ES468418A1 - Procedimiento para preparar un nuevo antibiotico con activi-dad inhibidora de beta-lactamasa - Google Patents
Procedimiento para preparar un nuevo antibiotico con activi-dad inhibidora de beta-lactamasaInfo
- Publication number
- ES468418A1 ES468418A1 ES468418A ES468418A ES468418A1 ES 468418 A1 ES468418 A1 ES 468418A1 ES 468418 A ES468418 A ES 468418A ES 468418 A ES468418 A ES 468418A ES 468418 A1 ES468418 A1 ES 468418A1
- Authority
- ES
- Spain
- Prior art keywords
- antibiotic
- derivatives
- bblactamase
- pss5
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- MHSNTZYKSLYGOM-RKDXNWHRSA-N PS-5 Chemical compound C1C(SCCNC(C)=O)=C(C(O)=O)N2C(=O)[C@H](CC)[C@H]21 MHSNTZYKSLYGOM-RKDXNWHRSA-N 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 238000004816 paper chromatography Methods 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Procedimiento para preparar un nuevo antibiótico con actividad inhibidora de beta-lactamasa, de fórmula general: **(Fórmula)** en la que R1 representa hidrógeno, alquilo inferior y trifenilmetilo y cuando R1 es hidrógeno las sales de dichos compuestos; caracterizado porque comprende cultivar aerobicamente, en un medio nutriente, un microorganismo capaz de producir la actividad antibiótica del compuesto de fórmula A en donde R1 es hidrógeno; aislar dicha actividad de los materiales cultivados; y opcionalmente convertir el compuesto de fórmula A en donde R1 es hidrógeno o sus sales a un compuesto de fórmula A en donde R1 es alquilo inferior o trifenilmetilo mediante reacción con un diazoalcano inferior o trifenilmetilo e Y es un átomo o un grupo que puede disociarse fácilmente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52035375A JPS604719B2 (ja) | 1977-03-31 | 1977-03-31 | β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES468418A1 true ES468418A1 (es) | 1979-10-01 |
Family
ID=12440142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES468418A Expired ES468418A1 (es) | 1977-03-31 | 1978-03-31 | Procedimiento para preparar un nuevo antibiotico con activi-dad inhibidora de beta-lactamasa |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS604719B2 (es) |
| BE (1) | BE865578A (es) |
| ES (1) | ES468418A1 (es) |
| SU (1) | SU738517A3 (es) |
| ZA (1) | ZA78915B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ190994A (en) | 1978-07-24 | 1981-10-19 | Merck & Co Inc | Z-2-acylamino-3-monosubstituted propenoates |
-
1977
- 1977-03-31 JP JP52035375A patent/JPS604719B2/ja not_active Expired
-
1978
- 1978-02-16 ZA ZA00780915A patent/ZA78915B/xx unknown
- 1978-03-31 SU SU782596895A patent/SU738517A3/ru active
- 1978-03-31 ES ES468418A patent/ES468418A1/es not_active Expired
- 1978-03-31 BE BE186475A patent/BE865578A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE865578A (fr) | 1978-10-02 |
| JPS604719B2 (ja) | 1985-02-06 |
| JPS53121702A (en) | 1978-10-24 |
| ZA78915B (en) | 1979-02-28 |
| SU738517A3 (ru) | 1980-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001002 |