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ES8304950A1 - "procedimiento para la preparacion de 2,4-diamino-(3,5-dimetoxi-4-metoxietoxibenzil)-pirimidina". - Google Patents

"procedimiento para la preparacion de 2,4-diamino-(3,5-dimetoxi-4-metoxietoxibenzil)-pirimidina".

Info

Publication number
ES8304950A1
ES8304950A1 ES514224A ES514224A ES8304950A1 ES 8304950 A1 ES8304950 A1 ES 8304950A1 ES 514224 A ES514224 A ES 514224A ES 514224 A ES514224 A ES 514224A ES 8304950 A1 ES8304950 A1 ES 8304950A1
Authority
ES
Spain
Prior art keywords
diamino
dimethoxy
pyrimidine
ethoxy
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514224A
Other languages
English (en)
Other versions
ES514224A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proter SpA
Original Assignee
Proter SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11207307&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8304950(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Proter SpA filed Critical Proter SpA
Publication of ES514224A0 publication Critical patent/ES514224A0/es
Publication of ES8304950A1 publication Critical patent/ES8304950A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2,4-DIAMINO-(3,5-DIMETOXI-4-METOXIETOXIBENCIL)-PIRIMIDINA. CONSISTE EN LA REACCION DE 3,5-DIMETOXI-4-METOXIETOXIBENZALDEHIDO CON 2,4-DIAMINO-6-HIDROXI-PIRIMIDINA EN UN DISOLVENTE INERTE, A UNA TEMPERATURA ENTRE 50 C Y 150 C; SEGUIDA DE REDUCCION CON HIDROGENO A PRESION, EN PRESENCIA DE PD SOBRE CARBON, A UNA TEMPERATURA ENTRE 50 C Y 100 C; HALOGENACION CON OXINALOGENURO DE FOSFORO, EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA ENTRE 100 C Y 120 C; Y DESHALOGENACION MEDIANTE HIDROGENOLISIS CON HIDROGENO EN PRESENCIA DE PD SOBRE CARBON A LA TEMPERATURA AMBIENTE, EN MEDIO ACETICO-ACETATO SODICO. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERICA.
ES514224A 1981-08-11 1982-07-22 "procedimiento para la preparacion de 2,4-diamino-(3,5-dimetoxi-4-metoxietoxibenzil)-pirimidina". Expired ES8304950A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23462/81A IT1138146B (it) 1981-08-11 1981-08-11 Processo per la produzione della 2,4-diammino-(3,5-dimetossi-4-metos sietossi-benzil)-pirimidina

Publications (2)

Publication Number Publication Date
ES514224A0 ES514224A0 (es) 1983-04-01
ES8304950A1 true ES8304950A1 (es) 1983-04-01

Family

ID=11207307

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514224A Expired ES8304950A1 (es) 1981-08-11 1982-07-22 "procedimiento para la preparacion de 2,4-diamino-(3,5-dimetoxi-4-metoxietoxibenzil)-pirimidina".

Country Status (10)

Country Link
US (1) US4485248A (es)
EP (1) EP0071741B1 (es)
AR (1) AR230272A1 (es)
AT (1) ATE16800T1 (es)
CA (1) CA1182819A (es)
DE (1) DE3267778D1 (es)
ES (1) ES8304950A1 (es)
IT (1) IT1138146B (es)
MX (1) MX156026A (es)
YU (1) YU161382A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2557372C (en) * 2004-03-05 2013-01-08 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 antagonists
JP4850913B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３及びｐ２ｘ２／３調節因子としてのジアミノピリジン
CA2619898C (en) * 2005-09-01 2014-03-18 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
JP4850911B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
DE2165362A1 (de) * 1970-12-29 1972-07-27 Nisshin Flour Milling Co. Ltd., Tokio .-Verfahren zur Herstellung von Pyrimidinderivaten
BE789904A (fr) * 1971-10-12 1973-04-10 Wellcome Found Procedes de synthese organique
YU34880B (en) * 1972-05-08 1980-04-30 Pliva Pharm & Chem Works Process for preparing 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine
US4143227A (en) * 1973-02-26 1979-03-06 Hoffmann-La Roche Inc. Process for substituted 5-benzyl-2,4-diamino-pyrimidines
US4255574A (en) * 1973-02-26 1981-03-10 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-pyrimidines
CA1084498A (en) * 1977-05-05 1980-08-26 Alexander E. Wick Benzylpyrimidines and process for the preparation thereof
GR71725B (es) * 1977-11-10 1983-06-22 Hoffmann La Roche
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase

Also Published As

Publication number Publication date
EP0071741A1 (en) 1983-02-16
ES514224A0 (es) 1983-04-01
IT8123462A0 (it) 1981-08-11
YU161382A (en) 1985-03-20
DE3267778D1 (en) 1986-01-16
CA1182819A (en) 1985-02-19
EP0071741B1 (en) 1985-12-04
ATE16800T1 (de) 1985-12-15
AR230272A1 (es) 1984-03-01
MX156026A (es) 1988-06-16
IT1138146B (it) 1986-09-17
US4485248A (en) 1984-11-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991102