FI109800B - Menetelmä TNF-a:lle spesifisten rekombinanttisten vasta-ainemolekyylien valmistamiseksi - Google Patents

Menetelmä TNF-a:lle spesifisten rekombinanttisten vasta-ainemolekyylien valmistamiseksi Download PDF

Info

Publication number: FI109800B
Authority: FI; Finland
Prior art keywords: ser; gly; antibody; thr; cdr
Prior art date: 1990-12-21

Application number

FI923737A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI923737L (fi

FI923737A0 (fi

Inventor

John Spencer Emtage

John Robert Adair

Diljeet Singh Athwal

Mark William Bodmer

Original Assignee

Celltech Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1992-08-20

Publication date

2002-10-15

1990-12-21 Priority claimed from PCT/GB1990/002017 external-priority patent/WO1991009967A1/en

1992-08-20 Application filed by Celltech Ltd filed Critical Celltech Ltd

1992-08-20 Publication of FI923737L publication Critical patent/FI923737L/fi

1992-08-20 Publication of FI923737A0 publication Critical patent/FI923737A0/fi

2002-10-15 Application granted granted Critical

2002-10-15 Publication of FI109800B publication Critical patent/FI109800B/fi

Links

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Classifications

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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins

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FI923737A 1990-12-21 1992-08-20 Menetelmä TNF-a:lle spesifisten rekombinanttisten vasta-ainemolekyylien valmistamiseksi FI109800B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB9002017		1990-12-21
PCT/GB1990/002017 WO1991009967A1 (en)	1989-12-21	1990-12-21	Humanised antibodies
GB9102300		1991-02-02
GB919109645A GB9109645D0 (en)	1991-05-03	1991-05-03	Recombinant antibodies
GB9109645		1991-05-03
PCT/GB1991/002300 WO1992011383A1 (en)	1990-12-21	1991-12-20	RECOMBINANT ANTIBODIES SPECIFIC FOR TNF$g(a)

Publications (3)

Publication Number	Publication Date
FI923737L FI923737L (fi)	1992-08-20
FI923737A0 FI923737A0 (fi)	1992-08-20
FI109800B true FI109800B (fi)	2002-10-15

Family

ID=10694434

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI923737A FI109800B (fi)	1990-12-21	1992-08-20	Menetelmä TNF-a:lle spesifisten rekombinanttisten vasta-ainemolekyylien valmistamiseksi

Country Status (21)

