[go: up one dir, main page]

ES8701752A1 - Un procedimiento para preparar derivados de bencimidazol - Google Patents

Un procedimiento para preparar derivados de bencimidazol

Info

Publication number
ES8701752A1
ES8701752A1 ES548409A ES548409A ES8701752A1 ES 8701752 A1 ES8701752 A1 ES 8701752A1 ES 548409 A ES548409 A ES 548409A ES 548409 A ES548409 A ES 548409A ES 8701752 A1 ES8701752 A1 ES 8701752A1
Authority
ES
Spain
Prior art keywords
6alkyl
halogen
hydrogen
preparation
benzimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548409A
Other languages
English (en)
Other versions
ES548409A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848427836A external-priority patent/GB8427836D0/en
Priority claimed from GB848432515A external-priority patent/GB8432515D0/en
Priority claimed from GB858518043A external-priority patent/GB8518043D0/en
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES8701752A1 publication Critical patent/ES8701752A1/es
Publication of ES548409A0 publication Critical patent/ES548409A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BENCIMIDAZOL Y COMPOSICIONES FARMACEUTICAS QUE LO CONTIENEN, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA (III), PUDIENDOSE OXIDAR EL COMPUESTO EN EL QUE NF0 A UN COMPUESTO EN EL QUE NF1 Y POSTERIORMENTE FORMAR UNA SAL FARMACEUTICAMENTE ACEPTABLE. SE USAN COMO INHIBIDORES DE LA ACTIVIDAD DE LA HB-KB ATPASA ESTIMULADA POR EL POTASIO, Y EN GENERAL EN INFLAMACIONES GASTROINTESTINALES.
ES548409A 1984-11-02 1985-10-31 Un procedimiento para preparar derivados de bencimidazol Expired ES8701752A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB848427836A GB8427836D0 (en) 1984-11-02 1984-11-02 Chemical compounds
GB848432515A GB8432515D0 (en) 1984-12-21 1984-12-21 Heterocyclic compounds
GB858518043A GB8518043D0 (en) 1985-07-17 1985-07-17 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
ES8701752A1 true ES8701752A1 (es) 1986-12-01
ES548409A0 ES548409A0 (es) 1986-12-01

Family

ID=27262502

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548409A Expired ES8701752A1 (es) 1984-11-02 1985-10-31 Un procedimiento para preparar derivados de bencimidazol

Country Status (19)

Country Link
EP (1) EP0184322B1 (es)
KR (1) KR930001410B1 (es)
CN (1) CN1013445B (es)
AR (1) AR241592A1 (es)
AU (1) AU576634B2 (es)
CA (1) CA1253150A (es)
DE (1) DE3574873D1 (es)
DK (1) DK501085A (es)
ES (1) ES8701752A1 (es)
FI (1) FI84718C (es)
GR (1) GR852643B (es)
HU (1) HU200763B (es)
IE (1) IE58587B1 (es)
JO (1) JO1406B1 (es)
NO (1) NO164541C (es)
NZ (1) NZ214024A (es)
PH (1) PH22303A (es)
PT (1) PT81420B (es)
ZW (1) ZW19185A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341314C (en) * 1984-07-06 2001-11-06 David Cox Derivatives of benzimidazole, benzothiazole and benzoxazole
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
GB8610607D0 (en) * 1986-04-30 1986-06-04 Smith Kline French Lab Chemical compounds
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
SK281823B6 (sk) * 1993-12-01 2001-08-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituované aminoalkylaminopyridíny, spôsob ich výroby, a farmaceutické prostriedky s ich obsahom a ich použitie
DK1187601T3 (da) 1999-06-07 2005-11-21 Altana Pharma Ag Hidtil ukendt præparat og administrationsform som omfatter en syrelabil protonpumpeinhibitor
US7241890B2 (en) 2001-10-30 2007-07-10 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
US8802139B2 (en) 2003-06-26 2014-08-12 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
MXPA06002997A (es) 2003-09-18 2007-02-08 Conforma Therapeutics Corp Novedosos compuestos heterociclicos como inhibidores- hsp90.
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
BRPI0609509A2 (pt) 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CN104825397A (zh) 2006-04-03 2015-08-12 伊萨·奥迪迪 含有机溶胶涂层的受控释放递送物件
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA825106B (en) * 1981-08-13 1983-04-27 Haessle Ab Novel pharmaceutical compositions
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
CA1341314C (en) * 1984-07-06 2001-11-06 David Cox Derivatives of benzimidazole, benzothiazole and benzoxazole
EP0178438A1 (en) * 1984-09-19 1986-04-23 Beecham Group Plc Novel compounds
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76837A0 (en) * 1984-10-31 1986-02-28 Byk Gulden Lomberg Chem Fab Benzimidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
FI864138A (fi) * 1985-10-16 1987-04-17 Fisons Plc Heterocykliska blandningar.
JPH10513593A (ja) * 1995-11-24 1998-12-22 フィリップス エレクトロニクス ネムローゼ フェンノートシャップ 触覚刺激によって強調された仮想現実を示す方法と、この方法を実行するシステム

