FI119640B - Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia - Google Patents

Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia Download PDF

Info

Publication number: FI119640B
Authority: FI; Finland
Prior art keywords: alkyl; formula; chloro; dihydro; amino
Prior art date: 1994-09-27

Application number

FI971274A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI971274A0 (fi

FI971274A7 (fi

Inventor

Daele Georges Henri Paul Van

Den Keybus Frans Maria Alf Van

Jean-Paul Rene Marie A Bosmans

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-27

Filing date

1997-03-26

Publication date

2009-01-30

1997-03-26 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1997-03-26 Publication of FI971274A0 publication Critical patent/FI971274A0/fi

1997-03-26 Publication of FI971274A7 publication Critical patent/FI971274A7/fi

2009-01-30 Application granted granted Critical

2009-01-30 Publication of FI119640B publication Critical patent/FI119640B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI971274A 1994-09-27 1997-03-26 Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia FI119640B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
EP94202792		1994-09-27
EP94202792		1994-09-27
US45548695A	1995-05-31	1995-05-31
US45548695		1995-05-31
EP9503691		1995-09-19
PCT/EP1995/003691 WO1996010027A1 (en)	1994-09-27	1995-09-19	N-substituted piperidinyl bicyclic benzoate derivatives

Publications (3)

Publication Number	Publication Date
FI971274A0 FI971274A0 (fi)	1997-03-26
FI971274A7 FI971274A7 (fi)	1997-03-26
FI119640B true FI119640B (fi)	2009-01-30

Family

ID=26136613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI971274A FI119640B (fi)	1994-09-27	1997-03-26	Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia

Country Status (23)

Country	Link
EP (1)	EP0784620B1 (pt)
JP (1)	JP3953097B2 (pt)
CN (1)	CN1068880C (pt)
AT (1)	ATE187453T1 (pt)
AU (1)	AU699152B2 (pt)
BR (1)	BR9509036A (pt)
CA (1)	CA2200578C (pt)
CZ (1)	CZ289031B6 (pt)
DE (1)	DE69513846T2 (pt)
DK (1)	DK0784620T3 (pt)
ES (1)	ES2141383T3 (pt)
FI (1)	FI119640B (pt)
GR (1)	GR3032646T3 (pt)
HU (1)	HU218698B (pt)
IL (1)	IL115413A (pt)
MY (1)	MY113202A (pt)
NO (1)	NO313238B1 (pt)
NZ (1)	NZ293605A (pt)
PL (1)	PL182502B1 (pt)
PT (1)	PT784620E (pt)
RU (1)	RU2154064C2 (pt)
WO (1)	WO1996010027A1 (pt)
ZA (1)	ZA958081B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002514643A (ja) *	1998-05-14	2002-05-21	エギシュヂョヂセルヂャールエルテー	ベンゾフラン誘導体、それを含有する製薬学的な組成物及びその活性成分の製造方法。
PL214274B1 (pl) *	2002-01-16	2013-07-31	Movetis N V	N-Tlenek prukaloprydu, sposób jego wytwarzania i zastosowanie oraz zawierająca go kompozycja i sposób jej wytwarzania
WO2005061483A2 (en) *	2003-12-23	2005-07-07	Bio-Medisinsk Innovasjon As	Modulators of peripheral 5-ht receptors
NZ551603A (en)	2004-06-24	2010-11-26	Incyte Corp	N-substituted piperidines and their use as pharmaceuticals
KR101561482B1 (ko)	2005-11-08	2015-10-20	버텍스 파마슈티칼스 인코포레이티드	Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제
NZ581259A (en)	2007-05-09	2012-07-27	Vertex Pharma	Modulators of cystic fibrosis transmembrane conductance regulator
NZ585794A (en)	2007-12-07	2012-05-25	Vertex Pharma	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
HUE031913T2 (en)	2007-12-07	2017-08-28	Vertex Pharma	Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
ES2647531T3 (es)	2008-02-28	2017-12-22	Vertex Pharmaceuticals Incorporated	Derivados de heteroarilo como moduladores de CFTR
ME02446B (me) *	2010-04-07	2016-09-20	Vertex Pharma	Čvrste forme 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksiamido)-3-metilpiridin-2-il)benzoeve kiseline
LT3150198T (lt)	2010-04-07	2021-12-10	Vertex Pharmaceuticals Incorporated	3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il)benzoinės rūgšties farmacinė kompozicija ir jos įvedimas
CN108066306B (zh)	2012-01-25	2021-09-07	沃泰克斯药物股份有限公司	药物制剂及其制备方法
NZ720958A (en)	2013-11-12	2022-02-25	Vertex Pharma	Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
PT3221692T (pt)	2014-11-18	2021-09-10	Vertex Pharma	Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1593569A3 (ru) *	1982-07-30	1990-09-15	Janssen Pharmaceutica Nv	Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
CA1317940C (en) *	1987-09-25	1993-05-18	Georges H. P. Van Daele	Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) *	1988-03-29	1989-10-19	Sandoz Ag	Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) *	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
EP0600955A1 (en) *	1991-08-20	1994-06-15	Smithkline Beecham Plc	5-ht4 receptor antagonists
MX9306311A (es) *	1992-10-13	1994-04-29	Smithkline Beecham Plc	Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

