[go: up one dir, main page]

FI112030B - Menetelmä S(+)-ibuprofeeni-partikkeleiden valmistamiseksi - Google Patents

Menetelmä S(+)-ibuprofeeni-partikkeleiden valmistamiseksi Download PDF

Info

Publication number
FI112030B
FI112030B FI962866A FI962866A FI112030B FI 112030 B FI112030 B FI 112030B FI 962866 A FI962866 A FI 962866A FI 962866 A FI962866 A FI 962866A FI 112030 B FI112030 B FI 112030B
Authority
FI
Finland
Prior art keywords
ibuprofen
solvent
tablets
particles
process according
Prior art date
Application number
FI962866A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI962866A0 (fi
FI962866A (fi
Inventor
Gerhard Hantich
Ernst Hesse
Torsten Moeller
Original Assignee
Gebro Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gebro Pharma Gmbh filed Critical Gebro Pharma Gmbh
Publication of FI962866A0 publication Critical patent/FI962866A0/fi
Publication of FI962866A publication Critical patent/FI962866A/fi
Application granted granted Critical
Publication of FI112030B publication Critical patent/FI112030B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyurethanes Or Polyureas (AREA)
FI962866A 1994-01-28 1996-07-16 Menetelmä S(+)-ibuprofeeni-partikkeleiden valmistamiseksi FI112030B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT0015894A AT401871B (de) 1994-01-28 1994-01-28 Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung
AT15894 1994-01-28
AT9500014 1995-01-26
PCT/AT1995/000014 WO1995020382A1 (de) 1994-01-28 1995-01-26 Verfahren zur herstellung von s(+)-ibuprofen-partikeln

Publications (3)

Publication Number Publication Date
FI962866A0 FI962866A0 (fi) 1996-07-16
FI962866A FI962866A (fi) 1996-07-16
FI112030B true FI112030B (fi) 2003-10-31

Family

ID=3483086

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962866A FI112030B (fi) 1994-01-28 1996-07-16 Menetelmä S(+)-ibuprofeeni-partikkeleiden valmistamiseksi

Country Status (20)

Country Link
US (1) US5869101A (sl)
EP (1) EP0741565B1 (sl)
JP (1) JP2840132B2 (sl)
AT (2) AT401871B (sl)
AU (1) AU689531B2 (sl)
CA (1) CA2181810C (sl)
CZ (1) CZ287998B6 (sl)
DE (1) DE59508198D1 (sl)
DK (1) DK0741565T3 (sl)
ES (1) ES2146744T3 (sl)
FI (1) FI112030B (sl)
GR (1) GR3033841T3 (sl)
HU (1) HU217798B (sl)
NO (1) NO313982B1 (sl)
NZ (1) NZ278551A (sl)
PL (1) PL179095B1 (sl)
PT (1) PT741565E (sl)
SI (1) SI9520030A (sl)
SK (1) SK282433B6 (sl)
WO (1) WO1995020382A1 (sl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225402B (en) 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
US6979735B1 (en) † 1999-04-01 2005-12-27 Dsm N.V. Agglomerates by crystallization
HU227045B1 (en) * 1999-12-09 2010-05-28 Reckitt Benckiser Healthcare Compressed tablet composition comprising a nsaid
KR100700721B1 (ko) * 2000-09-08 2007-03-27 지상철 안정성 및 용출율이 향상된 ｓ(+)-이부프로펜의 정제
GB0113839D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
JP2007513143A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 押出機を使用して好ましくはポロクサマーおよびグリセリドを含む多粒子アジスロマイシン組成物を製造するための噴霧凝固法
JP2007513139A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
EP1694304A2 (en) * 2003-12-04 2006-08-30 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
AU2004294817B2 (en) * 2003-12-04 2007-01-25 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
EP1689368B1 (en) * 2003-12-04 2016-09-28 Bend Research, Inc Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
CZ297830B6 (cs) * 2005-08-30 2007-04-11 I.Q.A., A. S. Zpusob výroby jemne krystalické smesi obsahující nesteroidní protizánetlivé lécivo, jemne krystalická smes pripravitelná tímto zpusobem a pevný farmaceutický prostredek tuto smes obsahující
CN105963259A (zh) * 2016-05-25 2016-09-28 山东理工大学 一种采用常压过滤制备布洛芬微球的方法
CN109956860B (zh) * 2019-03-08 2022-03-01 天津大学 一种布洛芬球形晶体的制备方法
CN110041191A (zh) * 2019-04-30 2019-07-23 湖南九典宏阳制药有限公司 一种培比洛芬的纯化方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
JPS52111533A (en) * 1976-03-12 1977-09-19 Kanebo Ltd Preparation of fine powder of ibuprophene
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4609675A (en) * 1984-08-17 1986-09-02 The Upjohn Company Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing
ES2055685T3 (es) * 1986-11-14 1994-09-01 Puetter Medice Chem Pharm Procedimiento para la obtencion de un medicamento que contiene ibuprofen.
GB8716975D0 (en) * 1987-07-17 1987-08-26 Boots Co Plc Therapeutic agents
US5198568A (en) * 1988-04-07 1993-03-30 Sepracor, Inc. Compounds useful in enzymatic resolution systems and their preparation
DE3833448A1 (de) * 1988-10-01 1990-04-12 Hoechst Ag Verfahren zur gewinnung von ibuprofen fuer die direkttablettierung
DE3833446A1 (de) * 1988-10-01 1990-04-05 Hoechst Ag Verfahren zur herstellung von arzneimittelwirkstoff-partikeln mit verbesserten fliess-, lager- und formulierungseigenschaften sowie arzneimittel, die diese arzneimittelwirkstoff-partikeln enthalten
EP0437451B1 (en) * 1988-10-05 1993-06-09 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
JPH082781B2 (ja) * 1988-10-18 1996-01-17 嘉明 川島 中空顆粒状医薬及びその製法
US5104656A (en) * 1989-06-16 1992-04-14 Seth Pyare L Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent
DE69108044T2 (de) * 1990-11-19 1995-07-06 Albemarle Corp Verfahren zur verbesserung der fliessencharakteristik von kristallinem ibuprofen.
DE4122591C1 (en) * 1991-07-08 1993-02-18 Roland 8012 Ottobrunn De Bodmeier Producing microcapsules of water insoluble polymer and active agent - includes dissolving or dispersing active agent in aq. polymer contg. gellable assistants
US5191114A (en) * 1991-10-09 1993-03-02 Sage Pharmaceuticals, Inc. Process for enhancing the flow characteristics of ibuprofen
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel

