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ES486893A1 - Procedimiento para la preparacion de material sustitutivo dehuesos - Google Patents

Procedimiento para la preparacion de material sustitutivo dehuesos

Info

Publication number
ES486893A1
ES486893A1 ES486893A ES486893A ES486893A1 ES 486893 A1 ES486893 A1 ES 486893A1 ES 486893 A ES486893 A ES 486893A ES 486893 A ES486893 A ES 486893A ES 486893 A1 ES486893 A1 ES 486893A1
Authority
ES
Spain
Prior art keywords
bone substitute
substitute material
water
material obtained
biological stability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES486893A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermedicat GmbH
Original Assignee
Intermedicat GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermedicat GmbH filed Critical Intermedicat GmbH
Publication of ES486893A1 publication Critical patent/ES486893A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Procedimiento para la preparación de material sustitutivo de huesos, con estabilidad biológica mejorada, a base de colágeno, caracterizado porque a) a partir de material natural que contiene colágeno, tal como huesos, se elimina la hemoglobina y otras proteínas solubles en agua, por tratamiento repetido con agua, b) a, partir del material obtenido en la etapa a) se eliminan albúmina y proteínas por tratamiento repetido con solución de H202, c) el material obtenido en la etapa b) se enjuaga con agua fría, d) el material obtenido en la etapa c) se desengrasa con disolventes orgánicos, e) el material obtenido en la etapa d) se trata con formadores de complejos o intercambiadores de iones, para la extracción por disolución de las porciones minerales del material de colágeno, f) el material obtenido en la etapa e) se trata por remojado con agua circulante para la eliminación de las sales residuales, g) el material obtenido en la etapa f) se liofiliza eventualmente de modo habitual, y h) el material obtenido se esteriliza de modo habitual, en especial con ayuda de irradiación, obteniéndose un material consistente en colágeno natural, que se obtiene ampliamente en su estructura molecular.
ES486893A 1978-12-16 1979-12-14 Procedimiento para la preparacion de material sustitutivo dehuesos Expired ES486893A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2854490A DE2854490C2 (de) 1978-12-16 1978-12-16 Knochenersatzmaterial mit verbesserter biologischer Stabilität auf Basis von Kollagen

Publications (1)

Publication Number Publication Date
ES486893A1 true ES486893A1 (es) 1980-07-01

Family

ID=6057451

Family Applications (1)

Application Number Title Priority Date Filing Date
ES486893A Expired ES486893A1 (es) 1978-12-16 1979-12-14 Procedimiento para la preparacion de material sustitutivo dehuesos

Country Status (7)

Country Link
EP (1) EP0012959B1 (es)
JP (1) JPS5584161A (es)
AT (1) ATE944T1 (es)
CA (1) CA1142430A (es)
DE (2) DE2854490C2 (es)
DK (1) DK154892C (es)
ES (1) ES486893A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
DE3124981A1 (de) * 1981-06-25 1983-01-13 Dr. Ruhland Nachfolger GmbH, 8425 Neustadt Wirkstoffhaltige kollageneinlage zum einfuehren in knochen oder weichteile und verfahren zu deren herstellung
EP0141004B1 (de) * 1983-10-20 1988-01-07 Oscobal Ag Knochenersatzmaterial auf der Basis natürlicher Knochen
JPS6162459A (ja) * 1984-07-06 1986-03-31 コラ−ゲン　コ−ポレイシヨン 骨の修復用コラーゲン製剤
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US5522894A (en) * 1984-12-14 1996-06-04 Draenert; Klaus Bone replacement material made of absorbable beads
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US5053049A (en) * 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US4678470A (en) * 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
AT398373B (de) * 1987-12-17 1994-11-25 Immuno Ag Biologisches resorbierbares implantationsmaterial sowie verfahren zur herstellung desselben
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
DE3835237C1 (es) * 1988-10-15 1989-12-28 B. Braun Melsungen Ag, 3508 Melsungen, De
EP0424159A3 (en) * 1989-10-19 1991-11-06 Osteotech, Inc., Aseptic processing of allograft bone and tissue
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
DE4425776C2 (de) * 1994-07-13 2002-08-29 Britta Hofmann Verfahren zur Herstellung eines verbesserten Kollagentransplantats mit aufgelockerter Struktur
IT1268641B1 (it) * 1994-10-24 1997-03-06 Giuseppe Oliva Inattivazione ed eliminazione di matrice organica da osso animale per xenotrapianti eterotopici.
FR2752382B1 (fr) * 1996-08-16 1998-10-09 Assist Publ Hopitaux De Paris Procede de traitement de produits d'origine humaine ou animale destines a une utilisation therapeutique
US5972368A (en) * 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
DE10157182A1 (de) * 2001-11-22 2003-06-05 Matricel Gmbh Verfahren zur Behandlung von Materialien biologischen Ursprungs und Elastin-Produkt
AT413075B (de) * 2003-02-25 2005-11-15 Austria Wirtschaftsserv Gmbh Verfahren zur herstellung eines knochenimplantatmaterials sowie vorrichtung zur durchführung dieses verfahrens
GB2431408A (en) * 2005-10-19 2007-04-25 Osta Technologies Cc Bone material and a process for the preparation of bone material

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE961654C (de) * 1954-06-16 1957-04-11 Armin Bauermeister Verfahren zur Praeparierung von zur Verpflanzung geeigneten Knochen
GB1068587A (en) * 1963-12-06 1967-05-10 Biorex Laboratories Ltd Dental fillers and bone cements comprising collagen
SU498005A1 (ru) * 1971-08-13 1976-01-05 Центральный научно-исследовательский институт стоматологии Стимулирующее противоспалительное средство дл лечени в стоматологии

Also Published As

Publication number Publication date
EP0012959A1 (de) 1980-07-09
DE2854490C2 (de) 1981-04-09
JPS5584161A (en) 1980-06-25
DK530279A (da) 1980-06-17
ATE944T1 (de) 1982-05-15
JPS619857B2 (es) 1986-03-26
DE2854490B1 (de) 1980-06-12
DK154892C (da) 1989-06-05
CA1142430A (en) 1983-03-08
EP0012959B1 (de) 1982-05-05
DK154892B (da) 1989-01-02
DE2962750D1 (en) 1982-06-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519