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ES8206443A1 - Un procedimiento para preparar un derivado de amidina - Google Patents

Un procedimiento para preparar un derivado de amidina

Info

Publication number
ES8206443A1
ES8206443A1 ES505460A ES505460A ES8206443A1 ES 8206443 A1 ES8206443 A1 ES 8206443A1 ES 505460 A ES505460 A ES 505460A ES 505460 A ES505460 A ES 505460A ES 8206443 A1 ES8206443 A1 ES 8206443A1
Authority
ES
Spain
Prior art keywords
formula
producing same
reaction
amidine compounds
complement agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505460A
Other languages
English (en)
Other versions
ES505460A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii and Co Ltd
Original Assignee
Torii and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12826980A external-priority patent/JPS5753454A/ja
Priority claimed from JP6494281A external-priority patent/JPS57179146A/ja
Application filed by Torii and Co Ltd filed Critical Torii and Co Ltd
Publication of ES505460A0 publication Critical patent/ES505460A0/es
Publication of ES8206443A1 publication Critical patent/ES8206443A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Power Steering Mechanism (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE AMIDINA Y DE SUS SALES DE ADICION DE ACIDO, FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE Z, R1 Y R2 PUEDEN SER VARIOS TIPOS RADICALES. CONSISTEN EN LA REACCION DE ESTERIFICACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE Z, R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), O UN DERIVADO REACTIVO DEL MISMO, CON 6-AMIDIN-2-NAFTOL O UNA SAL DE ADICION DE ACIDO DE ESTE. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UN AGENTE DE DESHIDRATACION-CONDENSACION, A UNA TEMPERATURA ENTRE -30 Y 80 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES ANTITRIPSINA, ANTIPLASMINA, ANTICALICREINA Y ANTITROMBINA.
ES505460A 1980-09-16 1981-09-14 Un procedimiento para preparar un derivado de amidina Expired ES8206443A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12826980A JPS5753454A (en) 1980-09-16 1980-09-16 Guanidinobenzoate and anticomplementary agent
JP6494281A JPS57179146A (en) 1981-04-28 1981-04-28 Amidine compound

Publications (2)

Publication Number Publication Date
ES505460A0 ES505460A0 (es) 1982-08-16
ES8206443A1 true ES8206443A1 (es) 1982-08-16

Family

ID=26406084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505460A Expired ES8206443A1 (es) 1980-09-16 1981-09-14 Un procedimiento para preparar un derivado de amidina

Country Status (17)

