FI20000060A - Sustained-release compositions of water-soluble peptides - Google Patents

Sustained-release compositions of water-soluble peptides Download PDF

Info

Publication number: FI20000060A
Authority: FI; Finland
Prior art keywords: sustained; water; release compositions; soluble peptides; peptides
Prior art date: 1989-07-07

Application number

FI20000060A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI109334B (en

Inventor

David Bodmer

Jones Wing Fong

Thomas Kissel

Hawkins Valliant Maulding

Oskar Nagele

Jane Edna Pearson

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-07

Filing date

2000-01-12

Publication date

2000-01-12

2000-01-12 Application filed by Novartis Ag filed Critical Novartis Ag

2000-01-12 Publication of FI20000060A publication Critical patent/FI20000060A/en

2002-07-15 Application granted granted Critical

2002-07-15 Publication of FI109334B publication Critical patent/FI109334B/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI20000060A 1989-07-07 2000-01-12 A method of forming a sustained release composition FI109334B (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US37702389A	1989-07-07	1989-07-07
US37702389		1989-07-07
US41134789A	1989-09-22	1989-09-22
US41134789		1989-09-22

Publications (2)

Publication Number	Publication Date
FI20000060A true FI20000060A (en)	2000-01-12
FI109334B FI109334B (en)	2002-07-15

Family

ID=27007654

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
FI903429A FI108611B (en)	1989-07-07	1990-07-06	Process for the preparation of microparticles
FI20000060A FI109334B (en)	1989-07-07	2000-01-12	A method of forming a sustained release composition
FI20000059A FI109543B (en)	1989-07-07	2000-01-12	A process for the preparation of a therapeutically useful octreotide diphoate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
FI903429A FI108611B (en)	1989-07-07	1990-07-06	Process for the preparation of microparticles

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI20000059A FI109543B (en)	1989-07-07	2000-01-12	A process for the preparation of a therapeutically useful octreotide diphoate

Country Status (27)

Country	Link
JP (5)	JPH0832624B2 (en)
KR (2)	KR100303681B1 (en)
AT (1)	AT406225B (en)
AU (2)	AU641407B2 (en)
BE (1)	BE1004486A3 (en)
CA (1)	CA2020477C (en)
CH (1)	CH685230A5 (en)
CY (1)	CY1965A (en)
DE (2)	DE4021517B4 (en)
DK (1)	DK175849B1 (en)
FI (3)	FI108611B (en)
FR (1)	FR2649319A1 (en)
GB (2)	GB2234896B (en)
GR (1)	GR1001121B (en)
HK (2)	HK97695A (en)
HU (2)	HU221294B1 (en)
IE (2)	IE64411B1 (en)
IL (3)	IL131880A (en)
IT (1)	IT1241460B (en)
LU (1)	LU87764A1 (en)
MY (1)	MY106722A (en)
NL (1)	NL195027C (en)
NO (2)	NO302928B1 (en)
NZ (1)	NZ234384A (en)
PT (1)	PT94628B (en)
SE (1)	SE512992C2 (en)
SG (1)	SG26416G (en)