Country	Link
US (1)	US20030199679A1 (es)
EP (3)	EP0626389B1 (es)
JP (3)	JP3145401B2 (es)
KR (1)	KR100253426B1 (es)
AT (2)	ATE134387T1 (es)
AU (2)	AU657937B2 (es)
BR (1)	BR9106232A (es)
CA (3)	CA2329482C (es)
DE (4)	DE69117284T2 (es)
DK (2)	DK0626389T3 (es)
ES (2)	ES2084338T3 (es)
FI (1)	FI109800B (es)
GB (2)	GB9109645D0 (es)
GR (1)	GR3019066T3 (es)
HU (2)	HUT62661A (es)
NL (1)	NL9120013A (es)
NO (2)	NO923231L (es)
NZ (2)	NZ260226A (es)
OA (1)	OA09666A (es)
PT (1)	PT99934B (es)
WO (1)	WO1992011383A1 (es)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
US20030225254A1 (en)	1989-08-07	2003-12-04	Rathjen Deborah Ann	Tumour necrosis factor binding ligands
CA2064915C (en)	1989-08-07	2001-05-29	Deborah A. Rathjen	Tumour necrosis factor binding ligands
US6284471B1 (en)	1991-03-18	2001-09-04	New York University Medical Center	Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US7192584B2 (en)	1991-03-18	2007-03-20	Centocor, Inc.	Methods of treating psoriasis with anti-TNF antibodies
US5919452A (en) *	1991-03-18	1999-07-06	New York University	Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US6277969B1 (en)	1991-03-18	2001-08-21	New York University	Anti-TNF antibodies and peptides of human tumor necrosis factor
AU675916B2 (en)	1991-06-14	1997-02-27	Genentech Inc.	Method for making humanized antibodies
US6800738B1 (en)	1991-06-14	2004-10-05	Genentech, Inc.	Method for making humanized antibodies
WO1994004679A1 (en) *	1991-06-14	1994-03-03	Genentech, Inc.	Method for making humanized antibodies
US6270766B1 (en)	1992-10-08	2001-08-07	The Kennedy Institute Of Rheumatology	Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
GB9221654D0 (en) *	1992-10-15	1992-11-25	Scotgen Ltd	Recombinant human anti-cytomegalovirus antibodies
FI952658A0 (fi) *	1992-12-01	1995-05-31	Protein Design Labs Inc	L-selektiinin kanssa reaktiivisia humanisoituja vasta-aineita
DK0614984T4 (da) †	1993-03-05	2010-12-20	Bayer Healthcare Llc	Humane monoklonale anti-TNF-alfa-antistoffer
DE4307508A1 (de) *	1993-03-10	1994-09-15	Knoll Ag	Verwendung von anti-TNF-Antikörpern als Arzneimittel bei der Behandlung von Herzinsuffizienz (Herzmuskelschwäche)
US6180377B1 (en) *	1993-06-16	2001-01-30	Celltech Therapeutics Limited	Humanized antibodies
US5463063A (en)	1993-07-02	1995-10-31	Celgene Corporation	Ring closure of N-phthaloylglutamines
AU707440B2 (en)	1994-03-29	1999-07-08	Celltech Therapeutics Limited	Antibodies against E-selectin
ATE219945T1 (de) *	1995-01-23	2002-07-15	Xenotech Inc	Zusammensetzung zur verhinderung von osteolyse und metastasen
US5641751A (en) *	1995-05-01	1997-06-24	Centocor, Inc.	Tumor necrosis factor inhibitors
US5817789A (en) *	1995-06-06	1998-10-06	Transkaryotic Therapies, Inc.	Chimeric proteins for use in transport of a selected substance into cells
US6090382A (en)	1996-02-09	2000-07-18	Basf Aktiengesellschaft	Human antibodies that bind human TNFα
US20140212413A1 (en) *	1995-12-11	2014-07-31	New York University	Methods of Treating TNF-alpha-Mediated Diseases Using Chimeric TNF-alpha Antibodies
WO1997029131A1 (en)	1996-02-09	1997-08-14	Basf Aktiengesellschaft	HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a)
US7608262B2 (en) *	1996-02-16	2009-10-27	The Kennedy Institute Of Rheumatology	Methods of preventing or treating thrombosis with tumor necrosis factor antagonists
EP0791360A3 (en) *	1996-02-29	1997-09-24	Bayer Corporation	Treatment of septic shock with anti-TNF antibodies
DK2070920T3 (da)	1996-07-24	2011-06-14	Celgene Corp	Substituerede 2-(2,6-dioxopiperidin-3-yl)phthalimider og 1-oxoisoindoliner og fremgangsmåde til at reducere TNF-a-niveauer
EP2305663B1 (en)	1996-07-24	2014-12-17	Celgene Corporation	Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines and method of reducing TNF alpha levels
