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ES276647A1 - Procedure for the manufacture of terciary amines (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the manufacture of terciary amines (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES276647A1
ES276647A1 ES276647A ES276647A ES276647A1 ES 276647 A1 ES276647 A1 ES 276647A1 ES 276647 A ES276647 A ES 276647A ES 276647 A ES276647 A ES 276647A ES 276647 A1 ES276647 A1 ES 276647A1
Authority
ES
Spain
Prior art keywords
lower alkyl
alkyl group
formula
translation
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES276647A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES276647A1 publication Critical patent/ES276647A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Process for the manufacture of tertiary amines of the general formula ** (See formula) ** in which R2 is a lower alkyl group; R3 is hydrogen or a lower alkyl group; R5 is a lower alkyl group; R6 is a methoxy or hydroxy group; R7 is chlorine, fluorine, bromine or a nitro group; X is a divalent hydrocarbon radical with at least two carbon atoms whose valences are separated from each other by two carbon atoms; Y n represents an integer value of 1 to 3, inclusive, and its salts, characterized in that it comprises reacting an isoquinoline compound of the general formula ** (See formula) ** where R2, R3, x and n have the same meaning as stated above R1 is chlorine, fluorine or bromine, R4 is methoxy or benzyloxy and m is 0 or an integer value of 1 to 3, inclusive, with an alkylating agent, when converting the quaternary salt, by a Hofmann-degrading reaction, into a compound of the formula ** (See formula) ** in which the symbols R1 to R4, m, n and X have the meaning expressed above, while R5 is a lower alkyl group, hydrogenating the carbon double bond of the side chain, further debenzylating the radical R4 in the case said radical represents benzoyloxy, nitrating the hydrogenated product in the case that the symbol m represents 0 and, if desired, converting the tertiary amine into a salt. (Machine-translation by Google Translate, not legally binding)
ES276647A 1961-04-21 1962-04-19 Procedure for the manufacture of terciary amines (Machine-translation by Google Translate, not legally binding) Expired ES276647A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH471261A CH410007A (en) 1961-04-21 1961-04-21 Process for the preparation of tertiary amines

Publications (1)

Publication Number Publication Date
ES276647A1 true ES276647A1 (en) 1962-10-16

Family

ID=4281191

Family Applications (1)

Application Number Title Priority Date Filing Date
ES276647A Expired ES276647A1 (en) 1961-04-21 1962-04-19 Procedure for the manufacture of terciary amines (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
BE (1) BE616393A (en)
CH (1) CH410007A (en)
ES (1) ES276647A1 (en)
FR (1) FR1824M (en)
GB (1) GB969077A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001009101A1 (en) * 1999-07-29 2001-02-08 EGIS Gyógyszergyár Rt. Isoquinoline derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the active substance

Also Published As

Publication number Publication date
GB969077A (en) 1964-09-09
BE616393A (en) 1962-10-15
CH410007A (en) 1966-03-31
FR1824M (en) 1963-05-20

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