ES421810A1 - Pyrimidopyrimidines - Google Patents
PyrimidopyrimidinesInfo
- Publication number
- ES421810A1 ES421810A1 ES421810A ES421810A ES421810A1 ES 421810 A1 ES421810 A1 ES 421810A1 ES 421810 A ES421810 A ES 421810A ES 421810 A ES421810 A ES 421810A ES 421810 A1 ES421810 A1 ES 421810A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- carbon atoms
- radical
- compound
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 hexamethyleneimino ring Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedure for the preparation of new pyrimido [5,4-d] pyrimidines of the general formula I, **(See formula)** wherein R1 signifies an alcohol radical with 2 or 3 carbon atoms, optionally substituted with an alkoxy radical with 1 to 3 carbon atoms; R2 means a hydroxyalkyl radical with 2 to 4 carbon atoms or a dihydroxyalkyl radical with 3 carbon atoms; R3 means an alcohol radical with 2 or 3 carbon atoms substituted with an alkoxy radical with 1 to 3 carbon atoms or with a hydroxyl group; y means a dialkoxylamino radical, each alcohol radical containing from 2 to 4 carbon atoms, containing the diallylamino group, a piperidino or hexamethyleneimino ring; as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula IIa is reacted, **(See formula)** with an amine of the general formula III, **(See formula)** or a compound of the general formula IIb, **(See formula)** with an amine of the general formula IV, H-R4 (IV) where R1 to R4 are as initially defined, Z1 and Z2 represent interchangeable radicals, where in a compound of general formula IIa one of the radicals Z1 may already represent the groups (see formula) or (see formula), or in a compound of the general formula IIb one of the radicals Z1 can represent the group R4, at elevated temperatures, and then, if desired, a compound of the general formula I obtained is transformed into its salts by addition of acid physiologically compatible with an organic or inorganic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2300661A DE2300661C3 (en) | 1973-01-08 | 1973-01-08 | Pyrimido [5,4-d] pyrimidines, their physiologically acceptable acid addition salts, processes for their preparation and medicaments containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES421810A1 true ES421810A1 (en) | 1976-04-16 |
Family
ID=5868472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES421810A Expired ES421810A1 (en) | 1973-01-08 | 1973-12-27 | Pyrimidopyrimidines |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS4995996A (en) |
| KR (1) | KR780000136B1 (en) |
| AT (1) | AT334378B (en) |
| BE (1) | BE809474A (en) |
| BG (1) | BG25987A3 (en) |
| CH (1) | CH590285A5 (en) |
| DD (1) | DD110496A5 (en) |
| DE (1) | DE2300661C3 (en) |
| DK (1) | DK133300C (en) |
| ES (1) | ES421810A1 (en) |
| FR (1) | FR2213066B1 (en) |
| GB (1) | GB1432731A (en) |
| HU (1) | HU166653B (en) |
| IE (1) | IE38725B1 (en) |
| IL (1) | IL43967A (en) |
| NL (1) | NL7400100A (en) |
| PH (1) | PH9640A (en) |
| PL (1) | PL91246B1 (en) |
| RO (1) | RO63660A (en) |
| SU (1) | SU509227A3 (en) |
| ZA (1) | ZA7493B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4388318A (en) * | 1981-09-29 | 1983-06-14 | Boehringer Ingelheim International Gmbh | Method of treating endotoxin shock with a pyrimido-pyrimidine derivative |
| US4963541A (en) * | 1989-02-22 | 1990-10-16 | Abbott Laboratories | Pyrimido-pyrimidine lipoxygenase inhibiting compounds |
-
1973
- 1973-01-08 DE DE2300661A patent/DE2300661C3/en not_active Expired
- 1973-12-10 AT AT1028473A patent/AT334378B/en active
- 1973-12-17 BG BG025269A patent/BG25987A3/en unknown
- 1973-12-27 SU SU1980992A patent/SU509227A3/en active
- 1973-12-27 JP JP49004765A patent/JPS4995996A/ja active Pending
- 1973-12-27 ES ES421810A patent/ES421810A1/en not_active Expired
- 1973-12-31 KR KR7302360A patent/KR780000136B1/en active
-
1974
- 1974-01-04 NL NL7400100A patent/NL7400100A/xx not_active Application Discontinuation
- 1974-01-04 DD DD175839A patent/DD110496A5/xx unknown
- 1974-01-04 CH CH8274A patent/CH590285A5/xx not_active IP Right Cessation
- 1974-01-05 RO RO197477199A patent/RO63660A/en unknown
- 1974-01-07 ZA ZA00740093A patent/ZA7493B/en unknown
- 1974-01-07 HU HUTO950A patent/HU166653B/hu unknown
- 1974-01-07 PL PL1974167952A patent/PL91246B1/pl unknown
- 1974-01-07 IL IL43967A patent/IL43967A/en unknown
- 1974-01-07 GB GB58674A patent/GB1432731A/en not_active Expired
- 1974-01-07 BE BE139590A patent/BE809474A/en unknown
- 1974-01-07 DK DK7474*#A patent/DK133300C/en active
- 1974-01-08 IE IE41/74A patent/IE38725B1/en unknown
- 1974-01-08 PH PH15387*UA patent/PH9640A/en unknown
- 1974-01-08 FR FR7400569A patent/FR2213066B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2300661B2 (en) | 1979-03-08 |
| DK133300B (en) | 1976-04-26 |
| DD110496A5 (en) | 1974-12-20 |
| BE809474A (en) | 1974-07-08 |
| BG25987A3 (en) | 1979-01-12 |
| DE2300661C3 (en) | 1979-10-31 |
| IE38725B1 (en) | 1978-05-24 |
| JPS4995996A (en) | 1974-09-11 |
| FR2213066B1 (en) | 1977-09-02 |
| NL7400100A (en) | 1974-07-10 |
| AT334378B (en) | 1976-01-10 |
| KR780000136B1 (en) | 1978-04-25 |
| IL43967A0 (en) | 1974-05-16 |
| DK133300C (en) | 1976-09-27 |
| ATA1028473A (en) | 1976-05-15 |
| DE2300661A1 (en) | 1974-07-18 |
| IE38725L (en) | 1974-07-08 |
| CH590285A5 (en) | 1977-07-29 |
| HU166653B (en) | 1975-04-28 |
| IL43967A (en) | 1977-05-31 |
| FR2213066A1 (en) | 1974-08-02 |
| PL91246B1 (en) | 1977-02-28 |
| SU509227A3 (en) | 1976-03-30 |
| RO63660A (en) | 1978-12-15 |
| GB1432731A (en) | 1976-04-22 |
| ZA7493B (en) | 1975-09-24 |
| PH9640A (en) | 1976-01-26 |
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