ES433990A1 - Procedimiento para la preparacion de derivados de diaminoci-clitoles. - Google Patents

Procedimiento para la preparacion de derivados de diaminoci-clitoles.

Info

Publication number: ES433990A1
Authority: ES; Spain
Prior art keywords: gentamicin; antibiotic; amino; derivatives; translation
Prior art date: 1974-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES433990A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

MSD International Holdings GmbH

Original Assignee

Scherico Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-03-19

Filing date

1975-01-21

Publication date

1977-03-01

1974-03-19 Priority claimed from US05/452,586 external-priority patent/US4029882A/en

1975-01-21 Application filed by Scherico Ltd filed Critical Scherico Ltd

1977-03-01 Publication of ES433990A1 publication Critical patent/ES433990A1/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
239000002253 acid Substances 0.000 abstract 4
229930182566 Gentamicin Natural products 0.000 abstract 3
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 3
229960002518 gentamicin Drugs 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
LKKVGKXCMYHKSL-LLZRLKDCSA-N gentamycin A Chemical compound O[C@H]1[C@H](NC)[C@@H](O)CO[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](N)C[C@H]1N LKKVGKXCMYHKSL-LLZRLKDCSA-N 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
CEAZRRDELHUEMR-CAMVTXANSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1r)-1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1[C@H]([C@@H](C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-CAMVTXANSA-N 0.000 abstract 1
XUFIWSHGXVLULG-BSBKYKEKSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1s)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUFIWSHGXVLULG-BSBKYKEKSA-N 0.000 abstract 1
BRZYSWJRSDMWLG-DJWUNRQOSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-[(1r)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H]([C@@H](C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-DJWUNRQOSA-N 0.000 abstract 1
XUSXOPRDIDWMFO-CTMSJIKGSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-[(1s)-1-aminoethyl]-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUSXOPRDIDWMFO-CTMSJIKGSA-N 0.000 abstract 1
ABCLPPNEPBAKRL-ROQIPNNMSA-N (2r,3s,4s,5r,6s)-2-[(1r)-1-aminoethyl]-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2r,3r,4r,5r)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H]([C@@H](C)N)O2)O)[C@@H](N)C[C@H]1N ABCLPPNEPBAKRL-ROQIPNNMSA-N 0.000 abstract 1
DAKDDLIZULPEFW-UHFFFAOYSA-N 2-[4,6-diamino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-4-(methylamino)oxane-3,5-diol Chemical compound OC1C(NC)C(O)COC1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N DAKDDLIZULPEFW-UHFFFAOYSA-N 0.000 abstract 1
-1 Antibiotic 66-40B Chemical compound 0.000 abstract 1
VIAXDDBFFSKHGA-UHFFFAOYSA-N Antibiotic G52 Natural products CNC1CC(N)C(OC2OCC(C)(O)C(NC)C2O)C(O)C1OC3OC(=CCC3N)CN VIAXDDBFFSKHGA-UHFFFAOYSA-N 0.000 abstract 1
WYJSPPYVEJPMJA-DJWUNRQOSA-N Antibiotic JI-20B Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H]([C@@H](C)N)O2)N)[C@@H](N)C[C@H]1N WYJSPPYVEJPMJA-DJWUNRQOSA-N 0.000 abstract 1
HFLKNINDVFJPQT-UHFFFAOYSA-N Gentamicin X2 Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CO)O2)N)C(N)CC1N HFLKNINDVFJPQT-UHFFFAOYSA-N 0.000 abstract 1
HFLKNINDVFJPQT-ZFAMMYHGSA-N Gentamicin X2 Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](N)C[C@H]1N HFLKNINDVFJPQT-ZFAMMYHGSA-N 0.000 abstract 1
URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 abstract 1
XUSXOPRDIDWMFO-UHFFFAOYSA-N Verdamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(O2)C(C)N)N)C(N)CC1N XUSXOPRDIDWMFO-UHFFFAOYSA-N 0.000 abstract 1
ARCVBMPERJRMKB-UHFFFAOYSA-N antibiotic g-52 Chemical compound O1C(CNC)=CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N ARCVBMPERJRMKB-UHFFFAOYSA-N 0.000 abstract 1
RHRAMPXHWHSKQB-GGEUKFTFSA-N betamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1N RHRAMPXHWHSKQB-GGEUKFTFSA-N 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
150000001718 carbodiimides Chemical class 0.000 abstract 1
RHRAMPXHWHSKQB-UHFFFAOYSA-N gentamicin B Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CN)O2)O)C(N)CC1N RHRAMPXHWHSKQB-UHFFFAOYSA-N 0.000 abstract 1
DNYGXMICFMACRA-UHFFFAOYSA-N gentamicin C1A Natural products O1C(CNC)CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N DNYGXMICFMACRA-UHFFFAOYSA-N 0.000 abstract 1
229930076781 gentamycin C1 Natural products 0.000 abstract 1
VEGXETMJINRLTH-BOZYPMBZSA-N gentamycin C1a Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N VEGXETMJINRLTH-BOZYPMBZSA-N 0.000 abstract 1
XUFIWSHGXVLULG-JYDJLPLMSA-N gentamycin C2 Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@@H](C)N)N)[C@@H](N)C[C@H]1N XUFIWSHGXVLULG-JYDJLPLMSA-N 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ES433990A 1974-03-19 1975-01-21 Procedimiento para la preparacion de derivados de diaminoci-clitoles. Expired ES433990A1 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US45257174A	1974-03-19	1974-03-19
US05/452,586 US4029882A (en)	1974-03-19	1974-03-19	Selective acylation of the C-1 amino group of aminoglycoside antibiotics
CH1060174		1974-07-31

