ES428892A1 - Procedimiento para la preparacion de nuevos pseudotrisacari-dos. - Google Patents

Procedimiento para la preparacion de nuevos pseudotrisacari-dos.

Info

Publication number: ES428892A1
Authority: ES; Spain
Prior art keywords: gentamicin; antibiotic; mutamicin; aminoglycosyl; pharmaceutically acceptable
Prior art date: 1974-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES428892A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

MSD International Holdings GmbH

Original Assignee

Scherico Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-03-19

Filing date

1974-08-02

Publication date

1977-02-16

1974-07-31 Priority claimed from CH1060274A external-priority patent/CH606076A5/xx

1974-08-02 Application filed by Scherico Ltd filed Critical Scherico Ltd

1977-02-16 Publication of ES428892A1 publication Critical patent/ES428892A1/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 2
230000003115 biocidal effect Effects 0.000 abstract 5
DNYGXMICFMACRA-UHFFFAOYSA-N gentamicin C1A Natural products O1C(CNC)CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N DNYGXMICFMACRA-UHFFFAOYSA-N 0.000 abstract 3
GCLCARAXIXZEAH-UHFFFAOYSA-N 2-[2,4-diamino-5-[[3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-3,6-dihydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)C(O)C1N GCLCARAXIXZEAH-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
-1 alcoholic Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
LKKVGKXCMYHKSL-LLZRLKDCSA-N gentamycin A Chemical compound O[C@H]1[C@H](NC)[C@@H](O)CO[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](N)C[C@H]1N LKKVGKXCMYHKSL-LLZRLKDCSA-N 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
URWAJWIAIPFPJE-VHLNBGGKSA-N (2r,3r,4r,5r)-2-[(1s,2r,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-VHLNBGGKSA-N 0.000 abstract 1
CEAZRRDELHUEMR-CAMVTXANSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1r)-1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1[C@H]([C@@H](C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-CAMVTXANSA-N 0.000 abstract 1
XUFIWSHGXVLULG-BSBKYKEKSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1s)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUFIWSHGXVLULG-BSBKYKEKSA-N 0.000 abstract 1
XUSXOPRDIDWMFO-CTMSJIKGSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-[(1s)-1-aminoethyl]-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUSXOPRDIDWMFO-CTMSJIKGSA-N 0.000 abstract 1
ABCLPPNEPBAKRL-ROQIPNNMSA-N (2r,3s,4s,5r,6s)-2-[(1r)-1-aminoethyl]-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2r,3r,4r,5r)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H]([C@@H](C)N)O2)O)[C@@H](N)C[C@H]1N ABCLPPNEPBAKRL-ROQIPNNMSA-N 0.000 abstract 1
YQGZDAPJXRYYLX-ZFAMMYHGSA-N Antibiotic JI-20A Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N YQGZDAPJXRYYLX-ZFAMMYHGSA-N 0.000 abstract 1
WYJSPPYVEJPMJA-DJWUNRQOSA-N Antibiotic JI-20B Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H]([C@@H](C)N)O2)N)[C@@H](N)C[C@H]1N WYJSPPYVEJPMJA-DJWUNRQOSA-N 0.000 abstract 1
DNYGXMICFMACRA-XHEDQWPISA-N Gentamicin C2b Chemical compound O1[C@H](CNC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N DNYGXMICFMACRA-XHEDQWPISA-N 0.000 abstract 1
HFLKNINDVFJPQT-UHFFFAOYSA-N Gentamicin X2 Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CO)O2)N)C(N)CC1N HFLKNINDVFJPQT-UHFFFAOYSA-N 0.000 abstract 1
HFLKNINDVFJPQT-ZFAMMYHGSA-N Gentamicin X2 Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](N)C[C@H]1N HFLKNINDVFJPQT-ZFAMMYHGSA-N 0.000 abstract 1
UTHKVKLHMFIYMO-UHFFFAOYSA-N Mutamicin 5 Natural products CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(=CCC3N)CN)C2N)OCC1(C)O UTHKVKLHMFIYMO-UHFFFAOYSA-N 0.000 abstract 1
URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 abstract 1
XUSXOPRDIDWMFO-UHFFFAOYSA-N Verdamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(O2)C(C)N)N)C(N)CC1N XUSXOPRDIDWMFO-UHFFFAOYSA-N 0.000 abstract 1
230000001476 alcoholic effect Effects 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
RHRAMPXHWHSKQB-GGEUKFTFSA-N betamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1N RHRAMPXHWHSKQB-GGEUKFTFSA-N 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
RHRAMPXHWHSKQB-UHFFFAOYSA-N gentamicin B Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CN)O2)O)C(N)CC1N RHRAMPXHWHSKQB-UHFFFAOYSA-N 0.000 abstract 1
229930076781 gentamycin C1 Natural products 0.000 abstract 1
VEGXETMJINRLTH-BOZYPMBZSA-N gentamycin C1a Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N VEGXETMJINRLTH-BOZYPMBZSA-N 0.000 abstract 1
XUFIWSHGXVLULG-JYDJLPLMSA-N gentamycin C2 Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@@H](C)N)N)[C@@H](N)C[C@H]1N XUFIWSHGXVLULG-JYDJLPLMSA-N 0.000 abstract 1
150000004678 hydrides Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
229960004744 micronomicin Drugs 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 abstract 1
229960000707 tobramycin Drugs 0.000 abstract 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 abstract 1
125000003944 tolyl group Chemical group 0.000 abstract 1