Also Published As

Publication number Publication date
SK96496A3 (en) 1997-01-08
CZ287998B6 (cs) 2001-03-14
PL179095B1 (pl) 2000-07-31
JP2840132B2 (ja) 1998-12-24
JPH09503522A (ja) 1997-04-08
DE59508198D1 (de) 2000-05-25
PL315655A1 (en) 1996-11-25
FI962866A0 (fi) 1996-07-16
WO1995020382A1 (de) 1995-08-03
CA2181810C (en) 2000-10-24
FI962866A (fi) 1996-07-16
AT401871B (de) 1996-12-27
PT741565E (pt) 2000-09-29
GR3033841T3 (en) 2000-10-31
NO962966D0 (no) 1996-07-15
SK282433B6 (sk) 2002-02-05
HU217798B (hu) 2000-04-28
SI9520030A (en) 1996-12-31
ATA15894A (de) 1996-05-15
NO313982B1 (no) 2003-01-13
ES2146744T3 (es) 2000-08-16
NZ278551A (en) 1997-10-24
AU1449995A (en) 1995-08-15
AU689531B2 (en) 1998-04-02
ATE191848T1 (de) 2000-05-15
HUT74853A (en) 1997-02-28
NO962966L (no) 1996-07-15
CZ213196A3 (en) 1996-10-16
DK0741565T3 (da) 2000-09-04
US5869101A (en) 1999-02-09
HU9602013D0 (en) 1996-09-30
EP0741565A1 (de) 1996-11-13
EP0741565B1 (de) 2000-04-19

Similar Documents

Publication Publication Date Title
FI112030B (fi) Menetelmä S(+)-ibuprofeeni-partikkeleiden valmistamiseksi
US4344934A (en) Therapeutic compositions with enhanced bioavailability
EP0012523B2 (en) Therapeutic compositions with enhanced bioavailability and process for their preparation
CS247079B2 (en) Production method of the divisable tablet with retarded realising of its effective substance
SK13312001A3 (sk) Spôsob prípravy stabilnej nehygroskopickej soli L(-)-karnitínu, granulát alebo prášok s obsahom kyslého fumarátu L(-)-karnitínu
RU2101009C1 (ru) Твердая лекарственная форма для орального применения с замедленным высвобождением активного вещества и способ ее изготовления (варианты)
JP2003531099A (ja) 改良された水溶解度をもつ医薬製剤
HRP20010589A2 (en) Polymorphic crystalline forms of celecoxib
JP2007145856A (ja) カルベジロール製剤
KR20030024833A (ko) 시탈로프람을 함유하는 약학 조성물
KR100310041B1 (ko) 틸리딘이수소오르토포스페이트,그제조방법및이를함유한의약제제
KR101519612B1 (ko) 옥스카르바제핀을 포함하는 방출 제어형 고체 제제의 제조 방법 및 그에 의해 얻어질 수 있는 제제
SK280552B6 (sk) Spôsob prípravy klodronátových prípravkov
EP2946771B1 (en) Water-dispersible tablet formulation comprising deferasirox
Patel et al. Formulation design of oxcarbazepine fast-release tablets prepared by melt granulation technique
JP2000239185A (ja) 医薬組成物
WO2007003447A2 (en) Coated granular formulations
Madarshahian et al. Solid phase wax coating of N-acetylcysteine (NAC) to decrease its solubility profile as a ready to mix supplement
RU2289422C2 (ru) Фармацевтическая композиция на основе ноопепта
MXPA06004435A (es) Formulacion farmaceutica que contiene un antagonista de ltd4, asi como procedimiento para su preparacion y su uso.
HU191102B (en) Process for producing pharmaceutical compositions of regulated dissolution of the active agents containing water-soluble inorganic pharmacons
CZ20004097A3 (cs) Orální lékové formy s reprodukovatelným uvolňováním účinných látek gatifloxacinu nebo jeho farmaceuticky přijatelných solí nebo hydrátů

Legal Events

Date Code Title Description
MM Patent lapsed