HU228769B1 (en)	1996-07-24	2013-05-28	Celgene Corp	Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US7276488B2 (en)	1997-06-04	2007-10-02	Oxford Biomedica (Uk) Limited	Vector system
ATE444358T1 (de)	1997-06-04	2009-10-15	Oxford Biomedica Ltd	Tumor gezielter vektor
DE19739685A1 (de) *	1997-09-10	1999-03-11	Eichel Streiber Christoph Von	Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
DE19746868A1 (de) *	1997-10-23	1999-04-29	Knoll Ag	Verwendung von TNF-Antagonisten als Arzneimittel zur Behandlung von septischen Erkrankungen
EP1032420A4 (en) *	1997-11-14	2004-09-15	Euro Celtique Sa	IMMUNOGLOBULIN MOLECULES WITH SYNTHETIC VARIABLE REGION AND MODIFIED SPECIFICITY
ES2250121T3 (es) *	1999-03-18	2006-04-16	Celgene Corporation	1-oxo- y 1,3-dioxoisoindolinas y su empleo en composiciones farmaceuticas para la reduccion de niveles de las citocinas inflamatorias.
US20040220103A1 (en)	1999-04-19	2004-11-04	Immunex Corporation	Soluble tumor necrosis factor receptor treatment of medical disorders
CN1423660A (zh)	1999-11-18	2003-06-11	牛津生物医学（英国）有限公司	抗体
JP2001299349A (ja) *	2000-04-19	2001-10-30	Suntory Ltd	新規組換え型抗体とそのｃｄｒのアミノ酸配列およびそれをコードする遺伝子
GB0013810D0 (en)	2000-06-06	2000-07-26	Celltech Chiroscience Ltd	Biological products
WO2002008217A2 (en)	2000-07-21	2002-01-31	Chugai Seiyaku Kabushiki Kaisha	COUMARIN DERIVATIVES USEFUL AS TNFα INHIBITORS
UA81743C2 (uk)	2000-08-07	2008-02-11	Центокор, Инк.	МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
US6709655B2 (en)	2001-02-28	2004-03-23	Instituto Bioclon, S.A. De C.V.	Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof
CA2868614A1 (en)	2001-06-08	2002-12-08	Abbott Laboratories (Bermuda) Ltd.	Methods of administering anti-tnf.alpha. antibodies
US20060073141A1 (en) *	2001-06-28	2006-04-06	Domantis Limited	Compositions and methods for treating inflammatory disorders
TWI334439B (en)	2001-08-01	2010-12-11	Centocor Inc	Anti-tnf antibodies, compositions, methods and uses
GB2378949B (en) *	2001-08-16	2005-09-07	Morten Steen Hanefeld Dziegiel	Recombinant anti-plasmodium falciparum antibodies
US20040018195A1 (en) *	2002-03-26	2004-01-29	Griswold Don Edgar	Diabetes-related immunoglobulin derived proteins, compositions, methods and uses
US20030206898A1 (en)	2002-04-26	2003-11-06	Steven Fischkoff	Use of anti-TNFalpha antibodies and another drug
JP4418745B2 (ja)	2002-05-28	2010-02-24	ユセベファルマソシエテアノニム	抗体ｐｅｇ位置異性体、それを含む組成物及びその使用
US7696320B2 (en)	2004-08-24	2010-04-13	Domantis Limited	Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
US20040033228A1 (en)	2002-08-16	2004-02-19	Hans-Juergen Krause	Formulation of human antibodies for treating TNF-alpha associated disorders
MY150740A (en)	2002-10-24	2014-02-28	Abbvie Biotechnology Ltd	Low dose methods for treating disorders in which tnf? activity is detrimental
EP1578799B8 (en)	2002-12-02	2011-03-23	Amgen Fremont Inc.	Antibodies directed to tumor necrosis factor and uses thereof
WO2004063335A2 (en) *	2003-01-08	2004-07-29	Applied Molecular Evolution	TNF-α BINDING MOLECULES
WO2004098578A2 (en) *	2003-05-12	2004-11-18	Altana Pharma Ag	Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517
US7892563B2 (en)	2003-05-20	2011-02-22	Wyeth Holdings Corporation	Methods for treatment of severe acute respiratory syndrome (SARS)
EP2340850A1 (en)	2004-02-10	2011-07-06	The Regents of the University of Colorado, a Body Corporate	Inhibition of factor B, the alternative complement pathway and methods related thereto
TWI439284B (zh)	2004-04-09	2014-06-01	Abbvie Biotechnology Ltd	用於治療ＴＮＦα相關失調症之多重可變劑量療法
GB0425972D0 (en)	2004-11-25	2004-12-29	Celltech R&D Ltd	Biological products
DE602005026571D1 (de) *	2004-12-29	2011-04-07	Yuhan Corp	Tumornekrosefaktor-alpha spezifische humanisierte antikörper
US7431927B2 (en)	2005-03-24	2008-10-07	Epitomics, Inc.	TNFα-neutralizing antibodies
CN101500607B (zh)	2005-05-16	2013-11-27	阿布维生物技术有限公司	TNFα抑制剂治疗腐蚀性多关节炎的用途
