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ES455933A1 - Procedimiento para la preparacion de nuevos esteroides. - Google Patents

Procedimiento para la preparacion de nuevos esteroides.

Info

Publication number
ES455933A1
ES455933A1 ES455933A ES455933A ES455933A1 ES 455933 A1 ES455933 A1 ES 455933A1 ES 455933 A ES455933 A ES 455933A ES 455933 A ES455933 A ES 455933A ES 455933 A1 ES455933 A1 ES 455933A1
Authority
ES
Spain
Prior art keywords
6beta
diene
bromo
fluoropregna
diones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455933A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PIENEL SpA
Original Assignee
PIENEL SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PIENEL SpA filed Critical PIENEL SpA
Publication of ES455933A1 publication Critical patent/ES455933A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos esteroides, tales como 2-bromo-6beta-fluoro-9alfa-halo-11beta, 17,21-trihidroxi-pregna-1,4-dieno-3-diona y sus 17,21-ésteres y 2-bromo-6beta-fluoruro-9alfa, 11 beta-dihalo-17,21-dihidroxipregna-1,4-dieno-3,20-diona y sus 17,21-ésteres, 17,21-alquilortoésteres y 17,21-acetales cíclicos de fórmula (A). ***
ES455933A 1974-02-27 1977-02-15 Procedimiento para la preparacion de nuevos esteroides. Expired ES455933A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
GB2998474 1974-07-05
GB3294574 1974-07-25
GB4998274 1974-11-19

Publications (1)

Publication Number Publication Date
ES455933A1 true ES455933A1 (es) 1978-05-01

Family

ID=27447687

Family Applications (3)

Application Number Title Priority Date Filing Date
ES435067A Expired ES435067A1 (es) 1974-02-27 1975-02-25 Procedimiento para la preparacion de nuevos esteroides.
ES455933A Expired ES455933A1 (es) 1974-02-27 1977-02-15 Procedimiento para la preparacion de nuevos esteroides.
ES455934A Expired ES455934A1 (es) 1974-02-27 1977-02-15 Procedimiento para la preparacion de nuevos esteroides.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES435067A Expired ES435067A1 (es) 1974-02-27 1975-02-25 Procedimiento para la preparacion de nuevos esteroides.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES455934A Expired ES455934A1 (es) 1974-02-27 1977-02-15 Procedimiento para la preparacion de nuevos esteroides.

Country Status (18)

Country Link
JP (1) JPS5614677B2 (es)
AR (1) AR218601A1 (es)
BE (1) BE826030A (es)
CA (1) CA1064476A (es)
CH (1) CH608243A5 (es)
DE (3) DE2508136C3 (es)
DK (1) DK144068C (es)
ES (3) ES435067A1 (es)
FI (1) FI56188C (es)
FR (1) FR2261776B1 (es)
GB (1) GB1499822A (es)
IE (1) IE42112B1 (es)
LU (1) LU71908A1 (es)
NO (1) NO144527C (es)
NZ (1) NZ176716A (es)
RO (1) RO78881A (es)
SE (1) SE410736B (es)
YU (3) YU108381A (es)

Also Published As

Publication number Publication date
FI56188C (fi) 1979-12-10
SE7502146L (es) 1975-08-28
FR2261776A1 (es) 1975-09-19
IE42112L (en) 1975-08-27
ES455934A1 (es) 1978-05-01
AR218601A1 (es) 1980-06-30
DE2533323C3 (de) 1979-07-12
DE2508136A1 (de) 1975-10-30
DE2533323A1 (de) 1976-02-12
NO144527C (no) 1981-09-23
SE410736B (sv) 1979-10-29
LU71908A1 (es) 1975-06-24
DE2533377A1 (de) 1976-02-05
DK61575A (es) 1975-10-27
CH608243A5 (en) 1978-12-29
YU108281A (en) 1982-02-28
NO750633L (es) 1975-08-28
JPS5614677B2 (es) 1981-04-06
FI56188B (fi) 1979-08-31
FI750537A (es) 1975-08-28
JPS50126652A (es) 1975-10-04
BE826030A (fr) 1975-06-16
DE2533377B2 (de) 1978-11-16
YU108381A (en) 1982-02-28
ES435067A1 (es) 1977-07-01
DE2508136B2 (de) 1978-11-02
DE2533323B2 (de) 1978-11-16
DK144068B (da) 1981-11-30
RO78881A (ro) 1982-07-06
IE42112B1 (en) 1980-06-04
FR2261776B1 (es) 1978-07-21
YU108481A (en) 1982-02-28
DK144068C (da) 1982-05-03
GB1499822A (en) 1978-02-01
NZ176716A (en) 1978-07-10
CA1064476A (en) 1979-10-16
NO144527B (no) 1981-06-09
DE2533377C3 (de) 1979-08-02
DE2508136C3 (de) 1979-06-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001