FI68229C - Analogifoerfarande foer framstaellning av nya terapeutiskt verkande derivat av perhydro-aza-heterocykler - Google Patents

Analogifoerfarande foer framstaellning av nya terapeutiskt verkande derivat av perhydro-aza-heterocykler Download PDF

Info

Publication number: FI68229C
Authority: FI; Finland
Prior art keywords: formula; hydroxy; group; hydrogen; trans
Prior art date: 1976-09-01

Application number

FI772566A

Other languages

English (en)

Finnish (fi)

Other versions

FI68229B (fi

FI772566A (fi

Inventor

Romeo Paioni

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-01

Filing date

1977-08-30

Publication date

1985-08-12

1977-08-30 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1978-03-02 Publication of FI772566A publication Critical patent/FI772566A/fi

1985-04-30 Application granted granted Critical

1985-04-30 Publication of FI68229B publication Critical patent/FI68229B/fi

1985-08-12 Publication of FI68229C publication Critical patent/FI68229C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI772566A 1976-09-01 1977-08-30 Analogifoerfarande foer framstaellning av nya terapeutiskt verkande derivat av perhydro-aza-heterocykler FI68229C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU75701		1976-09-01
LU75701		1976-09-01

Publications (3)

Publication Number	Publication Date
FI772566A FI772566A (fi)	1978-03-02
FI68229B FI68229B (fi)	1985-04-30
FI68229C true FI68229C (fi)	1985-08-12

Family

ID=19728341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI772566A FI68229C (fi)	1976-09-01	1977-08-30	Analogifoerfarande foer framstaellning av nya terapeutiskt verkande derivat av perhydro-aza-heterocykler

Country Status (29)

Country	Link
US (3)	US4160837A (de)
JP (1)	JPS5331659A (de)
AT (1)	AT361464B (de)
AU (1)	AU514675B2 (de)
BE (1)	BE858283A (de)
CA (1)	CA1112242A (de)
CH (5)	CH633776A5 (de)
CS (3)	CS205087B2 (de)
CY (1)	CY1212A (de)
DD (1)	DD132584A5 (de)
DE (1)	DE2738477A1 (de)
DK (1)	DK156301C (de)
ES (6)	ES462040A1 (de)
FI (1)	FI68229C (de)
FR (1)	FR2363559A1 (de)
GB (1)	GB1585133A (de)
GR (1)	GR72965B (de)
HK (1)	HK8884A (de)
HU (1)	HU179440B (de)
IE (1)	IE45511B1 (de)
IL (1)	IL52858A0 (de)
MY (1)	MY8500100A (de)
NL (1)	NL7709604A (de)
NO (1)	NO150081C (de)
NZ (1)	NZ185062A (de)
PT (1)	PT66955B (de)
SE (1)	SE437155B (de)
SG (1)	SG63783G (de)
ZA (1)	ZA775267B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE45511B1 (en) *	1976-09-01	1982-09-08	Ciba Geigy Ag	New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
MX6634E (es) *	1979-01-09	1985-09-12	Robins Co Inc A H	Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4251541A (en) *	1979-01-09	1981-02-17	A. H. Robins Company, Inc.	1-Substituted-3-arylthio-4-hydroxypyrrolidines
US4230718A (en) *	1979-01-09	1980-10-28	A. H. Robins Company, Inc.	1-Substituted-3,4-epoxypyrrolidines
US4585785A (en) *	1979-01-09	1986-04-29	A. H. Robins Company, Inc.	Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics
US4443462A (en) *	1979-08-06	1984-04-17	Merrell Dow Pharmaceuticals Inc.	Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
US4452809A (en) *	1980-03-10	1984-06-05	A. H. Robins Company, Inc.	Trans-4-(2-chlorophenoxy)-1-ethyl-3-pyrrolidinol and anti-depressant use thereof
IL74140A (en) *	1984-04-10	1988-05-31	Robins Co Inc A H	Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them
US4639528A (en) *	1985-02-21	1987-01-27	Bristol-Myers Company	Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane
US4797397A (en) *	1987-07-31	1989-01-10	Warner-Lambert Company	2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
DE68903425T2 (de) *	1988-05-20	1993-03-25	Zambon Spa	Verbindungen mit zentraler analgetischer verwendung, verfahren zu ihrer herstellung und arzneimittel die sie enthalten.
FR2696445B1 (fr) *	1992-10-01	1994-12-16	Rennes Inst Nal Sciences Appli	Composition pour l'obtention de produits à base de chaux pure, application de cette composition et procédé pour sa mise en Óoeuvre.
CZ292327B6 (cs) *	1995-09-07	2003-09-17	F. Hoffmann-La Roche Ag	Derivát 4-(oxyalkoxyfenyl)-3-oxypiperidinu, způsob jeho přípravy, meziprodukt pro jeho přípravu a farmaceutický prostředek, který ho obsahuje
JP3064425B2 (ja) *	1995-09-15	2000-07-12	ノイロサーチアクティーゼルスカブ	カルシウムチャンネル・ブロッカーとしてのピペリジン化合物
ES2426915T3 (es) *	2003-09-10	2013-10-25	Brentwood Equities Ltd.	Diastereoisómeros de 4-ariloxi-3-hidroxipiperidinas
US20070142389A1 (en) *	2005-12-20	2007-06-21	Pfizer Inc.	Piperidine derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU34026A1 (de) *	1954-12-23
US3117975A (en) *	1960-04-22	1964-01-14	Rohm & Haas	Substituted pyrrolidinones and piperidinones
US3260723A (en) *	1963-08-27	1966-07-12	Parke Davis & Co	4-phenoxy piperidines; alpha4-phenoxy piperideines
US3360526A (en) *	1964-01-15	1967-12-26	Bristol Myers Co	Heterocyclicamino methylene ethers of benzylphenols
US3446897A (en) *	1966-09-30	1969-05-27	Robins Co Inc A H	Compositions and methods for the control of cardiac arrhythmia with o-substituted pyrrolidinols and s-substituted thiopyrrolidinols
US3823151A (en) *	1968-08-02	1974-07-09	Ciba Geigy Corp	4,5,6,7-tetrahydrothieno(2,3-d)pyridines
DE1937459A1 (de) *	1968-08-02	1970-02-05	Ciba Geigy	Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung
CH500226A (de)	1968-08-02	1970-12-15	Ciba Geigy Ag	Verfahren zur Herstellung neuer Pyrimidinderivate
US3577432A (en) *	1968-12-23	1971-05-04	Robins Co Inc A H	1-substituted-3-phenoxypyrrolidines
GB1280699A (en) *	1968-12-23	1972-07-05	Robins Co Inc A H	0-substituted-4-phenoxypiperidines
US3542794A (en) *	1969-11-07	1970-11-24	Grover Cleveland Helsley	1-carbamoyl-4-phenoxypiperidines
US3686169A (en) *	1970-07-20	1972-08-22	Monsanto Co	Thiocycloamides
US3743645A (en) *	1970-10-19	1973-07-03	Robins Co Inc A H	1-substituted-4-phenoxypiperidines
JPS5119987B2 (de) *	1973-02-05	1976-06-22
US4065290A (en) *	1975-07-03	1977-12-27	Eli Lilly And Company	Herbicidal β-phenyl-4-piperidinones
IE45511B1 (en) *	1976-09-01	1982-09-08	Ciba Geigy Ag	New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
US4251541A (en)	1979-01-09	1981-02-17	A. H. Robins Company, Inc.	1-Substituted-3-arylthio-4-hydroxypyrrolidines
MX6634E (es)	1979-01-09	1985-09-12	Robins Co Inc A H	Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4230718A (en)	1979-01-09	1980-10-28	A. H. Robins Company, Inc.	1-Substituted-3,4-epoxypyrrolidines