AU2016204739C1 (en) *	2005-06-07	2017-10-19	Esbatech, An Alcon Biomedical Research Unit Llc	Stable and soluble antibodies inhibiting TNFalpha
US8067547B2 (en)	2005-06-07	2011-11-29	ESBATech, an Alcon Biomedical Research Unit, LLC	Stable and soluble antibodies inhibiting TNFα
AU2011265593B2 (en) *	2005-06-07	2013-08-15	Esbatech, An Alcon Biomedical Research Unit Llc	Stable and soluble antibodies inhibiting TNFalpha
AU2013207650B2 (en) *	2005-06-07	2016-04-21	Esbatech, An Alcon Biomedical Research Unit Llc	Stable and soluble antibodies inhibiting TNFalpha
CA2862540C (en)	2005-09-21	2018-07-31	The Regents Of The University Of California	Systems, compositions, and methods for local imaging and treatment of pain
WO2007070979A1 (en) *	2005-12-20	2007-06-28	Arana Therapeutics Limited	Chimeric antibodies with part new world primate binding regions
JP5259423B2 (ja)	2006-02-01	2013-08-07	セファロン・オーストラリア・ピーティーワイ・リミテッド	ドメイン抗体構築物
EP2738179A1 (en)	2006-04-05	2014-06-04	AbbVie Biotechnology Ltd	Antibody purification
US9605064B2 (en)	2006-04-10	2017-03-28	Abbvie Biotechnology Ltd	Methods and compositions for treatment of skin disorders
EP2010214A4 (en)	2006-04-10	2010-06-16	Abbott Biotech Ltd	USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
EP2007426A4 (en)	2006-04-10	2010-06-16	Abbott Biotech Ltd	COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS
WO2007137984A2 (en) *	2006-05-25	2007-12-06	Glaxo Group Limited	Modified humanised anti-interleukin-18 antibodies
EP2505651A3 (en)	2006-12-10	2013-01-09	Dyadic International, Inc.	Isolated fungus with reduced protease activity
WO2008098139A2 (en)	2007-02-07	2008-08-14	The Regents Of The University Of Colorado	Axl tyrosine kinase inhibitors and methods of making and using the same
JP2010528647A (ja)	2007-06-06	2010-08-26	ドマンティスリミテッド	ポリペプチド、抗体可変ドメインおよびアンタゴニスト
EP2171451A4 (en)	2007-06-11	2011-12-07	Abbott Biotech Ltd	METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS
CA2960659C (en)	2007-11-09	2021-07-13	The Salk Institute For Biological Studies	Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors
SG2013054218A (en)	2008-01-15	2014-10-30	Abbott Gmbh & Co Kg	Powdered protein compositions and methods of making same
US9365644B2 (en) *	2008-04-23	2016-06-14	Epitomics, Inc.	Anti-TNFα antibody
WO2009142186A1 (ja) *	2008-05-20	2009-11-26	株式会社カネカ	細胞障害性組成物
EP3858854A1 (en)	2008-06-25	2021-08-04	Novartis AG	Stable and soluble antibodies inhibiting tnf
CA2729012A1 (en)	2008-06-27	2009-12-30	Amgen Inc.	Ang-2 inhibition to treat multiple sclerosis
US8415291B2 (en)	2008-10-31	2013-04-09	Centocor Ortho Biotech Inc.	Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
PE20130528A1 (es) *	2010-04-07	2013-05-26	Abbvie Inc	PROTEINAS QUE SE UNEN AL TNF-alfa
CN102675460B (zh) *	2011-02-28	2015-08-19	珠海市丽珠单抗生物技术有限公司	抗肿瘤坏死因子α的人源化抗体
WO2012149197A2 (en)	2011-04-27	2012-11-01	Abbott Laboratories	Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013158273A1 (en)	2012-04-20	2013-10-24	Abbvie Inc.	Methods to modulate c-terminal lysine variant distribution
US9067990B2 (en)	2013-03-14	2015-06-30	Abbvie, Inc.	Protein purification using displacement chromatography
US9150645B2 (en)	2012-04-20	2015-10-06	Abbvie, Inc.	Cell culture methods to reduce acidic species
WO2013176754A1 (en)	2012-05-24	2013-11-28	Abbvie Inc.	Novel purification of antibodies using hydrophobic interaction chromatography
KR20150043523A (ko)	2012-09-02	2015-04-22	애브비 인코포레이티드	단백질 불균일성의 제어 방법
US9512214B2 (en)	2012-09-02	2016-12-06	Abbvie, Inc.	Methods to control protein heterogeneity
EP2830651A4 (en)	2013-03-12	2015-09-02	Abbvie Inc	HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS
WO2014151878A2 (en)	2013-03-14	2014-09-25	Abbvie Inc.	Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