Country Link
US (2) US4454338A (es)
EP (1) EP0048433B1 (es)
KR (1) KR860000264B1 (es)
AT (1) ATE20051T1 (es)
AU (1) AU527371B2 (es)
CA (1) CA1177488A (es)
CS (1) CS228534B2 (es)
DD (1) DD201779A5 (es)
DE (1) DE3174717D1 (es)
DK (1) DK155003C (es)
ES (1) ES8206443A1 (es)
FI (1) FI73975C (es)
GB (1) GB2083818B (es)
HU (1) HU185956B (es)
NO (1) NO153568C (es)
PH (1) PH18109A (es)
SU (1) SU1176832A3 (es)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
FR2500825B1 (fr) * 1981-02-27 1985-08-23 Torii & Co Ltd Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant
JPS57179147A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine derivative
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
US4818273A (en) * 1983-11-14 1989-04-04 The Dow Chemical Company Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds
JPS6133173A (ja) * 1984-07-25 1986-02-17 Torii Yakuhin Kk アミジン化合物
FR2568253B1 (fr) * 1984-07-26 1987-01-30 Torii Co Nouvelle amidine
GB2162171B (en) * 1984-07-26 1988-01-27 Torii & Co Ltd Amidine compounds
DE3427865A1 (de) * 1984-07-27 1986-02-06 Torii & Co., Tokio/Tokyo Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
US4709082A (en) * 1984-10-25 1987-11-24 Nissan Chemical Industries, Ltd. 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof
AU584502B2 (en) * 1987-03-30 1989-05-25 Shosuke Okamoto Phenylalanine derivatives and proteinase inhibitor
US4990537A (en) * 1988-07-11 1991-02-05 Banyu Pharmaceutical Co., Ltd. Anti influenza agent
US5116985A (en) * 1989-12-28 1992-05-26 Snow Brand Milk Products Co., Ltd. Isoquinoline derivatives and salts thereof
ATE119523T1 (de) * 1989-12-28 1995-03-15 Snow Brand Milk Products Co Ltd Isochinolinderivate und ihre salze als proteasehemmer.
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
JPH078789B2 (ja) * 1990-04-05 1995-02-01 鳥居薬品株式会社 脳血管攣縮治療剤
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
EP0703216B1 (en) * 1994-09-20 1999-04-07 Ono Pharmaceutical Co., Ltd. Amidinophenol derivatives as protease inhibitors
AU688628B2 (en) * 1994-12-02 1998-03-12 Yamanouchi Pharmaceutical Co., Ltd. Novel amidinonaphthyl derivative or salt thereof
DE69527854T2 (de) * 1995-01-05 2003-03-27 Torii Pharmaceutical Co., Ltd. Derivate substituierter amidinonaphthylester
US6388122B1 (en) 1996-04-10 2002-05-14 Ono Pharmaceutical Co., Ltd. Tryptase inhibitor and novel guanidino derivatives
AU7808198A (en) 1997-06-03 1998-12-21 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
WO1999024407A1 (en) * 1997-11-10 1999-05-20 Array Biopharma, Inc. Compounds which inhibit tryptase activity
US6066673A (en) 1998-03-12 2000-05-23 The Procter & Gamble Company Enzyme inhibitors
NZ506202A (en) 1998-03-19 2003-10-31 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
EP1073624A1 (en) * 1998-04-24 2001-02-07 Proteus Molecular Design Limited Aminomethyl-benzoic ester derivatives as tryptase inhibitors
US6362216B1 (en) 1998-10-27 2002-03-26 Array Biopharma Inc. Compounds which inhibit tryptase activity
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
NZ540767A (en) * 2002-11-27 2009-03-31 Dmi Biosciences Inc Treatment of diseases and conditions mediated by increased phosphorylation
EP1663196A2 (en) * 2003-09-25 2006-06-07 DMI Biosciences, Inc. Methods and products which utilize n-acyl-l-aspartic acid
EP2143431A1 (en) * 2005-05-17 2010-01-13 Santen Pharmaceutical Co., Ltd. Protective agent for neurocyte comprising amidino derivative as active ingredient
US20090253765A1 (en) * 2005-05-17 2009-10-08 Santen Pharmaceutical Co., Ltd. Angiogenesis Inhibitor Containing Amine Derivative as Active Ingredient
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
WO2010005087A1 (ja) * 2008-07-11 2010-01-14 味の素株式会社 アミジン誘導体
JP5706825B2 (ja) 2008-10-17 2015-04-22 シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. フェノール性オピオイドの放出が減弱された医薬組成物
CA2773340C (en) 2009-09-08 2019-07-23 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof
US9238020B2 (en) 2010-04-21 2016-01-19 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug
US20110262355A1 (en) 2010-04-21 2011-10-27 Jenkins Thomas E Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
EP2560486B1 (en) 2010-04-21 2018-11-21 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof
CN107080846A (zh) 2010-07-09 2017-08-22 詹姆斯.特林卡.格林 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统
RU2609412C2 (ru) 2011-01-11 2017-02-01 Сигничер Терапьютикс, Инк. Композиции, содержащие расщепляемое ферментами пролекарство оксикодона
WO2012096886A1 (en) 2011-01-11 2012-07-19 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
US8685916B2 (en) 2011-03-09 2014-04-01 Signature Therapeutics, Inc. Opioid prodrugs with heterocyclic linkers
CA2827662C (en) 2011-03-09 2020-07-14 Signature Therapeutics, Inc. Active agent prodrugs with heterocyclic linkers
AU2012309438A1 (en) 2011-09-15 2014-03-27 Astellas Pharma Inc. Guanidinobenzoic acid compound
CN103012214A (zh) * 2011-09-28 2013-04-03 南京长澳医药科技有限公司 一种萘莫司他盐酸盐及萘莫司他甲磺酸盐的制备方法
CA2905606C (en) * 2013-03-13 2021-03-09 Astellas Pharma Inc. Guanidino benzoic acid esters useful in treating renal disorders
CN103641749B (zh) * 2013-12-02 2016-02-10 山东永泰化工有限公司 一种甲磺酸萘莫司他的制备方法
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
CN110330447B (zh) * 2019-07-16 2022-04-15 北京赛升药业股份有限公司 一种甲磺酸萘莫司他中间体的制备方法及其应用
CN111803483B (zh) * 2020-01-21 2021-04-06 中国人民解放军军事科学院军事医学研究院 苯甲酸酯类化合物在治疗SARS-CoV-2感染方面的应用
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN111574409A (zh) * 2020-05-14 2020-08-25 河北省医疗器械与药品包装材料检验研究院(河北省医疗器械技术审评中心) 一种甲磺酸萘莫司他的重结晶工艺方法
CN113999145B (zh) * 2021-11-12 2023-02-03 开封明仁药业有限公司 一种甲磺酸萘莫司他的合成方法
WO2023118896A1 (en) 2021-12-23 2023-06-29 Subintro Limited Novel antiviral compositions comprising oleic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD89611A (es) *
DE1905813A1 (de) * 1968-07-04 1970-03-05 Akad Wissenschaften Ddr 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren
GB1472700A (en) * 1974-11-01 1977-05-04 Ono Pharmaceutical Co Guanidinobehzoic acid derivatives and process for preparing the same
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine

Also Published As

Publication number Publication date
EP0048433A3 (en) 1982-07-21
FI73975C (fi) 1987-12-10
NO153568C (no) 1986-05-21
NO153568B (no) 1986-01-06
US4454338A (en) 1984-06-12
NO813138L (no) 1982-03-17
AU527371B2 (en) 1983-03-03
ATE20051T1 (de) 1986-06-15
DK410681A (da) 1982-03-17
DD201779A5 (de) 1983-08-10
EP0048433A2 (en) 1982-03-31
DK155003B (da) 1989-01-23
CS228534B2 (en) 1984-05-14
FI812876L (fi) 1982-03-17
AU7506281A (en) 1982-03-25
SU1176832A3 (ru) 1985-08-30
ES505460A0 (es) 1982-08-16
FI73975B (fi) 1987-08-31
CA1177488A (en) 1984-11-06
GB2083818A (en) 1982-03-31
PH18109A (en) 1985-03-22
DE3174717D1 (en) 1986-07-03
DK155003C (da) 1989-05-29
EP0048433B1 (en) 1986-05-28
GB2083818B (en) 1984-05-10
US4532255A (en) 1985-07-30
KR830007527A (ko) 1983-10-21
KR860000264B1 (ko) 1986-03-22
HU185956B (en) 1985-04-28

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