI844030A FI844030A FI83509B FI 83509 B FI83509 B FI 83509B FI 844030 A FI844030 A FI 844030A FI 844030 A FI844030 A FI 844030A FI 83509 B FI83509 B FI 83509B
Authority
FI
Finland
Prior art keywords
crl
acetylaminophenyl
mice
induced
formula
Prior art date
Application number
FI844030A
Other languages
English (en)
Finnish (fi)
Other versions
FI83509C (sv
FI844030L (fi
FI844030A0 (fi
Inventor
Louis Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8316408A external-priority patent/FR2553408B1/fr
Priority claimed from FR8412963A external-priority patent/FR2569193B2/fr
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of FI844030A0 publication Critical patent/FI844030A0/fi
Publication of FI844030L publication Critical patent/FI844030L/fi
Publication of FI83509B publication Critical patent/FI83509B/fi
Application granted granted Critical
Publication of FI83509C publication Critical patent/FI83509C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (2)

1. Förfarande för framställning av farmaceutiskt användbara l- (acetylaminofenyl)-2-aminopropanonderivat med formeln I Ar-CO-CH(CH3)-NR1R2 (I) i vilken formel - Rx betecknar en C1-C4-alkylgrupp eller en cyklopropyl-grupp; - R2 betecknar en väteatom eller en C1-C4-alkylgrupp; - Rx och R2 tillsammans, med kväveatomen, tili vilken de är bundna, kan bilda en pyrrolidino-, morfolino-, tiomorfolino-, piperidino- eller 4-metylpiperazinogrupp, och - Ar betecknar en acetylaminofenylgrupp med formeln TY CH -}CONH'^\ / Z i vilken Y och Z, som kan vara lika eller olika, bäda betecknar en väteatom eller klor; och additionssalter av dessa föreningar, kännetecknat därav, att a) ett halogenderivat med formeln (III) ArCOCH(CH3)Hal (III) i vilken Ar betecknar en acetylaminofenylgrupp 58 83509 CH Ή Z i vilken Y är H eller Cl, Z är H eller Cl och Hal är Cl el-ler Br, omsätts med en amin med formeln (IV) HNR1R2 (IV) i vilken R-j^ och R2 betecknar detsamma som ovan, genom at an-vända mera än en mol av en amin med formeln (IV) per en mol av ett halogenderivat med formeln (III), eller b) ett 1-(aminofenyl)-2-amino-propanonderivat med formeln (V) — COCH(CH3)NRjR2 (V) =t=/ ' ' Z i vilken Y, Z, R1 och R2 betecknar detsamma som ovan, acety-leras med ett acetyleringsmedel, som finns i överskott i förhallande tili de stökiometriskä förhlillandena.
2. Förfarande enligt patentkravet 1, känneteck-n a t därav, att man framställer l-(4-acetylamino-3,5-di-klorfenyl)-2-isopropylamino-propanon, 1-(4-acetylaminofenyl)- 2-etylaminopropanon, 1-(4-acetylaminofenyl)-2-piperidinopro-panon, l-(4-acetylamino-3-klorfenyl)-2-pyrrolidinopropanon, l-(3-acetylaminofenyl)-2-piperidinopropanon, 1-(4-acetylaminofenyl ) -2isopropylaminopropanon , 1-(4-acetylaminofenyl)-2-tert.butylaminopropanon eller deras additionssalter.
FI844030A 1983-10-14 1984-10-12 Förfarande för framställning av farmaceutiskt användbara 1-(acetylamin ofenyl)-2-aminopropanonderivat FI83509C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8316408 1983-10-14
FR8316408A FR2553408B1 (fr) 1983-10-14 1983-10-14 Derives de 1-(4-acetylaminophenyl)-2-amino-propanone, leur utilisation en therapeutique et leur procede de preparation
FR8412963A FR2569193B2 (fr) 1984-08-20 1984-08-20 Derives de 1-(acetylaminophenyl)-2-amino-propanone, leur utilisation en therapeutique et leur procede de preparation
FR8412963 1984-08-20

Publications (4)

Publication Number Publication Date
FI844030A0 FI844030A0 (fi) 1984-10-12
FI844030L FI844030L (fi) 1985-04-15
FI83509B true FI83509B (fi) 1991-04-15
FI83509C FI83509C (sv) 1991-07-25

Family

ID=26223629

Family Applications (1)

Application Number Title Priority Date Filing Date
FI844030A FI83509C (sv) 1983-10-14 1984-10-12 Förfarande för framställning av farmaceutiskt användbara 1-(acetylamin ofenyl)-2-aminopropanonderivat

Country Status (18)

