ES8609361A1 - Procedimiento para tratar superficies hidrofobas para la supresion de su efecto adsorbente y desnaturalizante sobre proteinas - Google Patents
Procedimiento para tratar superficies hidrofobas para la supresion de su efecto adsorbente y desnaturalizante sobre proteinasInfo
- Publication number
- ES8609361A1 ES8609361A1 ES535482A ES535482A ES8609361A1 ES 8609361 A1 ES8609361 A1 ES 8609361A1 ES 535482 A ES535482 A ES 535482A ES 535482 A ES535482 A ES 535482A ES 8609361 A1 ES8609361 A1 ES 8609361A1
- Authority
- ES
- Spain
- Prior art keywords
- proteins
- aqueous solutions
- formula
- denaturation
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000007864 aqueous solution Substances 0.000 title abstract 2
- 238000004925 denaturation Methods 0.000 title 1
- 230000036425 denaturation Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000005661 hydrophobic surface Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
PROCEDIMIENTO DE SINTESIS DE PROTEINAS PROTEGIDAS Y SU APLICACION SOBRE UNA SUPERFICIE HIDROFOBA. COMPRENDE: A) AÑADIR A UN ALQUENILGLICOL O COMPUESTO HIDROXILICO SIMILAR, UNA BASE ACUOSA; B) AGREGAR SUCESIVAMENTE, A TEMPERATURA ELEVADA OXIDO DE PROPILENO, U OXIDO DE 1-BUTILENO Y OXIDO DE ETILENO; C) NEUTRALIZAR LA MEZCLA; D) SEPARAR LAS PORCIONES MAS VOLATILES; E) DESHIDRATAR, PARA OBTENER EL COMPUESTO DE FORMULA (I) CON EL QUE SE TRATA LA SUPERFICIE EN FORMA DE SOLUCION ACUOSA. SIENDO: R1, METILO, ETILO, O HIDROGENO POR LO MENOS EN EL 50% DE LOS CASOS; R2 Y R3, H O UN RADICAL ORGANICO; X, RADICAL DE FORMULA (II) O (III); Y N, UN NUMERO DE 4 A 400. SE APLICA A LA PREPARACION DE SOLUCIONES ACUOSAS DE PROTEINAS DE PESO MOLECULAR SUPERIOR A 8.500 DALTON PROTEGIDAS CONTRA ADSORCION DE INTERFASES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833325223 DE3325223A1 (de) | 1983-07-13 | 1983-07-13 | Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8609361A1 true ES8609361A1 (es) | 1986-09-01 |
| ES535482A0 ES535482A0 (es) | 1986-09-01 |
Family
ID=6203842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES534195A Granted ES534195A0 (es) | 1983-07-13 | 1984-07-11 | Procedimiento para preparar una solucion estable de proteina |
| ES535482A Expired ES8609361A1 (es) | 1983-07-13 | 1984-08-29 | Procedimiento para tratar superficies hidrofobas para la supresion de su efecto adsorbente y desnaturalizante sobre proteinas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES534195A Granted ES534195A0 (es) | 1983-07-13 | 1984-07-11 | Procedimiento para preparar una solucion estable de proteina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4637834A (es) |
| EP (1) | EP0131864B1 (es) |
| JP (1) | JPS6038398A (es) |
| KR (1) | KR920002934B1 (es) |
| AT (1) | ATE56876T1 (es) |
| AU (1) | AU579106B2 (es) |
| DE (2) | DE3325223A1 (es) |
| DK (1) | DK168030B1 (es) |
| ES (2) | ES534195A0 (es) |
| FI (1) | FI80276C (es) |
| GR (1) | GR81504B (es) |
| IE (1) | IE57694B1 (es) |
| IL (1) | IL72389A (es) |
| PT (1) | PT78892A (es) |
| ZA (1) | ZA845384B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3064888D1 (en) * | 1979-04-30 | 1983-10-27 | Hoechst Ag | Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization |
| JPS61277633A (ja) * | 1985-05-31 | 1986-12-08 | Toray Ind Inc | インタ−フエロン組成物 |
| US5183746A (en) * | 1986-10-27 | 1993-02-02 | Schering Aktiengesellschaft | Formulation processes for pharmaceutical compositions of recombinant β- |
| US4956274A (en) * | 1987-04-06 | 1990-09-11 | Microgenics Corporation | Reagent stabilization in enzyme-donor and acceptor assay |
| US5004605A (en) * | 1987-12-10 | 1991-04-02 | Cetus Corporation | Low pH pharmaceutical compositions of recombinant β-interferon |
| US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5078997A (en) * | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
| US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
| US5830452A (en) * | 1990-11-20 | 1998-11-03 | Chiron Corporation | Method for enhancing the anti-tumor therapeutic index of interleukin-2 |
| EP0639984A1 (en) * | 1992-04-07 | 1995-03-01 | Mallinckrodt Veterinary, Inc. | Lyophilized somatotropin formulations |
