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FI20021652L - Tratsodonin alkyylijohdannaisten valmistuksessa käyttökelpoisia välituotteita - Google Patents

Tratsodonin alkyylijohdannaisten valmistuksessa käyttökelpoisia välituotteita Download PDF

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Publication number
FI20021652L
FI20021652L FI20021652A FI20021652A FI20021652L FI 20021652 L FI20021652 L FI 20021652L FI 20021652 A FI20021652 A FI 20021652A FI 20021652 A FI20021652 A FI 20021652A FI 20021652 L FI20021652 L FI 20021652L
Authority
FI
Finland
Prior art keywords
trazodone
preparation
alkyl derivatives
intermediates useful
intermediates
Prior art date
Application number
FI20021652A
Other languages
English (en)
Swedish (sv)
Other versions
FI113266B (fi
Inventor
Leandro Baiocchi
Original Assignee
Angelini Ricerche S P A Soc Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angelini Ricerche S P A Soc Co filed Critical Angelini Ricerche S P A Soc Co
Publication of FI20021652L publication Critical patent/FI20021652L/fi
Application granted granted Critical
Publication of FI113266B publication Critical patent/FI113266B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI20021652A 1992-01-17 2002-09-16 Tratsodonin alkyylijohdannaisten valmistuksessa käyttökelpoisia välituotteita FI113266B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI920084A IT1258790B (it) 1992-01-17 1992-01-17 Alchil derivati del trazodone
ITMI920084 1992-01-17
EP9300080 1993-01-14
PCT/EP1993/000080 WO1993014091A1 (en) 1992-01-17 1993-01-14 Alkyl derivatives of trazodone with cns activity

Publications (2)

Publication Number Publication Date
FI20021652L true FI20021652L (fi) 2002-09-16
FI113266B FI113266B (fi) 2004-03-31

Family

ID=11361589

Family Applications (2)

Application Number Title Priority Date Filing Date
FI943386A FI110186B (fi) 1992-01-17 1994-07-15 Menetelmä terapeuttisesti aktiivisten 2-{3-[4-(3-kloorifenyyli)-1-piperatsinyyli]propyyli}-1,2,4-triatsoli[4,3-a]pyridin-3-(2H) onijohdannaisten valmistamiseksi
FI20021652A FI113266B (fi) 1992-01-17 2002-09-16 Tratsodonin alkyylijohdannaisten valmistuksessa käyttökelpoisia välituotteita

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI943386A FI110186B (fi) 1992-01-17 1994-07-15 Menetelmä terapeuttisesti aktiivisten 2-{3-[4-(3-kloorifenyyli)-1-piperatsinyyli]propyyli}-1,2,4-triatsoli[4,3-a]pyridin-3-(2H) onijohdannaisten valmistamiseksi

Country Status (25)

Country Link
EP (1) EP0623131B1 (fi)
JP (1) JP2856912B2 (fi)
KR (1) KR100254690B1 (fi)
AT (1) ATE136307T1 (fi)
AU (1) AU671973B2 (fi)
BG (1) BG61841B1 (fi)
BR (1) BR9305752A (fi)
CA (1) CA2128202C (fi)
CZ (1) CZ282910B6 (fi)
DE (1) DE69302087T2 (fi)
DK (1) DK0623131T3 (fi)
ES (1) ES2088270T3 (fi)
FI (2) FI110186B (fi)
GE (1) GEP20001939B (fi)
GR (1) GR3020420T3 (fi)
HU (5) HU217968B (fi)
IT (1) IT1258790B (fi)
NO (2) NO302365B1 (fi)
NZ (1) NZ246598A (fi)
PL (1) PL170913B1 (fi)
RO (1) RO113465B1 (fi)
RU (1) RU2126801C1 (fi)
SK (1) SK280561B6 (fi)
WO (1) WO1993014091A1 (fi)
ZA (1) ZA93292B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1268414B1 (it) * 1993-07-01 1997-02-27 Angelini Francesco Ist Ricerca Enantiomeri farmacologicamente attivi
AU718075B2 (en) * 1993-07-01 2000-04-06 Angelini Ricerche S.P.A. Societa Consortile Intermediates for the preparation of pharmacologically active enantiomers of triazolone compounds
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
MY139563A (en) * 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
TW200726765A (en) * 2005-06-17 2007-07-16 Bristol Myers Squibb Co Triazolopyridine cannabinoid receptor 1 antagonists
ITMI20051193A1 (it) * 2005-06-24 2006-12-25 Acraf Uso farmaceutico di una 1-3-clorofenil-3-alchilpiperazina
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
RU2706700C1 (ru) 2019-09-24 2019-11-20 Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100505A (en) * 1870-03-08 Improvement in sash-bolt
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
SE7610219L (sv) * 1975-09-24 1977-03-25 Sandoz Ag Nya dibenso /b,e//1,4/ diazepiner
CH624682A5 (fi) * 1976-11-10 1981-08-14 Sandoz Ag
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids

Also Published As

Publication number Publication date
CA2128202C (en) 2001-01-23
GR3020420T3 (en) 1996-10-31
FI943386L (fi) 1994-07-15
CA2128202A1 (en) 1993-07-22
JPH07503000A (ja) 1995-03-30
ITMI920084A1 (it) 1993-07-17
NO302365B1 (no) 1998-02-23
NO303686B1 (no) 1998-08-17
CZ173294A3 (en) 1995-02-15
DE69302087T2 (de) 1996-11-28
GEP20001939B (en) 2000-02-05
EP0623131A1 (en) 1994-11-09
BR9305752A (pt) 1997-01-28
HUT70761A (en) 1995-10-30
AU671973B2 (en) 1996-09-19
FI110186B (fi) 2002-12-13
KR100254690B1 (ko) 2000-05-01
RU94036769A (ru) 1997-04-20
HU217981B (hu) 2000-05-28
IT1258790B (it) 1996-02-29
HU9502177D0 (en) 1995-09-28
FI943386A0 (fi) 1994-07-15
NO942668D0 (no) 1994-07-15
PL170913B1 (pl) 1997-02-28
HU217982B (hu) 2000-05-28
NZ246598A (en) 1997-08-22
HU219493B (hu) 2001-04-28
HU217968B (hu) 2000-05-28
SK280561B6 (sk) 2000-03-13
BG61841B1 (bg) 1998-07-31
RU2126801C1 (ru) 1999-02-27
BG98896A (bg) 1995-03-31
HU9502179D0 (en) 1995-09-28
WO1993014091A1 (en) 1993-07-22
HU218678B (hu) 2000-10-28
HUT72591A (en) 1996-05-28
FI113266B (fi) 2004-03-31
ZA93292B (en) 1993-08-19
ITMI920084A0 (it) 1992-01-17
ATE136307T1 (de) 1996-04-15
HUT71512A (en) 1995-12-28
HUT71511A (en) 1995-12-28
HU9502178D0 (en) 1995-09-28
ES2088270T3 (es) 1996-08-01
HUT71513A (en) 1995-12-28
RO113465B1 (ro) 1998-07-30
DK0623131T3 (da) 1996-08-05
SK84694A3 (en) 1995-04-12
NO974462D0 (no) 1997-09-26
AU3350493A (en) 1993-08-03
NO942668L (no) 1994-09-16
EP0623131B1 (en) 1996-04-03
CZ282910B6 (cs) 1997-11-12
DE69302087D1 (de) 1996-05-09
JP2856912B2 (ja) 1999-02-10
NO974462L (no) 1994-09-16
HU9502180D0 (en) 1995-09-28
HU9402119D0 (en) 1994-09-28

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