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ES8704464A1 - Un procedimiento para la preparacion de derivados de imidazol. - Google Patents

Un procedimiento para la preparacion de derivados de imidazol.

Info

Publication number
ES8704464A1
ES8704464A1 ES544133A ES544133A ES8704464A1 ES 8704464 A1 ES8704464 A1 ES 8704464A1 ES 544133 A ES544133 A ES 544133A ES 544133 A ES544133 A ES 544133A ES 8704464 A1 ES8704464 A1 ES 8704464A1
Authority
ES
Spain
Prior art keywords
alpha
pharmaceutically acceptable
acceptable salt
substituted imidazoles
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544133A
Other languages
English (en)
Other versions
ES544133A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8704464A1 publication Critical patent/ES8704464A1/es
Publication of ES544133A0 publication Critical patent/ES544133A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Resins (AREA)
  • Steroid Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE IMIDAZOL. COMPRENDE: A) TRATAR A UN COMPUESTO DE FORMULA (II) CON UN REACTIVO DE GRIGNARD DE FORMULA (III); Y B) HACER REACCIONAR AL COMPUESTO DE A) CON UN REACTIVO DE GRIGNARD DE FORMULA (IV), PARA OBTENER UN COMPUESTO DE FORMULA (I) Y UNA SAL FARMACEUTICAMENTE ACEPTABLE. LAS REACCIONES A) Y B) SE REALIZAN EN UN DISOLVENTE COMO ETER Y A TEMPERATURAS ENTRE C20 Y 60JC. SIENDO: R1 Y R2, F O CL; Q, HIDROXI; Z, ALQUILO DE C 1 A 4; X, CL O BR; RM, R1 Y RN, R2. SE UTILIZAN PARA EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES ESTROGENO-DEPENDIENTES (CANCER DE MAMA EN LOS MAMIFEROS).
ES544133A 1984-06-18 1985-06-13 Un procedimiento para la preparacion de derivados de imidazol. Expired ES8704464A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62159784A 1984-06-18 1984-06-18

Publications (2)

Publication Number Publication Date
ES8704464A1 true ES8704464A1 (es) 1987-04-01
ES544133A0 ES544133A0 (es) 1987-04-01

Family

ID=24490833

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544133A Expired ES8704464A1 (es) 1984-06-18 1985-06-13 Un procedimiento para la preparacion de derivados de imidazol.

Country Status (17)

Country Link
EP (1) EP0168965B1 (es)
JP (1) JPS6112667A (es)
KR (1) KR860000267A (es)
AT (1) ATE38516T1 (es)
AU (1) AU4373785A (es)
CA (1) CA1238640A (es)
DE (1) DE3566115D1 (es)
DK (1) DK269785A (es)
ES (1) ES8704464A1 (es)
GR (1) GR851423B (es)
HU (1) HU195190B (es)
IL (1) IL75487A0 (es)
NZ (1) NZ212389A (es)
PH (1) PH21210A (es)
PT (1) PT80628B (es)
SU (1) SU1398774A3 (es)
ZA (1) ZA854400B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
GB2229719B (en) * 1989-03-30 1992-04-29 Farmos Oy Novel aromatase inhibiting 4(5)-imidazoles
PE20010781A1 (es) 1999-10-22 2001-08-08 Takeda Chemical Industries Ltd Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion
BRPI0906927A2 (pt) * 2008-01-18 2015-07-21 Allergan Inc Compostos de substituída-aril-(imidazol)-metil)-fenila como moduladores seletivos de subtipo de receptores alfa 2b e/ou alfa 2c adrenérgicos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946804A (en) * 1958-12-29 1960-07-26 Abbott Lab (5-methyl-4-imidazolyl)-diphenyl carbinol salts and lower alkyl quaternaries
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use

Also Published As

Publication number Publication date
ATE38516T1 (de) 1988-11-15
DK269785D0 (da) 1985-06-14
JPS6112667A (ja) 1986-01-21
DK269785A (da) 1985-12-19
PT80628B (en) 1987-04-28
KR860000267A (ko) 1986-01-27
IL75487A0 (en) 1985-10-31
EP0168965B1 (en) 1988-11-09
PH21210A (en) 1987-08-19
PT80628A (en) 1985-07-01
NZ212389A (en) 1987-11-27
SU1398774A3 (ru) 1988-05-23
CA1238640A (en) 1988-06-28
ZA854400B (en) 1987-02-25
DE3566115D1 (en) 1988-12-15
EP0168965A1 (en) 1986-01-22
HU195190B (en) 1988-04-28
GR851423B (es) 1985-11-25
AU4373785A (en) 1986-01-02
ES544133A0 (es) 1987-04-01
HUT38320A (en) 1986-05-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108