| EP0652766B2 (en) † | 1992-07-31 | 2008-03-19 | Genentech, Inc. | Human growth hormone aqueous formulation |
| ES2285632T3 (es) * | 1995-06-07 | 2007-11-16 | Novartis Vaccines And Diagnostics, Inc. | Formulacion acuosa que comprende tfpi y agentes solubilizadores. |
| US6790439B1 (en) | 1995-06-07 | 2004-09-14 | Zymogenetics, Inc. | Thrombopoietin compositions |
| MX9602398A (es) * | 1995-06-23 | 1997-02-28 | Kimberly Clark Co | Material polimerico modificado teniendo humectabilidad mejorada. |
| AUPN801296A0 (en) * | 1996-02-12 | 1996-03-07 | Csl Limited | Stabilised growth hormone formulation and method of preparation thereof |
| IL147253A0 (en) * | 1999-07-12 | 2002-08-14 | Grandis Biotech Gmbh | Growth hormone formulations |
| AR040527A1 (es) * | 2002-07-09 | 2005-04-13 | Grandis Biotech Gmbh | Formulaciones de hgh en alta concentracion que contienen glicina |
| ATE516306T1 (de) * | 2003-08-13 | 2011-07-15 | Novartis Vaccines & Diagnostic | Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen |
| CN100574801C (zh) | 2004-04-07 | 2009-12-30 | 阿雷斯贸易股份有限公司 | 液体生长激素制剂 |
| EP1847830A1 (en) * | 2006-04-20 | 2007-10-24 | TF Instruments, Inc. | Determining optimal concentrations of protective additives for biomolecules |
| WO2024133849A1 (en) * | 2022-12-22 | 2024-06-27 | The Protein Brewery B.V. | Ovalbumin fermentation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4439355A (en) * | 1976-12-02 | 1984-03-27 | Colgate-Palmolive Company | Elastic detergent product of improved foaming power after use |
| DE3064888D1 (en) * | 1979-04-30 | 1983-10-27 | Hoechst Ag | Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization |
| DE2917535C2 (de) * | 1979-04-30 | 1986-10-30 | Hoechst Ag, 6230 Frankfurt | Gegen Denaturierung beständige Insulinlösungen |
| WO1983000288A1 (en) * | 1981-07-17 | 1983-02-03 | Balschmidt, Per | A stable aqueous, therapeutic insulin preparation and a process for preparing it |
-
1983
- 1983-07-13 DE DE19833325223 patent/DE3325223A1/de not_active Withdrawn
-
1984
- 1984-07-06 DE DE8484107889T patent/DE3483287D1/de not_active Expired - Lifetime
- 1984-07-06 AT AT84107889T patent/ATE56876T1/de not_active IP Right Cessation
- 1984-07-06 EP EP84107889A patent/EP0131864B1/de not_active Expired - Lifetime
- 1984-07-11 FI FI842798A patent/FI80276C/fi not_active IP Right Cessation
- 1984-07-11 ES ES534195A patent/ES534195A0/es active Granted
- 1984-07-11 GR GR75278A patent/GR81504B/el unknown
- 1984-07-12 IL IL72389A patent/IL72389A/xx not_active IP Right Cessation
- 1984-07-12 AU AU30537/84A patent/AU579106B2/en not_active Expired
- 1984-07-12 IE IE1796/84A patent/IE57694B1/en not_active IP Right Cessation
- 1984-07-12 ZA ZA845384A patent/ZA845384B/xx unknown
- 1984-07-12 PT PT78892A patent/PT78892A/pt active IP Right Revival
- 1984-07-12 JP JP59143378A patent/JPS6038398A/ja active Granted
- 1984-07-12 KR KR1019840004074A patent/KR920002934B1/ko not_active IP Right Cessation
- 1984-07-12 DK DK342684A patent/DK168030B1/da not_active IP Right Cessation
- 1984-08-29 ES ES535482A patent/ES8609361A1/es not_active Expired
-
1986
- 1986-02-05 US US06/825,965 patent/US4637834A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0131864A2 (de) | 1985-01-23 |
| IL72389A (en) | 1988-11-30 |
| GR81504B (es) | 1984-12-11 |
| DK342684D0 (da) | 1984-07-12 |
| JPS6038398A (ja) | 1985-02-27 |
| PT78892A (de) | 1984-08-01 |
| EP0131864A3 (en) | 1987-08-26 |
| DE3483287D1 (de) | 1990-10-31 |
| JPH0582397B2 (es) | 1993-11-18 |
| AU579106B2 (en) | 1988-11-17 |
| FI80276C (fi) | 1990-05-10 |
| ZA845384B (en) | 1985-02-27 |
| KR850000971A (ko) | 1985-03-14 |
| US4637834A (en) | 1987-01-20 |
| FI842798A (fi) | 1985-01-14 |
| KR920002934B1 (ko) | 1992-04-10 |
| DK342684A (da) | 1985-01-14 |
| ES535482A0 (es) | 1986-09-01 |
| ES8600319A1 (es) | 1985-10-01 |
| AU3053784A (en) | 1985-01-17 |
| IL72389A0 (en) | 1984-11-30 |
| DK168030B1 (da) | 1994-01-24 |
| FI842798A0 (fi) | 1984-07-11 |
| EP0131864B1 (de) | 1990-09-26 |
| IE841796L (en) | 1985-01-13 |
| ATE56876T1 (de) | 1990-10-15 |
| FI80276B (fi) | 1990-01-31 |
| DE3325223A1 (de) | 1985-01-24 |
| IE57694B1 (en) | 1993-03-10 |
| ES534195A0 (es) | 1985-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20060307 |