Publications (1)

Publication Number	Publication Date
ES433990A1 true ES433990A1 (es)	1977-03-01

Family

ID=27176473

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES433990A Expired ES433990A1 (es)	1974-03-19	1975-01-21	Procedimiento para la preparacion de derivados de diaminoci-clitoles.

Country Status (11)

Country	Link
JP (1)	JPS5843398B2 (xx)
AT (1)	AT341088B (xx)
DD (1)	DD117871A5 (xx)
DK (1)	DK156070C (xx)
ES (1)	ES433990A1 (xx)
FI (1)	FI60714C (xx)
HU (1)	HU175673B (xx)
IT (1)	IT1049348B (xx)
LU (1)	LU71687A1 (xx)
NL (1)	NL183826C (xx)
NO (1)	NO140426C (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT2390255T (pt) *	2006-04-03	2016-10-24	Technion Res & Dev Foundation	Novos aminoglicosídeos e utilizações destes no tratamento de distúrbios genéticos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3780018A (en) *	1972-06-26	1973-12-18	Bristol Myers Co	Derivatives of gentamicin c1
US3796698A (en) *	1972-10-18	1974-03-12	Bristol Myers Co	Antibiotic derivatives of gentamicin c2
US3796699A (en) *	1972-11-06	1974-03-12	Bristol Myers Co	Antibiotic derivatives of gentamicin c1a

1975
- 1975-01-21 NO NO750168A patent/NO140426C/no unknown
- 1975-01-21 LU LU71687*A patent/LU71687A1/xx unknown
- 1975-01-21 NL NLAANVRAGE7500690,A patent/NL183826C/xx not_active IP Right Cessation
- 1975-01-21 IT IT19435/75A patent/IT1049348B/it active
- 1975-01-21 FI FI750141A patent/FI60714C/sv not_active IP Right Cessation
- 1975-01-21 AT AT42975A patent/AT341088B/de not_active IP Right Cessation
- 1975-01-21 ES ES433990A patent/ES433990A1/es not_active Expired
- 1975-01-22 JP JP50009654A patent/JPS5843398B2/ja not_active Expired
- 1975-01-22 DK DK018675A patent/DK156070C/da not_active IP Right Cessation
- 1975-01-23 DD DD183784A patent/DD117871A5/xx unknown
- 1975-01-23 HU HU75SCHE507A patent/HU175673B/hu unknown

Also Published As

Publication number	Publication date
LU71687A1 (xx)	1975-12-09
NL7500690A (nl)	1975-09-23
JPS5843398B2 (ja)	1983-09-27
FI60714B (fi)	1981-11-30
NO140426C (no)	1979-08-29
JPS50126640A (xx)	1975-10-04
NO140426B (no)	1979-05-21
DK18675A (xx)	1975-09-20
AT341088B (de)	1978-01-25
NO750168L (xx)	1975-09-22
IT1049348B (it)	1981-01-20
FI750141A (xx)	1975-09-20
FI60714C (fi)	1982-03-10
DK156070C (da)	1989-11-06
HU175673B (hu)	1980-09-28
DK156070B (da)	1989-06-19
ATA42975A (de)	1977-05-15
NL183826C (nl)	1989-02-01
NL183826B (nl)	1988-09-01
DD117871A5 (xx)	1976-02-05

Publication	Publication Date	Title
DK0495776T3 (da)	1995-07-03	Stabiliserende nitrogenoxid/primær amin-komplekser, der er anvendelige som cardiovaskulære midler
JPS5756485A (en)	1982-04-05	Cephem of penam compound and its preparation
FI812693L (fi)	1982-03-03	Benzoxazinderivat
GB1473733A (en)	1977-05-18	Pseudotrisaccharides and methods for their production
BR9813317A (pt)	2000-08-22	Composto, composição farmacêutica para tratar infecções bacterianas, e, processos para tratar infecções bacterianas, e para preparar um composto
JPS5356661A (en)	1978-05-23	Novel amino glycoside antibiotics derivatives
ES467964A1 (es)	1978-11-16	Procedimiento para la obtencion de derivados de los pseudo- trisacaridos.
CA2307788A1 (en)	1999-05-06	2-halo-6-o-substituted ketolide derivatives
IE40796L (en)	1975-09-19	Diaminocyclitols derivatives
JPS57131759A (en)	1982-08-14	2-oxoazetidine derivative, its preparation and use
ES433990A1 (es)	1977-03-01	Procedimiento para la preparacion de derivados de diaminoci-clitoles.
ES459832A1 (es)	1978-12-16	Procedimiento para preparar un aminoglicosido de 2-deoxies- treptamina.
JPS5798288A (en)	1982-06-18	Novel cephem compound or its salt, their preparation, and preventive and remedy for bacteriosis containing said compound as active component
GB1530643A (en)	1978-11-01	Aminoglycosides
ES421251A1 (es)	1976-04-01	Procedimiento para la produccion de un derivado 3'-desoxi de un antibiotico aminoglicosidico.
ES469303A1 (es)	1979-09-16	Un procedimiento para la preparacion de una 1-n-( amino- - hidroxialcanoil)kanamicina a o b
ES449457A1 (es)	1977-08-16	Procedimiento para la preparacion de nuevos pseudotrisacari-dos.
ES428892A1 (es)	1977-02-16	Procedimiento para la preparacion de nuevos pseudotrisacari-dos.
ES407519A1 (es)	1975-11-16	Procedimiento para la preparacion de nuevas 2-(5-nitro-2- furil)-tieno (2,3-d) pirimidas.
KR830006326A (ko)	1983-09-24	이스타마이신(istamycin) B계 화합물의 3-0-데메틸 유도체의 제조방법
JPS55329A (en)	1980-01-05	Novel xk-62-4 derivative
ES8402315A1 (es)	1984-01-16	Procedimiento para preparar derivados de aminoglicosidos.
GB874028A (en)	1961-08-02	Derivatives of antibiotics having a basic reaction, and a process for their preparation
GB1161908A (en)	1969-08-20	Antibiotically Active Derivatives of Rifamycin S and Rifamycin SV and Process for their Manufacture
JPS5782399A (en)	1982-05-22	2-deoxystreptamine aminoglycoside derivative and manufacture