WO2014159579A1 (en)	2013-03-14	2014-10-02	Abbvie Inc.	MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9017687B1 (en)	2013-10-18	2015-04-28	Abbvie, Inc.	Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2015051293A2 (en)	2013-10-04	2015-04-09	Abbvie, Inc.	Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en)	2013-10-18	2015-11-10	Abbvie, Inc.	Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en)	2013-10-18	2015-02-03	Abbvie Inc.	Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en)	2013-10-18	2015-07-21	Abbvie, Inc.	Low acidic species compositions and methods for producing and using the same
BR112016010106A2 (pt)	2013-11-06	2017-12-05	Astute Medical Inc	ensaios para igfbp7 com melhor desempenho em amostras biológicas
US20150139988A1 (en)	2013-11-15	2015-05-21	Abbvie, Inc.	Glycoengineered binding protein compositions
GB201522394D0 (en)	2015-12-18	2016-02-03	Ucb Biopharma Sprl	Antibodies
US10465003B2 (en)	2016-02-05	2019-11-05	Janssen Biotech, Inc.	Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
WO2017158101A1 (en)	2016-03-17	2017-09-21	Numab Innovation Ag	ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF
MA43716A (fr)	2016-03-17	2018-11-28	Numab Innovation Ag	Anticorps anti-tnf et fragments fonctionnels de ceux-ci
HUE052773T2 (hu)	2016-03-17	2021-05-28	Tillotts Pharma Ag	Anti-TNF alfa antitestek és funkcionális fragmenseik
EP3219727B1 (en)	2016-03-17	2020-12-16	Tillotts Pharma AG	Anti-tnf alpha-antibodies and functional fragments thereof
CA3011500A1 (en)	2016-03-17	2017-09-21	Numab Innovation Ag	Anti-tnfalpha-antibodies and functional fragments thereof
SI3464318T1 (sl)	2016-06-02	2021-07-30	Abbvie Inc.	Agonist glukokortikoidnega receptorja in njegovi imunokonjugati
WO2018140121A1 (en)	2017-01-30	2018-08-02	Janssen Biotech, Inc.	Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis
MX2019009377A (es)	2017-02-07	2019-12-11	Janssen Biotech Inc	Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la espondilitis anquilosante activa.
EP3409688A1 (en)	2017-05-31	2018-12-05	Tillotts Pharma Ag	Topical treatment of inflammatory bowel disease using anti-tnf-alpha antibodies and fragments thereof
EP3456739A1 (en)	2017-09-19	2019-03-20	Tillotts Pharma Ag	Use of anti-tnfalpha antibodies for treating wounds
EP3459528B1 (en)	2017-09-20	2022-11-23	Tillotts Pharma Ag	Preparation of solid dosage forms comprising antibodies by solution/suspension layering
ES2938608T3 (es)	2017-09-20	2023-04-13	Tillotts Pharma Ag	Método para preparar una forma farmacéutica sólida que comprende anticuerpos mediante granulación en húmedo, extrusión y esferonización
EP3459529A1 (en)	2017-09-20	2019-03-27	Tillotts Pharma Ag	Preparation of sustained release solid dosage forms comprising antibodies by spray drying
PE20201286A1 (es)	2017-12-01	2020-11-24	Abbvie Inc	Agonista del receptor de glucocorticoides e inmunoconjugados de este
US20210070854A1 (en) *	2017-12-29	2021-03-11	Board Of Regents, The University Of Texas System	Antimicrobial nanobodies
WO2020114616A1 (en)	2018-12-07	2020-06-11	Tillotts Pharma Ag	Topical treatment of immune checkpoint inhibitor induced diarrhoea, colitis or enterocolitis using antibodies and fragments thereof
IT201900000651A1 (it)	2019-01-16	2019-04-16	Pastore Lucio	Tecnologia di trasferimento genico
US20220127350A1 (en)	2019-01-31	2022-04-28	Numab Therapeutics AG	Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof
EP3972690A4 (en)	2019-05-23	2023-07-05	Janssen Biotech, Inc.	METHOD OF TREATMENT OF INFLAMMATORY BOWEL DISEASE USING COMBINATION THERAPY OF ANTIBODIES TO IL-23 AND TNF-ALPHA
US12258393B2 (en)	2020-05-21	2025-03-25	Janssen Biotech, Inc.	Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha
US20240270859A1 (en)	2020-12-09	2024-08-15	Hk Inno.N Corporation	ANTI-OX40L ANTIBODY, ANTI-OX40L/ANTI-TNFa BISPECIFIC ANTIBODY, AND USES THEREOF
WO2024200722A1 (en)	2023-03-28	2024-10-03	Tillotts Pharma Ag	Solid oral dosage form comprising antibodies for sustained release in the lower gastrointestinal tract

