ES8402295A1 - Novel benzodiazepine compound and intermediate - Google Patents
Novel benzodiazepine compound and intermediateInfo
- Publication number
- ES8402295A1 ES8402295A1 ES516052A ES516052A ES8402295A1 ES 8402295 A1 ES8402295 A1 ES 8402295A1 ES 516052 A ES516052 A ES 516052A ES 516052 A ES516052 A ES 516052A ES 8402295 A1 ES8402295 A1 ES 8402295A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydrogen
- phenyl
- alkyl group
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Phenyl-substituted pyrido-1,4-benzodiazepines of the formula < IMAGE > in which Ar are 2-, 3- or 4-pyridinyl, 2- or 3-thienyl, phenyl or substituted phenyl radicals R is hydrogen, a lower alkyl group or an alkyl group having an amino group at the end of the hydrocarbon chain Z can denote hydrogen, halogen, trifluoromethyl, lower alkyl, lower alkoxy, hydroxyl or nitro groups and Y is hydrogen, a lower alkyl radical or a hydroxyl radical and their pharmaceutically tolerable salts. They are prepared via 2-(aminopyridinyl)aminophenylaryl-methanones. The compounds according to the invention, like the arylmethanones also passed through in their preparation, are active antidepressive agents which can be used in appropriate pharmaceutical compositions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30508081A | 1981-09-24 | 1981-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES516052A0 ES516052A0 (en) | 1984-01-16 |
| ES8402295A1 true ES8402295A1 (en) | 1984-01-16 |
Family
ID=23179241
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507971A Expired ES8303348A1 (en) | 1981-09-24 | 1981-12-15 | Novel benzodiazepine compound and intermediate |
| ES516052A Expired ES8402295A1 (en) | 1981-09-24 | 1982-09-29 | Novel benzodiazepine compound and intermediate |
| ES516051A Granted ES516051A0 (en) | 1981-09-24 | 1982-09-29 | "PROCEDURE TO PREPARE PIRIDO (1,4) BENZODIAZEPINAS". |
| ES526563A Expired ES8604531A1 (en) | 1981-09-24 | 1983-10-19 | Novel benzodiazepine compound and intermediate |
| ES526562A Expired ES8504148A1 (en) | 1981-09-24 | 1983-10-19 | Novel benzodiazepine compound and intermediate |
| ES543328A Expired ES8607726A1 (en) | 1981-09-24 | 1985-05-21 | Novel benzodiazepine compound and intermediate |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507971A Expired ES8303348A1 (en) | 1981-09-24 | 1981-12-15 | Novel benzodiazepine compound and intermediate |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES516051A Granted ES516051A0 (en) | 1981-09-24 | 1982-09-29 | "PROCEDURE TO PREPARE PIRIDO (1,4) BENZODIAZEPINAS". |
| ES526563A Expired ES8604531A1 (en) | 1981-09-24 | 1983-10-19 | Novel benzodiazepine compound and intermediate |
| ES526562A Expired ES8504148A1 (en) | 1981-09-24 | 1983-10-19 | Novel benzodiazepine compound and intermediate |
| ES543328A Expired ES8607726A1 (en) | 1981-09-24 | 1985-05-21 | Novel benzodiazepine compound and intermediate |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5865290A (en) |
| KR (1) | KR890000764B1 (en) |
| BE (1) | BE891666A (en) |
| CA (1) | CA1199324A (en) |
| CH (1) | CH651833A5 (en) |
| DE (1) | DE3150522A1 (en) |
| DK (3) | DK186282A (en) |
| EG (1) | EG15904A (en) |
| ES (6) | ES8303348A1 (en) |
| FI (1) | FI71935C (en) |
| FR (1) | FR2515183B1 (en) |
| GR (1) | GR78473B (en) |
| HU (2) | HU189426B (en) |
| IE (1) | IE52493B1 (en) |
| IL (1) | IL64284A (en) |
| IN (1) | IN156080B (en) |
| IT (1) | IT1146728B (en) |
| LU (1) | LU83865A1 (en) |
| NL (1) | NL8200549A (en) |