1977
- 1977-08-03 IE IE1814/77A patent/IE45511B1/en not_active IP Right Cessation
- 1977-08-24 US US05/827,274 patent/US4160837A/en not_active Expired - Lifetime
- 1977-08-24 PT PT66955A patent/PT66955B/pt unknown
- 1977-08-25 CY CY1212A patent/CY1212A/xx unknown
- 1977-08-25 GB GB35711/77A patent/GB1585133A/en not_active Expired
- 1977-08-26 DE DE19772738477 patent/DE2738477A1/de active Granted
- 1977-08-29 CH CH1050177A patent/CH633776A5/de not_active IP Right Cessation
- 1977-08-29 GR GR54250A patent/GR72965B/el unknown
- 1977-08-30 FI FI772566A patent/FI68229C/fi not_active IP Right Cessation
- 1977-08-30 DD DD7700200806A patent/DD132584A5/de unknown
- 1977-08-30 FR FR7726303A patent/FR2363559A1/fr active Granted
- 1977-08-30 IL IL52858A patent/IL52858A0/xx not_active IP Right Cessation
- 1977-08-30 CA CA285,793A patent/CA1112242A/en not_active Expired
- 1977-08-31 NZ NZ185062A patent/NZ185062A/xx unknown
- 1977-08-31 AT AT627977A patent/AT361464B/de not_active IP Right Cessation
- 1977-08-31 ZA ZA00775267A patent/ZA775267B/xx unknown
- 1977-08-31 CS CS775690A patent/CS205087B2/cs unknown
- 1977-08-31 CS CS775690A patent/CS205085B2/cs unknown
- 1977-08-31 HU HU77CI1768A patent/HU179440B/hu unknown
- 1977-08-31 SE SE7709784A patent/SE437155B/xx not_active IP Right Cessation
- 1977-08-31 AU AU28385/77A patent/AU514675B2/en not_active Expired
- 1977-08-31 CS CS775690A patent/CS205084B2/cs unknown
- 1977-08-31 DK DK387177A patent/DK156301C/da not_active IP Right Cessation
- 1977-08-31 BE BE180578A patent/BE858283A/xx not_active IP Right Cessation
- 1977-08-31 NL NL7709604A patent/NL7709604A/xx not_active Application Discontinuation
- 1977-08-31 NO NO773009A patent/NO150081C/no unknown
- 1977-09-01 ES ES462040A patent/ES462040A1/es not_active Expired
- 1977-09-01 JP JP10427177A patent/JPS5331659A/ja active Granted
1978
- 1978-07-14 ES ES471739A patent/ES471739A1/es not_active Expired
- 1978-07-14 ES ES471740A patent/ES471740A1/es not_active Expired
- 1978-07-14 ES ES471738A patent/ES471738A1/es not_active Expired
1979
- 1979-03-30 ES ES479112A patent/ES479112A1/es not_active Expired
- 1979-04-02 ES ES479190A patent/ES479190A1/es not_active Expired
- 1979-04-05 US US06/027,337 patent/US4246269A/en not_active Expired - Lifetime
1980
- 1980-09-28 US US06/183,482 patent/US4320137A/en not_active Expired - Lifetime
1982
- 1982-08-31 CH CH517182A patent/CH637932A5/de not_active IP Right Cessation
- 1982-08-31 CH CH517282A patent/CH637933A5/de not_active IP Right Cessation
- 1982-09-01 CH CH519482A patent/CH637934A5/de not_active IP Right Cessation
- 1982-12-30 CH CH763082A patent/CH637935A5/de not_active IP Right Cessation
1983
- 1983-10-19 SG SG63783A patent/SG63783G/en unknown
1984
- 1984-02-01 HK HK88/84A patent/HK8884A/xx unknown
1985
- 1985-12-30 MY MY100/85A patent/MY8500100A/xx unknown