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US6204308B1 (en)	1999-03-01	2001-03-20	Novartis Ag	Organic compounds
EP1044683A1 (en)	1999-04-15	2000-10-18	Debio Recherche Pharmaceutique S.A.	One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) *	1999-11-16	2002-10-08	Atrix Laboratories, Inc.	Biodegradable polymer composition
KR100392501B1 (en) *	2000-06-28	2003-07-22	동국제약 주식회사	Preparation Method for Sustained Release Microparticles by Multiple Emulsion Method and Micropartic les Thereof
US6824822B2 (en) *	2001-08-31	2004-11-30	Alkermes Controlled Therapeutics Inc. Ii	Residual solvent extraction method and microparticles produced thereby
AU2002232824A1 (en)	2000-12-21	2002-07-01	Inhale Therapeutic Systems, Inc.	Induced phase transition method for the production of microparticles containing hydrophobic active agents
US20040097419A1 (en) *	2002-11-19	2004-05-20	Holger Petersen	Organic compounds
PE20050285A1 (en) *	2003-06-24	2005-06-09	Novartis Ag	PHARMACEUTICAL COMPOSITION INCLUDING CYCLIC ANALOGS OF SOMATOSTATIN
ES2600554T3 (en) *	2003-07-18	2017-02-09	Oakwood Laboratories L.L.C.	Prevention of polymer molecular weight reduction, impurity formation and gelation in polymeric compositions
MY158342A (en) *	2003-11-14	2016-09-30	Novartis Ag	Pharmaceutical composition
KR20060129394A (en) *	2004-02-26	2006-12-15	독립행정법인 과학기술진흥기구	Sustained release particulate preparations for injection of proteinaceous drugs and preparation method thereof
DE102004053373A1 (en) *	2004-11-02	2006-05-04	Justus-Liebig-Universität Giessen	Invention relating to nano / meso-fiber anisometric particles in the form of nano / meso-fiber tubes, cables and their curved or branched modifications
KR100741867B1 (en) *	2005-07-05	2007-07-24	전북대학교산학협력단	Method of Preparation of Double Layered Microspheres Using Oil-in-water and Solvent Evaporation
AR058591A1 (en) *	2005-12-22	2008-02-13	Novartis Ag	FORMULATION OF SUSTAINED RELEASE THAT INCLUDES OCTREOTIDE AND TWO OR MORE POLYMACTIDE-COGLICOLID POLYMERS
KR100816065B1 (en) *	2006-11-27	2008-03-24	동국제약 주식회사	Method for preparing sustained release microcapsules with excellent initial release control characteristics and microcapsules prepared by the same
AU2009209594A1 (en)	2008-01-30	2009-08-06	Novartis Ag	Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
USRE49251E1 (en)	2010-01-04	2022-10-18	Mapi Pharma Ltd.	Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
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JP5808413B2 (en) *	2010-09-30	2015-11-10	エボニックコーポレイションＥｖｏｎｉｋＣｏｒｐｏｒａｔｉｏｎ	Method for removing residual organic solvent from fine particles
TW201605488A (en)	2013-10-15	2016-02-16	大塚製藥股份有限公司	Drug for preventing and/or treating polycystic kidney disease
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1990
- 1990-06-25 HU HU974/90A patent/HU221294B1/en unknown
- 1990-07-03 GB GB9014704A patent/GB2234896B/en not_active Expired - Lifetime
- 1990-07-03 SG SG1995907374A patent/SG26416G/en unknown
- 1990-07-05 NZ NZ234384A patent/NZ234384A/en unknown
- 1990-07-05 IE IE43894A patent/IE64411B1/en not_active IP Right Cessation
- 1990-07-05 IL IL13188090A patent/IL131880A/en active IP Right Grant
- 1990-07-05 SE SE9002364A patent/SE512992C2/en not_active IP Right Cessation
- 1990-07-05 CA CA002020477A patent/CA2020477C/en not_active Expired - Lifetime
- 1990-07-05 NL NL9001537A patent/NL195027C/en not_active IP Right Cessation
- 1990-07-05 IE IE243590A patent/IE64216B1/en not_active IP Right Cessation
- 1990-07-05 AU AU58746/90A patent/AU641407B2/en not_active Expired
- 1990-07-05 NO NO903001A patent/NO302928B1/en not_active IP Right Cessation
- 1990-07-05 IT IT48113A patent/IT1241460B/en active IP Right Grant
- 1990-07-05 GR GR900100513A patent/GR1001121B/en not_active IP Right Cessation
- 1990-07-05 BE BE9000693A patent/BE1004486A3/en not_active IP Right Cessation
- 1990-07-05 IL IL13188190A patent/IL131881A/en active IP Right Grant
- 1990-07-05 FR FR9008718A patent/FR2649319A1/en active Granted
- 1990-07-05 CH CH2249/90A patent/CH685230A5/en not_active IP Right Cessation
- 1990-07-05 DK DK199001625A patent/DK175849B1/en not_active IP Right Cessation
- 1990-07-05 IL IL9498390A patent/IL94983A/en active IP Right Grant
- 1990-07-06 JP JP2177665A patent/JPH0832624B2/en not_active Expired - Lifetime
- 1990-07-06 FI FI903429A patent/FI108611B/en active IP Right Grant
- 1990-07-06 AT AT0144090A patent/AT406225B/en not_active IP Right Cessation
- 1990-07-06 MY MYPI90001133A patent/MY106722A/en unknown
- 1990-07-06 DE DE4021517A patent/DE4021517B4/en not_active Expired - Lifetime
- 1990-07-06 KR KR1019900010224A patent/KR100303681B1/en not_active IP Right Cessation
- 1990-07-06 DE DE4042752A patent/DE4042752B4/en not_active Expired - Lifetime
- 1990-07-06 PT PT94628A patent/PT94628B/en not_active IP Right Cessation
- 1990-07-09 LU LU87764A patent/LU87764A1/en unknown
1993
- 1993-03-25 GB GB9306204A patent/GB2265311B/en not_active Expired - Lifetime
1995
- 1995-04-18 JP JP7116539A patent/JPH07309897A/en active Pending
- 1995-04-18 JP JP7116486A patent/JP2931773B2/en not_active Expired - Lifetime
- 1995-06-15 HK HK97695A patent/HK97695A/en not_active IP Right Cessation
- 1995-06-28 HU HU95P/P00523P patent/HU211602A9/en unknown
- 1995-06-29 AU AU23321/95A patent/AU687553B2/en not_active Expired
- 1995-08-15 JP JP7228646A patent/JPH08198771A/en active Pending
1996
- 1996-10-31 HK HK197496A patent/HK197496A/en not_active IP Right Cessation
1997
- 1997-07-04 CY CY196597A patent/CY1965A/en unknown
1998
- 1998-08-26 NO NO19983923A patent/NO320444B1/en unknown
1999
- 1999-09-14 KR KR1019990039209A patent/KR100442931B1/en not_active IP Right Cessation
2000
- 2000-01-12 FI FI20000060A patent/FI109334B/en active
- 2000-01-12 FI FI20000059A patent/FI109543B/en active
2001
- 2001-01-15 JP JP2001006486A patent/JP2001233897A/en active Pending

