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ES2023560A6 - Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida. - Google Patents

Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.

Info

Publication number
ES2023560A6
ES2023560A6 ES9001867A ES9001867A ES2023560A6 ES 2023560 A6 ES2023560 A6 ES 2023560A6 ES 9001867 A ES9001867 A ES 9001867A ES 9001867 A ES9001867 A ES 9001867A ES 2023560 A6 ES2023560 A6 ES 2023560A6
Authority
ES
Spain
Prior art keywords
cephradine
production
stable form
intermediates used
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9001867A
Other languages
English (en)
Inventor
Meseguer Jose Diago
Codes Rafael Beaus
Ciriza Santiago Alonso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Gema SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gema SA filed Critical Gema SA
Publication of ES2023560A6 publication Critical patent/ES2023560A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE HIDRATO DE CEFRADINA Y SOLVATO DE CEFRADINA Y DIMETILFORMAMIDA BASADO EN CRISTALIZAR LA CEFRADINA DE UNA SOLUCION QUE LA CONTIENE; EN SU CASO EL HIDRATO DE CEFRADINA SE OBTIENE POR DISOLUCION DEL SOLVATO Y DIMETILFORMAMIDA EN ACIDO CLORHIDRICO Y POSTERIOR CRISTALIACION; A SU VEZ, ESTE SOLVATO Y DIMETILFORMAMIDA SE PREPARA TRATANDO UNA SOLUCION ACUOSA DE CEFRADINA Y DIMETILFORMAMIDA CON UNA BASE. EL COMPUESTO ES UN EFICAZ ANTIBIOTICO.
ES9001867A 1989-07-10 1990-07-09 Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida. Expired - Lifetime ES2023560A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37766889A 1989-07-10 1989-07-10

Publications (1)

Publication Number Publication Date
ES2023560A6 true ES2023560A6 (es) 1992-01-16

Family

ID=23490061

Family Applications (2)

Application Number Title Priority Date Filing Date
ES9001867A Expired - Lifetime ES2023560A6 (es) 1989-07-10 1990-07-09 Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.
ES90910701T Expired - Lifetime ES2063974T3 (es) 1989-07-10 1990-07-09 Una nueva forma estable de cefradina, un proceso para su produccion y compuestos intermedios usados en tal proceso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES90910701T Expired - Lifetime ES2063974T3 (es) 1989-07-10 1990-07-09 Una nueva forma estable de cefradina, un proceso para su produccion y compuestos intermedios usados en tal proceso.

Country Status (7)

Country Link
EP (1) EP0433428B1 (es)
JP (1) JPH089630B2 (es)
AT (1) ATE112780T1 (es)
DE (1) DE69013305T2 (es)
DK (1) DK0433428T3 (es)
ES (2) ES2023560A6 (es)
WO (1) WO1991000865A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2914324B2 (ja) * 1995-10-23 1999-06-28 味の素株式会社 ピペリジン誘導体の結晶並びにその製造中間体及び製造方法
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
EP1165049B2 (en) 1999-04-01 2011-07-06 DSM IP Assets B.V. Agglomerates by crystallisation
IN190389B (es) * 1999-07-14 2003-07-26 Ranbaxy Lab Ltd
WO2003055892A1 (en) * 2001-12-27 2003-07-10 Dsm Ip Assets B.V. Process for the stabilization of an acidic aqueous phase comprising cephradine
WO2005003367A2 (en) * 2003-07-03 2005-01-13 Dsm Ip Assets B.V. Process for the preparation of cephradine
US7550557B2 (en) 2003-08-29 2009-06-23 Louisiana Tech University Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
US7348399B2 (en) 2003-08-29 2008-03-25 Louisiana Tech University Foundation, Inc. Nanofabricated polypeptide multilayer films, coatings, and microcapsules
US7544770B2 (en) 2003-08-29 2009-06-09 Louisiana Tech Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
CN109134500A (zh) * 2017-07-19 2019-01-04 郝志艳 一种1/2水头孢拉定化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3781282A (en) * 1971-01-20 1973-12-25 W Garbrecht Cephalosporin process and product
US3819620A (en) * 1972-06-01 1974-06-25 Squibb & Sons Inc 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacet-amido)desacetoxycephalosporanic acid dihydrate
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
US4904776A (en) * 1987-04-24 1990-02-27 Rifar S.R.L. Method for producing crystalline cefadroxil hemihydrate
US4898938A (en) * 1987-08-03 1990-02-06 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate

Also Published As

Publication number Publication date
DK0433428T3 (da) 1994-12-05
DE69013305T2 (de) 1995-05-18
DE69013305D1 (de) 1994-11-17
JPH089630B2 (ja) 1996-01-31
WO1991000865A1 (en) 1991-01-24
ATE112780T1 (de) 1994-10-15
JPH04500819A (ja) 1992-02-13
EP0433428A1 (en) 1991-06-26
ES2063974T3 (es) 1995-01-16
EP0433428B1 (en) 1994-10-12

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Legal Events

Date Code Title Description
PC1A Transfer granted

Owner name: BIOCHEMIE S.A.

FD1A Patent lapsed

Effective date: 19981001