ES8607726A1 - Procedimiento para preparar pirido(i,4)benzodiazepinas - Google Patents
Procedimiento para preparar pirido(i,4)benzodiazepinasInfo
- Publication number
- ES8607726A1 ES8607726A1 ES543328A ES543328A ES8607726A1 ES 8607726 A1 ES8607726 A1 ES 8607726A1 ES 543328 A ES543328 A ES 543328A ES 543328 A ES543328 A ES 543328A ES 8607726 A1 ES8607726 A1 ES 8607726A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydrogen
- phenyl
- alkyl group
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 benzodiazepine compound Chemical class 0.000 title abstract 3
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR PIRIDO 1,4 BENZODIAZEPINAS. CONSISTE EN HACER REACCIONAR CON UNA DIALCOHILAMINA UN COMPUESTO DE FORMULA (II) PARA OBTENER UN COMPUESTO DE FORMULA (III) CORRESPONDIENTE AL PREPARADO PIRIDO 1,4 BENZODIAZEPINAS DE FORMULA (I), DONDE R SE ELIGE DEL GRUPO QUE CONSTA DE H, ALCOHILO INFERIOR, -ALC1-NR1R2 O ALC10NFCH-OC2H5; Z SE ELIGE DEL GRUPO QUE CONSTA DE H, HALOGENO, ALCOHILO Y OTROS; Y SE ELIGE DEL GRUPO QUE CONSTA DE H O 1-2 RADICALES ELEGIDOS DE ALCOHILO INFERIOR, ALCOXI INFERIOR O HIDROXILO, O PUEDEN SER IGUALES O DIFERENTES; N ES 0 O 1, Y CUANDON ES CERO LA LINEA DE TRAZOS ES UN DOBLE ENLACE. TIENEN APLICACIONES FARMACEUTICAS COMO ANTIDEPRESIVOS O COMO INTERMEDIOS EN LA PREPARACION DE OTROS ANTIDEPRESIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30508081A | 1981-09-24 | 1981-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8607726A1 true ES8607726A1 (es) | 1986-06-01 |
| ES543328A0 ES543328A0 (es) | 1986-06-01 |
Family
ID=23179241
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507971A Expired ES8303348A1 (es) | 1981-09-24 | 1981-12-15 | Procedimiento para preparar (2-(amonopiridinil)-amino-fenil-arilmetanonas. |
| ES516052A Expired ES8402295A1 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES516051A Granted ES516051A0 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES526563A Expired ES8604531A1 (es) | 1981-09-24 | 1983-10-19 | Procedimiento para preparar pirido(1,4)benzodiazepinas |
| ES526562A Expired ES8504148A1 (es) | 1981-09-24 | 1983-10-19 | Procedimiento para preparar pirido(1,4)benzodiazepinas |
| ES543328A Expired ES8607726A1 (es) | 1981-09-24 | 1985-05-21 | Procedimiento para preparar pirido(i,4)benzodiazepinas |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507971A Expired ES8303348A1 (es) | 1981-09-24 | 1981-12-15 | Procedimiento para preparar (2-(amonopiridinil)-amino-fenil-arilmetanonas. |
| ES516052A Expired ES8402295A1 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES516051A Granted ES516051A0 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES526563A Expired ES8604531A1 (es) | 1981-09-24 | 1983-10-19 | Procedimiento para preparar pirido(1,4)benzodiazepinas |
| ES526562A Expired ES8504148A1 (es) | 1981-09-24 | 1983-10-19 | Procedimiento para preparar pirido(1,4)benzodiazepinas |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5865290A (es) |
| KR (1) | KR890000764B1 (es) |
| BE (1) | BE891666A (es) |
| CA (1) | CA1199324A (es) |
| CH (1) | CH651833A5 (es) |
| DE (1) | DE3150522A1 (es) |
| DK (3) | DK186282A (es) |
| EG (1) | EG15904A (es) |
| ES (6) | ES8303348A1 (es) |
| FI (1) | FI71935C (es) |
| FR (1) | FR2515183B1 (es) |
| GR (1) | GR78473B (es) |
| HU (2) | HU189426B (es) |
| IE (1) | IE52493B1 (es) |
| IL (1) | IL64284A (es) |
| IN (1) | IN156080B (es) |
| IT (1) | IT1146728B (es) |
| LU (1) | LU83865A1 (es) |
| NL (1) | NL8200549A (es) |
| NO (1) | NO157700C (es) |
| NZ (1) | NZ198999A (es) |
| PH (2) | PH17847A (es) |
| PL (6) | PL143596B1 (es) |
| PT (1) | PT74286B (es) |
| SE (2) | SE448629B (es) |
| YU (1) | YU46128B (es) |
| ZA (1) | ZA817866B (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825549A (en) * | 1972-10-24 | 1974-07-23 | Squibb & Sons Inc | Certain dihydropyrido(2,1-b)(1,3)benzodi-azepines and benzodiazocines |
| DE2424811C3 (de) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SE422799B (sv) * | 1975-05-28 | 1982-03-29 | Merck & Co Inc | Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner |
-
1981
- 1981-11-05 SE SE8106573A patent/SE448629B/sv not_active IP Right Cessation
- 1981-11-12 ZA ZA817866A patent/ZA817866B/xx unknown