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4965271A (en) *	1986-12-31	1990-10-23	Hoechst Roussel Pharmaceuticals, Inc.	Method of inhibiting the activity of leukocyte derived cytokines
AU625613B2 (en) *	1988-01-05	1992-07-16	Novartis Ag	Novel chimeric antibodies
GB8805792D0 (en) *	1988-03-11	1988-04-13	Celltech Ltd	Medicaments
WO1990001950A1 (en) *	1988-08-19	1990-03-08	Celltech Limited	Pharmaceutical products for anti-neoplastic therapy
CA2018248A1 (en) *	1989-06-07	1990-12-07	Clyde W. Shearman	Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
GB8928874D0 (en) *	1989-12-21	1990-02-28	Celltech Ltd	Humanised antibodies
US5958413A (en) *	1990-11-01	1999-09-28	Celltech Limited	Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
GB9023783D0 (en) *	1990-11-01	1990-12-12	Celltech Ltd	Pharmaceutical product
CA2106299C (en) *	1991-03-18	2001-02-06	Junming Le	Monoclonal and chimeric antibodies specific for human tumor necrosis factor
DK0614984T4 (da) *	1993-03-05	2010-12-20	Bayer Healthcare Llc	Humane monoklonale anti-TNF-alfa-antistoffer

1991
- 1991-05-03 GB GB919109645A patent/GB9109645D0/en active Pending
- 1991-12-20 DE DE69117284T patent/DE69117284T2/de not_active Expired - Lifetime
- 1991-12-20 BR BR919106232A patent/BR9106232A/pt unknown
- 1991-12-20 CA CA002329482A patent/CA2329482C/en not_active Expired - Lifetime
- 1991-12-20 EP EP94201456A patent/EP0626389B1/en not_active Expired - Lifetime
- 1991-12-20 GB GB9217880A patent/GB2257145B/en not_active Expired - Fee Related
- 1991-12-20 ES ES92901287T patent/ES2084338T3/es not_active Expired - Lifetime
- 1991-12-20 DE DE4193302A patent/DE4193302C2/de not_active Expired - Lifetime
- 1991-12-20 CA CA002129554A patent/CA2129554C/en not_active Expired - Lifetime
- 1991-12-20 DE DE69133167T patent/DE69133167T2/de not_active Expired - Lifetime
- 1991-12-20 DK DK94201456T patent/DK0626389T3/da active
- 1991-12-20 AT AT92901287T patent/ATE134387T1/de not_active IP Right Cessation
- 1991-12-20 AT AT94201456T patent/ATE228853T1/de not_active IP Right Cessation
- 1991-12-20 DE DE914193302T patent/DE4193302T1/de active Pending
- 1991-12-20 CA CA002076540A patent/CA2076540C/en not_active Expired - Lifetime
- 1991-12-20 NL NL9120013A patent/NL9120013A/nl active Search and Examination
- 1991-12-20 AU AU91084/91A patent/AU657937B2/en not_active Expired
- 1991-12-20 DK DK92901287.0T patent/DK0516785T3/da active
- 1991-12-20 JP JP50146792A patent/JP3145401B2/ja not_active Expired - Lifetime
- 1991-12-20 KR KR1019920702000A patent/KR100253426B1/ko not_active Expired - Fee Related
- 1991-12-20 EP EP92901287A patent/EP0516785B1/en not_active Expired - Lifetime
- 1991-12-20 ES ES94201456T patent/ES2190434T3/es not_active Expired - Lifetime
- 1991-12-20 HU HU922605A patent/HUT62661A/hu unknown