Also Published As

Publication number	Publication date
HU179440B (en)	1982-10-28
DD132584A5 (de)	1978-10-11
FI68229B (fi)	1985-04-30
AU2838577A (en)	1979-03-08
CS205084B2 (en)	1981-04-30
DK387177A (da)	1978-03-02
GB1585133A (en)	1981-02-25
DE2738477C2 (de)	1989-11-09
DE2738477A1 (de)	1978-03-02
AU514675B2 (en)	1981-02-19
NO150081B (no)	1984-05-07
NO150081C (no)	1984-08-15
DK156301C (da)	1989-12-11
ES462040A1 (es)	1978-12-01
PT66955B (en)	1979-02-07
ZA775267B (en)	1978-07-26
PT66955A (en)	1977-09-01
CY1212A (en)	1984-04-06
IE45511L (en)	1978-03-01
CH637932A5 (de)	1983-08-31
US4246269A (en)	1981-01-20
ES479190A1 (es)	1979-07-01
JPS6340785B2 (de)	1988-08-12
US4320137A (en)	1982-03-16
ES479112A1 (es)	1979-07-01
BE858283A (fr)	1978-02-28
ATA627977A (de)	1980-08-15
CS205085B2 (en)	1981-04-30
IE45511B1 (en)	1982-09-08
CA1112242A (en)	1981-11-10
AT361464B (de)	1981-03-10
JPS5331659A (en)	1978-03-25
ES471738A1 (es)	1979-10-16
GR72965B (de)	1984-01-19
SE7709784L (sv)	1978-03-02
ES471740A1 (es)	1979-10-16
SE437155B (sv)	1985-02-11
IL52858A0 (en)	1977-10-31
DK156301B (da)	1989-07-31
US4160837A (en)	1979-07-10
NL7709604A (nl)	1978-03-03
CH637934A5 (de)	1983-08-31
FR2363559A1 (fr)	1978-03-31
NZ185062A (en)	1980-10-08
CH633776A5 (de)	1982-12-31
FI772566A (fi)	1978-03-02
NO773009L (no)	1978-03-02
MY8500100A (en)	1985-12-31
CS205087B2 (en)	1981-04-30
HK8884A (en)	1984-02-10
SG63783G (en)	1984-07-27
CH637935A5 (de)	1983-08-31
CH637933A5 (de)	1983-08-31
FR2363559B1 (de)	1982-03-26
ES471739A1 (es)	1979-10-16

Publication	Publication Date	Title
FI68229C (fi)	1985-08-12	Analogifoerfarande foer framstaellning av nya terapeutiskt verkande derivat av perhydro-aza-heterocykler
US2956062A (en)	1960-10-11	Esters of amino alcohols
EP0629190A1 (de)	1994-12-21	Verbindungen als calcium kanal antagoniste
CS228910B2 (en)	1984-05-14	Method of preparing new substituted alkyleneiminophenylalkyl amides of phenylalkane carboxylic acids
US5559238A (en)	1996-09-24	N-substituted trifluoromethylphenyltetrahydropyridenes process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them
GB2068373A (en)	1981-08-12	Cyclohexene derivatives
US4008277A (en)	1977-02-15	Benzo-bicyclononene derivatives
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