- 1981-11-12 NO NO813839A patent/NO157700C/no unknown
- 1981-11-13 IN IN1261/CAL/81A patent/IN156080B/en unknown
- 1981-11-13 IL IL64284A patent/IL64284A/xx unknown
- 1981-11-17 GR GR66553A patent/GR78473B/el unknown
- 1981-11-18 PH PH26507A patent/PH17847A/en unknown
- 1981-11-25 IE IE2769/81A patent/IE52493B1/en unknown
- 1981-12-09 IT IT68605/81A patent/IT1146728B/it active
- 1981-12-10 FI FI813976A patent/FI71935C/fi not_active IP Right Cessation
- 1981-12-15 ES ES507971A patent/ES8303348A1/es not_active Expired
- 1981-12-15 HU HU843212A patent/HU189426B/hu not_active IP Right Cessation
- 1981-12-15 HU HU813777A patent/HU187393B/hu not_active IP Right Cessation
- 1981-12-21 DE DE19813150522 patent/DE3150522A1/de not_active Withdrawn
- 1981-12-23 PL PL1981253538A patent/PL143596B1/pl unknown
- 1981-12-23 PL PL1981234426A patent/PL138859B1/pl unknown
- 1981-12-23 PL PL1981253539A patent/PL143597B1/pl unknown
- 1981-12-23 PL PL1981241409A patent/PL139381B1/pl unknown
- 1981-12-23 FR FR8124111A patent/FR2515183B1/fr not_active Expired
- 1981-12-23 PL PL1981241410A patent/PL137068B1/pl unknown
- 1981-12-23 PL PL1981253540A patent/PL143322B1/pl unknown
- 1981-12-30 BE BE0/206969A patent/BE891666A/fr not_active IP Right Cessation
-
1982
- 1982-01-05 LU LU83865A patent/LU83865A1/fr unknown
- 1982-01-12 EG EG11/82A patent/EG15904A/xx active
- 1982-01-14 JP JP57004813A patent/JPS5865290A/ja active Pending
- 1982-01-15 PT PT74286A patent/PT74286B/pt unknown
- 1982-01-18 CA CA000394367A patent/CA1199324A/en not_active Expired
- 1982-02-02 KR KR8200420A patent/KR890000764B1/ko active
- 1982-02-12 NL NL8200549A patent/NL8200549A/nl not_active Application Discontinuation
- 1982-02-18 NZ NZ198999A patent/NZ198999A/en unknown
- 1982-03-23 YU YU62582A patent/YU46128B/sh unknown
- 1982-04-15 CH CH2288/82A patent/CH651833A5/fr not_active IP Right Cessation
- 1982-04-26 DK DK186282A patent/DK186282A/da not_active Application Discontinuation
- 1982-09-29 ES ES516052A patent/ES8402295A1/es not_active Expired
- 1982-09-29 ES ES516051A patent/ES516051A0/es active Granted
-
1983
- 1983-10-19 ES ES526563A patent/ES8604531A1/es not_active Expired
- 1983-10-19 ES ES526562A patent/ES8504148A1/es not_active Expired
-
1984
- 1984-08-17 PH PH31120A patent/PH20536A/en unknown
-
1985
- 1985-05-21 ES ES543328A patent/ES8607726A1/es not_active Expired
-
1986
- 1986-02-17 SE SE8600688A patent/SE455305B/sv not_active IP Right Cessation
-
1987
- 1987-08-03 DK DK403487A patent/DK403487A/da not_active Application Discontinuation
- 1987-08-03 DK DK403387A patent/DK403387A/da not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9307580A (pt) | Compostos processo para a preparação dos mesmos composições farmacêuticas uso de um composto e processo de tratamento de um mamífero que inclui o ser humano | |
| EE04308B1 (et) | Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine | |
| ATE21900T1 (de) | Pyrimidinonderivate und diese enthaltende pharmazeutische zusammenstellungen. | |
| AU2397888A (en) | 2-substituted imidazo(2,1-b)-benzothiazoles | |
| ES8207526A1 (es) | Un procedimiento para la preparacion de nuevos derivados de la quinoleina. | |
| PT91435A (pt) | Processo para a preparacao de aril-alquil-aminas e -amidas possuindo propriedades anticonvulsivas e neuroprotectoras e de composicoes farmaceuticas que as contem | |
| IL108970A0 (en) | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives, their preparation and pharmaceutical compositions containing them | |
| ES8604531A1 (es) | Procedimiento para preparar pirido(1,4)benzodiazepinas | |
| MY120046A (en) | Angiogenesis inhibiting thiadiazolyl pyridazine derivatives. | |
| DE3363760D1 (en) | Benzamides, their salts, process for their preparation and pharmaceutical compositions containing them | |
| TW429147B (en) | Pharmaceutical composition for the treatment of CNS disorders | |
| IL61233A (en) | Guanidino thiazolylalkylamino(alkylthioalkylamino)nitro pyrroles,process for their preparation and pharmaceutical compositions containing them | |
| PT850225E (pt) | Intermediario para preparar um composto farmaceuticamente activo | |
| PT1068199E (pt) | N-ariloxietil-indoli-alquilaminas para o tratamento da depressao |