Country Link
US (3) US4877812A (sv)
EP (1) EP0138714B1 (sv)
AU (1) AU570076B2 (sv)
CA (1) CA1250838A (sv)
DE (1) DE3463764D1 (sv)
DK (1) DK164900C (sv)
ES (1) ES536969A0 (sv)
FI (1) FI83509C (sv)
GR (1) GR80636B (sv)
HU (1) HU194847B (sv)
IE (1) IE57807B1 (sv)
IL (1) IL73231A (sv)
MA (1) MA20246A1 (sv)
NO (1) NO164650C (sv)
NZ (1) NZ209871A (sv)
OA (1) OA07833A (sv)
PT (1) PT79328B (sv)
YU (1) YU43859B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2553407B1 (fr) * 1983-10-14 1986-01-03 Lafon Labor Derives de n-(4-acetylaminophenacyl)-amine, leur utilisation en therapeutique et leur procede de preparation
FR2569184A1 (fr) * 1984-08-20 1986-02-21 Lafon Labor Derives de 1-(aminophenyl) therapeutique et leur procede de preparation
US5236922A (en) * 1984-08-20 1993-08-17 Laboratoire L. Lafon Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives
FR2626878B1 (fr) * 1988-02-10 1990-06-08 Lafon Labor Derives de 1-(aminophenyl)-2-dimethylaminopropanone, procede de preparation et utilisation en therapeutique
FR2626879B1 (fr) * 1988-02-10 1990-06-08 Lafon Labor Derives de 1-(aminophenyl)-2-(n-2-hydroxyethylamino)-propanone, procede de preparation et utilisation en therapeutique
FR2653767B1 (fr) * 1989-10-30 1992-02-14 Lafon Labor Derives de 1-(aminophenyl)-2-piperidinopropanone, procede et utilisation en therapeutique.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE453614A (sv) * 1943-06-24
DE1015986B (de) * 1955-07-04 1957-09-19 Thomae Gmbh Dr K Licht- und Sonnenschutzmittel
FR1463813A (fr) * 1964-02-26 1966-07-22 Ciba Geigy Nouvelles amino-phénylcétones et procédé pour leur préparation
US4138581A (en) * 1969-04-01 1979-02-06 Sterling Drugs Inc. 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols
US3907812A (en) * 1969-07-16 1975-09-23 Sumitomo Chemical Co Butyrophenone derivatives
BE764238A (fr) * 1971-03-17 1971-09-13 Lilly Industries Ltd Derives de phenylalkylamine
JPS5946214B2 (ja) * 1975-05-29 1984-11-10 ウェルファイド株式会社 アミノケトン誘導体の製法
FR2443246A1 (fr) * 1978-12-05 1980-07-04 Pharmindustrie Nouveaux medicaments a base de derives de la phenyl-1 (piperidyl-4)-3 propanone-1
FR2553407B1 (fr) * 1983-10-14 1986-01-03 Lafon Labor Derives de n-(4-acetylaminophenacyl)-amine, leur utilisation en therapeutique et leur procede de preparation
FR2569184A1 (fr) * 1984-08-20 1986-02-21 Lafon Labor Derives de 1-(aminophenyl) therapeutique et leur procede de preparation

Also Published As

Publication number Publication date
ES8506596A1 (es) 1985-08-01
ES536969A0 (es) 1985-08-01
IE842555L (en) 1985-04-14
MA20246A1 (fr) 1985-07-01
DK484884A (da) 1985-04-15
NO164650B (no) 1990-07-23
EP0138714A3 (sv) 1985-06-19
PT79328B (fr) 1986-09-08
PT79328A (fr) 1984-11-01
IL73231A (en) 1988-07-31
GR80636B (en) 1985-02-13
US4963570A (en) 1990-10-16
EP0138714B1 (fr) 1987-05-20
DK164900B (da) 1992-09-07
HU194847B (en) 1988-03-28
DK484884D0 (da) 1984-10-10
OA07833A (fr) 1986-11-20
DK164900C (da) 1993-02-01
FI83509C (sv) 1991-07-25
EP0138714A2 (fr) 1985-04-24
HUT36470A (en) 1985-09-30
FI844030L (fi) 1985-04-15
YU174784A (en) 1987-10-31
AU3409284A (en) 1985-04-18
FI844030A0 (fi) 1984-10-12
NO164650C (no) 1990-10-31
NO844072L (no) 1985-04-15
YU43859B (en) 1989-12-31
AU570076B2 (en) 1988-03-03
DE3463764D1 (en) 1987-06-25
NZ209871A (en) 1988-04-29
IE57807B1 (en) 1993-04-21
CA1250838A (fr) 1989-03-07
US4877812A (en) 1989-10-31
IL73231A0 (en) 1985-01-31
US4933442A (en) 1990-06-12

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MM Patent lapsed
MM Patent lapsed

Owner name: LABORATOIRE L. LAFON