ES8201162A1 - Un procedimiento para la preparacion de un aducto de un al- dehido y triamtereno - Google Patents
Un procedimiento para la preparacion de un aducto de un al- dehido y triamterenoInfo
- Publication number
- ES8201162A1 ES8201162A1 ES498602A ES498602A ES8201162A1 ES 8201162 A1 ES8201162 A1 ES 8201162A1 ES 498602 A ES498602 A ES 498602A ES 498602 A ES498602 A ES 498602A ES 8201162 A1 ES8201162 A1 ES 8201162A1
- Authority
- ES
- Spain
- Prior art keywords
- triamterene
- pharmaceutical composition
- same
- composition containing
- aldehyde adducts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001288 triamterene Drugs 0.000 title abstract 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000001882 diuretic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Carbon And Carbon Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Inorganic Insulating Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN ADUCTO DE UN ALDEHIDO Y TRIAMTERENO, DE FORMULA (I), DONDE R SIGNIFICA HIDROGENO, ALQUILO CON 1 A 20 ATOMOS DE CARBONO, CICLOALQUILO CON 3 A 8 ATOMOS DE CARBONO, ARILO CON 6 A 10 ATOMOS DE CARBONO, ALQUINILO CON 2 A 20 ATOMOS DE CARBONO, CICLOALQUNILO DE 4 A 8 ATOMOS DE CARBONO O ACILO DE 1 A 22 ATOMOS DE CARBONO; N ES UN NUMERO DE 1 A 6. CONSISTE EN HACER REACCIONAR TRIAMTERENO CON UN ALDEHIDO RCHO, DONDE R TIENE EL SIGNIFICADO YA INDICADO, HASTA QUE SE OBTIENE UNA SOLUCION HOMOGENEA TRANSPARENTE, A TEMPERATURA AMBIENTE O CALENTANDO, EN PRESENCIA DE UN EXCESO DE ALDEHILO, CUANDO ESTE ES UN LIQUIDO O UN SOLIDO, O EN PRESENCIA DE UN DISOLVENTE INERTE, CUANDO EL ALDEHILO ES UN LIQUIDO O UN SOLIDO. UNA VEZ TERMINADA LA REACCION, EL DISOLVENTE SE SEPARA POR DESTILACION A PRESION REDUCIDA, Y EL ADUCTO FORMADO SE RECUPERA DE LA MEZCLA DE REACCION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/113,313 US4285947A (en) | 1980-01-18 | 1980-01-18 | Aldehyde adducts of triamterene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8201162A1 true ES8201162A1 (es) | 1981-12-01 |
| ES498602A0 ES498602A0 (es) | 1981-12-01 |
Family
ID=22348739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498602A Granted ES498602A0 (es) | 1980-01-18 | 1981-01-16 | Un procedimiento para la preparacion de un aducto de un al- dehido y triamtereno |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4285947A (es) |
| EP (1) | EP0032725B1 (es) |
| JP (1) | JPS56118082A (es) |
| AT (1) | ATE13184T1 (es) |
| DE (1) | DE3170356D1 (es) |
| DK (1) | DK19181A (es) |
| ES (1) | ES498602A0 (es) |
| GR (1) | GR73158B (es) |
| IE (1) | IE50808B1 (es) |
| PT (1) | PT72362B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE51421B1 (en) | 1980-08-01 | 1986-12-24 | Smith & Nephew Ass | Ophthalmic compositions containing triamterene |
| US4425346A (en) | 1980-08-01 | 1984-01-10 | Smith And Nephew Associated Companies Limited | Pharmaceutical compositions |
| US4526777A (en) * | 1983-01-06 | 1985-07-02 | Mylan Pharmaceuticals Inc. | Pharmaceutical combination composition and associated method |
| US4547498A (en) * | 1983-01-06 | 1985-10-15 | Mylan Pharmaceuticals Inc. | Pharmaceutical combination composition and associated method |
| DE3407695A1 (de) * | 1984-03-02 | 1985-09-12 | Röhm Pharma GmbH, 6108 Weiterstadt | Pteridinverbindungen mit pharmazeutischer wirksamkeit |
| US4804540A (en) * | 1987-12-16 | 1989-02-14 | G. D. Searle & Co. | Process for preparing the combination products of triamterene and hydrochlorothiazide |
| US4981852A (en) * | 1988-05-13 | 1991-01-01 | Multilan Ag | Chemical compounds triamterene and hydrochlorothiazide |
| US11690825B2 (en) | 2016-03-09 | 2023-07-04 | Board Of Regents, The University Of Texas System | 20-HETE receptor (GPR75) antagonists and methods of use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3127403A (en) * | 1964-03-31 | G-alkyl-z | ||
| US3081230A (en) * | 1960-09-08 | 1963-03-12 | Smith Kline French Lab | Diuretic and antihypertensive triaminoarylpteridines |
| US3534140A (en) * | 1968-08-14 | 1970-10-13 | Us Army | Triamino arylpteridines as an antifibrillatory agent |
-
1980
- 1980-01-18 US US06/113,313 patent/US4285947A/en not_active Expired - Lifetime
-
1981
- 1981-01-12 IE IE49/81A patent/IE50808B1/en not_active IP Right Cessation
- 1981-01-15 DE DE8181100269T patent/DE3170356D1/de not_active Expired
- 1981-01-15 AT AT81100269T patent/ATE13184T1/de not_active IP Right Cessation
- 1981-01-15 GR GR63870A patent/GR73158B/el unknown
- 1981-01-15 EP EP81100269A patent/EP0032725B1/en not_active Expired
- 1981-01-16 DK DK19181A patent/DK19181A/da not_active Application Discontinuation
- 1981-01-16 PT PT72362A patent/PT72362B/pt not_active IP Right Cessation
- 1981-01-16 ES ES498602A patent/ES498602A0/es active Granted
- 1981-01-19 JP JP624781A patent/JPS56118082A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| PT72362B (en) | 1984-10-09 |
| IE50808B1 (en) | 1986-07-23 |
| JPH038355B2 (es) | 1991-02-05 |
| EP0032725A1 (en) | 1981-07-29 |
| JPS56118082A (en) | 1981-09-16 |
| GR73158B (es) | 1984-02-13 |
| PT72362A (en) | 1981-02-01 |
| ES498602A0 (es) | 1981-12-01 |
| IE810049L (en) | 1981-07-18 |
| US4285947A (en) | 1981-08-25 |
| EP0032725B1 (en) | 1985-05-08 |
| DK19181A (da) | 1981-07-19 |
| ATE13184T1 (de) | 1985-05-15 |
| DE3170356D1 (en) | 1985-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |