ES433895A1 - PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. - Google Patents
PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES.Info
- Publication number
- ES433895A1 ES433895A1 ES433895A ES433895A ES433895A1 ES 433895 A1 ES433895 A1 ES 433895A1 ES 433895 A ES433895 A ES 433895A ES 433895 A ES433895 A ES 433895A ES 433895 A1 ES433895 A1 ES 433895A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- compound
- formula
- atom
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003939 benzylamines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 cyano, carbamoyl Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229960004011 methenamine Drugs 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedure for the preparation of new benzylamines of the general formula I **(See formula)** wherein R1 signifies a hydrogen atom or an optionally substituted aliphatic or aromatic acyl radical; R2 signifies a hydrogen, chlorine or bromine atom; R3 signifies a fluorine atom, a straight or branched chain C 1 -C 4 alcohol radical, a trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl group as well as the aminomethyl group of the formula **(See formula)** wherein R6 and R7, which may be the same or different, represent alcohol, cycloalcohyl or hydroxycycloalcohyl groups or together with the nitrogen atom a pyrrolidine, piperidine or morpholine ring; R4 and R5, which may be the same or different, represent hydrogen atoms, straight or branched chain alcohol radicals with 1 to 5 carbon atoms, which may be substituted with one or two hydroxy groups, alkenyl radicals with 2 to 4 carbon atoms. carbon, cycloalkyl radicals with 5 to 7 carbon atoms, optionally substituted with one or two hydroxy groups, benzyl groups, morpholinocarbonylmethyl or together with the nitrogen atom, signify a pyrrolidine, piperidine, hexamethylenamine, morpholine, E-methyl-pipe-razin ring or Camfidine, as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II is reduced **(See formula)** wherein R2 to R5 are as initially defined; and, if desired, a compound of the general formula I obtained in which R3 represents a cyano group, is transformed by partial hydrolysis into the corresponding carbamoyl compound of the general formula I, and/or a compound obtained of the general formula I, wherein R1 represents a hydrogen atom and R2, R3, R4 and R5 with the exception of radicals containing a hydrogen atom capable of reacting, are as initially defined, is acylated if desired subsequently, and/or a compound obtained from the general formula I is transformed, if desired, into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES433895A ES433895A1 (en) | 1974-02-05 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742405322 DE2405322A1 (en) | 1974-02-05 | 1974-02-05 | NEW METHODS FOR MANUFACTURING BENZYLAMINES |
| ES424432A ES424432A1 (en) | 1973-04-13 | 1974-03-20 | Substituted aminobenzylamines |
| ES433895A ES433895A1 (en) | 1974-02-05 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES433895A1 true ES433895A1 (en) | 1976-11-16 |
Family
ID=27185761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES433895A Expired ES433895A1 (en) | 1974-02-05 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES433895A1 (en) |
-
1975
- 1975-01-17 ES ES433895A patent/ES433895A1/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE7900987L (en) | ALKYLENDIAMINE DERIVATIVES | |
| SE7712630L (en) | PROCEDURE FOR THE PREPARATION OF O-ALKYLATED HYDROXYLAMINES | |
| ES424483A1 (en) | Hererocyclic derivatives of a guanidine | |
| ES470916A1 (en) | 4-Hydroxy-2-quinolinone-3-carboxylic acids, their preparation and pharmaceutical compositions containing them. | |
| ES443563A1 (en) | 2-methoxy-benzamide derivatives | |
| ES413260A1 (en) | Nn * 11 chikan 33 pirorijiniru * chiobenzuamidono seiho | |
| ES433895A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. | |
| ES433896A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. | |
| ES433899A1 (en) | Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) | |
| ES433894A1 (en) | Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) | |
| ES433898A1 (en) | Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) | |
| ES433897A1 (en) | Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) | |
| ES477076A1 (en) | 1-Naphthyl-acetic acid derivatives and their therapeutic applications | |
| ES433892A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. | |
| ES433891A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. | |
| ES400790A1 (en) | Procedure for the preparation of new acids 4- (4-bifenilil) - 4 - hydroxibutirics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) | |
| ES432789A1 (en) | PROCEDURE FOR THE PREPARATION OF BENZYTHAMINES. | |
| ES433893A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. | |
| ES452391A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW REPLACED ARILALCOHILAMINS. | |
| ES423226A1 (en) | Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding) | |
| ES433901A1 (en) | Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) | |
| ES427951A1 (en) | PROCEDURE FOR THE PREPARATION OF 2-ACILAMINE-BENZYLAMINES. | |
| ES406131A1 (en) | Procedure for the preparation of acids 4- (4-bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding) | |
| ES437041A1 (en) | A procedure for preparing 1-ftalazone derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES422085A1 (en) | Primary amino acylanilides methods of making the same and use as antiarrhythmic drugs |