ES454669A1 - Procedure for the preparation of new homoftalimidas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new homoftalimidas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES454669A1 ES454669A1 ES454669A ES454669A ES454669A1 ES 454669 A1 ES454669 A1 ES 454669A1 ES 454669 A ES454669 A ES 454669A ES 454669 A ES454669 A ES 454669A ES 454669 A1 ES454669 A1 ES 454669A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- compound
- group
- hydrogen atom
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 230000001476 alcoholic effect Effects 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- -1 hydroxy, amino Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QGNQEODJYRGEJX-UHFFFAOYSA-N 4h-isoquinoline-1,3-dione Chemical class C1=CC=C2C(=O)NC(=O)CC2=C1 QGNQEODJYRGEJX-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F7/00—Compounds of aluminium
- C01F7/02—Aluminium oxide; Aluminium hydroxide; Aluminates
- C01F7/04—Preparation of alkali metal aluminates; Aluminium oxide or hydroxide therefrom
- C01F7/14—Aluminium oxide or hydroxide from alkali metal aluminates
- C01F7/141—Aluminium oxide or hydroxide from alkali metal aluminates from aqueous aluminate solutions by neutralisation with an acidic agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Geology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of new homophthalimides of the general formula **(See formula)** wherein A and B, which may be the same or different, mean straight chain saturated C 2 -C 4 alcohol groups, optionally substituted with a methyl or phenyl group; R1, R2, R3 and R4, which may be the same or different, signify hydrogen, fluorine, chlorine or bromine atoms, hydroxy, amino, nitro or acetylamino groups, alcoholic, alkoxy or alcoholyl groups, and may contain the alcoholic portion in each case 1 to 3 carbon atoms; R5, R6, R7 and R8, which may be the same or different, signify hydrogen atoms, alcohol radicals with 1 to 4 carbon atoms, optionally substituted with a phenyl or methoxyphenyl group, or R5 together with R6 and/or R7 together with R8 signify straight chain saturated alcoholylene groups with 2 to 5 carbon atoms; and R9 means a hydrogen atom or an alcoholic group with 1 to 6 carbon atoms, possibly substituted by a phenyl group, as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a carbonyl compound is reacted of the general formula **(See formula)** wherein R1, R2, R5 and R6 are as initially defined; D means a saturated, straight-chain, 1 to 5 carbon alcohol group, optionally substituted with a methyl group; and R10 signifies a hydrogen atom, a methyl or phenyl group, with an amine of the general formula **(See formula)** where R9 is as defined at the beginning and E represents a hydrogen atom or a group of the general formula **(See formula)** R3, R4, R7, R8 and B being as defined at the beginning, in the presence of a reducing agent, and if desired a compound of the general formula I obtained according to the invention is transformed, in which at least one of the radicals R1 to R9 represents a hydrogen atom or one of the radicals R1 to R4 represents a hydroxy group, by alcoholization, in the corresponding alcoholic compound of the general formula I, and/or a compound of the general formula is transformed X, obtained according to the invention, in which at least one of the radicals R1 to R4 represents a hydrogen atom, by nitration, in the corresponding nitrated compound of the general formula I, and, if desired, a nitrated compound obtained in this way, it is transformed by reduction into the corresponding amine compound and, if desired, by subsequent acetylation, into the corresponding acetylamine compound of the general formula I, and/or a compound obtained is transformed or according to the invention of the general formula I, below, in its acid addition salts physiologically compatible with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762622690 DE2622690A1 (en) | 1976-05-21 | 1976-05-21 | Antiarrhythmic homo:phalimide derivs. of alkylamines - prepd. by reaction of (di) aminoalkyl-alkylamines and isochroman-diones or homo:phthalic acid derivs. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES454669A1 true ES454669A1 (en) | 1977-12-01 |
Family
ID=5978594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES454669A Expired ES454669A1 (en) | 1976-05-21 | 1976-12-29 | Procedure for the preparation of new homoftalimidas. (Machine-translation by Google Translate, not legally binding) |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT351543B (en) |
| DE (1) | DE2622690A1 (en) |
| ES (1) | ES454669A1 (en) |
| PH (1) | PH14634A (en) |
-
1976
- 1976-05-21 DE DE19762622690 patent/DE2622690A1/en not_active Ceased
- 1976-08-17 PH PH18796A patent/PH14634A/en unknown
- 1976-12-29 ES ES454669A patent/ES454669A1/en not_active Expired
-
1978
- 1978-04-17 AT AT265678A patent/AT351543B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PH14634A (en) | 1981-10-12 |
| DE2622690A1 (en) | 1977-12-08 |
| AT351543B (en) | 1979-07-25 |
| ATA265678A (en) | 1979-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |