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ES8502982A1 - Procedimiento para preparar derivados de piperazina - Google Patents

Procedimiento para preparar derivados de piperazina

Info

Publication number
ES8502982A1
ES8502982A1 ES533069A ES533069A ES8502982A1 ES 8502982 A1 ES8502982 A1 ES 8502982A1 ES 533069 A ES533069 A ES 533069A ES 533069 A ES533069 A ES 533069A ES 8502982 A1 ES8502982 A1 ES 8502982A1
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical preparations
piperazine derivatives
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533069A
Other languages
English (en)
Other versions
ES533069A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of ES533069A0 publication Critical patent/ES533069A0/es
Publication of ES8502982A1 publication Critical patent/ES8502982A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIPERAZINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE R3 REPRESENTA H O 1-3 ATOMOS DE HALOGENO, Y ES ALQUILO DE C 1 A 3, M ES 1, 2 O 3, H ES 0 O 1, CON LA CONDICION DE QUE M B N NO SEA MAYOR DE 3, CON EL COMPUESTO Y-MG-HAL, DONDE HAL REPRESENTA CL, BR O I PARA OBTENER DERIVADOS DE PIPERAZINA DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO Y DE AMONIO CUATERNARIO, HIDROLIZANDO EL COMPLEJO OBTENIDO. LA REACCION SE EFECTUA EN LAS CONDICIONES FAVORABLES PARA LAS REACCIONES DE GRIGNARD Y BAJO UNA ATMOSFERA DE GAS INERTE.TIENE APLICACIONES EN MEDICINA AL MOSTRAR ACTIVIDADES DOPAMINERGICA Y ANTICOLINERGICA.
ES533069A 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina Expired ES8502982A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8202636A NL8202636A (nl) 1982-06-29 1982-06-29 Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.

Publications (2)

Publication Number Publication Date
ES533069A0 ES533069A0 (es) 1985-02-01
ES8502982A1 true ES8502982A1 (es) 1985-02-01

Family

ID=19839950

Family Applications (3)

Application Number Title Priority Date Filing Date
ES523689A Expired ES8500252A1 (es) 1982-06-29 1983-06-29 Procedimiento para preparar derivados de piperazina.
ES533069A Expired ES8502982A1 (es) 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina
ES533068A Granted ES533068A0 (es) 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES523689A Expired ES8500252A1 (es) 1982-06-29 1983-06-29 Procedimiento para preparar derivados de piperazina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES533068A Granted ES533068A0 (es) 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina

Country Status (10)

Country Link
US (1) US4476129A (es)
EP (1) EP0099148B1 (es)
JP (1) JPS5920275A (es)
AT (1) ATE32512T1 (es)
DE (1) DE3375690D1 (es)
DK (1) DK297383A (es)
ES (3) ES8500252A1 (es)
GR (1) GR77523B (es)
NL (1) NL8202636A (es)
PT (1) PT76909B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US5001160A (en) * 1988-04-28 1991-03-19 Marion Laboratories, Inc. 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
WO1990013539A1 (en) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. New n-substituted piperazine derivatives and drug for improving functional disorder of brain
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
WO1998018769A1 (en) 1996-10-31 1998-05-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use as noncompetitive antagonists of dopamine reuptake
US6743797B2 (en) 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
GB0220214D0 (en) * 2002-08-30 2002-10-09 Novo Pharmaceuticals De Ltd Compounds and their use
AU2003300147A1 (en) * 2003-01-06 2004-08-10 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050054010A1 (en) * 2003-07-15 2005-03-10 Brown Arthur M. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050208595A1 (en) * 2004-03-19 2005-09-22 Brown Arthur M High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
US7381822B2 (en) * 2004-03-31 2008-06-03 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
RU2460731C2 (ru) 2007-05-14 2012-09-10 Ск Байофармасьютикалз Ко., Лтд. Карбамоилоксиарилалканоиларилпиперазиновое соединение, фармацевтические композиции, содержащие его, и способ лечения боли, беспокойства и депрессии
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2632465B1 (en) 2010-10-27 2015-12-30 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9056859B2 (en) 2010-10-29 2015-06-16 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013028474A1 (en) 2011-08-19 2013-02-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TW201317213A (zh) 2011-09-16 2013-05-01 Merck Sharp & Dohme 腎外髓質鉀通道抑制劑
US8999990B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8999991B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013066718A2 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9139585B2 (en) 2011-10-31 2015-09-22 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
EP2790511B1 (en) 2011-12-16 2016-09-14 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
WO2014059338A1 (en) * 2012-10-11 2014-04-17 Chanrx Corporation Novel piperazine compounds, pharmaceutical compositions containing the same and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals
WO2014059346A1 (en) * 2012-10-11 2014-04-17 Brown Arthur M Methods for the treatment of conditions involving dopamine through administration of piperazine compounds
WO2014059367A1 (en) * 2012-10-11 2014-04-17 Chanrx Corporation Pharmaceutical compositions containing enantiomerically pure and/or racemic mixtures of chiral piperazine compounds and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals through administration of said compositions
US9777002B2 (en) 2012-11-29 2017-10-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014099633A2 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9604998B2 (en) 2013-02-18 2017-03-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9765074B2 (en) 2013-03-15 2017-09-19 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014176497A1 (en) * 2013-04-26 2014-10-30 Chanrx Corporation Novel metabolites of vanoxerine compounds, pharmaceutical compositions containing the same and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals
WO2015017305A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp Inhibitors of the renal outer medullary potassium channel
WO2015073967A1 (en) * 2013-11-15 2015-05-21 Brown Arthur M Novel metabolites of vanoxerine compounds for the treatment of dopaminergic diseases
CN108329282B (zh) * 2018-01-16 2022-01-07 新乡医学院 一种苯基哌嗪类衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2350100A1 (fr) * 1976-05-06 1977-12-02 Sauba Lab Derives disubstitues de la piperazine, leur procede de preparation et leurs applications therapeutiques
FR2374318A1 (en) * 1976-12-14 1978-07-13 Gist Brocades Nv 1-Benzhydryl:oxy-alkyl-4-phenylalkyl- or cinnamyl-piperazine derivs. - with dopaminergic, anticholinergic and antiparkinson activity (BE 14.6.78)
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives

Also Published As

Publication number Publication date
DE3375690D1 (en) 1988-03-24
NL8202636A (nl) 1984-01-16
ES8507130A1 (es) 1985-08-16
PT76909B (en) 1986-01-24
EP0099148A1 (en) 1984-01-25
EP0099148B1 (en) 1988-02-17
JPS5920275A (ja) 1984-02-01
ATE32512T1 (de) 1988-03-15
GR77523B (es) 1984-09-24
ES523689A0 (es) 1984-10-01
ES533069A0 (es) 1985-02-01
PT76909A (en) 1983-07-01
US4476129A (en) 1984-10-09
ES533068A0 (es) 1985-08-16
DK297383A (da) 1983-12-30
ES8500252A1 (es) 1984-10-01
DK297383D0 (da) 1983-06-28

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