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ES8505384A1 - Procedimiento para preparar desoxirribonucleosidofosfonatos - Google Patents

Procedimiento para preparar desoxirribonucleosidofosfonatos

Info

Publication number
ES8505384A1
ES8505384A1 ES535627A ES535627A ES8505384A1 ES 8505384 A1 ES8505384 A1 ES 8505384A1 ES 535627 A ES535627 A ES 535627A ES 535627 A ES535627 A ES 535627A ES 8505384 A1 ES8505384 A1 ES 8505384A1
Authority
ES
Spain
Prior art keywords
denotes
general formula
see diagramm
given above
meanings given
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535627A
Other languages
English (en)
Other versions
ES535627A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES535627A0 publication Critical patent/ES535627A0/es
Publication of ES8505384A1 publication Critical patent/ES8505384A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4883—Amides or esteramides thereof, e.g. RP(NR'2)2 or RP(XR')(NR''2) (X = O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DESOXIRRIBONUCLEOXIDO-FOSFONATOS.CONSISTENTE EN: A) HACER REACCIONAR A UNA TEMPERATURA DE C80 A B100JC UN REACTIVO DE FOSFONILACION BIFUNCIONAL DE FORMULA (II), EN DONDE X ES CL O X, E Y ES UN GRUPO DE FORMULA (I) EN DONDE R1 Y R2 SON RADICALES ALQUILO, CON UN NUCLEOXIDO DE FORMULA (III), PARA FORMAR UN COMPUESTO DE FORMULA (IV); B) HACER REACCIONAR A UNA TEMPERATURA DE C20 A B100JC EL COMPUESTO DE FORMULA (IV) CON UN COMPUESTO DE FORMULA (V), PARA OBTENER UN COMPUESTO DE FORMULA (VI); Y E) OXIDAR EL COMPUESTO DE FORMULA (VI) PARA FORMAR EL COMPUESTO DE FORMULA (1), EN DONDE T ES UN GRUPO PROTECTOR, B UN RADICAL DE BASE DE NUCLEOXIDO, G UN GRUPO PROTECTOR, Z ES O,S U OTROS Y R UN ALQUILO DE C 1 A 8.SE UTILIZA EN LA CONSTRUCCION DE DIESTERES DE ACIDOS FOSFONICOS DE LOS NUCLEOXIDOS.
ES535627A 1983-09-06 1984-09-04 Procedimiento para preparar desoxirribonucleosidofosfonatos Expired ES8505384A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833332068 DE3332068A1 (de) 1983-09-06 1983-09-06 Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten

Publications (2)

Publication Number Publication Date
ES535627A0 ES535627A0 (es) 1985-05-16
ES8505384A1 true ES8505384A1 (es) 1985-05-16

Family

ID=6208339

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535627A Expired ES8505384A1 (es) 1983-09-06 1984-09-04 Procedimiento para preparar desoxirribonucleosidofosfonatos

Country Status (11)

Country Link
EP (1) EP0136543B1 (es)
JP (2) JPS6072899A (es)
AT (1) ATE38839T1 (es)
AU (2) AU570266B2 (es)
CA (1) CA1235079A (es)
DE (2) DE3332068A1 (es)
DK (3) DK162895C (es)
ES (1) ES8505384A1 (es)
GR (1) GR80287B (es)
IE (1) IE57904B1 (es)
PT (1) PT79172B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
DE59108644D1 (de) * 1990-07-02 1997-05-07 Hoechst Ag Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen
US5512668A (en) * 1991-03-06 1996-04-30 Polish Academy Of Sciences Solid phase oligonucleotide synthesis using phospholane intermediates
CA2140542A1 (en) * 1992-07-27 1994-02-03 Abeysingle Padmapriya Oligonucleotide alkylphosphonothioates
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
KR960700262A (ko) * 1993-01-08 1996-01-19 다알렌 반스톤 이합체 블록의 합성 및 그것의 올리고누클레오티드 어셈블리에의 사용 방법(synthesis of dimmer blocks and their use in assembling oligonucleotides)
CN1121721A (zh) * 1993-01-25 1996-05-01 海布里顿公司 寡核苷酸烷基膦酸酯和烷基硫代膦酸酯
KR100378965B1 (ko) * 1994-07-26 2003-08-21 소니 가부시끼 가이샤 화상전사방법및이것에사용하는피전사체,잉크리본
AU707369B2 (en) * 1995-05-26 1999-07-08 Genta Incorporated Compositions and methods for the synthesis of organophosphorus derivatives
AU2739797A (en) * 1996-05-03 1997-11-26 Hybridon, Inc. (in situ) preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
DE102004049339A1 (de) * 2004-10-08 2006-04-13 Basf Ag Verfahren zur Reinigung von phosphorhaltigen Chelat-Liganden
DE102007038930B4 (de) * 2007-08-13 2013-12-05 Universität Leipzig Neue chemische Verbindung und deren Verwendung in der Medizin, insbesondere für die Verwendung in der Tumortherapie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62834A0 (en) * 1980-05-14 1981-07-31 Ens Bio Logicals Inc Polynucleotide synthesis
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
EP0090789A1 (en) * 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten

Also Published As

Publication number Publication date
IE842268L (en) 1985-03-06
PT79172A (de) 1984-10-01
DK131591D0 (da) 1991-07-05
GR80287B (en) 1985-01-07
AU601257B2 (en) 1990-09-06
JPS6072899A (ja) 1985-04-24
DK162895C (da) 1992-05-11
DK167359B1 (da) 1993-10-18
EP0136543B1 (de) 1988-11-23
JPH0662662B2 (ja) 1994-08-17
DK424784D0 (da) 1984-09-05
ATE38839T1 (de) 1988-12-15
DE3475307D1 (en) 1988-12-29
AU3275684A (en) 1985-03-14
DK166585B (da) 1993-06-14
DK166585C (da) 1993-10-25
AU1138488A (en) 1988-07-14
DK131691A (da) 1991-07-05
ES535627A0 (es) 1985-05-16
EP0136543A2 (de) 1985-04-10
JPH05262787A (ja) 1993-10-12
DK131591A (da) 1991-07-05
JPH0531560B2 (es) 1993-05-12
DE3332068A1 (de) 1985-03-21
DK131691D0 (da) 1991-07-05
CA1235079A (en) 1988-04-12
IE57904B1 (en) 1993-05-05
EP0136543A3 (en) 1986-07-16
DK162895B (da) 1991-12-23
DK424784A (da) 1985-03-07
AU570266B2 (en) 1988-03-10
PT79172B (de) 1986-09-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050228