Classifications

- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES428892A 1974-03-19 1974-08-02 Procedimiento para la preparacion de nuevos pseudotrisacari-dos. Expired ES428892A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45260074A	1974-03-19	1974-03-19
CH1060274A CH606076A5 (es)	1973-08-06	1974-07-31

Publications (1)

Publication Number	Publication Date
ES428892A1 true ES428892A1 (es)	1977-02-16

Family

ID=25706976

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES428892A Expired ES428892A1 (es)	1974-03-19	1974-08-02	Procedimiento para la preparacion de nuevos pseudotrisacari-dos.
ES449456A Expired ES449456A1 (es)	1974-03-19	1976-07-01	Procedimiento para la preparacion de nuevos pseudotrisacari-dos.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES449456A Expired ES449456A1 (es)	1974-03-19	1976-07-01	Procedimiento para la preparacion de nuevos pseudotrisacari-dos.

Country Status (1)

Country	Link
ES (2)	ES428892A1 (es)

1974
- 1974-08-02 ES ES428892A patent/ES428892A1/es not_active Expired
1976
- 1976-07-01 ES ES449456A patent/ES449456A1/es not_active Expired

Also Published As

Publication number	Publication date
ES449456A1 (es)	1978-03-01

Publication	Publication Date	Title
GB1473733A (en)	1977-05-18	Pseudotrisaccharides and methods for their production
MX7096E (es)	1987-06-19	Metodo para preparacion de derivados de 2-oxoazetidina
KR830004332A (ko)	1983-07-09	린코마이신 및 클린다마이신의 제조방법
GB1494129A (en)	1977-12-07	Derivatives of diaminocyclitols and methods for their preparation
ES428892A1 (es)	1977-02-16	Procedimiento para la preparacion de nuevos pseudotrisacari-dos.
ES8403926A1 (es)	1984-04-01	Un procedimiento para la preparacion de una macrolida.
ES412656A1 (es)	1976-01-01	Procedimiento para la recuperacion de sistemas cataliticos.
EP1227086A4 (en)	2002-10-28	1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
ES449457A1 (es)	1977-08-16	Procedimiento para la preparacion de nuevos pseudotrisacari-dos.
ES400820A1 (es)	1975-02-01	Procedimiento para preparar 3-amino-imidazo (1,5-a) piridi-nas.
ES433990A1 (es)	1977-03-01	Procedimiento para la preparacion de derivados de diaminoci-clitoles.
ES421251A1 (es)	1976-04-01	Procedimiento para la produccion de un derivado 3'-desoxi de un antibiotico aminoglicosidico.
HUP9900263A2 (hu)	1999-09-28	11-Acetil-12,13-dioxabiciklo[8.2.1]tridecenon-származékok, eljárás ezek előállítására és az e vegyületeket tartalmazó gyógyászati készítmények
ES443468A1 (es)	1977-05-16	Procedimiento para la preparacion de pseudotrisacaridos ac- tivos como antibioticos.
JPS5782399A (en)	1982-05-22	2-deoxystreptamine aminoglycoside derivative and manufacture
ES374901A1 (es)	1972-04-01	Un procedimiento para producir derivados de benzomorfano.
ES257146A1 (es)	1960-12-01	Procedimiento para la obtenciën de nuevos derivados indëlicos basicos
JPS5665853A (en)	1981-06-03	Mycoplanesin derivative and its preparation
ES443467A1 (es)	1977-05-01	Procedimiento para la preparacion de pseudotrisacaridos ac- tivos como antibioticos.
ES442051A1 (es)	1977-04-01	Procedimiento para preparar aminoglicosidos de 2-deoxies- treptamina.
ES411018A2 (es)	1977-07-01	Un procedimiento de preparacion de nuevos n-amino terciario-metil-4'-dibenzo (b, e) oxepino-11-espiro-2'-dioxolanos-1', 3'.
ES394997A1 (es)	1974-04-01	Procedimiento para la preparacion de derivados de nitrofu- rano.
ES391805A1 (es)	1973-06-16	Un procedimiento para preparar un compuesto de purina.
ES387410A1 (es)	1973-05-16	Un procedimiento de preparacion de nuevas sales de mono- esteres de piridoxina.
ES390310A1 (es)	1974-06-16	Procedimiento para preparar derivados de imidocarbonato.