Also Published As

Publication number Publication date
NZ214024A (en) 1989-08-29
EP0184322A1 (en) 1986-06-11
FI84718B (fi) 1991-09-30
NO164541B (no) 1990-07-09
DK501085A (da) 1986-05-03
FI84718C (fi) 1992-01-10
JO1406B1 (en) 1986-11-30
CA1253150A (en) 1989-04-25
NO164541C (no) 1990-10-17
DK501085D0 (da) 1985-10-31
AU576634B2 (en) 1988-09-01
HU200763B (en) 1990-08-28
FI854267L (fi) 1986-05-03
FI854267A0 (fi) 1985-10-30
KR930001410B1 (ko) 1993-02-27
NO854369L (no) 1986-05-05
CN1013445B (zh) 1991-08-07
ZW19185A1 (en) 1986-05-21
HUT39176A (en) 1986-08-28
GR852643B (es) 1986-03-05
ES548409A0 (es) 1986-12-01
CN85108133A (zh) 1986-04-10
KR860004050A (ko) 1986-06-16
PH22303A (en) 1988-07-22
AR241592A1 (es) 1992-09-30
PT81420A (en) 1985-11-01
IE852684L (en) 1986-05-02
AU4920785A (en) 1986-05-08
PT81420B (pt) 1988-05-27
DE3574873D1 (en) 1990-01-25
EP0184322B1 (en) 1989-12-20
IE58587B1 (en) 1993-10-06

Similar Documents

Publication Publication Date Title
ES8701752A1 (es) Un procedimiento para preparar derivados de bencimidazol
PL262105A1 (en) The method of manufacture of new derivatives of benzimidazole
HUT43051A (en) Process for preparing pyridine-carboxylic acid derivatives and pharmaceutical compositions containing thereof as active ingredients
ES8801277A1 (es) Procedimiento para preparar (1,2,4) triazolo (1,5-c) quinazolinas
IE940326L (en) Benzimidazole derivatives substituted with a radical group¹and their use for inhibiting gastric acid secretion
ES8801187A1 (es) Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
DE3567650D1 (en) 1,5-benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions
ES8608518A1 (es) Un procedimiento para la preparacion de nuevas benzamidas.
ES8703448A1 (es) Procedimiento para la obtencion de neuropiranos sustituibles.
ES2001703A6 (es) Procedimiento para la preparracion de derrrivados de acidos 2-(2-imidazolin -2-il)- piridin -3- carboxilicos.
DE3571984D1 (en) New substituted benzimidazoles, a process for their preparation and their use for inhibiting gastric acid secretion
ES8707949A1 (es) Un procedimiento para preparar derivados de bencimidazol
ES8800156A1 (es) Procedimiento para preparar nuevos derivados 3-piridilmetilnaftilicos
ATE48840T1 (de) Benzimidazole.
ES8707204A1 (es) Procedimiento para preparar diazepinoindoles
EP0324184A3 (en) 2-amino-1,2,3,4-tetrahydroisoquinoline derivatives, method for their preparation and their use as medicines
GEP19980890B (en) Derivatives of N1-(1,2-Cis-halogeno¬-cyclopropyl) Substituted Pyridonecarbonic Acid
FR2592653A1 (fr) Derives de chromene, procede d'obtention et compositions pharmaceutiques.
MY101746A (en) 1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.
ES8703453A1 (es) Un procedimiento para preparar derivados de bencimidazol

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519