- 1991-12-20 WO PCT/GB1991/002300 patent/WO1992011383A1/en active IP Right Grant
- 1991-12-20 EP EP98202522A patent/EP0927758A3/en not_active Withdrawn
- 1991-12-23 NZ NZ260226A patent/NZ260226A/en not_active IP Right Cessation
- 1991-12-23 PT PT99934A patent/PT99934B/pt not_active IP Right Cessation
- 1991-12-23 NZ NZ241147A patent/NZ241147A/en not_active IP Right Cessation
1992
- 1992-08-18 NO NO92923231A patent/NO923231L/no not_active Application Discontinuation
- 1992-08-20 FI FI923737A patent/FI109800B/fi active
- 1992-08-21 OA OA60262A patent/OA09666A/en unknown
1994
- 1994-11-09 AU AU77723/94A patent/AU669083B2/en not_active Expired
1995
- 1995-06-20 HU HU95P/P00283P patent/HU211626A9/hu unknown
1996
- 1996-02-22 GR GR960400307T patent/GR3019066T3/el unknown
1997
- 1997-01-20 JP JP9008037A patent/JPH10136986A/ja active Pending
2000
- 2000-09-06 JP JP2000270382A patent/JP3383795B2/ja not_active Expired - Lifetime
2001
- 2001-06-11 NO NO20012882A patent/NO20012882D0/no not_active Application Discontinuation
2003
- 2003-04-22 US US10/422,049 patent/US20030199679A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20030199679A1 (en)	2003-10-23
KR100253426B1 (ko)	2000-04-15
HU211626A9 (en)	1995-12-28
DE69133167T2 (de)	2003-07-24
GB9217880D0 (en)	1992-10-28
GR3019066T3 (en)	1996-05-31
JP3145401B2 (ja)	2001-03-12
NO20012882L (no)	1992-10-20
DE4193302T1 (de)	1993-02-18
AU657937B2 (en)	1995-03-30
CA2076540A1 (en)	1992-06-22
OA09666A (en)	1993-05-15
GB9109645D0 (en)	1991-06-26
JPH05507418A (ja)	1993-10-28
EP0516785B1 (en)	1996-02-21
PT99934A (pt)	1993-01-29
ES2190434T3 (es)	2003-08-01
EP0626389B1 (en)	2002-12-04
FI923737L (fi)	1992-08-20
BR9106232A (pt)	1993-03-30
EP0516785A1 (en)	1992-12-09
ATE134387T1 (de)	1996-03-15
HU9202605D0 (en)	1992-10-28
CA2129554C (en)	1998-12-29
ES2084338T3 (es)	1996-05-01
NO923231L (no)	1992-10-20
DE4193302C2 (de)	2000-08-24
NO20012882D0 (no)	2001-06-11
CA2076540C (en)	2001-03-27
GB2257145A (en)	1993-01-06
EP0927758A3 (en)	2001-02-21
NZ260226A (en)	1995-04-27
AU669083B2 (en)	1996-05-23
CA2329482A1 (en)	1992-06-22
PT99934B (pt)	1998-08-31
DE69117284T2 (de)	1996-09-05
DE69133167D1 (de)	2003-01-16
CA2129554A1 (en)	1992-06-22
NZ241147A (en)	1995-04-27
AU9108491A (en)	1992-07-22
NL9120013A (nl)	1992-11-02
HUT62661A (en)	1993-05-28
JP3383795B2 (ja)	2003-03-04
CA2329482C (en)	2001-12-11
ATE228853T1 (de)	2002-12-15
DK0516785T3 (da)	1996-03-18
WO1992011383A1 (en)	1992-07-09
EP0927758A2 (en)	1999-07-07
DE69117284D1 (de)	1996-03-28
AU7772394A (en)	1995-03-09
JP2001114697A (ja)	2001-04-24
JPH10136986A (ja)	1998-05-26
GB2257145B (en)	1995-06-14
NO923231D0 (no)	1992-08-18
DK0626389T3 (da)	2003-03-31
EP0626389A1 (en)	1994-11-30
FI923737A0 (fi)	1992-08-20

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