Also Published As

Publication number	Publication date
HUT54037A (en)	1991-01-28
JP2931773B2 (en)	1999-08-09
JPH08198771A (en)	1996-08-06
FI903429A0 (en)	1990-07-06
PT94628A (en)	1991-03-20
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CA2020477C (en)	2000-11-21
HU221294B1 (en)	2002-09-28
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FI109334B (en)	2002-07-15
IL94983A (en)	1999-08-17
CY1965A (en)	1997-07-04
IT9048113A1 (en)	1992-01-05
GR1001121B (en)	1993-04-28
DE4042752B4 (en)	2009-05-07
NZ234384A (en)	1994-05-26
IT1241460B (en)	1994-01-17
CH685230A5 (en)	1995-05-15
DE4021517B4 (en)	2009-04-09
FR2649319B1 (en)	1994-12-09
NO320444B1 (en)	2005-12-05
LU87764A1 (en)	1992-03-11
FI109543B (en)	2002-08-30
GB9014704D0 (en)	1990-08-22
IL131880A (en)	2001-12-23
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HU903974D0 (en)	1990-11-28
NO903001L (en)	1991-01-08
KR100303681B1 (en)	2002-05-16
NL195027C (en)	2003-12-02
DK162590D0 (en)	1990-07-05
GB2234896A (en)	1991-02-20
AU641407B2 (en)	1993-09-23
AU2332195A (en)	1995-09-07
FI20000059A (en)	2000-01-12
BE1004486A3 (en)	1992-12-01
CA2020477A1 (en)	1991-01-08
HK197496A (en)	1996-11-08
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NO302928B1 (en)	1998-05-11
GR900100513A (en)	1991-12-10
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NO903001D0 (en)	1990-07-05

Publication	Publication Date	Title
FI20000060A (en)	2000-01-12	Sustained-release compositions of water-soluble peptides
HUT74088A (en)	1996-11-28	Sustained-release pharmaceutical composition
BR9007196A (en)	1991-12-10	COMPOSITION
SE8903042D0 (en)	1989-09-15	PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLOSPORINS
MX164910B (en)	1992-10-01	MICROBICIDAL COMPOSITIONS OF DIMETHYLAMINE-EPICLOROHIDRINE-AMINES
IT1232848B (en)	1992-03-05	COMPOSITION OF CLEAR SHAMPOO
SE9000221D0 (en)	1990-01-22	COMPOSITION
IT1243398B (en)	1994-06-10	COMPOSITIONS OF SUBSTANCES BASED ON DICHETOPIRROPOPRROLI
DK111489D0 (en)	1989-03-08	PEPTIDES
BR8900004A (en)	1989-08-15	HERBICIDIC COMPOSITIONS OF QUINOXALINYLOXYPHOPYROPANOATE HETEROCYCLIC-ALCOHYLENE COMPOUNDS
BR8906323A (en)	1990-10-02	COMPRESSOR SET
IT1240773B (en)	1993-12-17	IMPROVEMENT OF POZZOLANIC COMPOSITIONS.
DK549688A (en)	1989-04-02	PREPARATION OF PEPTIDES
IT9020923A1 (en)	1991-01-13	ASPECTS OF SWEETS
KR920700222A (en)	1992-02-19	Lyophilized peptide preparation
DE69027139D1 (en)	1996-07-04	Compositions
KR900015532U (en)	1990-09-01	Part of
NO177858C (en)	1995-12-06	Peptide
BR9005424A (en)	1991-09-17	COMPOSITION
DE69031954D1 (en)	1998-02-19	Fragrance composition
FI991120A0 (en)	1999-05-17	Water-soluble peptides' long-releasing compositions
ID1049B (en)	1996-10-29	COMPOSITION OF DETERGENTING BARS
KR900015545U (en)	1990-09-01	Jicheol-gu of Hwail
DK381789D0 (en)	1989-08-03	PEPTIDES
BR8902999A (en)	1990-12-26	GAME OF CRUCADE DAME