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ES8506596A1 - Procedimiento para la preparacion de nuevos derivados de 1-(acetilaminofenil)-2-amino-propanona - Google Patents

Procedimiento para la preparacion de nuevos derivados de 1-(acetilaminofenil)-2-amino-propanona

Info

Publication number
ES8506596A1
ES8506596A1 ES536969A ES536969A ES8506596A1 ES 8506596 A1 ES8506596 A1 ES 8506596A1 ES 536969 A ES536969 A ES 536969A ES 536969 A ES536969 A ES 536969A ES 8506596 A1 ES8506596 A1 ES 8506596A1
Authority
ES
Spain
Prior art keywords
group
acetylaminophenyl
piperazino
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536969A
Other languages
English (en)
Other versions
ES536969A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8316408A external-priority patent/FR2553408B1/fr
Priority claimed from FR8412963A external-priority patent/FR2569193B2/fr
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of ES8506596A1 publication Critical patent/ES8506596A1/es
Publication of ES536969A0 publication Critical patent/ES536969A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1-(ACTILAMINOFENIL)-2-AMINO-PROPANONA, DE FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA UN GRUPO ALQUILO C1-C4 O UN GRUPO CICLOALQUILO C3-C6; R2 REPRESENTA HIDROGENO O UN GRUPO ALQUILO; Y AR REPRESENTA UN GRUPO ACETILAMINOFENIL.CONSISTE EN HACER REACCIONAR UN DERIVADO HALOGENO DE FORMULA GENERAL (II), EN LA QUE HAL REPRESENTA CLORO O BROMO, CON UNA AMINA DE FORMULA GENERAL (III), A UNA TEMPERATURA COMPRENDIDA ENTRE 15 GRADOS Y LA TEMPERATURA DE REFLUJO DEL MEDIO REACCIONAL.DE APLICACION EN TERAPEUTICA, ESPECIALMENTE COMO AGENTES ANTIDEPRESIVOS DEL SISTEMA NERVIOSO CENTRAL.
ES536969A 1983-10-14 1984-10-11 Procedimiento para la preparacion de nuevos derivados de 1-(acetilaminofenil)-2-amino-propanona Granted ES536969A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8316408A FR2553408B1 (fr) 1983-10-14 1983-10-14 Derives de 1-(4-acetylaminophenyl)-2-amino-propanone, leur utilisation en therapeutique et leur procede de preparation
FR8412963A FR2569193B2 (fr) 1984-08-20 1984-08-20 Derives de 1-(acetylaminophenyl)-2-amino-propanone, leur utilisation en therapeutique et leur procede de preparation

Publications (2)

Publication Number Publication Date
ES8506596A1 true ES8506596A1 (es) 1985-08-01
ES536969A0 ES536969A0 (es) 1985-08-01

Family

ID=26223629

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536969A Granted ES536969A0 (es) 1983-10-14 1984-10-11 Procedimiento para la preparacion de nuevos derivados de 1-(acetilaminofenil)-2-amino-propanona

Country Status (18)

Country Link
US (3) US4877812A (es)
EP (1) EP0138714B1 (es)
AU (1) AU570076B2 (es)
CA (1) CA1250838A (es)
DE (1) DE3463764D1 (es)
DK (1) DK164900C (es)
ES (1) ES536969A0 (es)
FI (1) FI83509C (es)
GR (1) GR80636B (es)
HU (1) HU194847B (es)
IE (1) IE57807B1 (es)
IL (1) IL73231A (es)
MA (1) MA20246A1 (es)
NO (1) NO164650C (es)
NZ (1) NZ209871A (es)
OA (1) OA07833A (es)
PT (1) PT79328B (es)
YU (1) YU43859B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2553407B1 (fr) * 1983-10-14 1986-01-03 Lafon Labor Derives de n-(4-acetylaminophenacyl)-amine, leur utilisation en therapeutique et leur procede de preparation
FR2569184A1 (fr) * 1984-08-20 1986-02-21 Lafon Labor Derives de 1-(aminophenyl) therapeutique et leur procede de preparation
US5236922A (en) * 1984-08-20 1993-08-17 Laboratoire L. Lafon Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives
FR2626878B1 (fr) * 1988-02-10 1990-06-08 Lafon Labor Derives de 1-(aminophenyl)-2-dimethylaminopropanone, procede de preparation et utilisation en therapeutique
FR2626879B1 (fr) * 1988-02-10 1990-06-08 Lafon Labor Derives de 1-(aminophenyl)-2-(n-2-hydroxyethylamino)-propanone, procede de preparation et utilisation en therapeutique
FR2653767B1 (fr) * 1989-10-30 1992-02-14 Lafon Labor Derives de 1-(aminophenyl)-2-piperidinopropanone, procede et utilisation en therapeutique.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL114611B (es) * 1943-06-24
DE1015986B (de) * 1955-07-04 1957-09-19 Thomae Gmbh Dr K Licht- und Sonnenschutzmittel
FR1458118A (fr) * 1964-02-26 1966-03-04 Ciba Geigy Nouveaux amino-phényl-alcanols et procédé pour leur préparation
US4138581A (en) * 1969-04-01 1979-02-06 Sterling Drugs Inc. 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols
US3907812A (en) * 1969-07-16 1975-09-23 Sumitomo Chemical Co Butyrophenone derivatives
BE764238A (fr) * 1971-03-17 1971-09-13 Lilly Industries Ltd Derives de phenylalkylamine
FR2443246A1 (fr) * 1978-12-05 1980-07-04 Pharmindustrie Nouveaux medicaments a base de derives de la phenyl-1 (piperidyl-4)-3 propanone-1
FR2553407B1 (fr) * 1983-10-14 1986-01-03 Lafon Labor Derives de n-(4-acetylaminophenacyl)-amine, leur utilisation en therapeutique et leur procede de preparation
FR2569184A1 (fr) * 1984-08-20 1986-02-21 Lafon Labor Derives de 1-(aminophenyl) therapeutique et leur procede de preparation

Also Published As

Publication number Publication date
YU43859B (en) 1989-12-31
FI83509B (fi) 1991-04-15
NZ209871A (en) 1988-04-29
EP0138714A2 (fr) 1985-04-24
IL73231A (en) 1988-07-31
DK164900C (da) 1993-02-01
OA07833A (fr) 1986-11-20
IE842555L (en) 1985-04-14
FI83509C (fi) 1991-07-25
EP0138714A3 (es) 1985-06-19
DK484884A (da) 1985-04-15
HUT36470A (en) 1985-09-30
NO164650B (no) 1990-07-23
DK484884D0 (da) 1984-10-10
NO844072L (no) 1985-04-15
US4933442A (en) 1990-06-12
IL73231A0 (en) 1985-01-31
FI844030A0 (fi) 1984-10-12
EP0138714B1 (fr) 1987-05-20
CA1250838A (fr) 1989-03-07
NO164650C (no) 1990-10-31
GR80636B (en) 1985-02-13
DE3463764D1 (en) 1987-06-25
AU570076B2 (en) 1988-03-03
FI844030L (fi) 1985-04-15
HU194847B (en) 1988-03-28
ES536969A0 (es) 1985-08-01
US4877812A (en) 1989-10-31
DK164900B (da) 1992-09-07
YU174784A (en) 1987-10-31
IE57807B1 (en) 1993-04-21
AU3409284A (en) 1985-04-18
PT79328A (fr) 1984-11-01
MA20246A1 (fr) 1985-07-01
US4963570A (en) 1990-10-16
PT79328B (fr) 1986-09-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001