| NO (1) | NO157700C (en) |
| NZ (1) | NZ198999A (en) |
| PH (2) | PH17847A (en) |
| PL (6) | PL143596B1 (en) |
| PT (1) | PT74286B (en) |
| SE (2) | SE448629B (en) |
| YU (1) | YU46128B (en) |
| ZA (1) | ZA817866B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825549A (en) * | 1972-10-24 | 1974-07-23 | Squibb & Sons Inc | Certain dihydropyrido(2,1-b)(1,3)benzodi-azepines and benzodiazocines |
| DE2424811C3 (en) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinones, process for their preparation and medicaments containing them |
| SE422799B (en) * | 1975-05-28 | 1982-03-29 | Merck & Co Inc | ANALOGY PROCEDURE FOR PREPARATION OF 1,3-DIHYDROIMIDAZO (4,5-B) PYRIDIN-2-ONER |
-
1981
- 1981-11-05 SE SE8106573A patent/SE448629B/en not_active IP Right Cessation
- 1981-11-12 ZA ZA817866A patent/ZA817866B/en unknown
- 1981-11-12 NO NO813839A patent/NO157700C/en unknown
- 1981-11-13 IN IN1261/CAL/81A patent/IN156080B/en unknown
- 1981-11-13 IL IL64284A patent/IL64284A/en unknown
- 1981-11-17 GR GR66553A patent/GR78473B/el unknown
- 1981-11-18 PH PH26507A patent/PH17847A/en unknown
- 1981-11-25 IE IE2769/81A patent/IE52493B1/en unknown
- 1981-12-09 IT IT68605/81A patent/IT1146728B/en active
- 1981-12-10 FI FI813976A patent/FI71935C/en not_active IP Right Cessation
- 1981-12-15 ES ES507971A patent/ES8303348A1/en not_active Expired
- 1981-12-15 HU HU843212A patent/HU189426B/en not_active IP Right Cessation
- 1981-12-15 HU HU813777A patent/HU187393B/en not_active IP Right Cessation
- 1981-12-21 DE DE19813150522 patent/DE3150522A1/en not_active Withdrawn
- 1981-12-23 PL PL1981253538A patent/PL143596B1/en unknown
- 1981-12-23 PL PL1981234426A patent/PL138859B1/en unknown
- 1981-12-23 PL PL1981253539A patent/PL143597B1/en unknown
- 1981-12-23 PL PL1981241409A patent/PL139381B1/en unknown
- 1981-12-23 FR FR8124111A patent/FR2515183B1/en not_active Expired
- 1981-12-23 PL PL1981241410A patent/PL137068B1/en unknown
- 1981-12-23 PL PL1981253540A patent/PL143322B1/en unknown
- 1981-12-30 BE BE0/206969A patent/BE891666A/en not_active IP Right Cessation
-
1982
- 1982-01-05 LU LU83865A patent/LU83865A1/en unknown
- 1982-01-12 EG EG11/82A patent/EG15904A/en active
- 1982-01-14 JP JP57004813A patent/JPS5865290A/en active Pending
- 1982-01-15 PT PT74286A patent/PT74286B/en unknown
- 1982-01-18 CA CA000394367A patent/CA1199324A/en not_active Expired
- 1982-02-02 KR KR8200420A patent/KR890000764B1/en active
- 1982-02-12 NL NL8200549A patent/NL8200549A/en not_active Application Discontinuation
- 1982-02-18 NZ NZ198999A patent/NZ198999A/en unknown
- 1982-03-23 YU YU62582A patent/YU46128B/en unknown
- 1982-04-15 CH CH2288/82A patent/CH651833A5/en not_active IP Right Cessation
- 1982-04-26 DK DK186282A patent/DK186282A/en not_active Application Discontinuation
- 1982-09-29 ES ES516052A patent/ES8402295A1/en not_active Expired
- 1982-09-29 ES ES516051A patent/ES516051A0/en active Granted
-
1983
- 1983-10-19 ES ES526563A patent/ES8604531A1/en not_active Expired
- 1983-10-19 ES ES526562A patent/ES8504148A1/en not_active Expired
-
1984
- 1984-08-17 PH PH31120A patent/PH20536A/en unknown
-
1985
- 1985-05-21 ES ES543328A patent/ES8607726A1/en not_active Expired
-
1986
- 1986-02-17 SE SE8600688A patent/SE455305B/en not_active IP Right Cessation
-
1987
- 1987-08-03 DK DK403487A patent/DK403487A/en not_active Application Discontinuation
- 1987-08-03 DK DK403387A patent/DK403387A/en not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971001 |