ES354962A1 - PROCEDURE FOR THE PREPARATION OF NEW AMINO-KETONES. - Google Patents
PROCEDURE FOR THE PREPARATION OF NEW AMINO-KETONES.Info
- Publication number
- ES354962A1 ES354962A1 ES354962A ES354962A ES354962A1 ES 354962 A1 ES354962 A1 ES 354962A1 ES 354962 A ES354962 A ES 354962A ES 354962 A ES354962 A ES 354962A ES 354962 A1 ES354962 A1 ES 354962A1
- Authority
- ES
- Spain
- Prior art keywords
- radicals
- acid
- preparation
- general formula
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of new amino ketones of the general formula I: **(See formula)** wherein the Hal radicals signify a chlorine or bromine atom; R1 signifies a hydrogen, chlorine or bromine atom; R2 and R3, which may be the same or different, mean hydrogen atoms, straight or branched hip alcohol radicals, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, dialkyl-aminoalcohyl, cycloalkyl, phenyl, benzyl, or adamantyl, or together with the nitrogen atom, a pyrrolidino, piperidino, hexamethyleneimino, piperazino, morpholino, or canfidino ring, optionally substituted by lower alcohol radicals or phenyl radicals; R4 and R5, which may be the same or different, signify hydrogen atoms, alcohol radicals with 1 to 3 carbon atoms or phenyl groups and n signifies the number 1, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized because for the preparation of a compound of the formula I, in which the number 1 represents, a compound of the general formula II is reacted **(See formula)** in which the radicals Hal, R1, R4 and R5 have the meanings indicated initially, with formaldehyde and an amine in the presence of acids or with their mineral acid salts of the general formula III **(See formula)** in which the radicals R2, R3 have the meanings indicated initially and, provided that the compounds obtained are in the form of their salts by addition of acid, they are transformed into their bases if desired, and/or converted to the bases free according to usual methods in acid addition salts physiologically compatible with an organic or inorganic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0034103 | 1967-06-15 | ||
| DET0036005 | 1968-03-06 | ||
| DET0036083 | 1968-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES354962A1 true ES354962A1 (en) | 1970-01-16 |
Family
ID=27213188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES354962A Expired ES354962A1 (en) | 1967-06-15 | 1968-06-12 | PROCEDURE FOR THE PREPARATION OF NEW AMINO-KETONES. |
Country Status (2)
| Country | Link |
|---|---|
| CH (5) | CH502986A (en) |
| ES (1) | ES354962A1 (en) |
-
1968
- 1968-06-11 CH CH1677770A patent/CH502986A/en not_active IP Right Cessation
- 1968-06-11 CH CH1677970A patent/CH520105A/en not_active IP Right Cessation
- 1968-06-11 CH CH1677670A patent/CH501588A/en not_active IP Right Cessation
- 1968-06-11 CH CH1677870A patent/CH501589A/en not_active IP Right Cessation
- 1968-06-11 CH CH867668A patent/CH502985A/en not_active IP Right Cessation
- 1968-06-12 ES ES354962A patent/ES354962A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH502986A (en) | 1971-02-15 |
| CH520105A (en) | 1972-03-15 |
| CH501588A (en) | 1971-01-15 |
| CH502985A (en) | 1971-02-15 |
| CH501589A (en) | 1971-01-15 |
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