1995
- 1995-09-19 PL PL95319997A patent/PL182502B1/pl not_active IP Right Cessation
- 1995-09-19 CZ CZ1997918A patent/CZ289031B6/cs not_active IP Right Cessation
- 1995-09-19 HU HU9701944A patent/HU218698B/hu not_active IP Right Cessation
- 1995-09-19 DK DK95933400T patent/DK0784620T3/da active
- 1995-09-19 AT AT95933400T patent/ATE187453T1/de not_active IP Right Cessation
- 1995-09-19 ES ES95933400T patent/ES2141383T3/es not_active Expired - Lifetime
- 1995-09-19 NZ NZ293605A patent/NZ293605A/en not_active IP Right Cessation
- 1995-09-19 JP JP51133896A patent/JP3953097B2/ja not_active Expired - Fee Related
- 1995-09-19 AU AU36081/95A patent/AU699152B2/en not_active Ceased
- 1995-09-19 PT PT95933400T patent/PT784620E/pt unknown
- 1995-09-19 RU RU97107464/04A patent/RU2154064C2/ru not_active IP Right Cessation
- 1995-09-19 CA CA002200578A patent/CA2200578C/en not_active Expired - Lifetime
- 1995-09-19 CN CN95195300A patent/CN1068880C/zh not_active Expired - Fee Related
- 1995-09-19 EP EP95933400A patent/EP0784620B1/en not_active Expired - Lifetime
- 1995-09-19 BR BR9509036A patent/BR9509036A/pt not_active IP Right Cessation
- 1995-09-19 DE DE69513846T patent/DE69513846T2/de not_active Expired - Lifetime
- 1995-09-19 WO PCT/EP1995/003691 patent/WO1996010027A1/en not_active Ceased
- 1995-09-22 IL IL11541395A patent/IL115413A/xx not_active IP Right Cessation
- 1995-09-26 MY MYPI95002870A patent/MY113202A/en unknown
- 1995-09-26 ZA ZA958081A patent/ZA958081B/xx unknown
1997
- 1997-03-24 NO NO19971376A patent/NO313238B1/no not_active IP Right Cessation
- 1997-03-26 FI FI971274A patent/FI119640B/fi active
2000
- 2000-02-11 GR GR20000400344T patent/GR3032646T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE187453T1 (de)	1999-12-15
CN1166171A (zh)	1997-11-26
CN1068880C (zh)	2001-07-25
FI971274A0 (fi)	1997-03-26
PL319997A1 (en)	1997-09-01
RU2154064C2 (ru)	2000-08-10
CA2200578C (en)	2006-11-07
PT784620E (pt)	2000-05-31
JP3953097B2 (ja)	2007-08-01
WO1996010027A1 (en)	1996-04-04
EP0784620B1 (en)	1999-12-08
CZ91897A3 (en)	1997-12-17
ZA958081B (en)	1997-03-26
NO971376D0 (no)	1997-03-24
DE69513846T2 (de)	2000-07-06
GR3032646T3 (en)	2000-06-30
BR9509036A (pt)	1997-10-14
NO313238B1 (no)	2002-09-02
HUT77173A (hu)	1998-03-02
CZ289031B6 (cs)	2001-10-17
HU218698B (hu)	2000-11-28
NO971376L (no)	1997-05-05
IL115413A0 (en)	1995-12-31
ES2141383T3 (es)	2000-03-16
IL115413A (en)	2000-02-17
DE69513846D1 (de)	2000-01-13
PL182502B1 (pl)	2002-01-31
DK0784620T3 (da)	2000-05-22
CA2200578A1 (en)	1996-04-04
FI971274A7 (fi)	1997-03-26
AU699152B2 (en)	1998-11-26
NZ293605A (en)	1998-07-28
MY113202A (en)	2001-12-31
JPH10506118A (ja)	1998-06-16
AU3608195A (en)	1996-04-19
MX9702363A (es)	1997-10-31
EP0784620A1 (en)	1997-07-23

Publication	Publication Date	Title
FI101624B (fi)	1998-07-31	Menetelmä terapeuttisesti käyttökelpoisten N-(3-hydroksi-4-piperidinyy li)(dihydrobentsofuraani-, dihydro-2H-bentsopyraani- tai dihydrobentso dioksiini)karboksamidijohdannaisten valmistamiseksi ja välituote
FI119640B (fi)	2009-01-30	Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia
KR100500372B1 (ko)	2005-07-11	위장운동 조절성 3- 또는 4-치환된4-(아미노메틸)-피페리딘 유도체의 비사이클릭 벤즈아미드
FI101622B (fi)	1998-07-31	Menetelmä terapeuttisesti aktiivisten N-(4-piperidyyli)(dihydrobentsof uraani)karboksamidi- tai N-(4-piperidyyli)(dihydro-2H-bentsopyraani)ka rboksamidijohdannaisten valmistamiseksi ja välituote
FI94129B (fi)	1995-04-13	Menetelmä terapeuttisesti käyttökelpoisten N-(1-alkyyli-3-hydroksi-4-piperidinyyli)bentsamidien valmistamiseksi
US6544997B1 (en)	2003-04-08	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US5053411A (en)	1991-10-01	N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
CN1068881C (zh)	2001-07-25	苯基－氧代－烷基－(4－哌啶基)苯甲酸酯衍生物
AU718695B2 (en)	2000-04-20	Esters of 3-hydroxy-piperidinemethanol derivatives
WO2005030722A1 (ja)	2005-04-07	Ｎ－置換－ｎ－（４－ピペリジニル）アミド誘導体
KR100388253B1 (ko)	2003-10-04	N-치환된피페리디닐바이사이클릭벤조에이트유도체
USRE34201E (en)	1993-03-23	N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
HUT77311A (hu)	1998-03-30	Fenil-oxo-alkil-(4-piperidinil)-benzoát-származékok, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és alkalmazásuk
MXPA97002363A (es)	1998-07-03	Derivados biciclicos de benzoato de piperidinilon-substituidos
MXPA01006409A (en)	2001-12-13	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
MXPA97002356A (en)	1998-07-03	Derivatives of phenyl-oxy-alkyl- (4-piperidinyl) benzo